Genistein arrests cell cycle progression of A549 cells at the G 2/M phase and depolymerizes interphase microtubules through binding to a unique site of tubulin

Biochemistry

Volumn 49, Issue 8, 2010, Pages 1702-1712

  Mukherjee, Sumita ^a   Acharya, Bipul Ranjan ^a   Bhattacharyya, Bhabatarak ^b   Chakrabarti, Gopal ^a  

^a UNIVERSITY OF CALCUTTA   (India)

^b BOSE INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

A549 CELLS; ANTIPROLIFERATIVE ACTIVITIES; ASSOCIATION RATE CONSTANTS; CARCINOMA CELLS; CELL VIABILITY; CELL-CYCLE PROGRESSION; CONCENTRATION-DEPENDENT; DISSOCIATION CONSTANT; DOSE-DEPENDENT MANNER; GENISTEIN; IN-VITRO; ISOFLAVONES; MICROTUBULES; MITOTIC INDEX; MOLAR RATIO; TRYPTOPHAN FLUORESCENCE; VINBLASTINE; WESTERN BLOTS;

AMINO ACIDS; BINDING ENERGY; DISSOCIATION; FLOW CYTOMETRY; FLUORESCENCE; PURIFICATION; RATE CONSTANTS; STOICHIOMETRY;

EXPERIMENTS;

GENISTEIN; TUBULIN;

ARTICLE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL VIABILITY; CONTROLLED STUDY; DRUG INHIBITION; DRUG STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; G2 PHASE; GENISTEIN; HUMANS; INTERPHASE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULES; MOLECULAR STRUCTURE; PROTEIN BINDING; TUBULIN;

EID: 77749304742     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901760d     Document Type: Article

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