Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 9, 2010, Pages 4305-4310

  Potter, K J ^a   Abedini, A ^b   Marek, P ^c   Klimek, A M ^a   Butterworth, S ^a   Driscoll, M ^c   Baker, R ^d   Nilsson, M R ^e   Warnock, G L ^a   Oberholzer, J ^f   Bertera, S ^g   Trucco, M ^g   Korbutt, G S ^h   Fraser, P E ⁱ   Raleigh, D P ^c   Verchere, C B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b Columbia University ^*  (United States)

^c STONY BROOK UNIVERSITY   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e MCDANIEL COLLEGE   (United States)

^f UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^g CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^h UNIVERSITY OF ALBERTA   (Canada)

ⁱ UNIVERSITY OF TORONTO   (Canada)

Author keywords

Amylin; Diabetes; Islet transplantation; Pig; Xenotransplantation

Indexed keywords

AMYLIN; SYNTHETIC PEPTIDE; THIOFLAVINE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; CIRCULAR DICHROISM; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GRAFT SURVIVAL; HUMAN; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; IMMUNE DEFICIENCY; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET TRANSPLANTATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN BINDING; RAT; SPECIES DIFFERENCE; STREPTOZOCIN DIABETES; SWINE; TRANSMISSION ELECTRON MICROSCOPY; XENOTRANSPLANTATION;

AMINO ACID SEQUENCE; AMYLOID; ANIMALS; CIRCULAR DICHROISM; GRAFT REJECTION; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; SWINE;

MUS; SUIDAE; SUS;

EID: 77749297972     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909024107     Document Type: Article

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