Harmful delayed effects of exogenous isolation enzymes on isolated human islets: Relevance to clinical transplantation

American Journal of Transplantation

Volumn 5, Issue 11, 2005, Pages 2671-2681

  Balamurugan, A N ^a,b   He, Jing ^b   Guo, Fengli ^c   Stolz, Donna B ^c   Bertera, Suzanne ^b   Geng, Xuehui ^c   Ge, Xinhui ^b   Trucco, Massimo ^b   Bottino, Rita ^b  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Human islets; Insulin secretion; Islet isolation; Islet transplantation; Liberase

Indexed keywords

CD11B ANTIGEN; CELL ADHESION MOLECULE; COLLAGENASE; ENZYME; FLUORESCEIN ISOTHIOCYANATE; INSULIN; LIBERASE HI; PADGEM PROTEIN; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; LIBERASE; THERMOLYSIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ISOLATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOELECTRON MICROSCOPY; IN VITRO STUDY; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RELEASE; INTERNALIZATION; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BAGG ALBINO MOUSE; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; METABOLISM; MOUSE MUTANT; PANCREAS ISLET; PATHOLOGY; PHYSIOLOGY; SECRETION; ULTRASTRUCTURE;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; COLLAGENASES; HUMANS; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED BALB C; MICE, SCID; MICROSCOPY, CONFOCAL; MICROSCOPY, IMMUNOELECTRON; PROTO-ONCOGENE PROTEINS C-BCL-2; THERMOLYSIN;

EID: 33644793661     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2005.01078.x     Document Type: Article

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