Variability of CD3 membrane expression and T cell activation capacity

Cytometry Part B - Clinical Cytometry

Volumn 78, Issue 2, 2010, Pages 105-114

  El Hentati, Fatima Zahra ^a   Gruy, Frederic ^a   Iobagiu, Cristina ^b   Lambert, Claude ^a,b  

^a ECOLE DES MINES DE SAINT ETIENNE   (France)

^b UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

Author keywords

Activation kinetics; CD3; Membrane density; T cells

Indexed keywords

CD3 ANTIGEN; CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN;

ANALYTICAL PARAMETERS; ANTIGEN EXPRESSION; ARTICLE; CELL KINETICS; CLINICAL ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; IN VITRO STUDY; KIDNEY GRAFT; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD3; CELL MEMBRANE; COMPUTER SIMULATION; FLOW CYTOMETRY; HUMANS; KINETICS; LYMPHOCYTE ACTIVATION; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTE SUBSETS;

EID: 77749280258     PISSN: 15524949     EISSN: 15524957     Source Type: Journal    
DOI: 10.1002/cyto.b.20496     Document Type: Article

References (42)

1. Corr M, Slanetz AE, Boyd LF, Jelonek MT, Khilko S, al-Ramadi BK, Kim YS, Maher SE, Bothwell AL, Margulies DH. T cell receptor-MHC class I peptide interactions: Affinity, kinetics, and specificity. Science 1994;265:946-949.
2. Bachmann MF, Sebzda E, Kundig TM, Shahinian A, Speiser DE, Mak TW, Ohashi PS. T cell responses are governed by avidity and co-stimulatory thresholds. Eur J Immunol 1996;26:2017-2022.
3. Carreno LJ, Gonzalez PA, Kalergis AM. Modulation of T cell function by TCR/pMHC binding kinetics. Immunobiology 2006;211:47-64.
4. Madrenas J. Differential signalling by variant ligands of the T cell receptor and the kinetic model of T cell activation. Life Sci 1999;64:717-731.
5. Margulies DH. Interactions of TCRs with MHC-peptide complexes: A quantitative basis for mechanistic models. Curr Opin Immunol 1997;9:390-395.
6. Grakoui A, Bromley SK, Sumen C, Davis MM, Shaw AS, Allen PM, Dustin ML. The immunological synapse: A molecular machine controlling T cell activation. Science 1999;285:221-227.
7. Denkberg G, Cohen CJ, Reiter Y. Critical role for CD8 in binding of MHC tetramers to TCR: CD8 antibodies block specific binding of human tumor-specific MHC-peptide tetramers to TCR. J Immunol 2001;167:270-276.
8. Feito MJ, Ballester S, Diez-Orejas R, Ojeda G, Criado G, Portoles P, Rojo JM. CD4 dependence of activation threshold and TCR signalling in mouse T lymphocytes. Scand J Immunol 1997;45:166-174.
9. Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson IA, Teyton L. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 1996;384:577-581.
10. Lanzavecchia A, Lezzi G, Viola A. From TCR engagement to T cell activation: A kinetic view of T cell behavior. Cell 1999;96:1-4.
11. Gouaillard C, Huchenq-Champagne A, Arnaud J, Chen Cl CL, Rubin B. Evolution of T cell receptor (TCR) alpha beta heterodimer assembly with the CD3 complex. Eur J Immunol 2001;31:3798-3805.
12. Valitutti S, Muller S, Salio M, Lanzavecchia A. Degradation of T cell receptor (TCR)-CD3-zeta complexes after antigenic stimulation. J Exp Med 1997;185:1859-1864.
13. Favier B, Burroughs NJ, Wedderburn L, Valitutti S. TCR dynamics on the surface of living T cells. Int Immunol 2001;13:1525-1532.
14. Liu H, Rhodes M, Wiest DL, Vignali DA. On the dynamics of TCR:CD3 complex cell surface expression and downmodulation. Immunity 2000;13:665-675.
15. Labrecque N, Whitfield LS, Obst R, Waltzinger C, Benoist C, Mathis D. How much TCR does a T cell need? Immunity 2001;15:71-82.
16. Rabinowitz JD, Beeson C, Lyons DS, Davis MM, McConnell HM. Kinetic discrimination in T-cell activation. Proc Natl Acad Sci USA 1996;93:1401-1405.
17. Demotz S, Grey HM, Sette A. The minimal number of class II MHC-antigen complexes needed for T cell activation. Science 1990;249:1028-1030.
18. Hudrisier D, Kessler B, Valitutti S, Horvath C, Cerottini JC, Luescher IF. The efficiency of antigen recognition by CD8+ CTL clones is determined by the frequency of serial TCR engagement. J Immunol 1998;161:553-562.
19. Itoh Y, Hemmer B, Martin R, Germain RN. Serial TCR engagement and down-modulation by peptide: MHC molecule ligands: Relationship to the quality of individual TCR signaling events. J Immunol 1999;162:2073-2080.
20. Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 1995;375:148-151.
21. Kalergis AM, Boucheron N, Doucey MA, Palmieri E, Goyarts EC, Vegh Z, Luescher IF, Nathenson SG. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol 2001;2:229-234.
22. Rosette C, Werlen G, Daniels MA, Holman PO, Alam SM, Travers PJ, Gascoigne NR, Palmer E, Jameson SC. The impact of duration versus extent of TCR occupancy on T cell activation: A revision of the kinetic proofreading model. Immunity 2001;15:59-70.
23. Williams CB, Engle DL, Kersh GJ, Michael White J, Allen PM. A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex. J Exp Med 1999;189:1531-1544.
24. Bettens F, Kristensen F, Walker C, Schwulera U, Bonnard GD, de Weck AL. Lymphokine regulation of activated (G1) lymphocytes. II. Glucocorticoid and anti-Tac-induced inhibition of human T lymphocyte proliferation. J Immunol 1984;132:261-265.
25. Caruso A, Licenziati S, Corulli M, Canaris AD, De Francesco MA, Fiorentini S, Peroni L, Fallacara F, Dima F, Balsari A, Turano A. Flow cytometric analysis of activation markers on stimulated T cells and their correlation with cell proliferation. Cytometry 1997;27:71-76.
26. Bidot C, Gruy F, Haudin CS, El Hentati F, Guy B, Lambert C. Mathematical modeling of T-cell activation kinetic. J Comput Biol 2008;15:105-128.
27. Fallon EM, Lauffenburger DA. Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response. Biotechnol Prog 2000;16:905-916.
28. Lord GM, Lechler RI, George AJ. A kinetic differentiation model for the action of altered TCR ligands. Immunol Today 1999;20:33-39.
29. Sousa J, Carneiro J. A mathematical analysis of TCR serial triggering and down-regulation. Eur J Immunol 2000;30:3219-3227.
30. Lambert C, Genin C. CD3 bright lymphocyte population reveal gammadelta T cells. Cytometry Part B Clin Cytom 2004;61B:45-53.
31. Mullersman JE, White G, Tung KS. Differential staining of human alpha beta and gamma delta T cells by the fluorescein conjugate of an anti-CD3 monoclonal antibody. Clin Exp Immunol 1991;84:324-328.
32. Nicolas L, Monneret G, Debard AL, Blesius A, Gutowski MC, Salles G, Bienvenu J. Human gammadelta T cells express a higher TCR/CD3 complex density than alphabeta T cells. Clin Immunol 2001;98:358-363.
33. Thibault G, Bardos P. Compared TCR and CD3 epsilon expression on alpha beta and gamma delta T cells. Evidence for the association of two TCR heterodimers with three CD3 epsilon chains in the TCR/CD3 complex. J Immunol 1995;154:3814-3820.
34. Carding SR, Egan PJ. Gammadelta T cells: Functional plasticity and heterogeneity. Nat Rev Immunol 2002;2:336-345.
35. Hviid L, Akanmori BD, Loizon S, Kurtzhals JA, Ricke CH, Lim A, Koram KA, Nkrumah FK, Mercereau-Puijalon O, Behr C. High frequency of circulating gamma delta T cells with dominance of the v(delta)1 subset in a healthy population. Int Immunol 2000;12:797-805.
36. Lafarge X, Merville P, Cazin MC, Berge F, Potaux L, Moreau JF, Dechanet-Merville J. Cytomegalovirus infection in transplant recipients resolves when circulating gammadelta T lymphocytes expand, suggesting a protective antiviral role. J Infect Dis 2001;184:533-541.
37. Lambert C, Iobagiu C, Genin C. Enumeration of peripheral lymphocyte subsets using 6 vs. 4 color staining: A clinical evaluation of a new flowcytometer. Cytometry Part B Clin Cytom 2006;70B:29-38.
38. Sloot PM, Hoekstra AG, Figdor CG. Osmotic response of lymphocytes measured by means of forward light scattering: Theoretical considerations. Cytometry 1988;9:636-641.
39. Semyanov K, Zharinov A, Tarasov P, Yurkin M, Skribunov I, van Bockstaele D, Maltsev V. Optics of leukocytes. In: Hoekstra A, Maltsev V, Videen G, editors. Optics of Biological Particles. NATO Science Series 2007; p. 269-280.
40. McKeithan TW. Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci USA 1995;92:5042-5046.
41. Leytin V, Shapiro H, Novikov I, Radnay J. Flow cytometric analysis of the platelet surface area and surface density of glycoprotein IIb-IIIa of unactivated human platelets of various sizes. Biochem Biophys Res Commun 1996;226:94-100.
42. Mahalingam M. Analysis of surface density of expression of molecules by flow cytometry. Cytometry 1996;24:190.