Critical role for CD8 in binding of MHC tetramers to TCR: CD8 antibodies block specific binding of human tumor-specific MHC-peptide tetramers to TCR

Journal of Immunology

Volumn 167, Issue 1, 2001, Pages 270-276

  Denkberg, G ^a   Cohen, C J ^a   Reiter, Y ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; T LYMPHOCYTE RECEPTOR;

ARTICLE; DOWN REGULATION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTERNALIZATION; LYMPHOCYTE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; RECEPTOR BINDING; T LYMPHOCYTE;

EID: 0035399799     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.1.270     Document Type: Article

References (30)

1. The T cell receptor as a mulicomponent signaling machine: CD4/CD8 coreceptors and CD45 in T cell activation
2. Role of CD4 and CD8 in T cell activation and differentiation
3. CD4 and CD8: Modulators of TCR recognition of Ag and of immune responses?
4. A kinase-independent function of Lck in potentiating Ag-specific T cell activation
5. TCR antagonists and partial agonists
6. CD8 modulation of T cell Ag receptor-ligand interactions on living cytotoxic T lymphocytes
7. CD8 enhances formation of stable TCR/MHC class I molecule complexes
8. Autologous rat myelin basic protein is a partial agonist that is converted into a full antagonist upon blockade of CD4: Evidence for the integration of efficacious and nonefficacious signals during T cell Ag recognition
9. Endogenous altered peptide ligands can affect peripheral T cell responses
10. CD4 augments the response of a T cell to agonist but not to antagonist ligands
11. The efficiency of CD4 recruitment to ligand-engaged TCR controls the agonist/partial agonist properties of peptide-MHC molecule ligands
12. Variant TCR ligands: New insights into the molecular basis of Ag-dependent signal transduction and T cell activation
13. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: The role of CD4 coreceptor
14. Detection of Ag-specific T cells with multivalent soluble class II MHC covalent peptide complexes
15. Initiation of signal transduction through the TCR requires the multivalent engagement of peptide/MHC ligands
16. TCR and coreceptor CD8αα bind peptide-MHC independently and with distinct kinetics
17. Activated CD8 binding to class I protein mediated by the TCR results in signaling
18. Critical role for CD8 in TCR binding and activation by peptide/major histocompatibility complex multimers
19. Phenotypic analysis of Ag-specific T lymphocytes
20. Counting Ag-specific CD8 T cells: A reevaluation of bystander activation during viral infection
21. Characterization of circulating T cells specific for tumor-associated Ags in melanoma patients
22. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA
23. High frequency of skin-homing melanocyte-specific cytotoxic T lymphocytes in autoimmune vitiligo
24. Cutting edge: Rapid cloning of tumor-specific CTL suitable for adoptive immunotherapy of melanoma
25. Recombinant human single-chain MHC-peptide complexes made from E. coli by in vitro refolding: Functional single-chain MHC-peptide complexes and tetramers with tumor associated Ags
26. T cell clones from melanoma patients immunized against an anchor-modified gp100 peptide display discordant effector phenotypes
27. Establishment of gp100 and MART-1/Melan-A-specific cytotoxic T lymphocyte clones using in vitro immunization against preselected highly immunogenic melanoma cell clones
28. Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent
29. + T cells
30. Competition of peptide-MHC class I tetrameric complexes with anti-CD3 provides evidence for specificity of peptide binding to the TCR complex