Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain

Experimental Neurology

Volumn 222, Issue 1, 2010, Pages 70-85

  Kornum, Birgitte R ^a   Stott, Simon R W ^b   Mattsson, Bengt ^b   Wisman, Liselijn ^b   Ettrup, Anders ^a   Hermening, Stephan ^b,c   Knudsen, Gitte M ^a   Kirik, Deniz ^b  

^a Rigshospitalet   (Denmark)

^b LUND UNIVERSITY   (Sweden)

^c Amsterdam Molecular Therapeutics   (Netherlands)

Author keywords

Adeno associated viral vectors; Confocal microscopy; Cortex; In vivo gene transfer; Neonate; Pig; Rat; Stereology; Striatum; Swine

Indexed keywords

GREEN FLUORESCENT PROTEIN; NEURON SPECIFIC NUCLEAR PROTEIN; PARVOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; CONTROLLED STUDY; CORPUS STRIATUM; FEMALE; FOREBRAIN; FRONTAL CORTEX; GENE EXPRESSION; GENETIC MANIPULATION; HIPPOCAMPUS; MINIPIG; NEOCORTEX; NEWBORN; NONHUMAN; OLFACTORY BULB; PRIORITY JOURNAL; RAT; SEPTUM PELLUCIDUM; TISSUE DISTRIBUTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT;

ANIMALS; ANIMALS, NEWBORN; CELL LINE, TRANSFORMED; CORPUS STRIATUM; DEPENDOVIRUS; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NEURONS; PHOSPHOPYRUVATE HYDRATASE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; SWINE; TIME FACTORS; TRANSDUCTION, GENETIC; TRANSFECTION;

EID: 77649338568     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2009.12.009     Document Type: Article

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