Hippocampal kindling epileptogenesis upregulates neuronal cyclooxygenase-2 expression in neocortex

Experimental Neurology

Volumn 179, Issue 2, 2003, Pages 167-175

  Tu, Bin ^a   Bazan, Nicolas G ^a  

^a LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Afterdischarge threshold; Cyclooxygenase 2; Cytosolic phospholipase A2; Epilepsy; Epileptogenesis; Kindling

Indexed keywords

ARACHIDONIC ACID; BRAIN ENZYME; CYCLOOXYGENASE 2; DIMETHYL SULFOXIDE; NIMESULIDE; PHOSPHOLIPASE A2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN DEPTH STIMULATION; BRAIN INJURY; BRAIN NERVE CELL; CATALYSIS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; EPILEPTOGENESIS; GENETIC CODE; HIPPOCAMPUS; KINDLING; MALE; MOLECULAR BIOLOGY; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SYNAPSE; UPREGULATION;

ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOSOL; DISEASE MODELS, ANIMAL; ENZYME INDUCTION; EPILEPSY; HIPPOCAMPUS; ISOENZYMES; KINDLING, NEUROLOGIC; MALE; NEOCORTEX; NEURONS; PHOSPHOLIPASES A; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; RNA, MESSENGER; SULFONAMIDES; UP-REGULATION;

EID: 0037331287     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4886(02)00019-5     Document Type: Article

References (27)

1. Adams J., Collaco-Moraes Y., de Belleroche J. Cyclooxygenase-2 induction in cerebral cortex an intracellular response to synaptic excitation . J. Neurochem. 66:1996;6-13.
2. Bazan N.G. Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain. Biochim. Biophys. Act. 218:1970;1-10.
3. Bazan N.G. Changes in free fatty acids of brain by drug-induced convulsions, electroshock and anaesthesia. J. Neurochem. 18:1971;1379-1385.
4. Bazan N.G., Rakowski H. Increased levels of brain free fatty acids after electroconvulsive shock. Life. Sci. 9:1970;501-507.
5. Bazan N.G., Birkle D.L., Tang W., Reddy T.S. The accumulation of free arachidonic acid, diacylglycerols, prostaglandins, and lipoxygenase reaction products in the brain during experimental epilepsy. Adv. Neurol. 44:1986;879-902.
6. Bazan N.G., Packard M.G., Teather L., Allan G. Bioactive lipids in excitatory neurotransmission and neuronal plasticity. Neurochem. Int. 30:1997;225-231.
7. Birkle D.L., Bazan N.G. Effect of bicuculline-induced status epilepticus on prostaglandins and hydroxyeicosatetraenoic acids in rat brain subcellular fractions. J. Neurochem. 48:1987;1768-1778.
8. Dash P.K., Mach S.A., Moore A.N. Regional expression and role of cyclooxygenase-2 following experimental traumatic brain injury. J. Neurotraum. 17:2000;69-81.
9. Freeman J.M., Vining E.P.G., Pillas D.J., Pyzik P.L., Casey J.C., Kelly M.T. The efficacy of the ketogenic diet-1998 a prospective evaluation of intervention in 150 children. Pediatrics. 102:1998;1358-1363.
10. Goddard G.V., McIntyre D.C., Leech C.K. A permanent change in brain function resulting from daily electrical stimulation. Exp. Neurol. 25:1969;295-330.
11. Ho L., Osaka H., Aisen P.S., Pasinetti G.M. Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death. J. Neuroimmunol. 89:1998;142-149.
12. Kajiwara K., Nagawawa H., Shimizu-Nishikawa S., Ookuri T., Kimura M., Sugaya E. Molecular characterization of seizure-related genes isolated by differential screening. Biochem. Biophys. Res. Commun. 219:1996;795-799.
13. Kaufmann W.E., Worley P.F., Pegg J., Bremer M., Isakson P. COX-2, a synaptically induced enzyme, is expressed by excitatory neurons as postsynaptic sites in rat cerebral cortex. Proc. Natl. Acad. Sci. USA. 93:1996;2317-2321.
14. Loscher W. Pharmacology of glutamate receptor antagonist in the kindling model of epilepsy. Progr. Neurobiol. 54:1998;721-741.
15. Lothman E.W., Williamson J.M. Rapid kindling with recurrent hippocampal seizures. Epilepsy Res. 14:1993;209-220.
16. Marcheselli V.L., Bazan N.G. Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. J. Biol. Chem. 271:1996;24794-24799.
17. Nakayama M., Uchimura K., Zhu R.L., Nagayama T., Rose M.E., Stetler R.A., Isakson P.C., Chen J., Graham S.H. Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia. Proc. Natl. Acad. Sci. USA. 95:1998;10954-10959.
18. Racine R.J. Modification of seizure activity by electrical stimulation I. After-discharge threshold. Electroenceph. Clin. Neurophysiol. 32:1972;269-279.
19. Racine R.J. Modification of seizure activity by electrical stimulation II Motor seizure . Electroenceph. Clin. Neurophysol. 32:1972;281-294.
20. Sandhya T.L., Ong W.Y., Horrocks L.A., Farooqui A.A.A. Light and electron microscopic study of cytoplasmic phospholipases A2 and cyclooxygenase-2 in the hippocampus after kainate lesions. Brain Res. 788:1998;223-231.
21. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA. 91:1994;12013-12017.
22. Subbaramaiah K., Zakim D., Weksler B.B., Dannenberg A.J. Inhibition of cyclooxygenase a novel approach to cancer prevention . Proc. Soc. Exp. Biol. Med. 216:1997;201-210.
23. Tavares I.A., Bishai P.M., Bennett A. Activity of nimesulide on constitutive and inducible cyclooxygenases. Arzneimittel-Forschun. 45:1995;1093-1095.
24. Tocco G., Freire-Moar J., Schreiber S.S., Sakhi S.H., Aisen P.S., Pasinetti G.M. Maturational regulation and regional induction of cyclooxygenase-2 in rat brain implications for Alzheimer's disease . Exp. Neurol. 144:1997;339-349.
25. Visioli F., Rodriguez de Turco E.B., Kreisman N.R., Bazan N.G. Membrane lipid degradation is related to interictal cortical activity in a series of seizures. Metab. Brain Dis. 9:1994;161-170.
26. Wilingale H.L., Gradiner N.J., McLynont N., Gilblett S., Grubb B.D. Prostanoids synthesized by cyclo-oxygenase isoforms in rat spinal cord and their contribution to the development of neuronal hyperexcitability. Br. J. Pharmacol. 122:1997;1593-1604.
27. Yamagata K., Andreasson K.I., Kaufmann W.E., Barnes C.A., Worley P.F. Expression of a mitogen-inducible cyclooxygenase in brain neurons regulation by synaptic activity and glucocorticoids . Neuron. 11:1993;371-386.