-
1
-
-
0042844744
-
Natural products as sources of new drugs over the period 1981-2002
-
Newman, D. J., Cragg, G. M., and Snader, K. M., Natural products as sources of new drugs over the period 1981-2002, J. Nat. Prod., 66, 1022, 2003.
-
(2003)
J. Nat. Prod.
, vol.66
, pp. 1022
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
2
-
-
1442310087
-
A tale of two tumor targets: Topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy
-
Cragg, G. M. and Newman, D. J., A tale of two tumor targets: Topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy, J. Nat. Prod., 67, 232, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 232
-
-
Cragg, G.M.1
Newman, D.J.2
-
3
-
-
0034642532
-
Cyclin-dependent kinase inhibitors: Useful targets in cell cycle regulation
-
Sielecki, T. et al., Cyclin-dependent kinase inhibitors: Useful targets in cell cycle regulation, J. Med. Chem., 43, 1, 2000.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1
-
-
Sielecki, T.1
-
4
-
-
0028176485
-
Potent inhibition of cdc2 kinase activity by the flavanoid, l86-8275
-
Losiewicz, M. D. et al., Potent inhibition of cdc2 kinase activity by the flavanoid, l86-8275, Biochem. Biophys. Res. Comm., 201, 589, 1994.
-
(1994)
Biochem. Biophys. Res. Comm.
, vol.201
, pp. 589
-
-
Losiewicz, M.D.1
-
5
-
-
0028917771
-
Anti-tumoral activity of flavone l 86-8275
-
Czech, J. et al., Anti-tumoral activity of flavone l 86-8275, Int. J. Oncol., 6, 31, 1995.
-
(1995)
Int. J. Oncol.
, vol.6
, pp. 31
-
-
Czech, J.1
-
6
-
-
0042303844
-
Cyclin-dependent kinase inhibitors
-
Dai, Y. and Grant, S., Cyclin-dependent kinase inhibitors, Curr. Opin. Pharmacol., 3, 362, 2003.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 362
-
-
Dai, Y.1
Grant, S.2
-
7
-
-
0037392444
-
Issues and progress with protein kinase inhibitors for cancer treatment
-
Dancey, J. and Sausville, E. A., Issues and progress with protein kinase inhibitors for cancer treatment, Nature Rev. Drug Disc., 2, 296, 2003.
-
(2003)
Nature Rev. Drug Disc.
, vol.2
, pp. 296
-
-
Dancey, J.1
Sausville, E.A.2
-
8
-
-
0242708738
-
Small-molecule cyclin-dependent kinase modulators
-
Senderowicz, A. M., Small-molecule cyclin-dependent kinase modulators, Oncogene, 22, 6609, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 6609
-
-
Senderowicz, A.M.1
-
9
-
-
0037665145
-
Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials
-
Meijer, L. and Raymond, E., Roscovitine and other purines as kinase inhibitors. From starfish oocytes to clinical trials, Acc. Chem. Res., 36, 417, 2003.
-
(2003)
Acc. Chem. Res.
, vol.36
, pp. 417
-
-
Meijer, L.1
Raymond, E.2
-
10
-
-
0001052186
-
Inhibitors of two enzymes which metabolize cytokinins
-
Parker, C. W., Entsch, B., and Letham, D., Inhibitors of two enzymes which metabolize cytokinins, Phytochemistry, 25, 303, 1986.
-
(1986)
Phytochemistry
, vol.25
, pp. 303
-
-
Parker, C.W.1
Entsch, B.2
Letham, D.3
-
11
-
-
0033150476
-
Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors
-
Chang, Y. T. et al., Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors, Chem. Biol., 6, 361, 1999.
-
(1999)
Chem. Biol.
, vol.6
, pp. 361
-
-
Chang, Y.T.1
-
12
-
-
0024239320
-
Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists
-
Evans, B. E. et al., Methods for drug discovery: Development of potent, selective, orally effective cholecystokinin antagonists, J. Med. Chem., 31, 2235, 1988.
-
(1988)
J. Med. Chem.
, vol.31
, pp. 2235
-
-
Evans, B.E.1
-
13
-
-
0033606988
-
New 4-point pharmacophore method for molecular similarity and diversity applications: Overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged sub-structures
-
Mason, J. S. et al., New 4-point pharmacophore method for molecular similarity and diversity applications: Overview of the method and applications, including a novel approach to the design of combinatorial libraries containing privileged sub-structures, J. Med. Chem., 42, 3251, 1999.
-
(1999)
J. Med. Chem.
, vol.42
, pp. 3251
-
-
Mason, J.S.1
-
14
-
-
35448950092
-
Privileged structures — an update
-
Doherty, A. M., Ed., Academic Press, San Diego, CA
-
Patchett, A. A. and Nargund, R. P., Privileged structures — an update, in Ann. Repts. Med. Chem., Doherty, A. M., Ed., Academic Press, San Diego, CA, 2000, Vol. 35, pp 289–298.
-
(2000)
Ann. Repts. Med. Chem
, vol.35
, pp. 289-298
-
-
Patchett, A.A.1
Nargund, R.P.2
-
15
-
-
0034684250
-
Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans
-
Nicolaou, K. C. et al., Natural product-like combinatorial libraries based on privileged structures. 1. General principles and solid-phase synthesis of benzopyrans, J. Am. Chem. Soc., 122, 9939, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9939
-
-
Nicolaou, K.C.1
-
16
-
-
0034684225
-
Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using nanokans and optical encoding
-
Nicolaou, K. C. et al., Natural product-like combinatorial libraries based on privileged structures. 2. Construction of a 10,000-membered benzopyran library by directed split-and-pool chemistry using nanokans and optical encoding, J. Am. Chem. Soc., 122, 9954, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9954
-
-
Nicolaou, K.C.1
-
17
-
-
0034684186
-
Natural product-like combinatorial libraries based on privileged structures. 3. The “libraries from libraries” principle for diversity enhancement of bezopyran libraries
-
Nicolaou, K. C. et al., Natural product-like combinatorial libraries based on privileged structures. 3. The “libraries from libraries” principle for diversity enhancement of bezopyran libraries, J. Am. Chem. Soc., 122, 9968, 2000.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 9968
-
-
Nicolaou, K.C.1
-
18
-
-
0000853567
-
Polymer-supported selenium reagents for organic synthesis
-
Nicolaou, K. C. et al., Polymer-supported selenium reagents for organic synthesis, Chem. Comm., 1947, 1998.
-
(1998)
Chem. Comm
, vol.1947
-
-
Nicolaou, K.C.1
-
19
-
-
0034526302
-
Combinatorial synthesis of novel and potent inhibitors of NADH: Ubiquinone oxidoreductase
-
Nicolaou, K. C. et al., Combinatorial synthesis of novel and potent inhibitors of NADH: Ubiquinone oxidoreductase, Chem. Biol., 7, 979, 2000.
-
(2000)
Chem. Biol.
, vol.7
, pp. 979
-
-
Nicolaou, K.C.1
-
20
-
-
0035382954
-
Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries
-
Nicolaou, K. C. et al., Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries, ChemBioChem, 460, 2001.
-
(2001)
Chembiochem
, pp. 460
-
-
Nicolaou, K.C.1
-
21
-
-
0038274333
-
Discovery and optimization of non-steroidal FXR agonists from natural productlike libraries
-
Nicolaou, K. C. et al., Discovery and optimization of non-steroidal FXR agonists from natural productlike libraries, Org. Biomol. Chem., 1, 908, 2003.
-
(2003)
Org. Biomol. Chem.
, vol.1
, pp. 908
-
-
Nicolaou, K.C.1
-
22
-
-
0037738531
-
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
-
Downes, M. et al., A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR, Mol. Cell, 11, 1079, 2003.
-
(2003)
Mol. Cell
, vol.11
, pp. 1079
-
-
Downes, M.1
-
23
-
-
1442310075
-
Natural products from endophytic microorganisms
-
Strobel, G. et al., Natural products from endophytic microorganisms, J. Nat. Prod., 67, 257, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 257
-
-
Strobel, G.1
-
24
-
-
1442285458
-
Antitumor activity of bruceantin. An old drug with new promise
-
Cuendet, M. and Pezzuto, J. M., Antitumor activity of bruceantin. An old drug with new promise, J. Nat. Prod., 67, 269, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 269
-
-
Cuendet, M.1
Pezzuto, J.M.2
-
25
-
-
1842425398
-
Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoalean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferatorsactivated receptor-γ expression, Gynecol
-
Melichar, B. et al., Growth-inhibitory effect of a novel synthetic triterpenoid, 2-cyano-3,12-dioxoalean-1,9-dien-28-oic acid, on ovarian carcinoma cell lines not dependent on peroxisome proliferatorsactivated receptor-γ expression, Gynecol. Oncol., 93, 149, 2004.
-
(2004)
Oncol.
, vol.93
, pp. 149
-
-
Melichar, B.1
-
26
-
-
0344406759
-
Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer
-
Li, Y. et al., Selective killing of cancer cells by β-lapachone: Direct checkpoint activation as a strategy against cancer, Proc. Natl. Acad. Sci., USA, 100, 2674, 2003.
-
(2003)
Proc. Natl. Acad. Sci., USA
, vol.100
, pp. 2674
-
-
Li, Y.1
-
27
-
-
1542405235
-
β-lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-κB in human colon cancer HCT-116 cells
-
Choi, B. T., Cheong, J., and Choi, Y. H., β-lapachone-induced apoptosis is associated with activation of caspase-3 and inactivation of NF-κB in human colon cancer HCT-116 cells, Anti-Cancer Drugs, 14, 845, 2003.
-
(2003)
Anti-Cancer Drugs
, vol.14
, pp. 845
-
-
Choi, B.T.1
Cheong, J.2
Choi, Y.H.3
-
28
-
-
3042518847
-
Recent studies on natural products as anticancer agents
-
Ravelo, A. G. et al., Recent studies on natural products as anticancer agents, Curr. Topics Med. Chem., 4, 241, 2004.
-
(2004)
Curr. Topics Med. Chem.
, vol.4
, pp. 241
-
-
Ravelo, A.G.1
-
29
-
-
0036558479
-
Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics
-
Scott, J. D. and Williams, R. M., Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics, Chem. Rev., 102, 1669, 2002.
-
(2002)
Chem. Rev.
, vol.102
, pp. 1669
-
-
Scott, J.D.1
Williams, R.M.2
-
30
-
-
0041921146
-
Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp
-
Oku, N. et al., Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp., J. Nat. Prod., 66, 1136, 2003.
-
(2003)
J. Nat. Prod.
, vol.66
, pp. 1136
-
-
Oku, N.1
-
31
-
-
0034622873
-
A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris
-
Fontana, A. et al., A new antitumor isoquinoline alkaloid from the marine nudibranch Jorunna funebris, Tetrahedron, 56, 7305, 2000.
-
(2000)
Tetrahedron
, vol.56
, pp. 7305
-
-
Fontana, A.1
-
32
-
-
0041629457
-
Intracellular bacteria associated with the ascidian Ecteinascidia turbinata: Phylogenetic and in situ hybridization analysis
-
Moss, C. et al., Intracellular bacteria associated with the ascidian Ecteinascidia turbinata: Phylogenetic and in situ hybridization analysis, Mar. Biol., 143, 99, 2003.
-
(2003)
Mar. Biol.
, vol.143
, pp. 99
-
-
Moss, C.1
-
33
-
-
0022534636
-
Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity
-
Zabriskie, T. M. et al., Jaspamide, a modified peptide from a Jaspis sponge, with insecticidal and antifungal activity, J. Am. Chem. Soc., 108, 3123, 1986.
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 3123
-
-
Zabriskie, T.M.1
-
34
-
-
4243562790
-
Jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis sp
-
Crews, P., Manes, L. V., and Boehler, M., Jasplakinolide, a cyclodepsipeptide from the marine sponge, Jaspis sp., Tetrahedron Lett., 27, 2797, 1986.
-
(1986)
Tetrahedron Lett.
, vol.27
, pp. 2797
-
-
Crews, P.1
Manes, L.V.2
Boehler, M.3
-
35
-
-
0033058149
-
New jaspamide derivatives from the marine sponge Jaspis splendans collected in Vanuatu
-
Zampella, A. et al., New jaspamide derivatives from the marine sponge Jaspis splendans collected in Vanuatu, J. Nat. Prod., 62, 332, 1999.
-
(1999)
J. Nat. Prod.
, vol.62
, pp. 332
-
-
Zampella, A.1
-
36
-
-
0028244823
-
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to f-actin
-
Bubb, M. R. et al., Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to f-actin, J. Biol. Chem., 269, 14869, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14869
-
-
Bubb, M.R.1
-
37
-
-
0028966114
-
Jasplakinolide’s inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton
-
Senderowicz, A. M. et al., Jasplakinolide’s inhibition of the growth of prostate carcinoma cells in vitro with disruption of the actin cytoskeleton, J. Nat. Can. Inst., 87, 46, 1995.
-
(1995)
J. Nat. Can. Inst.
, vol.87
, pp. 46
-
-
Senderowicz, A.M.1
-
38
-
-
0023199134
-
Stereostructures of geodiamolides A and B, novel cyclodepsipeptides from the marine sponge Geodia sp
-
Chan, W. R. et al., Stereostructures of geodiamolides A and B, novel cyclodepsipeptides from the marine sponge Geodia sp., J. Org. Chem., 52, 3091, 1987.
-
(1987)
J. Org. Chem.
, vol.52
, pp. 3091
-
-
Chan, W.R.1
-
39
-
-
0032859532
-
New geodiamolides from the sponge Cymbastela sp. Collected in Papua New Guinea
-
Coleman, J. E., Van Soest, R. W. M., and Andersen, R. J., New geodiamolides from the sponge Cymbastela sp. collected in Papua New Guinea, J. Nat. Prod., 62, 1137, 1999.
-
(1999)
J. Nat. Prod.
, vol.62
, pp. 1137
-
-
Coleman, J.E.1
Van Soest, R.W.M.2
Andersen, R.J.3
-
40
-
-
0028971654
-
Chondramides A-D, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (Myxobacteria). Production, physico-chemical and biological properties
-
Kunze, B. et al., Chondramides A-D, new antifungal and cytostatic depsipeptides from Chondromyces crocatus (myxobacteria). Production, physico-chemical and biological properties, J. Antibiotics, 48, 1262, 1995.
-
(1995)
J. Antibiotics
, vol.48
, pp. 1262
-
-
Kunze, B.1
-
41
-
-
0032556187
-
The chondramides: Cytostatic agents from myxobacteria acting on the actin cytoskeleton
-
Sasse, F. et al., The chondramides: Cytostatic agents from myxobacteria acting on the actin cytoskeleton, J. Nat. Can. Inst., 90, 1559, 1998.
-
(1998)
J. Nat. Can. Inst.
, vol.90
, pp. 1559
-
-
Sasse, F.1
-
42
-
-
0023726527
-
Mycalamide A, an antiviral compound from a New Zealand sponge of the genus Mycale
-
Perry, N. B. et al., Mycalamide A, an antiviral compound from a New Zealand sponge of the genus Mycale, J. Am. Chem. Soc., 110, 4850, 1988.
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 4850
-
-
Perry, N.B.1
-
43
-
-
1242296319
-
Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa
-
Pettit, G. R. et al., Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa, J. Med. Chem., 47, 1149, 2004.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 1149
-
-
Pettit, G.R.1
-
44
-
-
3042706094
-
Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family
-
Cichewicz, R. H., Valeriote, F. A., and Crews, P., Psymberin, a potent sponge-derived cytotoxin from Psammocinia distantly related to the pederin family, Org. Lett., 6, 1951, 2004.
-
(2004)
Org. Lett.
, vol.6
, pp. 1951
-
-
Cichewicz, R.H.1
Valeriote, F.A.2
Crews, P.3
-
45
-
-
0345868584
-
A formal synthesis of (-)-mycalamide A
-
Trost, B. M., Yang, H., and Probst, G. D., A formal synthesis of (-)-mycalamide A, J. Am. Chem. Soc., 126, 48, 2004.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 48
-
-
Trost, B.M.1
Yang, H.2
Probst, G.D.3
-
46
-
-
0036009127
-
Molecular identification of an endosymbiotic bacterium associated with pederin biosynthesis in Paederus sabaeus (Coleoptera: Staphylinidae)
-
Kellner, R. L. L., Molecular identification of an endosymbiotic bacterium associated with pederin biosynthesis in Paederus sabaeus (coleoptera: Staphylinidae), Insect Biochem. Mol. Biol., 32, 389, 2002.
-
(2002)
Insect Biochem. Mol. Biol.
, vol.32
, pp. 389
-
-
Kellner, R.L.L.1
-
47
-
-
10744231115
-
Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles
-
Piel, J., Hofer, I., and Hui, D., Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles, J. Bact., 186, 1280, 2004.
-
(2004)
J. Bact.
, vol.186
, pp. 1280
-
-
Piel, J.1
Hofer, I.2
Hui, D.3
-
48
-
-
0037195174
-
A polyketide synthase-peptide synthase gene cluster from an uncultured bacterial symbiont of Paederus beetles
-
Piel, J., A polyketide synthase-peptide synthase gene cluster from an uncultured bacterial symbiont of Paederus beetles, Proc. Natl. Acad. Sci. USA, 99, 14002, 2002.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14002
-
-
Piel, J.1
-
49
-
-
84892190009
-
Biotransformation and biosynthetic studies of the manzamine alkaloids
-
Abs S14
-
Kasanah, N. et al., Biotransformation and biosynthetic studies of the manzamine alkaloids, Abs. Pap. 6th Int. Mar. Biotech. Conf., Abs S14, 2003.
-
(2003)
Abs. Pap. 6Th Int. Mar. Biotech. Conf
-
-
Kasanah, N.1
-
50
-
-
84892326794
-
Solving limited supplies of marine pharmaceuticals through the rational and highthroughput modification of high yielding marine natural producer scaffolds
-
Abs. S14
-
Yousaf, M. et al., Solving limited supplies of marine pharmaceuticals through the rational and highthroughput modification of high yielding marine natural producer scaffolds, Abs. Pap. 6th Int. Mar. Biotech. Conf., Abs. S14, 2003.
-
(2003)
Abs. Pap. 6Th Int. Mar. Biotech. Conf
-
-
Yousaf, M.1
-
51
-
-
0036795821
-
Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments
-
Mincer, T. J. et al., Widespread and persistent populations of a major new marine actinomycete taxon in ocean sediments, Appl. Environ. Microbiol., 68, 5005, 2002.
-
(2002)
Appl. Environ. Microbiol.
, vol.68
, pp. 5005
-
-
Mincer, T.J.1
-
52
-
-
0037455147
-
Salinosporamide A; a highly cytotoxic proteosome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
-
Feling, R. H. et al., Salinosporamide A; a highly cytotoxic proteosome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora, Angew. Chem. Int. Ed., 42, 355, 2003.
-
(2003)
Angew. Chem. Int. Ed
, vol.42
, pp. 355
-
-
Feling, R.H.1
-
53
-
-
0026065338
-
Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells
-
Omura, S. et al., Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells, J. Antibiot., 44, 113, 1991.
-
(1991)
J. Antibiot.
, vol.44
, pp. 113
-
-
Omura, S.1
-
54
-
-
0033022744
-
Total synthesis and biological activity of lactacystin, omuralide and analogs
-
Corey, E. J. and Li, W. D., Total synthesis and biological activity of lactacystin, omuralide and analogs, Chem. Pharm. Bull., 47, 1, 1999.
-
(1999)
Chem. Pharm. Bull.
, vol.47
, pp. 1
-
-
Corey, E.J.1
Li, W.D.2
-
55
-
-
0029033981
-
Inhibition of proteosome activities and subunit-specific amino-terminal threonine modification by lactacystin
-
Fenteany, G. et al., Inhibition of proteosome activities and subunit-specific amino-terminal threonine modification by lactacystin, Science, 268, 726, 1995.
-
(1995)
Science
, vol.268
, pp. 726
-
-
Fenteany, G.1
-
56
-
-
0034864799
-
Proteosome inhibitors: From research tools to drug candidates
-
Kisselev, A. F. and Goldberg, A. L., Proteosome inhibitors: From research tools to drug candidates, Chem. Biol., 8, 739, 2001.
-
(2001)
Chem. Biol.
, vol.8
, pp. 739
-
-
Kisselev, A.F.1
Goldberg, A.L.2
-
57
-
-
2442720189
-
A simple stereocontrolled synthesis of salinosporamide A
-
Reddy, L. J., Saravanan, P., and Corey, E. J., A simple stereocontrolled synthesis of salinosporamide A, J. Am. Chem. Soc., 126, 6230, 2004.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 6230
-
-
Reddy, L.J.1
Saravanan, P.2
Corey, E.J.3
-
58
-
-
4344650390
-
Marine natural products and related compounds in clinical and advanced preclinical trials
-
Newman, D. J. and Cragg, G. M., Marine natural products and related compounds in clinical and advanced preclinical trials, J. Nat. Prod., 67, 1216, 2004.
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1216
-
-
Newman, D.J.1
Cragg, G.M.2
-
59
-
-
0023236004
-
Brominated tyrosine metabolites from an unidentified sponge
-
Arabshahi, L. and Schmitz, F. J., Brominated tyrosine metabolites from an unidentified sponge, J. Org. Chem., 52, 3584, 1987.
-
(1987)
J. Org. Chem.
, vol.52
, pp. 3584
-
-
Arabshahi, L.1
Schmitz, F.J.2
-
60
-
-
0000055673
-
Phenolic constituents of Psammaplysilla
-
Quinoa, E. and Crews, P., Phenolic constituents of Psammaplysilla, Tet. Lett., 28, 3229, 1987.
-
(1987)
Tet. Lett.
, vol.28
, pp. 3229
-
-
Quinoa, E.1
Crews, P.2
-
61
-
-
0038627550
-
Psammaplins from the sponge Pseudoceritina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase
-
Pina, I. C. et al., Psammaplins from the sponge Pseudoceritina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase, J. Org. Chem., 68, 3866, 2003.
-
(2003)
J. Org. Chem.
, vol.68
, pp. 3866
-
-
Pina, I.C.1
-
62
-
-
10744229917
-
N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: Discovery of (2e)-n-hydroxy-3-[4-[[2-hydroxyethyl)[2-(1h-indol-3-yl)ethyl]amino]methyl]-phenyl]-2-propenamide (NVP-LAQ824)
-
Remiszewski, S. W. et al., N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: Discovery of (2e)-n-hydroxy-3-[4-[[2-hydroxyethyl[2-(1h-indol-3-yl)ethyl]aminomethyl]-phenyl]-2-propenamide (NVP-LAQ824), J. Med. Chem., 46, 4609, 2003.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4609
-
-
Remiszewski, S.W.1
-
63
-
-
0141953928
-
The discovery of NVP-LAQ824: From concept to clinic
-
Remiszewski, S. W., The discovery of NVP-LAQ824: From concept to clinic, Curr. Med. Chem., 10, 2393, 2003.
-
(2003)
Curr. Med. Chem
, vol.10
, pp. 2393
-
-
Remiszewski, S.W.1
-
64
-
-
0141593496
-
NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma
-
Catley, L. et al., NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma, Blood, 102, 2615, 2003.
-
(2003)
Blood
, vol.102
, pp. 2615
-
-
Catley, L.1
-
65
-
-
0025014776
-
Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells
-
Yoshida, M. et al., Effects of leptomycin B on the cell cycle of fibroblasts and fission yeast cells, Exp. Cell Res., 187, 150, 1990.
-
(1990)
Exp. Cell Res.
, vol.187
, pp. 150
-
-
Yoshida, M.1
-
66
-
-
0028318159
-
Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression
-
Nishi, K. et al., Leptomycin B targets a regulatory cascade of crm1, a fission yeast nuclear protein, involved in control of higher order chromosome structure and gene expression, J. Biol. Chem., 269, 6320, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6320
-
-
Nishi, K.1
-
67
-
-
0032146749
-
Leptomycin B inhibition of signal-mediated nuclear export by direct binding to crm1
-
Kudo, N. et al., Leptomycin B inhibition of signal-mediated nuclear export by direct binding to crm1, Exp. Cell Res., 242, 540, 1998.
-
(1998)
Exp. Cell Res.
, vol.242
, pp. 540
-
-
Kudo, N.1
-
68
-
-
0033529866
-
Leptomycin B inactivates crm1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
-
Kudo, N. et al., Leptomycin B inactivates crm1/exportin 1 by covalent modification at a cysteine residue in the central conserved region, Proc. Natl. Acad. Sci., USA, 96, 9112, 1999.
-
(1999)
Proc. Natl. Acad. Sci., USA
, vol.96
, pp. 9112
-
-
Kudo, N.1
-
69
-
-
0034630158
-
A comparison of the activity, sequence specificity, and crm1-dependence of different nuclear export signals
-
Henderson, B. R. and Eleftheriou, A., A comparison of the activity, sequence specificity, and crm1-dependence of different nuclear export signals, Exp. Cell Res., 256, 213, 2000.
-
(2000)
Exp. Cell Res.
, vol.256
, pp. 213
-
-
Henderson, B.R.1
Eleftheriou, A.2
-
70
-
-
0035122485
-
Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of bcr-abl tyrosine kinase
-
Vigneri, P. and Wang, J. Y. J., Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of bcr-abl tyrosine kinase, Nat. Med., 7, 228, 2001.
-
(2001)
Nat. Med.
, vol.7
, pp. 228
-
-
Vigneri, P.1
Wang, J.Y.J.2
-
71
-
-
0037268889
-
Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs
-
Yashiroda, Y. and Yoshida, M., Nucleo-cytoplasmic transport of proteins as a target for therapeutic drugs, Curr. Med. Chem., 10, 741, 2003.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 741
-
-
Yashiroda, Y.1
Yoshida, M.2
-
72
-
-
0037694131
-
Palmarumycins C1-C16 from Coniothyrium: Isolation, structure elucidation, and biological activity
-
Krohn, K. et al., Palmarumycins C1-C16 from Coniothyrium: Isolation, structure elucidation, and biological activity, Liebigs Ann. Chem., 1099, 1994.
-
(1994)
Liebigs Ann. Chem
, pp. 1099
-
-
Krohn, K.1
-
73
-
-
0142144338
-
The thioredoxin redox inhibitors 1-methylpropyl 2-imidazoyl disulfide and pleurotin inhibit hypoxia-induced factor 1-α and vascular endothelial growth factor formation, Mol. Can
-
Welsh, S. J. et al., The thioredoxin redox inhibitors 1-methylpropyl 2-imidazoyl disulfide and pleurotin inhibit hypoxia-induced factor 1-α and vascular endothelial growth factor formation, Mol. Can. Therap., 2, 235, 2003.
-
(2003)
Therap.
, vol.2
, pp. 235
-
-
Welsh, S.J.1
-
74
-
-
0035829182
-
New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthaquinone spiroketal natural product lead
-
Wipf, P. et al., New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthaquinone spiroketal natural product lead, Bioorg. Med. Chem. Lett., 11, 2637, 2001.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2637
-
-
Wipf, P.1
-
75
-
-
0035147618
-
Antimitotic actions of a novel analog of the fungal metabolite palmarumycin CP1
-
Lazo, J. et al., Antimitotic actions of a novel analog of the fungal metabolite palmarumycin CP1, J. Pharmacol. Exp. Ther., 296, 364, 2001.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.296
, pp. 364
-
-
Lazo, J.1
-
76
-
-
2942700238
-
Natural product based inhibitors of the thioredoxin-thioredoxin reductase system
-
Wipf, P. et al., Natural product based inhibitors of the thioredoxin-thioredoxin reductase system, Org. Biomol. Chem., 2, 1651, 2004.
-
(2004)
Org. Biomol. Chem.
, vol.2
, pp. 1651
-
-
Wipf, P.1
-
77
-
-
0035940873
-
Identification of an indigo precursor from leaves of Isatis tinctoria (Woad)
-
Maugard, T. et al., Identification of an indigo precursor from leaves of Isatis tinctoria (Woad), Phytochemistry, 58, 897, 2001.
-
(2001)
Phytochemistry
, vol.58
, pp. 897
-
-
Maugard, T.1
-
78
-
-
0042894451
-
Tyrian purple: 6,6′-dibromoindigo and related compounds
-
Cooksey, C. J., Tyrian purple: 6,6′-dibromoindigo and related compounds, Molecules, 6, 736, 2001.
-
(2001)
Molecules
, vol.6
, pp. 736
-
-
Cooksey, C.J.1
-
79
-
-
0035079979
-
Expression and isolation of antimicrobial small molecules from soil DNA libraries
-
MacNeil, I. A. et al., Expression and isolation of antimicrobial small molecules from soil DNA libraries, J. Mol. Microbiol. Biotechnol., 3, 301, 2001.
-
(2001)
J. Mol. Microbiol. Biotechnol.
, vol.3
, pp. 301
-
-
Macneil, I.A.1
-
80
-
-
0035943634
-
Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine
-
Adachi, J. et al., Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine, J. Biol. Chem., 276, 31475, 2001.
-
(2001)
J. Biol. Chem.
, vol.276
-
-
Adachi, J.1
-
81
-
-
0002345422
-
Chemical constituents of a traditional Chinese medicine Qing Dai
-
Chen, D. and Xie, J., Chemical constituents of a traditional Chinese medicine Qing Dai, Zhongcaoyao, 15, 534, 1984.
-
(1984)
Zhongcaoyao
, vol.15
, pp. 534
-
-
Chen, D.1
Xie, J.2
-
82
-
-
0036332286
-
Indirubin and mesoindigo in the treatment of chronic myelogenous leukemia in China
-
Xiao, Z. et al., Indirubin and mesoindigo in the treatment of chronic myelogenous leukemia in China, Leuk. Lymphoma, 43, 1763, 2002.
-
(2002)
Leuk. Lymphoma
, vol.43
, pp. 1763
-
-
Xiao, Z.1
-
83
-
-
0346875916
-
GSK-3-selective inhibitors derived from Tyrian purple indirubins
-
Meijer, L. et al., GSK-3-selective inhibitors derived from Tyrian purple indirubins, Chem. Biol., 10, 1255, 2003.
-
(2003)
Chem. Biol.
, vol.10
, pp. 1255
-
-
Meijer, L.1
-
84
-
-
2442589341
-
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases
-
Polychronopoulos, P. et al., Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases, J. Med. Chem., 47, 935, 2004.
-
(2004)
J. Med. Chem.
, vol.47
, pp. 935
-
-
Polychronopoulos, P.1
-
85
-
-
0038768712
-
Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals
-
Denison, M. S. and Nagy, S. R., Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals, Annu. Rev. Pharmacol. Toxicol., 43, 309, 2003.
-
(2003)
Annu. Rev. Pharmacol. Toxicol.
, vol.43
, pp. 309
-
-
Denison, M.S.1
Nagy, S.R.2
-
86
-
-
3042629590
-
Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediates the antiproliferative effects of indirubins
-
Knockaert, M. et al., Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediates the antiproliferative effects of indirubins, Oncogene, 23, 4400, 2004.
-
(2004)
Oncogene
, vol.23
, pp. 4400
-
-
Knockaert, M.1
-
87
-
-
0037805644
-
Biotechnological prospects from metagenomics
-
Schloss, P. D. and Handelsman, J., Biotechnological prospects from metagenomics, Curr. Opin. Biotechnol., 14, 303, 2003.
-
(2003)
Curr. Opin. Biotechnol.
, vol.14
, pp. 303
-
-
Schloss, P.D.1
Handelsman, J.2
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