Preparation of sustained release matrix pellets by melt agglomeration in the fluidized bed: Influence of formulation variables and modelling of agglomerate growth

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 74, Issue 3, 2010, Pages 503-512

  Pauli Bruns, Anette ^a   Knop, Klaus ^a   Lippold, Bernhard C ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Fluidized bed; Growth mechanism; Matrix; Melt agglomeration; Microcrystalline wax; Pellets; Sustained release

Indexed keywords

THEOPHYLLINE;

ARTICLE; DISSOLUTION; DRUG PELLET; FLUIDIZED BED; MELTING POINT; MICROCRYSTALLINE SUSPENSION; PARTICLE SIZE; POROSITY; REPRODUCIBILITY; SCANNING ELECTRON MICROSCOPY; SUSTAINED RELEASE FORMULATION; SUSTAINED RELEASE PREPARATION;

ADHESIVENESS; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG IMPLANTS; EXCIPIENTS; MODELS, CHEMICAL; PARTICLE SIZE; PHASE TRANSITION; SURFACE PROPERTIES; THEOPHYLLINE;

EID: 77649193500     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2009.12.005     Document Type: Article

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