Melt pelletization with polyethylene glycol in a rotary processor

International Journal of Pharmaceutics

Volumn 275, Issue 1-2, 2004, Pages 141-153

  Vilhelmsen, Thomas ^a   Kristensen, Jakob ^a   Schæfer, Torben ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Friction plate; Melt agglomeration; Polyethylene glycol; Rotary processor; Spheronization

Indexed keywords

MACROGOL;

AIRFLOW; ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); FACTORIAL ANALYSIS; FRICTION; MELTING POINT; PARTICLE SIZE; PELLET EXTRUSION; PRIORITY JOURNAL; SURFACE PROPERTY;

ADHESIVENESS; DRUG COMPOUNDING; FRICTION; LACTOSE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; TABLETS; TRANSITION TEMPERATURE;

EID: 1842638378     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2004.01.027     Document Type: Article

References (39)

1. Abberger T. Influence of binder properties, method of addition, powder type and operating conditions on fluid-bed melt granulation and resulting tablet properties. Pharmazie. 56:2001;949-952.
2. Abberger T., Henck J.O. Kornbildungsmechanismen bei der Schmelzgranulierung in der Wirbelschicht und ihre Auswirkungen auf die Tablettierung. Pharmazie. 55:2000;521-526.
3. Abberger T., Seo A., Schæfer T. The effect of droplet size and powder particle size on the mechanisms of nucleation and growth in fluid bed melt agglomeration. Int. J. Pharm. 249:2002;185-197.
4. Craig D.Q.M., Newton J.M. Characterisation of polyethylene glycols using differential scanning calorimetry. Int. J. Pharm. 74:1991;33-41.
5. Eliasen H., Kristensen H.G., Schæfer T. Growth mechanisms in melt agglomeration with a low viscosity binder. Int. J. Pharm. 186:1999;149-159.
6. Eliasen H., Schæfer T., Kristensen H.G. Effects of binder rheology on melt agglomeration in a high shear mixer. Int. J. Pharm. 176:1998;73-83.
7. European Pharmacopoeia, 2002. European Pharmacopoeia, fourth ed. Council of Europe, Strasbourg, pp. 207-208.
8. Hamdani J., Moës A.J., Amighi K. Development and evaluation of prolonged release pellets obtained by the melt pelletization process. Int. J. Pharm. 245:2002;167-177.
9. Heng P.W.S., Liew C.V., Gu L. Influence of teardrop studs on rotating frictional base plate on spheroid quality in rotary spheronization. Int. J. Pharm. 241:2002;173-184.
10. Heng P.W.S., Wong T.W., Chan L.W. Influence of production variables on the sphericity of melt pellets. Chem. Pharm. Bull. 48:2000;420-424.
11. Heng P.W.S., Wong T.W., Cheong W.S. Investigation of melt agglomeration process with a hydrophobic binder in combination with sucrose stearate. Eur. J. Pharm. Sci. 19:2003;381-393.
12. Heng P.W.S., Wong T.W., Shu J.J., Wan L.S.C. A new method for the control of size of pellets in the melt pelletization process with a high shear mixer. Chem. Pharm. Bull. 47:1999;633-638.
13. Holm P., Bonde M., Wigmore T. Pelletization by granulation in a roto-processor RP-2. Part I: Effects of process and product variables on granule growth. Pharm. Technol. Eur. 8(8):1996;22-36.
14. Johansen A., Schæfer T. Effects of interactions between powder particle size and binder viscosity on agglomerate growth mechanisms in a high shear mixer. Eur. J. Pharm. Sci. 12:2001;297-309.
15. Kidokoro M., Haramiishi Y., Sagasaki S., Shimizu T., Yamamoto Y. Application of fluidized hot-melt granulation (FHMG) for the preparation of granules for tableting; properties of granules and tablets prepared by FHMG. Drug Dev. Ind. Pharm. 28:2002;67-76.
16. Kinget R., Kemel R. Preparation and properties of granulates containing solid dispersions. Acta Pharm. Technol. 31:1985;57-62.
17. Kristensen J., Schæfer T., Kleinebudde P. Direct pelletization in a rotary processor controlled by torque measurements. I. Influence of process variables. Pharm. Dev. Technol. 5:2000a;247-256.
18. Kristensen, J., Schæfer, T., Kleinebudde, P., 2000b. Direct pelletization in a rotary processor controlled by torque measurements. II: Effects of changes in the content of microcrystalline cellulose. AAPS PharmSci. 2, Article 24.
19. Liew C.V., Gu L., Heng P.W.S. The influence of operational variables on mean size and size distribution of spheroids produced by rotary spheronization using teardrop studs. Int. J. Pharm. 242:2002;345-348.
20. Podczeck F., Rahman S.R., Newton J.M. Evaluation of a standardised procedure to assess the shape of pellets using image analysis. Int. J. Pharm. 192:1999;123-138.
21. Podczeck F., Newton J.M. A shape factor to characterize the quality of spheroids. J. Pharm. Pharmacol. 46:1994;82-85.
22. Reo, J.P., Roche, E.J., 1996. Dry granulation using a fluidized bed. European Patent EP 0,582,380 B1 (4 September 1996).
23. Royce A., Suryawanshi J., Shah U., Vishnupad K. Alternative granulation technique: melt granulation. Drug Dev. Ind. Pharm. 22:1996;917-924.
24. Schæfer T. Melt pelletization in a high shear mixer. X. Agglomeration of binary mixtures. Int. J. Pharm. 139:1996;149-159.
25. Schæfer T. Growth mechanisms in melt agglomeration in high shear mixers. Powder Technol. 117:2001;68-82.
26. Schæfer T., Holm P., Kristensen H.G. Melt pelletization in a high shear mixer. I. Effects of process variables and binder. Acta Pharm. Nord. 4:1992a;133-140.
27. Schæfer T., Holm P., Kristensen H.G. Melt pelletization in a high shear mixer. II. Power consumption and granule growth. Acta Pharm. Nord. 4:1992b;141-148.
28. Schæfer T., Holm P., Kristensen H.G. Melt pelletization in a high shear mixer. III. Effects of lactose quality. Acta Pharm. Nord. 4:1992c;245-252.
29. Schæfer T., Mathiesen C. Melt pelletization in a high shear mixer. IX. Effects of binder particle size. Int. J. Pharm. 139:1996a;139-148.
30. Schæfer T., Mathiesen C. Melt pelletization in a high shear mixer. VIII. Effects of binder viscosity. Int. J. Pharm. 139:1996b;125-138.
31. Schæfer T., Taagegaard B., Thomsen L.J., Kristensen H.G. Melt pelletization in a high shear mixer. IV. Effects of process variables in a laboratory scale mixer. Eur. J. Pharm. Sci. 1:1993;125-131.
32. Seo A., Holm P., Kristensen H.G., Schæfer T. The preparation of agglomerates containing solid dispersions of diazepam by melt agglomeration in a high shear mixer. Int. J. Pharm. 259:2003;161-171.
33. Seo A., Holm P., Schæfer T. Effects of droplet size and type of binder on the agglomerate growth mechanisms by melt agglomeration in a fluidised bed. Eur. J. Pharm. Sci. 16:2002;95-105.
34. Seo A., Schæfer T. Melt agglomeration with polyethylene glycol beads at a low impeller speed in a high shear mixer. Eur. J. Pharm. Biopharm. 52:2001;315-325.
35. Thomas P.W. Errors in the estimation of lactose in lactalbumin using the phenol sulphuric method. N. Z. J. Dairy Sci. Technol. 19:1984;177-180.
36. Ukita K., Murakami T. Preparation of essential oils loaded granule by melt granulation. Drug Dev. Ind. Pharm. 20:1994;981-992.
37. Vertommen J., Kinget R. The influence of five selected processing and formulation variables on the particle size, particle size distribution, and friability of pellets produced in a rotary processor. Drug Dev. Ind. Pharm. 23:1997;39-46.
38. Wan L.S.C., Heng P.W.S., Liew C.V. The role of moisture and gap air pressure in the formation of spherical granules by rotary processing. Drug Dev. Ind. Pharm. 20:1994;2551-2561.
39. Yanze F.M., Duru C., Jacob M. A process to produce effervescent tablets: fluidized bed dryer melt granulation. Drug Dev. Ind. Pharm. 26:2000;1167-1176.