Preparation of the controlled-release matrix tablets of theophylline with micronized low-substituted hydroxypropyl cellulose by a fluidized hot-melt granulation method

S.T.P. Pharma Sciences

Volumn 11, Issue 2, 2001, Pages 145-150

  Kojima, M ^a   Nakagami, H ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Controlled release matrix tablet; Fluidized hot melt granulation method; Glycerol esters of fatty acids; Hydroxypropyl cellulose; Micronized low substituted hydroxypropyl cellulose; Theophylline

Indexed keywords

DRUG CARRIER; FATTY ACID DERIVATIVE; HYDROXYPROPYLCELLULOSE; MACROGOL; MAGNESIUM STEARATE; STEARIC ACID; THEOPHYLLINE;

ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED RELEASE FORMULATION; FLOW; FLUIDIZED BED; HYDROPHILICITY; MATRIX TABLET; MELTING POINT; TABLET COMPRESSION; TABLET FORMULATION; TABLET MANUFACTURE; TABLET PROPERTY;

EID: 0035073215     PISSN: 11571489     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Overview of controlled-release drug delivery
2. The use of micronized cellulose disintegrants as insoluble swellable matrices for sustained-release tablets
3. In vitro evaluation of micronized low-substituted hydroxypropylcellulose as an insoluble swellable matrix for sustained-release tablets
4. Evaluation of sustained-release procainamide tablets made from micronized low-substituted hydroxypropyl-cellulose in dogs
5. Computer optimization for the formulation of controlled-release theophylline tablet made of micronized low-substituted hydroxypropylcellulose and methylcellulose
6. Low-substituted hydroxypropylcellulose as a sustained-drug release matrix base or disintegrant depending on its particle size and loading in formulation
7. The effect of particle size, degree of hydroxypropyl substitution and moisture content of low-substituted hydroxypropylcellulose on the compactability of acetaminophen and drug release rate of the resultant tablets
8. Preparation of a sustained-release matrix tablet of acetaminophen with pulverized low-substituted hydroxypropylcellulose via dry granulation
9. Preparation of prolonged-release matrix tablet of acetaminophen with pulverized low-substituted hydroxypropylcellulose via wet granulation
10. The evaluation of formulation and processing conditions of melt granulation process
11. The use of Precirol to prepare sustained release tablets of theophylline and quinidine gluconate
12. Characterization of hot-melt fluid bed coating process for fine granules
13. Study of fluidized melt-granulation. I. Examination of the factors on the granulation
14. Evaluating flow properties of solids
15. Sustained release of theophylline from hydroxypropylcellulose tablets