Melt pelletisation of a hygroscopic drug in a high shear mixer - Part 1. Influence of process variables

International Journal of Pharmaceutics

Volumn 188, Issue 2, 1999, Pages 131-143

  Thies, R ^a   Kleinebudde, P ^b  

^a UNIVERSITY OF KIEL   (Germany)

^b MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Glycerol monostearate; Granulation mechanism; High shear mixer; Hygroscopic drug; Melt pelletisation

Indexed keywords

EXCIPIENT; GLYCEROL STEARATE; MYVAPLEX 600P; UNCLASSIFIED DRUG; VALPROIC ACID;

ARTICLE; DRUG GRANULATION; DRUG MIXTURE; DRUG PELLET; DRUG SOLUBILITY; PARTICLE SIZE; PRIORITY JOURNAL; SHEAR STRESS; TORQUE; WETTABILITY;

CHEMISTRY, PHARMACEUTICAL; DRUG COMPOUNDING; EXCIPIENTS; GLYCERIDES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; REPRODUCIBILITY OF RESULTS; STATISTICS; TEMPERATURE; TIME FACTORS; VALPROIC ACID;

EID: 0032826026     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00214-8     Document Type: Article

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