Melt pelletization in high shear mixer using a hydrophobic melt binder: Influence of some apparatus and process variables

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 52, Issue 3, 2001, Pages 305-313

  Voinovich, D ^a   Moneghini, M ^a   Perissutti, B ^a   Franceschinis, E ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

Author keywords

10 liter High shear mixer; D optimal design; Melt pelletization; Paracetamol; Stearic acid

Indexed keywords

LACTOSE; PARACETAMOL; STEARIC ACID;

APPARATUS; ARTICLE; DRUG GRANULATION; DRUG MANUFACTURE; MELTING POINT; METHODOLOGY; PARTICLE SIZE; PHARMACEUTICAL ENGINEERING; PROCESS CONTROL; SHEAR RATE; VALIDATION PROCESS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CHEMISTRY, PHARMACEUTICAL; HYDROPHOBICITY; LACTOSE; STEARIC ACIDS; TABLETS; TECHNOLOGY, PHARMACEUTICAL;

EID: 0034757135     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00196-5     Document Type: Article

References (18)

1. High shear mixer granulators
2. Melt granulation in a laboratory scale high shear mixer
3. Melt granulation in a laboratory scale high shear mixer. I. Effect of process variables and binder
4. Melt granulation in a laboratory scale high shear mixer. IV. Effect of process variables in a laboratory scale mixer
5. Effects of process variables and their interactions on melt pelletization in a high shear mixer
6. Melt granulation in a laboratory scale high shear mixer. V. Effect of apparatus variables
7. Screening of high shear mixer melt granulation process variables using an asymmetrical factorial design
8. Prolonged release matrix pellets prepared by melt pelletization I: Process variables
9. Influence of processing on the characteristics of matrix pellets based on microcrystalline waxes and starch derivatives
10. Melt pelletisation of a hygroscopic drug in a high shear mixer. Part 1. Influence of process variables
11. Preparation in high shear mixer of sustained-release pellets by melt pelletisation
12. Prolonged release matrix pellets prepared by melt pelletization. II. Hydrophobic substances as meltable binders
13. Experimental research methodology applied to wet pelletization in a high shear mixer. Part I
14. Prolonged release matrix pellets prepared by melt pelletization I. Process variables
15. Experimental design for a granulation process with a priori criteria
16. Exchange algorithms. Methods for non-standard designs