메뉴 건너뛰기




Volumn 42, Issue 4, 2010, Pages 238-244

Clinical implications of novel aspects of biliary pathophysiology

Author keywords

Cholangiocarcinoma; Cholangiocyte; Cholangiopathies; Neuroendocrine; Proliferation

Indexed keywords

BILE ACID; ESTROGEN; GLUCAGON LIKE PEPTIDE 1; GROWTH HORMONE; OPIATE PEPTIDE; SEROTONIN; TAUROCHOLIC ACID; TAUROLITHOCHOLIC ACID; URSODEOXYCHOLIC ACID; VASCULOTROPIN;

EID: 77649192568     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2010.01.005     Document Type: Short Survey
Times cited : (18)

References (98)
  • 1
    • 0036241046 scopus 로고    scopus 로고
    • The pathobiology of biliary epithelia
    • Alpini G., McGill J.M., and LaRusso N.F. The pathobiology of biliary epithelia. Hepatology 35 (2002) 1256-1268
    • (2002) Hepatology , vol.35 , pp. 1256-1268
    • Alpini, G.1    McGill, J.M.2    LaRusso, N.F.3
  • 2
    • 0036698246 scopus 로고    scopus 로고
    • Functional heterogeneity of cholangiocytes
    • Marzioni M., Glaser S.S., Francis H., et al. Functional heterogeneity of cholangiocytes. Semin Liver Dis 22 (2002) 227-240
    • (2002) Semin Liver Dis , vol.22 , pp. 227-240
    • Marzioni, M.1    Glaser, S.S.2    Francis, H.3
  • 3
    • 0027023607 scopus 로고
    • Vanishing bile duct disorders
    • Desmet V.J. Vanishing bile duct disorders. Prog Liver Dis 10 (1992) 89-121
    • (1992) Prog Liver Dis , vol.10 , pp. 89-121
    • Desmet, V.J.1
  • 4
  • 6
    • 47149112544 scopus 로고    scopus 로고
    • Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment
    • Blechacz B., and Gores G.J. Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment. Hepatology 48 (2008) 308-321
    • (2008) Hepatology , vol.48 , pp. 308-321
    • Blechacz, B.1    Gores, G.J.2
  • 8
    • 33846205222 scopus 로고    scopus 로고
    • Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver
    • Alvaro D., Mancino M.G., Glaser S., et al. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 132 (2007) 415-431
    • (2007) Gastroenterology , vol.132 , pp. 415-431
    • Alvaro, D.1    Mancino, M.G.2    Glaser, S.3
  • 9
    • 0024339289 scopus 로고
    • Biliary victories: studies of isolated biliary epithelial cells
    • Vierling J.M. Biliary victories: studies of isolated biliary epithelial cells. J Lab Clin Med 113 (1989) 663-664
    • (1989) J Lab Clin Med , vol.113 , pp. 663-664
    • Vierling, J.M.1
  • 10
    • 0030918442 scopus 로고    scopus 로고
    • Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion
    • Alpini G., Glaser S., Robertson W., et al. Large but not small intrahepatic bile ducts are involved in secretin-regulated ductal bile secretion. Am J Physiol 272 (1997) G1064-G1074
    • (1997) Am J Physiol , vol.272
    • Alpini, G.1    Glaser, S.2    Robertson, W.3
  • 11
    • 0031958588 scopus 로고    scopus 로고
    • Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation
    • Alpini G., Glaser S.S., Ueno Y., et al. Heterogeneity of the proliferative capacity of rat cholangiocytes after bile duct ligation. Am J Physiol 274 (1998) G767-G775
    • (1998) Am J Physiol , vol.274
    • Alpini, G.1    Glaser, S.S.2    Ueno, Y.3
  • 12
    • 0029864329 scopus 로고    scopus 로고
    • Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver
    • Alpini G., Roberts S., Kuntz S.M., et al. Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology 110 (1996) 1636-1643
    • (1996) Gastroenterology , vol.110 , pp. 1636-1643
    • Alpini, G.1    Roberts, S.2    Kuntz, S.M.3
  • 13
    • 0030900791 scopus 로고    scopus 로고
    • Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation
    • Alpini G., Ulrich C., Roberts S., et al. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol 272 (1997) G289-G297
    • (1997) Am J Physiol , vol.272
    • Alpini, G.1    Ulrich, C.2    Roberts, S.3
  • 14
    • 0029976124 scopus 로고    scopus 로고
    • A morphometric study of the epithelium lining the rat intrahepatic biliary tree
    • Benedetti A., Bassotti C., Rapino K., et al. A morphometric study of the epithelium lining the rat intrahepatic biliary tree. J Hepatol 24 (1996) 335-342
    • (1996) J Hepatol , vol.24 , pp. 335-342
    • Benedetti, A.1    Bassotti, C.2    Rapino, K.3
  • 15
    • 0027950288 scopus 로고
    • Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation
    • Alpini G., Ulrich II C.D., Phillips J.O., et al. Upregulation of secretin receptor gene expression in rat cholangiocytes after bile duct ligation. Am J Physiol 266 (1994) G922-G928
    • (1994) Am J Physiol , vol.266
    • Alpini, G.1    Ulrich II, C.D.2    Phillips, J.O.3
  • 16
    • 0030709280 scopus 로고    scopus 로고
    • Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes
    • Glaser S.S., Rodgers R.E., Phinizy J.L., et al. Gastrin inhibits secretin-induced ductal secretion by interaction with specific receptors on rat cholangiocytes. Am J Physiol 273 (1997) G1061-G1070
    • (1997) Am J Physiol , vol.273
    • Glaser, S.S.1    Rodgers, R.E.2    Phinizy, J.L.3
  • 18
    • 0027523995 scopus 로고
    • Regulation of membrane chloride currents in rat bile duct epithelial cells
    • Fitz J.G., Basavappa S., McGill J., et al. Regulation of membrane chloride currents in rat bile duct epithelial cells. J Clin Invest 91 (1993) 319-328
    • (1993) J Clin Invest , vol.91 , pp. 319-328
    • Fitz, J.G.1    Basavappa, S.2    McGill, J.3
  • 19
    • 0030844035 scopus 로고    scopus 로고
    • Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions
    • Alvaro D., Alpini G., Jezequel A.M., et al. Role and mechanisms of action of acetylcholine in the regulation of rat cholangiocyte secretory functions. J Clin Invest 100 (1997) 1349-1362
    • (1997) J Clin Invest , vol.100 , pp. 1349-1362
    • Alvaro, D.1    Alpini, G.2    Jezequel, A.M.3
  • 20
    • 0023863239 scopus 로고
    • Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules
    • Alpini G., Lenzi R., Sarkozi L., et al. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. J Clin Invest 81 (1988) 569-578
    • (1988) J Clin Invest , vol.81 , pp. 569-578
    • Alpini, G.1    Lenzi, R.2    Sarkozi, L.3
  • 21
    • 0030832592 scopus 로고    scopus 로고
    • +-dependent bile acid transporter in large but not small rat cholangiocytes
    • +-dependent bile acid transporter in large but not small rat cholangiocytes. Gastroenterology 113 (1997) 1734-1740
    • (1997) Gastroenterology , vol.113 , pp. 1734-1740
    • Alpini, G.1    Glaser, S.S.2    Rodgers, R.3
  • 22
    • 0032974180 scopus 로고    scopus 로고
    • Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from bile duct ligated rat liver
    • LeSage G., Glaser S., Marucci L., et al. Acute carbon tetrachloride feeding induces damage of large but not small cholangiocytes from bile duct ligated rat liver. Am J Physiol 276 (1999) G1289-G1301
    • (1999) Am J Physiol , vol.276
    • LeSage, G.1    Glaser, S.2    Marucci, L.3
  • 23
    • 0031467883 scopus 로고    scopus 로고
    • Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter
    • Lazaridis K.N., Pham L., Tietz P., et al. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter. J Clin Invest 100 (1997) 2714-2721
    • (1997) J Clin Invest , vol.100 , pp. 2714-2721
    • Lazaridis, K.N.1    Pham, L.2    Tietz, P.3
  • 24
    • 0036171510 scopus 로고    scopus 로고
    • Tissue distribution and induction of human multidrug resistant protein 3
    • Scheffer G.L., Kool M., de Haas M., et al. Tissue distribution and induction of human multidrug resistant protein 3. Lab Invest 82 (2002) 193-201
    • (2002) Lab Invest , vol.82 , pp. 193-201
    • Scheffer, G.L.1    Kool, M.2    de Haas, M.3
  • 25
    • 0034718614 scopus 로고    scopus 로고
    • Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties
    • Lazaridis K.N., Tietz P., Wu T., et al. Alternative splicing of the rat sodium/bile acid transporter changes its cellular localization and transport properties. Proc Natl Acad Sci USA 97 (2000) 11092-11097
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11092-11097
    • Lazaridis, K.N.1    Tietz, P.2    Wu, T.3
  • 26
    • 30844460667 scopus 로고    scopus 로고
    • OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    • Ballatori N., Christian W.V., Lee J.Y., et al. OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology 42 (2005) 1270-1279
    • (2005) Hepatology , vol.42 , pp. 1270-1279
    • Ballatori, N.1    Christian, W.V.2    Lee, J.Y.3
  • 27
    • 0034755796 scopus 로고    scopus 로고
    • Bile acid feeding stimulates proliferative activity of both small and large cholangiocytes through activation and membrane translocation of protein kinase C alpha
    • Alpini G., Ueno Y., Glaser S., et al. Bile acid feeding stimulates proliferative activity of both small and large cholangiocytes through activation and membrane translocation of protein kinase C alpha. Hepatology 34 (2001) 868-876
    • (2001) Hepatology , vol.34 , pp. 868-876
    • Alpini, G.1    Ueno, Y.2    Glaser, S.3
  • 28
    • 0034755796 scopus 로고    scopus 로고
    • Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes
    • Alpini G., Ueno Y., Glaser S.S., et al. Bile acid feeding increased proliferative activity and apical bile acid transporter expression in both small and large rat cholangiocytes. Hepatology 34 (2001) 868-876
    • (2001) Hepatology , vol.34 , pp. 868-876
    • Alpini, G.1    Ueno, Y.2    Glaser, S.S.3
  • 29
    • 0032899948 scopus 로고    scopus 로고
    • Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion
    • Alpini G., Glaser S., Ueno Y., et al. Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion. Gastroenterology 116 (1999) 179-186
    • (1999) Gastroenterology , vol.116 , pp. 179-186
    • Alpini, G.1    Glaser, S.2    Ueno, Y.3
  • 30
    • 0030760489 scopus 로고    scopus 로고
    • Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes
    • Alpini G., Glaser S., Robertson W., et al. Bile acids stimulate proliferative and secretory events in large but not small cholangiocytes. Am J Physiol 273 (1997) G518-G529
    • (1997) Am J Physiol , vol.273
    • Alpini, G.1    Glaser, S.2    Robertson, W.3
  • 31
    • 0036238347 scopus 로고    scopus 로고
    • Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha
    • Alpini G., Baiocchi L., Glaser S., et al. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology 35 (2002) 1041-1052
    • (2002) Hepatology , vol.35 , pp. 1041-1052
    • Alpini, G.1    Baiocchi, L.2    Glaser, S.3
  • 32
    • 34047212040 scopus 로고    scopus 로고
    • Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver
    • Marzioni M., Ueno Y., Glaser S., et al. Cytoprotective effects of taurocholic acid feeding on the biliary tree after adrenergic denervation of the liver. Liver Int 27 (2007) 558-568
    • (2007) Liver Int , vol.27 , pp. 558-568
    • Marzioni, M.1    Ueno, Y.2    Glaser, S.3
  • 33
    • 17644443179 scopus 로고    scopus 로고
    • Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct ligated rats
    • Marzioni M., LeSage G., Glaser S., et al. Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct ligated rats. Am J Physiol 284 (2003) G837-G852
    • (2003) Am J Physiol , vol.284
    • Marzioni, M.1    LeSage, G.2    Glaser, S.3
  • 35
    • 33144482595 scopus 로고    scopus 로고
    • 2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts
    • 2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. Am J Pathol 168 (2006) 398-409
    • (2006) Am J Pathol , vol.168 , pp. 398-409
    • Marzioni, M.1    Francis, H.2    Benedetti, A.3
  • 36
    • 0036789129 scopus 로고    scopus 로고
    • Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats
    • Alpini G., Glaser S., Alvaro D., et al. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Gastroenterology 123 (2002) 1226-1237
    • (2002) Gastroenterology , vol.123 , pp. 1226-1237
    • Alpini, G.1    Glaser, S.2    Alvaro, D.3
  • 38
    • 0032990637 scopus 로고    scopus 로고
    • Cholinergic system modulates growth, apoptosis and secretion of cholangiocytes from bile duct ligated rats
    • LeSage G., Alvaro D., Benedetti A., et al. Cholinergic system modulates growth, apoptosis and secretion of cholangiocytes from bile duct ligated rats. Gastroenterology 117 (1999) 191-199
    • (1999) Gastroenterology , vol.117 , pp. 191-199
    • LeSage, G.1    Alvaro, D.2    Benedetti, A.3
  • 39
    • 0026729794 scopus 로고
    • Alteration in sympathetic nerve activity during liver regeneration in rats after partial hepatectomy
    • Iwai M., and Shimazu T. Alteration in sympathetic nerve activity during liver regeneration in rats after partial hepatectomy. J Auton Nerv Syst 41 (1992) 209-214
    • (1992) J Auton Nerv Syst , vol.41 , pp. 209-214
    • Iwai, M.1    Shimazu, T.2
  • 40
    • 7044286463 scopus 로고    scopus 로고
    • Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP
    • LeSage G.D., Alvaro D., Glaser S., et al. Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP. Hepatology 40 (2004) 1116-1127
    • (2004) Hepatology , vol.40 , pp. 1116-1127
    • LeSage, G.D.1    Alvaro, D.2    Glaser, S.3
  • 41
    • 35048864288 scopus 로고    scopus 로고
    • The {alpha}2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats
    • Francis H., LeSage G., Demorrow S., et al. The {alpha}2-adrenergic receptor agonist UK 14,304 inhibits secretin-stimulated ductal secretion by downregulation of the cAMP system in bile duct-ligated rats. Am J Physiol Cell Physiol 293 (2007) C1252-C1262
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Francis, H.1    LeSage, G.2    Demorrow, S.3
  • 42
    • 33645834553 scopus 로고    scopus 로고
    • Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt
    • Glaser S., Alvaro D., Francis H., et al. Adrenergic receptor agonists prevent bile duct injury induced by adrenergic denervation by increased cAMP levels and activation of Akt. Am J Physiol Gastrointest Liver Physiol 290 (2006) G813-G826
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Glaser, S.1    Alvaro, D.2    Francis, H.3
  • 43
    • 35348873697 scopus 로고    scopus 로고
    • Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function
    • Fava G., Marzioni M., Francis H., et al. Novel interaction of bile acid and neural signaling in the regulation of cholangiocyte function. Hepatol Res 37 Suppl. 3 (2007) S420-S429
    • (2007) Hepatol Res , vol.37 , Issue.SUPPL. 3
    • Fava, G.1    Marzioni, M.2    Francis, H.3
  • 44
    • 0036305838 scopus 로고    scopus 로고
    • Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes
    • Alvaro D., Alpini G., Onori P., et al. Effect of ovariectomy on the proliferative capacity of intrahepatic rat cholangiocytes. Gastroenterology 123 (2002) 336-344
    • (2002) Gastroenterology , vol.123 , pp. 336-344
    • Alvaro, D.1    Alpini, G.2    Onori, P.3
  • 45
    • 0034464275 scopus 로고    scopus 로고
    • Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats
    • Alvaro D., Alpini G., Onori P., et al. Estrogens stimulate proliferation of intrahepatic biliary epithelium in rats. Gastroenterology 119 (2000) 1681-1691
    • (2000) Gastroenterology , vol.119 , pp. 1681-1691
    • Alvaro, D.1    Alpini, G.2    Onori, P.3
  • 46
    • 19944425111 scopus 로고    scopus 로고
    • Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
    • Marzioni M., Glaser S., Francis H., et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 128 (2005) 121-137
    • (2005) Gastroenterology , vol.128 , pp. 121-137
    • Marzioni, M.1    Glaser, S.2    Francis, H.3
  • 47
    • 33947262609 scopus 로고    scopus 로고
    • Endogenous opioid peptides and chronic liver disease: from bedside to bench
    • Marzioni M., Svegliati Baroni G., Alpini G., et al. Endogenous opioid peptides and chronic liver disease: from bedside to bench. J Hepatol 46 (2007) 583-586
    • (2007) J Hepatol , vol.46 , pp. 583-586
    • Marzioni, M.1    Svegliati Baroni, G.2    Alpini, G.3
  • 48
    • 0036268170 scopus 로고    scopus 로고
    • Hepatic Met-enkephalin immunoreactivity is enhanced in primary biliary cirrhosis
    • Bergasa N.V., Liau S., Homel P., et al. Hepatic Met-enkephalin immunoreactivity is enhanced in primary biliary cirrhosis. Liver 22 (2002) 107-113
    • (2002) Liver , vol.22 , pp. 107-113
    • Bergasa, N.V.1    Liau, S.2    Homel, P.3
  • 49
    • 0026718627 scopus 로고
    • Central mu-opioid receptors are down-regulated in a rat model of cholestasis
    • Bergasa N.V., Rothman R.B., Vergalla J., et al. Central mu-opioid receptors are down-regulated in a rat model of cholestasis. J Hepatol 15 (1992) 220-224
    • (1992) J Hepatol , vol.15 , pp. 220-224
    • Bergasa, N.V.1    Rothman, R.B.2    Vergalla, J.3
  • 50
    • 0029859359 scopus 로고    scopus 로고
    • Hepatic concentrations of proenkephalin-derived opioids are increased in a rat model of cholestasis
    • Bergasa N.V., Vergalla J., Swain M.G., et al. Hepatic concentrations of proenkephalin-derived opioids are increased in a rat model of cholestasis. Liver 16 (1996) 298-302
    • (1996) Liver , vol.16 , pp. 298-302
    • Bergasa, N.V.1    Vergalla, J.2    Swain, M.G.3
  • 51
    • 0026716652 scopus 로고
    • Endogenous opioids accumulate in plasma in a rat model of acute cholestasis
    • Swain M.G., Rothman R.B., Xu H., et al. Endogenous opioids accumulate in plasma in a rat model of acute cholestasis. Gastroenterology 103 (1992) 630-635
    • (1992) Gastroenterology , vol.103 , pp. 630-635
    • Swain, M.G.1    Rothman, R.B.2    Xu, H.3
  • 52
    • 0028910476 scopus 로고
    • Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver
    • Bergasa N.V., Sabol S.L., Young III W.S., et al. Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver. Am J Physiol 268 (1995) G346-G354
    • (1995) Am J Physiol , vol.268
    • Bergasa, N.V.1    Sabol, S.L.2    Young III, W.S.3
  • 53
    • 33646336861 scopus 로고    scopus 로고
    • Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis
    • Marzioni M., Alpini G., Saccomanno S., et al. Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis. Gastroenterology 130 (2006) 1831-1847
    • (2006) Gastroenterology , vol.130 , pp. 1831-1847
    • Marzioni, M.1    Alpini, G.2    Saccomanno, S.3
  • 54
    • 26244464254 scopus 로고    scopus 로고
    • The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis
    • Alvaro D., Metalli V.D., Alpini G., et al. The intrahepatic biliary epithelium is a target of the growth hormone/insulin-like growth factor 1 axis. J Hepatol 43 (2005) 875-883
    • (2005) J Hepatol , vol.43 , pp. 875-883
    • Alvaro, D.1    Metalli, V.D.2    Alpini, G.3
  • 55
    • 33646472475 scopus 로고    scopus 로고
    • Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism
    • Gaudio E., Barbaro B., Alvaro D., et al. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 130 (2006) 1270-1282
    • (2006) Gastroenterology , vol.130 , pp. 1270-1282
    • Gaudio, E.1    Barbaro, B.2    Alvaro, D.3
  • 56
    • 33745770227 scopus 로고    scopus 로고
    • Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats
    • Gaudio E., Barbaro B., Alvaro D., et al. Administration of r-VEGF-A prevents hepatic artery ligation-induced bile duct damage in bile duct ligated rats. Am J Physiol Gastrointest Liver Physiol 291 (2006) G307-G317
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.291
    • Gaudio, E.1    Barbaro, B.2    Alvaro, D.3
  • 57
    • 0036158954 scopus 로고    scopus 로고
    • Biological actions and therapeutic potential of the glucagon-like peptides
    • Drucker D.J. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122 (2002) 531-544
    • (2002) Gastroenterology , vol.122 , pp. 531-544
    • Drucker, D.J.1
  • 58
    • 34447095397 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis
    • Marzioni M., Alpini G., Saccomanno S., et al. Glucagon-like peptide-1 and its receptor agonist exendin-4 modulate cholangiocyte adaptive response to cholestasis. Gastroenterology 133 (2007) 244-255
    • (2007) Gastroenterology , vol.133 , pp. 244-255
    • Marzioni, M.1    Alpini, G.2    Saccomanno, S.3
  • 59
    • 67649637819 scopus 로고    scopus 로고
    • Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis
    • Marzioni M., Alpini G., Saccomanno S., et al. Exendin-4, a glucagon-like peptide 1 receptor agonist, protects cholangiocytes from apoptosis. Gut 58 (2009) 990-997
    • (2009) Gut , vol.58 , pp. 990-997
    • Marzioni, M.1    Alpini, G.2    Saccomanno, S.3
  • 60
    • 0036918960 scopus 로고    scopus 로고
    • Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1
    • Bulotta A., Hui H., Anastasi E., et al. Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J Mol Endocrinol 29 (2002) 347-360
    • (2002) J Mol Endocrinol , vol.29 , pp. 347-360
    • Bulotta, A.1    Hui, H.2    Anastasi, E.3
  • 61
    • 0033512486 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells
    • Zhou J., Wang X., Pineyro M.A., et al. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48 (1999) 2358-2366
    • (1999) Diabetes , vol.48 , pp. 2358-2366
    • Zhou, J.1    Wang, X.2    Pineyro, M.A.3
  • 62
    • 3042716499 scopus 로고    scopus 로고
    • Ductular cell proliferation in islet cell neogenesis induced by incomplete ligation of the pancreatic duct in dogs
    • Nagaya M., Kubota S., Isogai A., et al. Ductular cell proliferation in islet cell neogenesis induced by incomplete ligation of the pancreatic duct in dogs. Surg Today 34 (2004) 586-592
    • (2004) Surg Today , vol.34 , pp. 586-592
    • Nagaya, M.1    Kubota, S.2    Isogai, A.3
  • 63
    • 0037062515 scopus 로고    scopus 로고
    • In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells
    • Yang L., Li S., Hatch H., et al. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci USA 99 (2002) 8078-8083
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8078-8083
    • Yang, L.1    Li, S.2    Hatch, H.3
  • 64
    • 0037532351 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes
    • Hanada S., Harada M., Koga H., et al. Tumor necrosis factor-alpha and interferon-gamma directly impair epithelial barrier function in cultured mouse cholangiocytes. Liver Int 23 (2003) 3-11
    • (2003) Liver Int , vol.23 , pp. 3-11
    • Hanada, S.1    Harada, M.2    Koga, H.3
  • 65
    • 0037370065 scopus 로고    scopus 로고
    • Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes
    • Spirli C., Fabris L., Duner E., et al. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. Gastroenterology 124 (2003) 737-753
    • (2003) Gastroenterology , vol.124 , pp. 737-753
    • Spirli, C.1    Fabris, L.2    Duner, E.3
  • 66
    • 0034959516 scopus 로고    scopus 로고
    • Proinflammatory cytokines inhibit secretion in rat bile duct epithelium
    • Spirli C., Nathanson M.H., Fiorotto R., et al. Proinflammatory cytokines inhibit secretion in rat bile duct epithelium. Gastroenterology 121 (2001) 156-169
    • (2001) Gastroenterology , vol.121 , pp. 156-169
    • Spirli, C.1    Nathanson, M.H.2    Fiorotto, R.3
  • 67
    • 0030791506 scopus 로고    scopus 로고
    • Promotion of leukocyte transendothelial cell migration by chemokines derived from human biliary epithelial cells in vitro
    • Morland C.M., Fear J., McNab G., et al. Promotion of leukocyte transendothelial cell migration by chemokines derived from human biliary epithelial cells in vitro. Proc Assoc Am Physicians 109 (1997) 372-382
    • (1997) Proc Assoc Am Physicians , vol.109 , pp. 372-382
    • Morland, C.M.1    Fear, J.2    McNab, G.3
  • 68
    • 11844294973 scopus 로고    scopus 로고
    • CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver
    • Heydtmann M., Lalor P.F., Eksteen J.A., et al. CXC chemokine ligand 16 promotes integrin-mediated adhesion of liver-infiltrating lymphocytes to cholangiocytes and hepatocytes within the inflamed human liver. J Immunol 174 (2005) 1055-1062
    • (2005) J Immunol , vol.174 , pp. 1055-1062
    • Heydtmann, M.1    Lalor, P.F.2    Eksteen, J.A.3
  • 69
    • 33745298438 scopus 로고    scopus 로고
    • Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10
    • Eksteen B., Miles A., Curbishley S.M., et al. Epithelial inflammation is associated with CCL28 production and the recruitment of regulatory T cells expressing CCR10. J Immunol 177 (2006) 593-603
    • (2006) J Immunol , vol.177 , pp. 593-603
    • Eksteen, B.1    Miles, A.2    Curbishley, S.M.3
  • 70
    • 0036296996 scopus 로고    scopus 로고
    • High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6
    • Xu B., Broome U., Ericzon B.G., et al. High frequency of autoantibodies in patients with primary sclerosing cholangitis that bind biliary epithelial cells and induce expression of CD44 and production of interleukin 6. Gut 51 (2002) 120-127
    • (2002) Gut , vol.51 , pp. 120-127
    • Xu, B.1    Broome, U.2    Ericzon, B.G.3
  • 71
    • 34247196579 scopus 로고    scopus 로고
    • Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis
    • Karrar A., Broome U., Sodergren T., et al. Biliary epithelial cell antibodies link adaptive and innate immune responses in primary sclerosing cholangitis. Gastroenterology 132 (2007) 1504-1514
    • (2007) Gastroenterology , vol.132 , pp. 1504-1514
    • Karrar, A.1    Broome, U.2    Sodergren, T.3
  • 72
    • 0025157052 scopus 로고
    • Nerves and perisinusoidal cells in human liver
    • Bioulac-Sage P., Lafon M.E., Saric J., et al. Nerves and perisinusoidal cells in human liver. J Hepatol 10 (1990) 105-112
    • (1990) J Hepatol , vol.10 , pp. 105-112
    • Bioulac-Sage, P.1    Lafon, M.E.2    Saric, J.3
  • 73
    • 43049094474 scopus 로고    scopus 로고
    • Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis
    • Salas J.T., Banales J.M., Sarvide S., et al. Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology 134 (2008) 1482-1493
    • (2008) Gastroenterology , vol.134 , pp. 1482-1493
    • Salas, J.T.1    Banales, J.M.2    Sarvide, S.3
  • 74
    • 55549146529 scopus 로고    scopus 로고
    • Genetic factors of susceptibility and of severity in primary biliary cirrhosis
    • Poupon R., Ping C., Chretien Y., et al. Genetic factors of susceptibility and of severity in primary biliary cirrhosis. J Hepatol 49 (2008) 1038-1045
    • (2008) J Hepatol , vol.49 , pp. 1038-1045
    • Poupon, R.1    Ping, C.2    Chretien, Y.3
  • 75
    • 67649205149 scopus 로고    scopus 로고
    • EASL Clinical Practice Guidelines: management of cholestatic liver diseases
    • EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol 51 (2009) 237-267
    • (2009) J Hepatol , vol.51 , pp. 237-267
  • 76
    • 0036788262 scopus 로고    scopus 로고
    • Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles
    • Fickert P., Zollner G., Fuchsbichler A., et al. Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles. Gastroenterology 123 (2002) 1238-1251
    • (2002) Gastroenterology , vol.123 , pp. 1238-1251
    • Fickert, P.1    Zollner, G.2    Fuchsbichler, A.3
  • 77
    • 3242727039 scopus 로고    scopus 로고
    • Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    • Fickert P., Fuchsbichler A., Wagner M., et al. Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 127 (2004) 261-274
    • (2004) Gastroenterology , vol.127 , pp. 261-274
    • Fickert, P.1    Fuchsbichler, A.2    Wagner, M.3
  • 78
    • 32044467118 scopus 로고    scopus 로고
    • 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    • Fickert P., Wagner M., Marschall H.U., et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 130 (2006) 465-481
    • (2006) Gastroenterology , vol.130 , pp. 465-481
    • Fickert, P.1    Wagner, M.2    Marschall, H.U.3
  • 79
    • 68049143345 scopus 로고    scopus 로고
    • Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice
    • Halilbasic E., Fiorotto R., Fickert P., et al. Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-/- mice. Hepatology 49 (2009) 1972-1981
    • (2009) Hepatology , vol.49 , pp. 1972-1981
    • Halilbasic, E.1    Fiorotto, R.2    Fickert, P.3
  • 80
    • 56949089276 scopus 로고    scopus 로고
    • Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures
    • Buis C.I., Geuken E., Visser D.S., et al. Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures. J Hepatol 50 (2009) 69-79
    • (2009) J Hepatol , vol.50 , pp. 69-79
    • Buis, C.I.1    Geuken, E.2    Visser, D.S.3
  • 81
    • 20844433859 scopus 로고    scopus 로고
    • Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis
    • Alvaro D., Invernizzi P., Onori P., et al. Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis. J Hepatol 41 (2004) 905-912
    • (2004) J Hepatol , vol.41 , pp. 905-912
    • Alvaro, D.1    Invernizzi, P.2    Onori, P.3
  • 82
    • 0032901383 scopus 로고    scopus 로고
    • The pruritus of cholestasis
    • Jones E.A., and Bergasa N.V. The pruritus of cholestasis. Hepatology 29 (1999) 1003-1006
    • (1999) Hepatology , vol.29 , pp. 1003-1006
    • Jones, E.A.1    Bergasa, N.V.2
  • 83
    • 0024211842 scopus 로고
    • Opioid peptides and primary biliary cirrhosis
    • Thornton J.R., and Losowsky M.S. Opioid peptides and primary biliary cirrhosis. Br Med J 297 (1988) 1501-1504
    • (1988) Br Med J , vol.297 , pp. 1501-1504
    • Thornton, J.R.1    Losowsky, M.S.2
  • 84
    • 0027198566 scopus 로고
    • Plasma from patients with the pruritus of cholestasis induces opioid receptor-mediated scratching in monkeys
    • Bergasa N.V., Thomas D.A., Vergalla J., et al. Plasma from patients with the pruritus of cholestasis induces opioid receptor-mediated scratching in monkeys. Life Sci 53 (1993) 1253-1257
    • (1993) Life Sci , vol.53 , pp. 1253-1257
    • Bergasa, N.V.1    Thomas, D.A.2    Vergalla, J.3
  • 85
    • 0036679047 scopus 로고    scopus 로고
    • Opiate antagonist therapy for the pruritus of cholestasis: the avoidance of opioid withdrawal-like reactions
    • Jones E.A., Neuberger J., and Bergasa N.V. Opiate antagonist therapy for the pruritus of cholestasis: the avoidance of opioid withdrawal-like reactions. Q J Med 95 (2002) 547-552
    • (2002) Q J Med , vol.95 , pp. 547-552
    • Jones, E.A.1    Neuberger, J.2    Bergasa, N.V.3
  • 86
    • 33947409205 scopus 로고    scopus 로고
    • Sertraline as a first-line treatment for cholestatic pruritus
    • Mayo M.J., Handem I., Saldana S., et al. Sertraline as a first-line treatment for cholestatic pruritus. Hepatology 45 (2007) 666-674
    • (2007) Hepatology , vol.45 , pp. 666-674
    • Mayo, M.J.1    Handem, I.2    Saldana, S.3
  • 87
    • 67349261559 scopus 로고    scopus 로고
    • Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth
    • Marzioni M., Invernizzi P., Candelaresi C., et al. Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth. Dig Liver Dis 41 (2009) 523-533
    • (2009) Dig Liver Dis , vol.41 , pp. 523-533
    • Marzioni, M.1    Invernizzi, P.2    Candelaresi, C.3
  • 88
    • 56449096956 scopus 로고    scopus 로고
    • Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth
    • Alpini G., Invernizzi P., Gaudio E., et al. Serotonin metabolism is dysregulated in cholangiocarcinoma, which has implications for tumor growth. Cancer Res 68 (2008) 9184-9193
    • (2008) Cancer Res , vol.68 , pp. 9184-9193
    • Alpini, G.1    Invernizzi, P.2    Gaudio, E.3
  • 89
    • 0030752474 scopus 로고    scopus 로고
    • Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis
    • Washington K., Clavien P.A., and Killenberg P. Peribiliary vascular plexus in primary sclerosing cholangitis and primary biliary cirrhosis. Hum Pathol 28 (1997) 791-795
    • (1997) Hum Pathol , vol.28 , pp. 791-795
    • Washington, K.1    Clavien, P.A.2    Killenberg, P.3
  • 90
    • 33847636334 scopus 로고    scopus 로고
    • Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries
    • Beaussier M., Wendum D., Schiffer E., et al. Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries. Lab Invest 87 (2007) 292-303
    • (2007) Lab Invest , vol.87 , pp. 292-303
    • Beaussier, M.1    Wendum, D.2    Schiffer, E.3
  • 91
    • 33745710682 scopus 로고    scopus 로고
    • Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma
    • Alvaro D., Barbaro B., Franchitto A., et al. Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am J Pathol 169 (2006) 877-888
    • (2006) Am J Pathol , vol.169 , pp. 877-888
    • Alvaro, D.1    Barbaro, B.2    Franchitto, A.3
  • 92
    • 58149214162 scopus 로고    scopus 로고
    • Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor
    • Mancino A., Mancino M.G., Glaser S.S., et al. Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. Dig Liver Dis 41 (2009) 156-163
    • (2009) Dig Liver Dis , vol.41 , pp. 156-163
    • Mancino, A.1    Mancino, M.G.2    Glaser, S.S.3
  • 93
    • 34848926887 scopus 로고    scopus 로고
    • Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis
    • Alvaro D., Macarri G., Mancino M.G., et al. Serum and biliary insulin-like growth factor I and vascular endothelial growth factor in determining the cause of obstructive cholestasis. Ann Intern Med 147 (2007) 451-459
    • (2007) Ann Intern Med , vol.147 , pp. 451-459
    • Alvaro, D.1    Macarri, G.2    Mancino, M.G.3
  • 94
    • 34447267513 scopus 로고    scopus 로고
    • Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    • Amori R.E., Lau J., and Pittas A.G. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. J Am Med Assoc 298 (2007) 194-206
    • (2007) J Am Med Assoc , vol.298 , pp. 194-206
    • Amori, R.E.1    Lau, J.2    Pittas, A.G.3
  • 95
    • 67649635785 scopus 로고    scopus 로고
    • GLP-1 analogues: a new therapeutic approach to prevent ductopenia in cholangiopathies?
    • Beuers U., and Goke B. GLP-1 analogues: a new therapeutic approach to prevent ductopenia in cholangiopathies?. Gut 58 (2009) 902-903
    • (2009) Gut , vol.58 , pp. 902-903
    • Beuers, U.1    Goke, B.2
  • 96
    • 0032171526 scopus 로고    scopus 로고
    • Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
    • Sasatomi K., Noguchi K., Sakisaka S., et al. Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. J Hepatol 29 (1998) 409-416
    • (1998) J Hepatol , vol.29 , pp. 409-416
    • Sasatomi, K.1    Noguchi, K.2    Sakisaka, S.3
  • 97
    • 53049099679 scopus 로고    scopus 로고
    • Leptin enhances cholangiocarcinoma cell growth
    • Fava G., Alpini G., Rychlicki C., et al. Leptin enhances cholangiocarcinoma cell growth. Cancer Res 68 (2008) 6752-6761
    • (2008) Cancer Res , vol.68 , pp. 6752-6761
    • Fava, G.1    Alpini, G.2    Rychlicki, C.3
  • 98
    • 34548308940 scopus 로고    scopus 로고
    • A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis
    • Fickert P., Stoger U., Fuchsbichler A., et al. A new xenobiotic-induced mouse model of sclerosing cholangitis and biliary fibrosis. Am J Pathol 171 (2007) 525-536
    • (2007) Am J Pathol , vol.171 , pp. 525-536
    • Fickert, P.1    Stoger, U.2    Fuchsbichler, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.