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Volumn 41, Issue 7, 2009, Pages 523-533

Human cholangiocarcinoma development is associated with dysregulation of opioidergic modulation of cholangiocyte growth

Author keywords

Cholangiocarcinoma; Endogenous opioid peptides; Proliferation; Survival

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; DELTA OPIATE RECEPTOR; ELONGATION FACTOR 2 KINASE; MITOGEN ACTIVATED PROTEIN KINASE; OPIATE AGONIST; OPIATE PEPTIDE; OPIATE RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C ALPHA;

EID: 67349261559     PISSN: 15908658     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dld.2008.09.011     Document Type: Article
Times cited : (12)

References (53)
  • 2
    • 3042789089 scopus 로고    scopus 로고
    • Worldwide trends in mortality from biliary tract malignancies
    • Patel T. Worldwide trends in mortality from biliary tract malignancies. BMC Cancer 2 (2002) 10
    • (2002) BMC Cancer , vol.2 , pp. 10
    • Patel, T.1
  • 4
    • 0028332691 scopus 로고
    • Recent advances in the management of cholangiocarcinomas
    • Vauthey J.N., and Blumgart L.H. Recent advances in the management of cholangiocarcinomas. Semin Liver Dis 14 (1994) 109-114
    • (1994) Semin Liver Dis , vol.14 , pp. 109-114
    • Vauthey, J.N.1    Blumgart, L.H.2
  • 6
  • 7
    • 33646336861 scopus 로고    scopus 로고
    • Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis
    • Marzioni M., Alpini G., Saccomanno S., de Minicis S., Glaser S., Francis H., et al. Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis. Gastroenterology 130 (2006) 1831-1847
    • (2006) Gastroenterology , vol.130 , pp. 1831-1847
    • Marzioni, M.1    Alpini, G.2    Saccomanno, S.3    de Minicis, S.4    Glaser, S.5    Francis, H.6
  • 8
    • 0029823510 scopus 로고    scopus 로고
    • Opioid growth factor tonically inhibits human colon cancer cell proliferation in tissue culture
    • Zagon I.S., Hytrek S.D., and McLaughlin P.J. Opioid growth factor tonically inhibits human colon cancer cell proliferation in tissue culture. Am J Physiol 271 (1996) R511-R518
    • (1996) Am J Physiol , vol.271
    • Zagon, I.S.1    Hytrek, S.D.2    McLaughlin, P.J.3
  • 9
    • 0033090992 scopus 로고    scopus 로고
    • Human pancreatic cancer cell proliferation in tissue culture is tonically inhibited by opioid growth factor
    • Zagon I.S., Smith J.P., and McLaughlin P.J. Human pancreatic cancer cell proliferation in tissue culture is tonically inhibited by opioid growth factor. Int J Oncol 14 (1999) 577-584
    • (1999) Int J Oncol , vol.14 , pp. 577-584
    • Zagon, I.S.1    Smith, J.P.2    McLaughlin, P.J.3
  • 10
    • 0031007342 scopus 로고    scopus 로고
    • Opioid growth factor is present in human and mouse gastrointestinal tract and inhibits DNA synthesis
    • Zagon I.S., Wu Y., and McLaughlin P.J. Opioid growth factor is present in human and mouse gastrointestinal tract and inhibits DNA synthesis. Am J Physiol 272 (1997) R1094-R1104
    • (1997) Am J Physiol , vol.272
    • Zagon, I.S.1    Wu, Y.2    McLaughlin, P.J.3
  • 11
    • 0032402977 scopus 로고    scopus 로고
    • Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems
    • Panagiotou S., Hatzoglou A., Calvo F., Martin P.M., and Castanas E. Modulation of the estrogen-regulated proteins cathepsin D and pS2 by opioid agonists in hormone-sensitive breast cancer cell lines (MCF7 and T47D): evidence for an interaction between the two systems. J Cell Biochem 71 (1998) 416-428
    • (1998) J Cell Biochem , vol.71 , pp. 416-428
    • Panagiotou, S.1    Hatzoglou, A.2    Calvo, F.3    Martin, P.M.4    Castanas, E.5
  • 12
    • 0033134813 scopus 로고    scopus 로고
    • Opioid agonists modify breast cancer cell proliferation by blocking cells to the G2/M phase of the cycle: involvement of cytoskeletal elements
    • Panagiotou S., Bakogeorgou E., Papakonstanti E., Hatzoglou A., Wallet F., Dussert C., et al. Opioid agonists modify breast cancer cell proliferation by blocking cells to the G2/M phase of the cycle: involvement of cytoskeletal elements. J Cell Biochem 73 (1999) 204-211
    • (1999) J Cell Biochem , vol.73 , pp. 204-211
    • Panagiotou, S.1    Bakogeorgou, E.2    Papakonstanti, E.3    Hatzoglou, A.4    Wallet, F.5    Dussert, C.6
  • 13
    • 0032746019 scopus 로고    scopus 로고
    • Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor
    • Bisignani G.J., McLaughlin P.J., Ordille S.D., Beltz M.S., Jarowenko M.V., and Zagon I.S. Human renal cell cancer proliferation in tissue culture is tonically inhibited by opioid growth factor. J Urol 162 (1999) 2186-2191
    • (1999) J Urol , vol.162 , pp. 2186-2191
    • Bisignani, G.J.1    McLaughlin, P.J.2    Ordille, S.D.3    Beltz, M.S.4    Jarowenko, M.V.5    Zagon, I.S.6
  • 14
    • 0033128701 scopus 로고    scopus 로고
    • Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor
    • McLaughlin P.J., Levin R.J., and Zagon I.S. Regulation of human head and neck squamous cell carcinoma growth in tissue culture by opioid growth factor. Int J Oncol 14 (1999) 991-998
    • (1999) Int J Oncol , vol.14 , pp. 991-998
    • McLaughlin, P.J.1    Levin, R.J.2    Zagon, I.S.3
  • 16
    • 0023977236 scopus 로고
    • Establishment and characterization of a human cholangiocellular carcinoma cell line
    • Kusaka Y., Muraoka A., Tokiwa T., and Sato J. Establishment and characterization of a human cholangiocellular carcinoma cell line. Hum Cell 1 (1988) 92-94
    • (1988) Hum Cell , vol.1 , pp. 92-94
    • Kusaka, Y.1    Muraoka, A.2    Tokiwa, T.3    Sato, J.4
  • 17
  • 18
    • 29244458370 scopus 로고    scopus 로고
    • gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway
    • Fava G., Marucci L., Glaser S., Francis H., De Morrow S., Benedetti A., et al. gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. Cancer Res 65 (2005) 11437-11446
    • (2005) Cancer Res , vol.65 , pp. 11437-11446
    • Fava, G.1    Marucci, L.2    Glaser, S.3    Francis, H.4    De Morrow, S.5    Benedetti, A.6
  • 20
    • 0037426950 scopus 로고    scopus 로고
    • Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion
    • Bao L., Jin S.X., Zhang C., Wang L.H., Xu Z.Z., Zhang F.X., et al. Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. Neuron 37 (2003) 121-133
    • (2003) Neuron , vol.37 , pp. 121-133
    • Bao, L.1    Jin, S.X.2    Zhang, C.3    Wang, L.H.4    Xu, Z.Z.5    Zhang, F.X.6
  • 21
    • 2942731605 scopus 로고    scopus 로고
    • Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons
    • Zhang N., Rogers T.J., Caterina M., and Oppenheim J.J. Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons. J Immunol 173 (2004) 594-599
    • (2004) J Immunol , vol.173 , pp. 594-599
    • Zhang, N.1    Rogers, T.J.2    Caterina, M.3    Oppenheim, J.J.4
  • 23
    • 19944425111 scopus 로고    scopus 로고
    • Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin
    • Marzioni M., Glaser S., Francis H., Marucci L., Benedetti A., Alvaro D., et al. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 128 (2005) 121-137
    • (2005) Gastroenterology , vol.128 , pp. 121-137
    • Marzioni, M.1    Glaser, S.2    Francis, H.3    Marucci, L.4    Benedetti, A.5    Alvaro, D.6
  • 24
    • 63449094817 scopus 로고    scopus 로고
    • Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor
    • Mancino A., Mancino M.G., Glaser S., Alpini G., Bolognese A., Izzo L., et al. Estrogens stimulate the proliferation of human cholangiocarcinoma by inducing the expression and secretion of vascular endothelial growth factor. Dig Liver Dis (2008)
    • (2008) Dig Liver Dis
    • Mancino, A.1    Mancino, M.G.2    Glaser, S.3    Alpini, G.4    Bolognese, A.5    Izzo, L.6
  • 25
    • 0036211298 scopus 로고    scopus 로고
    • Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
    • Qiao L., Yacoub A., Studer E., Gupta S., Pei X.Y., Grant S., et al. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 35 (2002) 779-789
    • (2002) Hepatology , vol.35 , pp. 779-789
    • Qiao, L.1    Yacoub, A.2    Studer, E.3    Gupta, S.4    Pei, X.Y.5    Grant, S.6
  • 26
    • 33846864450 scopus 로고    scopus 로고
    • Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes
    • Bucher B.T., Feng X., Jeyabalan G., Zhang B., Shao L., Guo Z., et al. Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes. J Surg Res 138 (2007) 15-21
    • (2007) J Surg Res , vol.138 , pp. 15-21
    • Bucher, B.T.1    Feng, X.2    Jeyabalan, G.3    Zhang, B.4    Shao, L.5    Guo, Z.6
  • 28
    • 0027932181 scopus 로고
    • Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro
    • Matsumoto K., Fujii H., Michalopoulos G., Fung J.J., and Demetris A.J. Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro. Hepatology 20 (1994) 376-382
    • (1994) Hepatology , vol.20 , pp. 376-382
    • Matsumoto, K.1    Fujii, H.2    Michalopoulos, G.3    Fung, J.J.4    Demetris, A.J.5
  • 29
    • 0032714310 scopus 로고    scopus 로고
    • Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line
    • Park J., Tadlock L., Gores G.J., and Patel T. Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line. Hepatology 30 (1999) 1128-1133
    • (1999) Hepatology , vol.30 , pp. 1128-1133
    • Park, J.1    Tadlock, L.2    Gores, G.J.3    Patel, T.4
  • 30
    • 0036322129 scopus 로고    scopus 로고
    • ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions
    • Endo K., Yoon B.I., Pairojkul C., Demetris A.J., and Sirica A.E. ERBB-2 overexpression and cyclooxygenase-2 up-regulation in human cholangiocarcinoma and risk conditions. Hepatology 36 (2002) 439-450
    • (2002) Hepatology , vol.36 , pp. 439-450
    • Endo, K.1    Yoon, B.I.2    Pairojkul, C.3    Demetris, A.J.4    Sirica, A.E.5
  • 31
    • 0036697788 scopus 로고    scopus 로고
    • Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets
    • Sirica A.E., Lai G.H., Endo K., Zhang Z., and Yoon B.I. Cyclooxygenase-2 and ERBB-2 in cholangiocarcinoma: potential therapeutic targets. Semin Liver Dis 22 (2002) 303-313
    • (2002) Semin Liver Dis , vol.22 , pp. 303-313
    • Sirica, A.E.1    Lai, G.H.2    Endo, K.3    Zhang, Z.4    Yoon, B.I.5
  • 32
    • 1842584647 scopus 로고    scopus 로고
    • Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation
    • Zhang Z., Lai G.H., and Sirica A.E. Celecoxib-induced apoptosis in rat cholangiocarcinoma cells mediated by Akt inactivation and Bax translocation. Hepatology 39 (2004) 1028-1037
    • (2004) Hepatology , vol.39 , pp. 1028-1037
    • Zhang, Z.1    Lai, G.H.2    Sirica, A.E.3
  • 33
    • 0036268170 scopus 로고    scopus 로고
    • Hepatic Met-enkephalin immunoreactivity is enhanced in primary biliary cirrhosis
    • Bergasa N.V., Liau S., Homel P., and Ghali V. Hepatic Met-enkephalin immunoreactivity is enhanced in primary biliary cirrhosis. Liver 22 (2002) 107-113
    • (2002) Liver , vol.22 , pp. 107-113
    • Bergasa, N.V.1    Liau, S.2    Homel, P.3    Ghali, V.4
  • 34
    • 0028910476 scopus 로고
    • Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver
    • Bergasa N.V., Sabol S.L., Young III W.S., Kleiner D.E., and Jones E.A. Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver. Am J Physiol 268 (1995) G346-354
    • (1995) Am J Physiol , vol.268
    • Bergasa, N.V.1    Sabol, S.L.2    Young III, W.S.3    Kleiner, D.E.4    Jones, E.A.5
  • 35
    • 0029859359 scopus 로고    scopus 로고
    • Hepatic concentrations of proenkephalin-derived opioids are increased in a rat model of cholestasis
    • Bergasa N.V., Vergalla J., Swain M.G., and Jones E.A. Hepatic concentrations of proenkephalin-derived opioids are increased in a rat model of cholestasis. Liver 16 (1996) 298-302
    • (1996) Liver , vol.16 , pp. 298-302
    • Bergasa, N.V.1    Vergalla, J.2    Swain, M.G.3    Jones, E.A.4
  • 37
    • 26444449475 scopus 로고    scopus 로고
    • The delta opioid receptor 1 is expressed by proliferating bile ductules in rats with cholestasis: implications for the study of liver regeneration and malignant transformation of biliary epithelium
    • Nicoll J., Axiotis C.A., and Bergasa N.V. The delta opioid receptor 1 is expressed by proliferating bile ductules in rats with cholestasis: implications for the study of liver regeneration and malignant transformation of biliary epithelium. Med Hypotheses 65 (2005) 1099-1105
    • (2005) Med Hypotheses , vol.65 , pp. 1099-1105
    • Nicoll, J.1    Axiotis, C.A.2    Bergasa, N.V.3
  • 38
    • 18044374488 scopus 로고    scopus 로고
    • Nuclear hormone receptor co-repressors
    • Baniahmad A. Nuclear hormone receptor co-repressors. J Steroid Biochem Mol Biol 93 (2005) 89-97
    • (2005) J Steroid Biochem Mol Biol , vol.93 , pp. 89-97
    • Baniahmad, A.1
  • 39
    • 21544483506 scopus 로고    scopus 로고
    • Functional and therapeutic significance of Akt deregulation in malignant melanoma
    • Robertson G.P. Functional and therapeutic significance of Akt deregulation in malignant melanoma. Cancer Metastasis Rev 24 (2005) 273-285
    • (2005) Cancer Metastasis Rev , vol.24 , pp. 273-285
    • Robertson, G.P.1
  • 40
    • 34250378332 scopus 로고    scopus 로고
    • Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts
    • DeMorrow S., Glaser S., Francis H., Venter J., Vaculin B., Vaculin S., et al. Opposing actions of endocannabinoids on cholangiocarcinoma growth: recruitment of Fas and Fas ligand to lipid rafts. J Biol Chem 282 (2007) 13098-13113
    • (2007) J Biol Chem , vol.282 , pp. 13098-13113
    • DeMorrow, S.1    Glaser, S.2    Francis, H.3    Venter, J.4    Vaculin, B.5    Vaculin, S.6
  • 41
    • 33745710682 scopus 로고    scopus 로고
    • Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma
    • Alvaro D., Barbaro B., Franchitto A., Onori P., Glaser S., Alpini G., et al. Estrogens and insulin-like growth factor 1 modulate neoplastic cell growth in human cholangiocarcinoma. Am J Pathol 169 (2006) 877-888
    • (2006) Am J Pathol , vol.169 , pp. 877-888
    • Alvaro, D.1    Barbaro, B.2    Franchitto, A.3    Onori, P.4    Glaser, S.5    Alpini, G.6
  • 42
    • 0022516721 scopus 로고
    • Calmodulin: a potential target for cancer chemotherapeutic agents
    • Hait W.N., and Lazo J.S. Calmodulin: a potential target for cancer chemotherapeutic agents. J Clin Oncol 4 (1986) 994-1012
    • (1986) J Clin Oncol , vol.4 , pp. 994-1012
    • Hait, W.N.1    Lazo, J.S.2
  • 43
    • 0025865899 scopus 로고
    • Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma
    • Ito H., Wang J.Z., and Shimura K. Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma. Anticancer Res 11 (1991) 249-252
    • (1991) Anticancer Res , vol.11 , pp. 249-252
    • Ito, H.1    Wang, J.Z.2    Shimura, K.3
  • 44
    • 0142244186 scopus 로고    scopus 로고
    • The combination of calmodulin antagonists and interferon-gamma induces apoptosis through caspase-dependent and -independent pathways in cholangiocarcinoma cells
    • Ahn E.Y., Pan G., Oh J.H., Tytler E.M., and McDonald J.M. The combination of calmodulin antagonists and interferon-gamma induces apoptosis through caspase-dependent and -independent pathways in cholangiocarcinoma cells. Am J Pathol 163 (2003) 2053-2063
    • (2003) Am J Pathol , vol.163 , pp. 2053-2063
    • Ahn, E.Y.1    Pan, G.2    Oh, J.H.3    Tytler, E.M.4    McDonald, J.M.5
  • 45
    • 38749124678 scopus 로고    scopus 로고
    • Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein
    • Chen Y., Xu J., Jhala N., Pawar P., Zhu Z.B., Ma L., et al. Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3′-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. Am J Pathol 169 (2006) 1833-1842
    • (2006) Am J Pathol , vol.169 , pp. 1833-1842
    • Chen, Y.1    Xu, J.2    Jhala, N.3    Pawar, P.4    Zhu, Z.B.5    Ma, L.6
  • 46
    • 20444452357 scopus 로고    scopus 로고
    • Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells
    • Kobayashi S., Werneburg N.W., Bronk S.F., Kaufmann S.H., and Gores G.J. Interleukin-6 contributes to Mcl-1 up-regulation and TRAIL resistance via an Akt-signaling pathway in cholangiocarcinoma cells. Gastroenterology 128 (2005) 2054-2065
    • (2005) Gastroenterology , vol.128 , pp. 2054-2065
    • Kobayashi, S.1    Werneburg, N.W.2    Bronk, S.F.3    Kaufmann, S.H.4    Gores, G.J.5
  • 48
    • 4444314778 scopus 로고    scopus 로고
    • The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells
    • Wu T., Leng J., Han C., and Demetris A.J. The cyclooxygenase-2 inhibitor celecoxib blocks phosphorylation of Akt and induces apoptosis in human cholangiocarcinoma cells. Mol Cancer Ther 3 (2004) 299-307
    • (2004) Mol Cancer Ther , vol.3 , pp. 299-307
    • Wu, T.1    Leng, J.2    Han, C.3    Demetris, A.J.4
  • 49
    • 34547107052 scopus 로고    scopus 로고
    • Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways
    • Lin S.J., Chang C., Ng A.K., Wang S.H., Li J.J., and Hu C.P. Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways. Apoptosis 12 (2007) 1659-1670
    • (2007) Apoptosis , vol.12 , pp. 1659-1670
    • Lin, S.J.1    Chang, C.2    Ng, A.K.3    Wang, S.H.4    Li, J.J.5    Hu, C.P.6
  • 50
    • 34648846495 scopus 로고    scopus 로고
    • Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis
    • Shen J., Jiang J., Wei Y., Zhou L., Liu D., Zhou J., et al. Two specific inhibitors of the phosphatidylinositol 3-kinase LY294002 and wortmannin up-regulate beta1,4-galactosyltransferase I and thus sensitize SMMC-7721 human hepatocarcinoma cells to cycloheximide-induced apoptosis. Mol Cell Biochem 304 (2007) 361-367
    • (2007) Mol Cell Biochem , vol.304 , pp. 361-367
    • Shen, J.1    Jiang, J.2    Wei, Y.3    Zhou, L.4    Liu, D.5    Zhou, J.6
  • 51
    • 0031902606 scopus 로고    scopus 로고
    • Dysregulation of apoptosis in hepatocellular carcinoma
    • Thorgeirsson S.S., Teramoto T., and Factor V.M. Dysregulation of apoptosis in hepatocellular carcinoma. Semin Liver Dis 18 (1998) 115-122
    • (1998) Semin Liver Dis , vol.18 , pp. 115-122
    • Thorgeirsson, S.S.1    Teramoto, T.2    Factor, V.M.3
  • 52
    • 36248985545 scopus 로고    scopus 로고
    • G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis
    • New D.C., Wu K., Kwok A.W., and Wong Y.H. G protein-coupled receptor-induced Akt activity in cellular proliferation and apoptosis. FEBS J 274 (2007) 6025-6036
    • (2007) FEBS J , vol.274 , pp. 6025-6036
    • New, D.C.1    Wu, K.2    Kwok, A.W.3    Wong, Y.H.4
  • 53
    • 33947262609 scopus 로고    scopus 로고
    • Endogenous opioid peptides and chronic liver disease: from bedside to bench
    • Marzioni M., Svegliati Baroni G., Alpini G., and Benedetti A. Endogenous opioid peptides and chronic liver disease: from bedside to bench. J Hepatol 46 (2007) 583-586
    • (2007) J Hepatol , vol.46 , pp. 583-586
    • Marzioni, M.1    Svegliati Baroni, G.2    Alpini, G.3    Benedetti, A.4


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