Glucagon-Like Peptide-1 and Its Receptor Agonist Exendin-4 Modulate Cholangiocyte Adaptive Response to Cholestasis

Gastroenterology

Volumn 133, Issue 1, 2007, Pages 244-255

  Marzioni, Marco ^a   Alpini, Gianfranco ^b,c   Saccomanno, Stefania ^a   Candelaresi, Cinzia ^a   Venter, Juliet ^c   Rychlicki, Chiara ^a   Fava, Giammarco ^a   Francis, Heather ^c   Trozzi, Luciano ^a   Glaser, Shannon ^c   Benedetti, Antonio ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE (CALCIUM,CALMODULIN) II; PROTEIN KINASE C ALPHA; RECEPTOR BLOCKING AGENT;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BILE DUCT DISEASE; CELL GROWTH; CHOLANGIOCYTE; CHOLESTASIS; CONTROLLED STUDY; EPITHELIUM CELL; HEPATOBILIARY SYSTEM; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PANCREAS CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 34447095397     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.04.007     Document Type: Article

References (54)

1. Lazaridis K.N., Strazzabosco M., and LaRusso N.F. The cholangiopathies: disorders of biliary epithelia. Gastroenterology 127 (2004) 1565-1577
2. Annual Report of the U.S. Organ Procurement and Transplantation Network and the Scientific Registry for Transplant Recipients (2001), Department of Health and Human Services, Health Resources and Services Administration, Office of Special Programs, Division of Transplantation, Rockville, MD Transplant data 1991-2001
3. Alvaro D., Mancino M.G., Glaser S., Gaudio E., Marzioni M., Francis H., and Alpini G. Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver. Gastroenterology 132 (2007) 415-431
4. Marzioni M., Glaser S., Francis H., Marucci L., Benedetti A., Alvaro D., Taffetani S., Ueno Y., Roskams T., Phinizy J.L., Venter J., Fava G., LeSage G., and Alpini G. Autocrine/paracrine regulation of the growth of the biliary tree by the neuroendocrine hormone serotonin. Gastroenterology 128 (2005) 121-137
5. Marzioni M., Alpini G., Saccomanno S., de Minicis S., Glaser S., Francis H., Trozzi L., Venter J., Orlando F., Fava G., Candelaresi C., Macarri G., and Benedetti A. Endogenous opioids modulate the growth of the biliary tree in the course of cholestasis. Gastroenterology 130 (2006) 1831-1847
6. Gaudio E., Barbaro B., Alvaro D., Glaser S., Francis H., Ueno Y., Meininger C.J., Franchitto A., Onori P., Marzioni M., Taffetani S., Fava G., Stoica G., Venter J., Reichenbach R., De Morrow S., Summers R., and Alpini G. Vascular endothelial growth factor stimulates rat cholangiocyte proliferation via an autocrine mechanism. Gastroenterology 130 (2006) 1270-1282
7. Roskams T., van den Oord J.J., De Vos R., and Desmet V.J. Neuroendocrine features of reactive bile ductules in cholestatic liver disease. Am J Pathol 137 (1990) 1019-1025
8. Brubaker P.L., and Drucker D.J. Minireview: glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 145 (2004) 2653-2659
9. Drucker D.J. Biological actions and therapeutic potential of the glucagon-like peptides. Gastroenterology 122 (2002) 531-544
10. Drucker D.J. Glucagon-like peptides: regulators of cell proliferation, differentiation, and apoptosis. Mol Endocrinol 17 (2003) 161-171
11. Fineman M.S., Bicsak T.A., Shen L.Z., Taylor K., Gaines E., Varns A., Kim D., and Baron A.D. Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes. Diabetes Care 26 (2003) 2370-2377
12. Bulotta A., Hui H., Anastasi E., Bertolotto C., Boros L.G., Di Mario U., and Perfetti R. Cultured pancreatic ductal cells undergo cell cycle re-distribution and beta-cell-like differentiation in response to glucagon-like peptide-1. J Mol Endocrinol 29 (2002) 347-360
13. Zhou J., Wang X., Pineyro M.A., and Egan J.M. Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells. Diabetes 48 (1999) 2358-2366
14. Yang L., Li S., Hatch H., Ahrens K., Cornelius J.G., Petersen B.E., and Peck A.B. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci U S A 99 (2002) 8078-8083
15. Nagaya M., Kubota S., Isogai A., Tadokoro M., and Akashi K. Ductular cell proliferation in islet cell neogenesis induced by incomplete ligation of the pancreatic duct in dogs. Surg Today 34 (2004) 586-592
16. Chu J.Y., Yung W.H., and Chow B.K. Secretin: a pleiotrophic hormone. Ann N Y Acad Sci 1070 (2006) 27-50
17. Grapin-Botton A. Ductal cells of the pancreas. Int J Biochem Cell Biol 37 (2005) 504-510
18. Niwa T., Nimura Y., and Niki I. Lack of effect of incretin hormones on insulin release from pancreatic islets in the bile duct-ligated rats. Am J Physiol Endocrinol Metab 280 (2001) E59-E64
19. Nakagawa A., Satake H., Nakabayashi H., Nishizawa M., Furuya K., Nakano S., Kigoshi T., Nakayama K., and Uchida K. Receptor gene expression of glucagon-like peptide-1, but not glucose-dependent insulinotropic polypeptide, in rat nodose ganglion cells. Auton Neurosci 110 (2004) 36-43
20. Redondo A., Trigo M.V., Acitores A., Valverde I., and Villanueva-Penacarrillo M.L. Cell signalling of the GLP-1 action in rat liver. Mol Cell Endocrinol 204 (2003) 43-50
21. Ding X., Saxena N.K., Lin S., Gupta N.A., and Anania F.A. Exendin-4, a glucagon-like protein-1 (GLP-1) receptor agonist, reverses hepatic steatosis in ob/ob mice. Hepatology 43 (2006) 173-181
22. Hui H., Nourparvar A., Zhao X., and Perfetti R. Glucagon-like peptide-1 inhibits apoptosis of insulin-secreting cells via a cyclic 5′-adenosine monophosphate-dependent protein kinase A- and a phosphatidylinositol 3-kinase-dependent pathway. Endocrinology 144 (2003) 1444-1455
23. Thorens B., Porret A., Buhler L., Deng S.P., Morel P., and Widmann C. Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42 (1993) 1678-1682
24. Guibert C., Marthan R., and Savineau J.P. 5-HT induces an arachidonic acid-sensitive calcium influx in rat small intrapulmonary artery. Am J Physiol Lung Cell Mol Physiol 286 (2004) L1228-L1236
25. Maga G., and Hubscher U. Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 116 (2003) 3051-3060
26. Ozyazgan S., Kutluata N., Afsar S., Ozdas S.B., and Akkan A.G. Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats. Pharmacology 74 (2005) 119-126
27. Alpini G., Glaser S., Alvaro D., Ueno Y., Marzioni M., Francis H., Baiocchi L., Stati T., Barbaro B., Phinizy J.L., Mauldin J., and LeSage G. Bile acid depletion and repletion regulate cholangiocyte growth and secretion by a phosphatidylinositol 3-kinase-dependent pathway in rats. Gastroenterology 123 (2002) 1226-1237
28. Alpini G., Lenzi R., Sarkozi L., and Tavoloni N. Biliary physiology in rats with bile ductular cell hyperplasia. Evidence for a secretory function of proliferated bile ductules. J Clin Invest 81 (1988) 569-578
29. Tseng C.C., Zhang X.Y., and Wolfe M.M. Effect of GIP and GLP-1 antagonists on insulin release in the rat. Am J Physiol 276 (1999) E1049-E1054
30. Ishii M., Vroman B., and LaRusso N.F. Isolation and morphological characterization of bile duct epithelial cells from normal rat liver. Gastroenterology 97 (1989) 1236-1247
31. LeSage G., Alvaro D., Glaser S., Francis H., Marucci L., Roskams T., Phinizy J.L., Marzioni M., Benedetti A., Taffetani S., Barbaro B., Fava G., Ueno Y., and Alpini G. Alpha-1 adrenergic receptor agonists modulate ductal secretion of BDL rats via Ca(2+)- and PKC-dependent stimulation of cAMP. Hepatology 40 (2004) 1116-1127
32. LeSage G., Benedetti A., Glaser S., Marucci L., Tretjak Z., Caligiuri A., Rodgers R., Phinizy J.L., Baiocchi L., Francis H., Lasater J., Ugili L., and Alpini G. Acute carbon tetrachloride feeding selectively damages large, but not small, cholangiocytes from normal rat liver. Hepatology 29 (1999) 307-319
33. Alpini G., Ulrich C., Roberts S., Phillips J.O., Ueno Y., Podila P.V., Colegio O., LeSage G., Miller L.J., and LaRusso N.F. Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation. Am J Physiol 272 (1997) G289-G297
34. LeSage G., Marucci L., Alvaro D., Glaser S., Benedetti A., Marzioni M., Patel T., Francis H., Phinizy J.L., and Alpini G. Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity. Hepatology 36 (2002) 641-651
35. Rothenberg M.E., Eilertson C.D., Klein K., Zhou Y., Lindberg I., McDonald J.K., Mackin R.B., and Noe B.D. Processing of mouse proglucagon by recombinant prohormone convertase 1 and immunopurified prohormone convertase 2 in vitro. J Biol Chem 270 (1995) 10136-10146
36. Xiao Q., Jeng W., and Wheeler M.B. Characterization of glucagon-like peptide-1 receptor-binding determinants. J Mol Endocrinol 25 (2000) 321-335
37. Kanno N., LeSage G., Glaser S., and Alpini G. Regulation of cholangiocyte bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 281 (2001) G612-G625
38. Alpini G., Prall R.T., and LaRusso N.F. The pathobiology of biliary epithelia. In: Arias I.M., Boyer J.L., Chisari F.V., Fausto N., Jakoby W., Schachter D., and Shafritz D.A. (Eds). The liver; biology and pathobiology. 4th ed. (2001), Lippincott Williams & Wilkins, Philadelphia, PA 421-435
39. Alvaro D., Gigliozzi A., and Attili A.F. Regulation and deregulation of cholangiocyte proliferation. J Hepatol 33 (2000) 333-340
40. Roskams T., Cassiman D., De Vos R., and Libbrecht L. Neuroregulation of the neuroendocrine compartment of the liver. Anat Rec A Discov Mol Cell Evol Biol 280 (2004) 910-923
41. Alvaro D., Invernizzi P., Onori P., Franchitto A., De Santis A., Crosignani A., Sferra R., Ginanni-Corradini S., Mancino M.G., Maggioni M., Attili A.F., Podda M., and Gaudio E. Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis. J Hepatol 41 (2004) 905-912
42. Lopez-Delgado M.I., Morales M., Villanueva-Penacarrillo M.L., Malaisse W.J., and Valverde I. Effects of glucagon-like peptide 1 on the kinetics of glycogen synthase a in hepatocytes from normal and diabetic rats. Endocrinology 139 (1998) 2811-2817
43. 2+ influx through L-type voltage-gated calcium channels mediate Raf-independent activation of extracellular regulated kinase in response to glucagon-like peptide-1 in pancreatic beta-cells. J Biol Chem 277 (2002) 48146-48151
44. Cantley L.C. The phosphoinositide 3-kinase pathway. Science 296 (2002) 1665-1667
45. Marra F., Arrighi M.C., Fazi M., Caligiuri A., Pinzani M., Romanelli R.G., Efsen E., Laffi G., and Gentilini P. Extracellular signal-regulated kinase activation differentially regulates platelet-derived growth factor's actions in hepatic stellate cells, and is induced by in vivo liver injury in the rat. Hepatology 30 (1999) 951-958
46. 2+-dependent cytoprotective effects of ursodeoxycholic and tauroursodeoxycholic acid on the biliary epithelium in a rat model of cholestasis and loss of bile ducts. Am J Pathol 168 (2006) 398-409
47. Marzioni M., LeSage G., Glaser S., Patel T., Marienfeld C., Ueno Y., Francis H., Alvaro D., Phinizy J.L., Tadlock L., Benedetti A., Marucci L., Baiocchi L., and Alpini G. Taurocholate prevents the loss of intrahepatic bile ducts due to vagotomy in bile duct ligated rats. Am J Physiol 284 (2003) G837-G852
48. Belcheva M.M., Szucs M., Wang D., Sadee W., and Coscia C.J. Mu-opioid receptor-mediated ERK activation involves calmodulin-dependent epidermal growth factor receptor transactivation. J Biol Chem 276 (2001) 33847-33853
49. Minagawa N., Ehrlich B.E., and Nathanson M.H. Calcium signaling in cholangiocytes. World J Gastroenterol 12 (2006) 3466-3470
50. Berridge M.J., Lipp P., and Bootman M.D. The versatility and universality of calcium signalling. Nat Rev Mol Cell Biol 1 (2000) 11-21
51. Hirata K., Dufour J.F., Shibao K., Knickelbein R., O'Neill A.F., Bode H.P., Cassio D., St-Pierre M.V., LaRusso N.F., Leite M.F., and Nathanson M.H. Regulation of Ca(2+) signaling in rat bile duct epithelia by inositol 1,4,5-trisphosphate receptor isoforms. Hepatology 36 (2002) 284-296
52. Shibao K., Hirata K., Robert M.E., and Nathanson M.H. Loss of inositol 1,4,5-trisphosphate receptors from bile duct epithelia is a common event in cholestasis. Gastroenterology 125 (2003) 1175-1187
53. Alpini G., Baiocchi L., Glaser S., Ueno Y., Marzioni M., Francis H., Phinizy J.L., Angelico M., and LeSage G. Ursodeoxycholate and tauroursodeoxycholate inhibit cholangiocyte growth and secretion of BDL rats through activation of PKC alpha. Hepatology 35 (2002) 1041-1052
54. Ahlgren U., Jonsson J., and Edlund H. The morphogenesis of the pancreatic mesenchyme is uncoupled from that of the pancreatic epithelium in IPF1/PDX1-deficient mice. Development 122 (1996) 1409-1416