Expression of CD45 isoforms correlates with differential proliferative responses of peripheral CD4+ and CD8+ T cells

Immunology Letters

Volumn 129, Issue 1, 2010, Pages 39-46

  Seki, Iwao ^a,b   Suzuki, Mihoko ^a   Miyasaka, Nobuyuki ^a   Kohsaka, Hitoshi ^a,c  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b SANTEN PHARMACEUTICAL CO LTD   (Japan)

^c Institute of Physical and Chemical Research   (Japan)

Author keywords

CD45; Cell proliferation; IL 2; Jak; Protein tyrosine phosphatase; STAT; T cells

Indexed keywords

CD45 ANTIGEN; CD45RBC ANTIGEN; CD45RO ANTIGEN; INTERLEUKIN 2 RECEPTOR; JANUS KINASE; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL LEVEL; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; IMMUNE RESPONSE; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSGENE;

ANIMALS; ANTIGENS, CD45; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELL SEPARATION; CLONING, MOLECULAR; FLOW CYTOMETRY; INTERLEUKIN-2; JANUS KINASE 1; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 77649190524     PISSN: 01652478     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imlet.2009.12.020     Document Type: Article

References (43)

1. Foulds K.E., Zenewicz L.A., Shedlock D.J., Jiang J., Troy A.E., and Shen H. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J Immunol 168 (2002) 1528-1532
2. Murali-Krishna K., Miller J.D., Slansky J., and Ahmed R. Counting antigen-specific CD8 T cells: a re-evaluation of bystander activation during vial infection. Immunity 8 (1998) 177-187
3. + T cells during the primary immune response to Epstein-Barr virus in vivo. J Exp Med 187 (1998) 1395-1402
4. + T cell expansions in normal individuals and patients with rheumatoid arthritis. J Immunol 154 (1995) 3538-3547
5. Posnett D.N., Sinha R., Kabak S., and Russo C. Clonal populations of T cells in normal elderly humans: the T cell equivalent to "Benign monoclonal gammapathy". J Exp Med 179 (1994) 609-618
6. + subsets. Mech Ageing Dev 123 (2002) 375-390
7. Nishio J., Suzuki M., Miyasaka N., and Kohsaka H. Clonal biases of peripheral CD8 T cell repertoire directly reflects local inflammation in polymyositis. J Immunol 167 (2001) 4051-4058
8. Tanchot C., Lemonnier F.A., Perarnau B., Freitas A.A., and Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science 276 (1997) 2057-2062
9. Schluns K.S., and Lefrancois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol 3 (2003) 269-279
10. Surh C.D., and Sprent J. Regulation of mature T cell homeostasis. Semin Immunol 17 (2005) 183-191
11. + cells. J Exp Med 195 (2002) 1523-1532
12. Kovanen P.E., and Leonard W.J. Cytokines and immunodeficiency diseases: critical roles of the gamma(c)-dependent cytokines interleukins 2, 4, 7, 9, 15, and 21, and their signaling pathways. Immunol Rev 202 (2004) 67-83
13. Papageorgiou A.C., and Wikman L.E. Is JAK3 a new drug target for immunomodulation-based therapies?. Trends Pharmacol Sci 25 (2004) 558-562
14. Ferrari-Lacraz S., Zanelli E., Neuberg M., Donskoy E., Kim Y.S., Zheng X.X., et al. Targeting IL-15 receptor-bearing cells with an antagonist mutant IL-15/Fc protein prevents disease development and progression in murine collagen-induced arthritis. J Immunol 173 (2004) 5818-5826
15. Penninger J.M., Irie-Sasaki J., Sasaki T., and Oliveria-dos-Santos A.J. CD45: new jobs for an old acquaintance. Nat Immunol 2 (2001) 389-396
16. Hermiston M.L., Xu Z., and Weiss A. CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol 21 (2003) 107-137
17. Holms N. CD45: all is not yet crystal clear. Immunology 117 (2005) 145-155
18. Koretzky G.A., Picus J., Thomas M.L., and Weiss A. Tyrosine phosphatase CD45 is essential for coupling T cell antigen receptor to the phosphatidylinositol pathway. Nature 346 (1990) 66-68
19. Pingel J.T., and Thomas M.L. Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation. Cell 58 (1989) 1055-1065
20. Xu Z., and Weiss A. Negative regulation of CD45 by differential homodimerization of the alternatively spliced isoforms. Nat Immunol 3 (2002) 764-771
21. Takeda A., Matsuda A., Paul R.M., and Yaseen N.R. CD45-associated protein inhibits CD45 dimerization and up-regulates its protein tyrosine phosphatase activity. Blood 103 (2004) 3440-3447
22. Greer S.F., Wang Y., Raman C., and Justement L.B. CD45 function is regulated by an acidic 19-amino acid insert in domain II that serves as binding and phosphoacceptor site for casein kinase 2. J Immunol 166 (2001) 7208-7218
23. Rogers P.R., Pilapil S., Hayakawa K., Roman P.L., and Parker D.C. CD45 alternative exon expression in murine and human CD4+ T cell subsets. J Immunol 148 (1992) 4054-4065
24. Fukuhara K., Okumura M., Shiono H., Inoue M., Kadota Y., Miyoshi S., et al. A study on CD45 isoform expression during T-cell development and selection events in the human thymus. Hum Immunol 63 (2002) 394-404
25. Czyzyk J., Leitenberg D., Taylor T., and Bottomly K. Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1. Mol Cell Biol 20 (2000) 8740-8747
26. Novak T.J., Farber D., Leitenberg D., Hong S.C., Johnson P., and Bottomly K. Isoforms of the transmembrane tyrosine phosphatase CD45 differentially affect T cell recognition. Immunity 1 (1994) 109-119
27. Chui D., Ong C.J., Johnson P., Teh H.S., and Marth J.D. Specific CD45 isoforms differentially regulate T cell receptor signaling. EMBO J 13 (1994) 798-807
28. Johnson P., Greenbaum L., Bottomly K., and Trowbridge I.S. Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies. J Exp Med 169 (1989) 1179-1184
29. Kitamura T., Koshino Y., Shibata F., Oki T., Nakajima H., Nosaka T., et al. Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp Hematol 31 (2003) 1007-1014
30. Kitamura K., Maiti A., Ng D.H., Johnson P., Maizel A.L., and Takeda A. Characterization of the interaction between CD45 and CD45-AP. J Biol Chem 270 (1995) 21151-21157
31. Rider D.A., and Young S.P. Measuring the specific activity of the CD45 protein tyrosine phosphatase. J Immunol 277 (2003) 127-134
32. Dutton R.W., Bradley L.M., and Swain S.L. T cell memory. Annu Rev Immunol 16 (1998) 201-223
33. + T cells. J Exp Med 194 (2001) 1711-1719
34. Kishihara K., Penninger J., Wallace V.A., Kundig T.M., Kwai K., Wakeham A., et al. Normal B lymphocyte development but T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 74 (1993) 143-156
35. + thymocytes, and in B cell maturation. J Exp Med 183 (1996) 1707-1718
36. Ilangumaran S., and Rottapel R. Regulation of cytokine receptor signaling by SOCS1. Immunol Rev 192 (2003) 196-211
37. Yasukawa H., Sasaki A., and Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol 18 (2000) 143-164
38. Aman J.M., Migone T., Sasaki A., Ascherman D.P., Zhu M., Soldani E., et al. CIS associates with the interleukin-2 receptor β chain and inhibits interleukin-2-dependent signaling. J Biol Chem 274 (1999) 30266-30272
39. Imoto M., Tanaka S., Deguchi A., Hayakawa A., and Umezawa K. In situ inhibition of protein-tyrosine phosphatase by dephostatin. Cell Pharmacol 2 (1995) 199-203
40. Haque S.J., Harbor P., Tabrizi M., Yi T., and Williams B.R.G. Protein-tyrosine phosphatase Shp-1 is a negative regulator of IL-4- and IL-13-dependent signal transduction. J Biol Chem 273 (1998) 33893-33896
41. Lord J.D., McIntosh B.C., Greenberg P.D., and Nelson B.H. The IL-2 receptor promotes lymphocyte proliferation and induction of the c-myc, bcl-2, and bcl-x genes through the trans-activation domain of stat5. J Immunol 164 (2000) 2533-2541
42. O'Shea J.J., Park H., Pesu M., Borie D., and Changelian P. New strategies for immunosuppression: interfering with cytokines by targeting the Jak/Stat pathway. Curr Opin Rheumatol 17 (2005) 305-311
43. Borie D.C., Si M.S., Morris R.E., Reitz B.A., and Changelian P.S. JAK3 inhibition as a new concept for immune suppression. Curr Opin Invest Drugs 4 (2003) 1297-1303