Antiplatelet antibodies in WASP(-) mice correlate with evidence of increased in vivo platelet consumption

Experimental Hematology

Volumn 37, Issue 11, 2009, Pages 1353-1363

  Marathe, Bindumadhav M ^a   Prislovsky, Amanda ^b   Astrakhan, Alexander ^c   Rawlings, David J ^c,d   Wan, Jim Y ^a   Strom, Ted S ^a,b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SEATTLE CHILDREN S RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 CHLOROMETHYLFLUORESCEIN DIACETATE; CD47 ANTIGEN; FLUORESCENT DYE; IMMUNOGLOBULIN G ANTIBODY; THROMBOCYTE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ANTIBODY DETECTION; ANTIGEN BINDING; ARTICLE; CELL LABELING; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLOW CYTOMETRY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THROMBOCYTE COUNT; THROMBOCYTOPENIA; WISKOTT ALDRICH SYNDROME;

ANIMALS; ANTIGENS, CD47; AUTOANTIBODIES; AUTOIMMUNE DISEASES; BLOOD PLATELETS; BONE MARROW; MALE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; OPSONIN PROTEINS; PHAGOCYTOSIS; PLATELET COUNT; SPLEEN; SPLENOMEGALY; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN;

MURINAE; MUS;

EID: 70349816649     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2009.08.007     Document Type: Article

References (33)

1. Baldini M.G. Nature of the platelet defect in the Wiskott-Aldrich syndrome. Ann N Y Acad Sci 201 (1972) 437-444
2. Grottum K.A., Hovig T., Holmsen H., Abrahamsen A.F., Jeremic M., and Seip M. Wiskott-Aldrich syndrome: qualitative platelet defects and short platelet survival. Br J Haematol 17 (1969) 373-388
3. Ochs H.D., Slichter S.J., Harker L.A., Von Behrens W.E., Clark R.A., and Wedgwood R.J. The Wiskott-Aldrich syndrome: studies of lymphocytes, granulocytes, and platelets. Blood 55 (1980) 243-252
4. Hanson S.R., and Slichter S.J. Platelet kinetics in patients with bone marrow hypoplasia: evidence for a fixed platelet requirement. Blood 66 (1985) 1105-1109
5. Kajiwara M., Nonoyama S., Eguchi M., et al. WASP is involved in proliferation and differentiation of human haemopoietic progenitors in vitro. Br J Haematol 107 (1999) 254-262
6. Luthi J.N., Gandhi M.J., and Drachman J.G. X-linked thrombocytopenia caused by a mutation in the Wiskott-Aldrich syndrome (WAS) gene that disrupts interaction with the WAS protein (WASP)-interacting protein (WIP). Exp Hematol 31 (2003) 150-158
7. Sabri S., Foudi A., Boukour S., et al. Deficiency in the Wiskott-Aldrich protein induces premature proplatelet formation and platelet production in the bone marrow compartment. Blood 108 (2006) 134-140
8. Dupuis-Girod S., Medioni J., Haddad E., et al. Autoimmunity in Wiskott-Aldrich syndrome: risk factors, clinical features, and outcome in a single-center cohort of 55 patients. Pediatrics 111 (2003) e622-e627
9. Humblet-Baron S., Sather B., Anover S., et al. Wiskott-Aldrich syndrome protein is required for regulatory T cell homeostasis. J Clin Invest 117 (2007) 407-418
10. Mullen C., Anderson K.D., and Blaese R.M. Splenectomy and/or bone marrow transplantation in the management of the Wiskott-Aldrich syndrome: long-term followup of 52 cases. Blood 82 (1993) 2961-2966
11. Notarangelo L.D., Mazza C., Giliani S., et al. Missense mutations of the WASP gene cause intermittent X-linked thrombocytopenia. Blood 99 (2002) 2268-2269
12. Corash L., Shafer B., and Blaese R.M. Platelet-associated immunoglobulin, platelet size, and the effect of splenectomy in the Wiskott-Aldrich syndrome. Blood 65 (1985) 1439-1443
13. Kanegane H., Nomura K., Miyawaki T., et al. X-linked thrombocytopenia identified by flow cytometric demonstration of defective Wiskott-Aldrich syndrome protein in lymphocytes. Blood 95 (2000) 1110-1111
14. Litzman J., Jones A., Hann I., Chapel H., Strobel S., and Morgan G. Intravenous immunoglobulin, splenectomy, and antibiotic prophylaxis in Wiskott-Aldrich syndrome. Arch Dis Child 75 (1996) 436-439
15. Semple J.W., Siminovitch K.A., Mody M., et al. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol 97 (1997) 747-754
16. Prislovsky A., Marathe B., Hosni A., et al. Rapid platelet turnover in WASP(-) mice correlates with increased ex vivo phagocytosis of opsonized WASP(-) platelets. Exp Hematol 36 (2008) 609-623
17. Mizutani H., Engelman R.W., Kurata Y., Ikehara S., and Good R.A. Development and characterization of monoclonal antiplatelet autoantibodies from autoimmune thrombocytopenic purpura-prone (NZW x BXSB)F1 mice. Blood 82 (1993) 837-844
18. Snapper S.B., Rosen F.S., Mizoguchi E., et al. Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity 9 (1998) 81-91
19. Kitamura D., Roes J., Kuhn R., and Rajewsky K.A. B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350 (1991) 423-426
20. Ault K.A., Rinder H.M., Mitchell J., Carmody M.B., Vary C.P., and Hillman R.S. The significance of platelets with increased RNA content (reticulated platelets). A measure of the rate of thrombopoiesis. Am J Clin Pathol 98 (1992) 637-646
21. George J.N. Platelet immunoglobulin G: its significance for the evaluation of thrombocytopenia and for understanding the origin of alpha-granule proteins. Blood 76 (1990) 859-870
22. Olsson M., Bruhns P., Frazier W.A., Ravetch J.V., and Oldenborg P.A. Platelet homeostasis is regulated by platelet expression of CD47 under normal conditions and in passive immune thrombocytopenia. Blood 105 (2005) 3577-3582
23. Nimmerjahn F., and Ravetch J.V. Divergent immunoglobulin g subclass activity through selective Fc receptor binding. Science 310 (2005) 1510-1512
24. Oldenborg P.A. Role of CD47 in erythroid cells and in autoimmunity. Leuk Lymphoma 45 (2004) 1319-1327
25. Gross B.S., Wilde J.I., Quek L., Chapel H., Nelson D.L., and Watson S.P. Regulation and function of WASp in platelets by the collagen receptor, glycoprotein VI. Blood 94 (1999) 4166-4176
26. Rengan R., Ochs H.D., Sweet L.I., et al. Actin cytoskeletal function is spared, but apoptosis is increased, in WAS patient hematopoietic cells. Blood 95 (2000) 1283-1292
27. Falet H., Hoffmeister K.M., Neujahr R., and Hartwig J.H. Normal Arp2/3 complex activation in platelets lacking WASp. Blood 100 (2002) 2113-2122
28. Andreansky S., Liu C.H., Turner S.J., et al. WASP- mice Exhibit Defective Immune Responses to Influenza A Virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG. Exp Hematol 33 (2005) 443-451
29. Birks J.W., Klassen L.W., and Gurney C.W. Hypoxia-induced thrombocytopenia in mice. J Lab Clin Med 86 (1975) 230-238
30. McDonald T.P., Clift R.E., and Cottrell M.B. Large, chronic doses of erythropoietin cause thrombocytopenia in mice. Blood 80 (1992) 352-358
31. Santoso S., Zimmermann U., Neppert J., and Mueller-Eckhardt C. Receptor patching and capping of platelet membranes induced by monoclonal antibodies. Blood 67 (1986) 343-349
32. White J.G., and Escolar G. Induction of receptor clustering, patching, and capping on surface-activated platelets. Lab Invest 63 (1990) 332-340
33. Hezard N., Simon G., Mace C., Jallu V., Kaplan C., and Nguyen P. Is flow cytometry accurate enough to screen platelet autoantibodies?. Transfusion 48 (2008) 513-518