T and B cell responses to HDM allergens and antigens

Immunologic Research

Volumn 37, Issue 3, 2007, Pages 187-199

  Thomas, Wayne R ^a,b   Hales, Belinda J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Allergen; House dust mite; lgE; lgG; Nonallergen; T Cell

Indexed keywords

CD4 ANTIGEN; CD45RO ANTIGEN; CYTOKINE; HOUSE DUST ALLERGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G4; INTERLEUKIN 2 RECEPTOR ALPHA;

ANTIBODY PRODUCTION; ANTIBODY TITER; ANTIGEN BINDING; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DERMATOPHAGOIDES; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HIGH RISK POPULATION; HOUSE DUST ALLERGY; HUMAN; IMMUNOGENICITY; IMMUNOGLOBULIN PRODUCTION; IMMUNOSTIMULATION; MOLECULAR CLONING; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; REVIEW; SKIN TEST; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; WESTERN BLOTTING;

ALLERGENS; ANIMALS; ANTIGENS; B-LYMPHOCYTES; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULINS; LYMPHOCYTE ACTIVATION; PYROGLYPHIDAE; T-LYMPHOCYTES; TH1 CELLS; TH2 CELLS;

EID: 35348879694     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02697369     Document Type: Review

References (141)

1. Huss K, Adkinson NF, Jr, Eggleston PA, Dawson C, Van Natta ML, Hamilton RG: House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program. J Allergy Clin Immunol 2001;107:48-54.
2. Arlian LG, Bernstein D, Bernstein IL, e t al: Prevalence of dust mites in the homes of people with asthma living in eight different geographic areas of the United States. J Allergy Clin Immunol 1992;90(3 Pt 1):292-300.
3. Sakaguchi M, Inouye S, Yasueda H, Irie T, Yoshizawa S, Shida T: Measurement of allergens associated with dust mite allergy. II. Concentrations of airborne mite allergens (Der I and Der II) in the house. Int Arch Allergy Appl Immunol 1989;90:190-193.
4. Lind P, Hansen OC, Horn N: The binding of mouse hybridoma and human IgE antibodies to the major fecal allergen, Der p I, of Dermatophagoides pteronyssinus. Relative binding site location and species specificity studied by solid-phase inhibition assays with radiolabeled antigen. J Immunol 1988;140:4256-4262.
5. Erwin EA, Wickens K, Custis NJ, et al: Cat and dust mite sensitivity and tolerance in relation to wheezing among children raised with high exposure to both allergens. J Allergy Clin Immunol 2005;115:74-79.
6. Trombone AP, Tobias KR, Ferriani VP, et al: Use of a chimeric ELISA to investigate immunoglobulin E antibody responses to Der p 1 and Der p 2 in mite-allergic patients with asthma, wheezing and/or rninitis. Clin Exp Allergy 2002;32:1323-1328.
7. Hales BJ, Martin AC, Pearce LJ, et al: IgE and IgG anti-house dust mite specificities in allergic disease. J Allergy Clin Immunol 2006;118:361-367.
8. Chua KY, Stewart GA, Thomas WR, et al: Sequence analysis of cDNA coding for a major house dust mite allergen, Der p 1, Homology with cysteine proteases. J Exp Med 1988;167:175-182.
9. Tovey ER, Chapman MD, Platts-Mills TA: Mite faeces are a major source of house dust allergens. Nature 1981;289:592-593.
10. Gough L, Sewell HF, Shakib F: The proteolytic activity of the major dust mite allergen Der p 1 enhances the IgE antibody response to a bystander antigen. Clin Exp Allergy 2001;3:1594 [???]1598.
11. Kikuchi Y, Takai T, Kuhara T, et al: Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses. J Immunol 2006;177:1609-1617.
12. Takai T, Kato T, Ota M, et al: Recombinant Derp 1 and Der f 1 with in vitro enzymatic activity to cleave human CD23, CD25 and alpha1-antitrypsin, and in vivo IgE-eliciting activity in mice. Int Arch Allergy Immunol 2005;137:194-200.
13. Asokananthan N, Graham PT, Stewatt DJ, et al: House dust mite allergens induce proinflammatory cytokines from respiratory epithelial cells: the cysteine protease allergen, Der p 1, activates protease-activated receptor (PAR)-2 and inactivates PAR-1. J Immunol 2002;169:4572-4578.
14. Stewart GA, Robinson C: The immunobiology of allergenic peptidases. Clin Exp Allergy 2003;33:3-6.
15. Charbonnier AS, Hammad H, Gosset P, et al: Derp 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response. J Leukoc Biol 2003;73:91-99.
16. Pichavant M, Charbonnier AS, Taront S, et al: Asthmatic broncnial epithelium activated by the proteolytic allergen Der p 1 increases selective dendritic cell recruitment. J Allergy Clin Immunol 2005;115:771-778.
17. McCall C, Hunter S, Stedman K, et al: Characterization and cloning of a major high molecular weight house dust mite allergen (Der f 15) for dogs. Vet Immunol Immunopathol 2001;78:231-247.
18. Nuttall TJ, Pembetton AD, Lamb JR, Hill PB: Peripheral blood mononuclear cell responses to major and minor Dermatophagoides allergens in canine atopic dermatitis. Vet Immunol Immunopathol 2002;84:143-150.
19. Weber E, Hunter S, Stedman K, et al: Identification, characterization, and cloning of a complementary DNA encoding a 60-kd house dust mite allergen (Der f 18) for human beings and dogs. J Allergy Clin Immunol 2003;112:79-86.
20. Johannessen BR, Skov LK, et al: Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity. FEBS Lett 2005;579:1208-1212.
21. Mueller GA, Benjamin DC, Rule GS: Tertiary structure of the major house dust mite allergen Der p 2: sequential and structural homologies. Biochemistry 1998;37:12707-12714.
22. Ichikawa S, Takai T, Inoue T, et al: NMR study on the major mite allergen Der f 2: its refined tetfiary structure, epitopes for monoclonal antibodies and characteristics shared by ML protein group members. J Biochem (Tokyo) 2005;137:255-263.
23. Gruber A, Mancek M, Wagner H, Kirschning CJ, Jerala R: Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition. J Biol Chem 2004;279:28475-28482.
24. Yasueda H, Mita H, Akiyama K, et al: Allergens from Dermatophagoides mites with chymotryptic activity. Clin Exp Allergy 1993;23:384-390.
25. King C, Simpson RJ, Moritz RL, Reed GE, Thompson PJ, Stewart GA: The isolation and characterization of a novel collagenolytic serine protease allergen (Der p 9) from the dust mite Dermatophagoides pteronyssinus. J Allergy Clin Immunol 1996;98:739-747.
26. Chan SL, Ong ST, Ong SY, Chew FT, Mok YK: Nuclear magnetic resonance structure-based epitope mapping and modulation of dust mite group 13 allergen as a hypoallergen. J Immunol 2006;176:4852-4860.
27. Westritschnig K, Sibanda E, Thomas W, et al: Analysis of the sensitization profile towards allergens in central Africa. Clin Exp Allergy 2003;33:22-27.
28. Satinover SM, Reefer AJ, Pomes A, Chapman MD, Platts-Mills TA, Woodfolk JA: Specific IgE and IgG antibody-binding patterns to recombinant cockroach allergens. J Allergy Clin Immunol 2005;115:803-809.
29. Yi FC, Cheong N, Shek PC, Wang DY, Chua KY, Lee BW: Identification of shared and unique immunoglobulin E epitopes of the highly conserved tropomyosins in Blomia tropicalis and Dermatophagoides pteronyssinus. Clin Exp Allergy 2002;32:1203-1210.
30. Aki T, Kodama T, Fujikawa A, et al: Immunochemical characterization of recombinant and native tropomyosins as a new allergen from the house dust mite, Dermatophagoides farinae. J Allergy Clin Immunol 1995;96:74-83.
31. Femandes J, Reshef A, Patton L, Ayuso R, Reese G, Lehrer SB: Immunoglobulin E antibody reactivity to the major shrimp allergen, tropomyosin, in unexposed Orthodox Jews. Clin Exp Allergy 2003;33:956-961.
32. Kawamoto S, Aki T, Yamashita M, et al: Toward elucidating the full spectrum of mite allergens - state of the art. J Biosci Bioeng 2002;94:285-298.
33. Miyamoto T, Akiyama K, Ohta K, Urata C, Horiucni Y: Studies in atopic asthma with emphasis on correlation among various tests and various antibodies. J Allergy Clin Immunol 1981;67:279-284.
34. Macaubas C, Sly PD, Burton R et al: Regulation of T-helper cell responses to inhalant allergen during early childhood. Clin Exp Allergy 1999;29:1223-1231.
35. Oshika E, Kuroki Y, Sakiyama Y, Matsumoto S: Measurement of IgG subclass antibodies to tile group II antigen of Dermatophagoides pteronyssinus (Der p II) in sera from children with bronchial asthma. Ann Allergy 1992;69:427-432.
36. Chapman MD, Platts-Mills TA: Measurement of IgG, IgA and IgE antibodies to Dermatophagoides pteronyssinus by antigen-binding assay, using a partially purified fraction of mite extract (F4P1). Clin Exp lmmunol 1978;34:126-136.
37. Tame A, Sakiyama Y, Kobayashi I, Terai I, Kobayashi K: Differences in titres of IgE, IgG4 and other IgG subclass anti-Der p 2 antibodies in allergic and non-allergic patients measured with recombinant allergen. Clin Exp Allergy 1996;26:43-49.
38. Bahceciler NN, Arikan C, Taylor A, et al: Impact of sublingual immunotherapy on specific antibody levels in asthmatic children allergic to house dust mites. Int Arch Allergy Immunol 2005;136:287-294.
39. Jutel M, Akdis M, Budak F, et al: IL-10 and TGF-beta cooperate in tile regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol 2003;33:1205-1214.
40. Smith AM, Yamaguchi H, Platts-Mills TA, Fu SM: Prevalence of IgG anti-Der p 2 antibodies in children from high and low antigen exposure groups: relationship of IgG and subclass antibody responses to exposure and allergic symptoms. Clin Immunol Immunopathol 1998;86:102-109.
41. Noguchi E, Shibasaki M, Isoyama S, Takita H: Comparisons of IgE, IgG, and IgG4 responsiveness to Dermatophagoides farinae in children by immunoblotting. Allergy 1996;51:907-913.
42. Lin KL, Wang SY, Hsieh KH: Analysis of house dust mite-specific IgE, IgG4, and IgG antibodies during immunotherapy in asthmatic children. Ann Allergy 1991;67:63-69.
43. Tsai L, Sun Y, Chat R et al: Sequence analysis and expression of a cDNA clone encoding a 98-kDa allergen in Dermatophagoides farinae. Clin Exp Allergy 1999;29:1606-1613.
44. Tsai LC, Peng HJ, Lee CS, et al: Molecular cloning and characterization of full-length cDNAs encoding a novel high-molecular-weight Dermatophagoides pteronyssinus mite allergen, Der p 11. Allergy 2005;60:927-937.
45. Fujikawa A, Uchida K, Yanagidani A, et al: Altered antigenicity of M-177, a 177-kDa allergen from the house dust mite Dermatophagoides farinae, in stored extract. Clin Exp Allergy 1998;28:1549-1558.
46. Fujikawa A, Ishimaru N, Seto A, et al: Cloning and characterization of a new allergen, Mag 3, from tile house dust mite, Dermatophagoides farinae: cross-reactivity with high-molecular-weight allergen. Mol Immunol 1996;33:311-319.
47. O'Neil SE, Heinrich TK, Hales B J, et al: The chitinase allergens Der p 15 and Der p 18 from Dermatophagoides pteronyssinus. Clin Exp Allergy 2006;36:831-839.
48. O'Hehir RE, Bal V, Quint D, et al: An in vitro model of allergen-dependent IgE synthesis by human B lymphocytes: comparison of the response of an atopic and a non-atopic individual to Dermatophagoides spp. (house dust mite). Immunology 1989;66:499-504.
49. Parronchi P, Macchia D, Piccinni MR et al: Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 1991;88:4538-[???]4542.
50. Wierenga EA, Snoek M, Jansen HM, Bos JD, van Lier RA, Kapsenberg ML: Human atopen-specific types 1 and 2 T helper cell clones. J Immunol 1991;147:2942-2949.
51. Halvorsen R, Bosnes V, Thotsby E: T cell responses to a Dermatophagoides farinae allergen preparation in allergics and healthy controls. Int Arch Allergy Appl Immunol 1986;80:62-69.
52. Bellinghausen I, Brand U, Knop J, Saloga J: Comparison of allergen-stimulated dendritic cells from atopic and nonatopic donors dissecting their effect on autologous naive and memory T helper cells of such donors. J Allergy Clin Immunol 2000;105:988-996.
53. McHugh SM, Lachmann PJ, Ewan PW: Peripheral blood mononuclear cells from house dust mite allergic patients produce IL-2 in response to specific allergen challenge. Clin Exp Allergy 1993;23:137-144.
54. Chang JH, Chart H, Quirce S, et al: In vitro T-lymphocyte response and house dust mite-induced bronchoconstriction. J Allergy Clin Immunol 1996;98:922-931.
55. Till S, Dickason R, Huston D, et al: IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: relationship to expression of allergic disease. J Allergy Clin Immunol 1997;99:563-569.
56. Nurse B, Puterman AS, Haus M, Berman D, Weinberg EG, Potter PC: PBMCs from both atopic asthmatic and nonatopic children show a TH2 cytokine response to house dust mite allergen. J Allergy Clin Immunol 2000;106:84-91.
57. O'Brien RM, Thomas WR: Immune reactivity to Der p I and Der p II in house dust mite sensitive patients attending paediatric and adult allergy clinics. Clin Exp Allergy 1994;24:737-742.
58. Cavaillon JM, Fitting C, Guinnepain MT, Rassemont R, David B: Lymphocyte proliferative responses to the purified Dermatophagoides farinae major allergen in untreated and hyposensitized atopic patients. Allergy 1988;43:146-151.
59. Fujii S, Ono K, Shigeta S, Jyo T, Yamashita U: Human T cell responses to recombinant mite antigens of Dermatophagoides farinae. Clin Exp Immunol 1997;108:284-288.
60. Rawle FC, Mitchell EB, Platts-Mills TA: T cell responses to the major allergen from the house dust mite Dermatophagoides pteronyssinus, Antigen P1: comparison of patients with asthma, atopic dermatitis, and perennial rhinitis. J Immunol 1984;133:195-201.
61. Shint JB, Taketomi EA, Platts-Mills TA: Human T-cell responses to Trichophyton tonsurans: inhibition using the serum free medium Aim V. Clin Exp Allergy 1997;27:1184-1192.
62. Richards D, Chapman MD, Sasama J, Lee TH, Kemeny DM: Immune memory in CD4+ CD45RA+ T cells. Immunology 1997;91:331-339.
63. Burastero SE, Fenoglio D, Crimi E, Brusasco V, Rossi GA: Frequency of allergen-specific T lymphocytes in blood and bronchial response to allergen in asthma. J Allergy Clin Immunol 1993;91:1075-1081.
64. Khirwadkar K, Schmitz M, Kabelitz D: Frequency analysis of allergen-reactive T-lymphocytes in individuals allergic against the house-dust mite Dermatophagoides pteronyssinus. Int Arch Allergy Immunol 1992;98:6-12.
65. Ford D, Burger D: Precursor frequency of antigen-specific T cells: effects of sensitization in vivo and in vitro. Cell Immunol 1983;79:334-344.
66. Gabaglia CR, Valle MT, Fenoglio D, Barcinski MA, Manca F: Cd4(+) T cell response to Leishmania spp. in non-infected individuals. Hum Immunol 2000;61:531-537.
67. Avanzini MA, Belloni C, Soncini R, et al: Increment of recombinant hepatitis B surface antigen-specific T-cell precursors after revaocination of slow responder children. Vaccine 2001;19:2819-2824.
68. Assing K, Nielsen CH, Poulsen LK: Immunological characteristics of subjects with asymptomatic skin sensitization to birch and grass pollen. Clin Exp Allergy 2006;36:283-292.
69. Byron KA, O'Brien RM, Varigos GA, Wootton AM: Dermatophagoides pteronyssinus II-induced interleukin-4 and interferon-gamma expression by freshly isolated lymphocytes of atopic individuals. Clin Exp Allergy 1994;24:878-883.
70. O'Brien RM, Xu H, Rolland JM, Byron KA, Thomas WR: Allergen-specific production of interferon-gamma by peripheral blood mononuclear cells and CD8 T cells in allergic disease and following immunotherapy. Clin Exp Allergy 2000;30:333-340.
71. Hales BJ, Shen H, Thomas WR: Cytokine responses to Der p 1 and Der p 7: house dust mite allergens with different IgE-binding activities. Clin Exp Allergy 2000;30:934-943.
72. Smart JM, Kemp AS: Increased Th1 and Th2 allergen-induced cytokine responses in children with tropic disease. Clin Exp Allergy 2002;32:796-802.
73. Akdis M, Verhagen J, Taylor A, et al: Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. J Exp Med 2004;199:1567-1575.
74. Héaton T, Rowe J, Turner S, et al: An immunoepidemiological approach to asthma: identification of in-vitro T-cell response patterns associated with different wheezing phenotypes in children. Lancet 2005;365:142-149.
75. Gardner LM, Spyroglou L, O'Hehir RE, Rolland JM: Increased allergen concentration enhances IFN-gamma production by allergic donor T cells expressing a peripheral tissue trafficking phenotype. Allergy 2004;59:1308-1317.
76. Kircher MF, Haeusler T, Nickel R, Lamb JR, Renz H, Beyer K: Vbeta18.1(+) and V(alpha)2.3(+) T-cell subsets are associated with house dust mite allergy in human subjects. J Allergy Clin Immunol 2002;109:517-523.
77. Li Y, Simons FE, Jay FT, HayGlass KT: Allergen-driven limiting dilution analysis of human IL-4 and IFN-gamma production in allergic rhinitis and clinically tolerant individuals. Int Immunol 1996;8:897-904.
78. Looney RJ, Pudiak D, Rosenfeld SI: Cytokine production by mite-specific T cells from donors with mild tropic disease. J Allergy Clin Immunol 1994;93:476-483.
79. Leonard C, Tormey V, Burke C, Poulter LW: Allergen-induced cytoldne production in atopic disease and its relationship to disease severity. Am J Respir Cell Mol Biol 1997;17:368-375.
80. Hales BJ, Chu NR, Bosco A, Smith W, Heinrich TK, Thomas WR: Determinants of house dust mite allergenicity. Allergy Clinical Immunol Int 2006;18:65-70.
81. Epton MJ, Dilworth RJ, Smith W, Thomas WR: Sensitisation to the lipid-binding apolipophorin allergen Der p 14 and the peptide Mag-1. Int Arch Allergy Immunol 2001;124:57-60.
82. Kimura JY, Ohta N, Ishi A, Nagano T, Usui M: Functional characterization of lymphocyte response to fractionated house dust mite antigens (Dermatophagoides pteronyssinus) in atopic and non-atopic individuals. Immunology 1990;70:385-390.
83. Okano M, Nagano T, Ono T, Masuda Y, Ohta N: Clonal analysis of human T-cell responses to fractionated house dust mite antigens (Dermatophagoides pteronyssinus). Int Arch Allergy Immunol 1993;101:82-88.
84. Matsumoto K, Gauvreau GM, Rerecich T, Watson RM, Wood LJ, O'Byrne PM: IL-10 production in circulating T cells differs between allergen-induced isolated early and dual asthmatic responders. J Allergy Clin Immunol 2002;109:281-286.
85. Hales B J, Hazell LA, Smith W, Thomas WR: Genetic variation of Der p 2 allergens: effects on T cell responses and immunoglobulin E binding. Clin Exp Allergy 2002;32:1461-1467.
86. Robinson DS, Tsicopoulos A, Meng Q, Durham S, Kay AB, Hamid Q: Increased interleukin-10 messenger RNA expression in atopic allergy and asthma. Am J Respir Cell Mol Biol 1996;14:113-117.
87. Ling EM, Smith T, Nguyen XD, et al: Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet 2004;363:608-615.
88. Taylor AL, Hale J, J. HB, Dunstan JA, R. TW, L. PS: FOXP3 mRNA expression at 6 months of age is not affected by giving probiotics from birth, but is higher in infants who develop atopic dermatitis. Pediatr Allergy Immunol 2006;in press.
89. Macaubas C, Lee PT, Smallacombe TB, et al: Reciprocal patterns of allergen-induced GATA-3 expression in peripheral Nood mononuclear cells from atopics vs. non-atopics. Clin Exp Allergy 2002;32:97-106.
90. Wardlaw AJ, Guillen C, Morgan A: Mechanisms of T cell migration to the lung. Clin Exp Alleggy 2005;35:4-7.
91. Kallinich T, Schmidt S, Hamelmann E, et al: Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients. Clin Exp Allergy 2005;35:26-33.
92. Panina-Bordignon P, Papi A, Mafiani M, et al: The CC chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-c hallenged atopic asthmatics, J Clin Invest 2001;107:1357-1364.
93. Liu L, Jarjour NN, Busse WW, Kelly EA: Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma. Am J Respir Crit Care Med 2004;169:1118-1124.
94. Bochner BS, Hudson SA, Xiao HQ, Liu MC: Release of both CCR4-active and CXCR3-active chemokines during human allergic pulmonary late-phase reactions. J Allergy Clin Immunol 2003;112:930-934.
95. Nouri-Aria KT, Wilson D, Francis JN, et al: CCR4 in human allergen-induced late responses in tile skin and lung. Eur J Immunol 2002;32:1933-1938.
96. Frew AJ, Kay AB: The pattern of human late-phase skin reactions to extracts of aeroallergens. J Allergy Clin Immunol 1988;81:1117-1121.
97. Seneviratne SL, Jones L, King AS, et al: Allergen-specific CDS(+) T cells and atopic disease. J Clin Invest 2002;110:1283-1291.
98. Kim YK, Oh SY, Oh HB, et al: Positive association between HLA-DRB1*07 and specific IgE responses to purified major allergens of D. pteronyssinus (Der p 1 and Der p 2). Ann Allergy Asthma Immunol 2002;88:170-174.
99. Hu C, Hsu PN, Lin RH, Hsieh KH, Chua KY: HLA DPB1*0201 allele is regatively associated with immunoglobulin E responsiveness sgecific for house dust mite allergens in Taiwan. Clin Exp Allergy 2000;30:538-545.
100. Moffatt MF, Schou C, Faux JA, et al: Association between quantitative traits underlying asthma and the HLA-DRB1 locus in a family-based population sample. Eur J Hum Genet 2001;9:341-346.
101. O'Brien RM, Thomas WR, Nicholson I, Lamb JR, Tait BD: An immunogenetic analysis of the T-cell recognition of the major house dust mite allergen Der p 2: identification of high- and low-responder HLA-DQ alleles and localization of T-cell epitopes. Immunology 1995;86:176-182.
102. O'Brien RM, Tait BD, Varney MD, Thomas WR: HLA-DPB1 alleles in house dust mite allergic patients. Eur J Immunogenet 1999;26:281-284.
103. Higgins JA, Thorpe CJ, Hayball JD, O'Hehir RE, Lamb JR: Overlapping T-cell epitopes in tile group I allergen of Dermatophagoides species restricted by HLA-DP and HLA-DR class II molecules. J Allergy Clin Immunol 1994;93:891-899.
104. Yssel H, Johnson KE, Schneider PV, et al: T cell activation-inducing epitopes of the house dust mite allergen Der p I. Proliferation and lymphokine production patterns by Der p I-specific CD4+ T cell clones. J hnmunol 1992;148:738-745.
105. Matsuoka T, Kohrogi H, Ando M, Nishimura Y, Matsushita S: Dermatophagoides farinae-1-derived peptides and HLA molecules recognized by T cells from atopic individuals. Int Arch Allergy Immunol 1997;112:365-370.
106. Tsitoura DC, Verhoef A, Gelder CM, O'Hehir RE, Lamb JR: Altered T cell ligands derived from a major house dust mite allergen enhance IFN-gamma but not IL-4 production by human CD4+ T cells. J Immunol 1996;157:2160-2165.
107. Joost van Neerven R, van t' Hof W, Ringrose JH, et al: T cell epitopes of house dust mite major allergen Der p II. J Immunol 1993;151:2326-2335.
108. Verhoef A, Higgins JA, Thorpe CJ, et al: Clonal analysis of the atopic immune response to the group 2 allergen of Dermatophagoides spp.: identification of HLA-DR and -DQ restricted T cell epitopes. Int Immunol 1993;5:1589-1597.
109. van Neerven RJ, van de Pol MM, Wierenga EA, Aalberse RC, Jansen HM, Kapsenberg ML: Peptide specificity and HLA restriction do not dictate lymphokine production by allergen-specific T-lymphocyte clones. Immunology 1994;82:351-356.
110. O'Hehir RE, Eckels DD, Frew AJ, Kay AB, Lamb JR: MHC class II restriction specificity of cloned human T lymphocytes reactive with Dermatophagoides farinae (house dustmite). Immunology 1988;64:627-631.
111. O'Hehir RE, Math B, Berte C, et al: Direct evidence for a functional role of HLA-DRB1 and -DRB3 gene products in the recognition of Dermatophagoides spp. (house dust mite) by helper T lymphocytes. Int Immunol 1990;2:885-892.
112. Hales BJ, Thomas WR: T-cell sensitization to epitopes from the house dust mites Dermatophagoides pteronyssinus and Euroglyphus maynei. Clin Exp Allergy 1997;27:868-875.
113. Wedderburn LR, O'Hehir RE, Hewitt CR, Lamb JR, Owen MJ: In vivo clonal dominance and limited T-cell receptor usage in human CD4+ T-cell recognition of house dust mite allergens. Proc Natl Acad Sci USA 1993;90:8214-8218.
114. Jahn-Schmid B, Fischer GF, Bohle B, et al: Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1*01. J Allergy Clin Immunol 2005;115:399-404.
115. O'Hehir RE, Verhoef A, Panagiotopoulou E, et al: Analysis of human T cell responses to the group II allergen of Dermatophagoides species: localization of major antigenic sites. J Allergy Clin Immunol 1993;92:105-113.
116. Smith WA, Hales BJ, Jarnicki AG, Thomas WR: Allergens of wild house dust mites: environmental Der p 1 and Der p 2 sequence polymorphisms. J Allergy Clin Immunol 2001;107:985-992.
117. Piboonpocanun S, Malainual N, Jirapongsananuruk O, Vichyanond P, Thomas WR: Genetic polymorphisms of major house dust mite allergens. Clin Exp Allergy 2006;36:510-516.
118. Sigurs N, Hattevig G, Kjellman B, Kjellman NI, Nilsson L, Bjorksten B: Appearance of atopic disease in relation to serum IgE antibodies in children followed up from birth for 4 to 15 years. J Allergy Clin Immunol 1994;94:757-763.
119. Upham JW, Holt PG, Taylor A, Thornton CA, Prescott SL: HLA-DR expression on neonatal monocytes is associated with allergen-specific immune responses. J Allergy Clin Immunol 2004;114:1202-1208.
120. Miles EA, Warner JA, Jones AC, Colwell BM, Bryant TN, Warner JO: Peripheral blood mononuclear cell proliferative responses in the first year of life in babies born to allergic parents. Clin Exp Allergy 1996;26:780-788.
121. Prescott SL, Macaubas C, Holt BJ, et al: Transplacental priming of the human immune system to environmental allergens: universal skewing of initial T cell responses toward the Th2 cytokine profile. J Immunol 1998;160:4730-4737.
122. Smillie FI, Elderfield AJ, Patel F, et al: Lymphoproliferative responses in cord blood and at one year: no evidence for the effect of in utero exposure to dust mite allergens. Clin Exp Allergy 2001;31:1194-1204.
123. Chan-Yeung M, Ferguson A, Chan H, et al: Umbilical cord blood mononuclear cell proliferative response to house dust mite does not predict the development of allergic rhinitis and asthma. J Allergy Clin Immunol 1999;104:317-321.
124. van der Velden VH, Laan MP, Baert MR, de Waal Malefyt R, Neijens HJ, Savelkoul HF: Selective development of a strong Th2 cytokine profile in high-risk children who develop atopy: risk factors and regulatory role of IFN-gamma, IL-4 and IL-10. Clin Exp Allergy 2001;31:997-1006.
125. Marks GB, Zhou J, Yang HS, Joshi PA, Bishop GA, Britton WJ: Cord Nood mononuclear cell cytokine responses in relation to maternal house dust mite allergen exposure. Clin Exp Allergy 2002;32:355-360.
126. Thornton CA, Upham JW, Wikstrom ME, et al: Functional maturation of CD4+CD25+CTLA4+CD45RA+ T regulatory cells in human neonatal T cell responses to environmental antigens/allergens. J Immunol 2004;173:3084-3092.
127. Devereux G, Seaton A, Barker RN: In utero priming of allergen-specific helper T cells. Clin Exp Allergy 2001;31:1686-1695.
128. Piccinni MP, Mecacci F, Sampognaro S, et al: Aeroallergen sensitization can occur during fetal life. Int Arch Allergy Immunol 1993;102:301-303.
129. Prescott SL, Macaubas C, Smallacombe T, Holt BJ, Sly PD, Holt PG: Development of allergen-specific T-cell memory in atopic and normal children. Lancet 1999;353:196-200.
130. Yabuhara A, Macaubas C, Prescott SL, et al: TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood. Clin Exp Allergy 1997;27:1261-1269.
131. Tedeschi A, Barcella M, Bo GA, Miadonna A: Onset of allergy and asthma symptoms in extra-European immigrants to Milan, Italy: possible role of environmental factors. Clin Exp Allergy 2003;33:449-454.
132. Tovey ER, Chapman MD, Wells CW, Platts-Mills TA: The distribution of dust mite allergen in the houses of patients with asthma. Am Rev Respir Dis 1981;124:630-635.
133. Heymann PW, Chapman MD, Aalberse RC, Fox JW, Platts-Mills TA: Antigenic and structural analysis of group II allergens (Der f II and Der p II) from house dust mites (Dermatophagoides spp). J Allergy Clin Immunol 1989;83:1055-1067.
134. Ramos JD, Teo AS, Ou KL, et al: Comparative allergenicity studies of native and recombinant Blomia tropicalis Paramyosin (Blot 11). Allergy 2003;58:412-419.
135. Li CS, Hsu CW, Chua KY, Hsieh KH, Lin RH: Environmental distribution of house dust mite allergen (Der p 5). JAllergy Clin hnmunol 1996;97:857-859.
136. Shen HD, Lin WL, Tsai LC, et al: Characterization of the allergen Der f 7 from house dust mite extracts by species-specific and crosareactive monoclonal antibodies. Clin Exp Allergy 1997;27:824-832.
137. Stewart GA, Kollinger MR, King CM, Thompson PJ: A comparative study of three serine proteases from Dermatophagoides pteronyssinus and D. farinae. Allergy 1994;49:553-560.
138. Weghofer M, Thomas WR, Pittner G, Horak F, Valenta R, Vrtala S: Comparison of purified Dermatophagoides pteronyssinus allergens and extract by two-dimensional immunoblotting and quantitative immunoglobulin E inhibitions. Clin Exp Allergy 2005;35:1384-1391.
139. Batard T, Hrabina A, Bi XZ, et al: Production and proteomic characterization of pharmaceutical-grade Dermatophagoides pteronyssinus and Dermatophagoides farinae extracts for allergy vaccines. Int Arch Allergy Immunol 2006;140:295-305.
140. Holt PG, Clough JB, Holt BJ, et al: Genetic "risk" for atopy is associated with delayed posmatal maturation of T-cell competence. Clin Exp Allergy 1992;22:1093-1099.
141. Epton MJ, Smith W, Hales B J, Hazell L, Thompson PJ, Thomas WR: Non-allergenic antigen in allergic sensitization: responses to the mite ferritin heavy chain antigen by allergic and non-allergic subjects. Clin Exp Allergy 2002;32:1341-1347.