Evidence for dimeric BACE-mediated APP processing

Biochemical and Biophysical Research Communications

Volumn 393, Issue 1, 2010, Pages 21-27

  Jin, Shaobo ^a   Agerman, Karin ^b   Kolmodin, Karin ^b   Gustafsson, Elin ^b   Dahlqvist, Camilla ^b   Jureus, Anders ^b   Liu, Gang ^b   Fälting, Johanna ^b   Berg, Stefan ^b   Lundkvist, Johan ^b   Lendahl, Urban ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

Secretase; Alzheimer's disease; Aspartyl protease; Endosome

Indexed keywords

AMYLOID PRECURSOR PROTEIN; ASPARTIC ACID; ASPARTIC PROTEINASE; BETA SECRETASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; ENDOPLASMIC RETICULUM; ENDOSOME; ENZYME ACTIVITY; GLYCOSYLATION; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROCESSING;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; CATALYTIC DOMAIN; HYDROPHOBICITY; MICE; MICE, KNOCKOUT; MUTATION; PROTEIN MULTIMERIZATION;

EID: 77549083896     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.064     Document Type: Article

References (17)

1. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., and Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 (1999) 735-741
2. Yan R., Bienkowski M.J., Shuck M.E., Miao H., Tory M.C., Pauley A.M., Brashier J.R., Stratman N.C., Mathews W.R., Buhl A.E., Carter D.B., Tomasselli A.G., Parodi L.A., Heinrikson R.L., and Gurney M.E. Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 402 (1999) 533-537
3. Capell A., Steiner H., Willem M., Kaiser H., Meyer C., Walter J., Lammich S., Multhaup G., and Haass C. Maturation and pro-peptide cleavage of beta-secretase. J. Biol. Chem. 275 (2000) 30849-30854
4. He X., Chang W.P., Koelsch G., and Tang J. Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2. FEBS Lett. 524 (2002) 183-187
5. Benjannet S., Elagoz A., Wickham L., Mamarbachi M., Munzer J.S., Basak A., Lazure C., Cromlish J.A., Sisodia S., Checler F., Chretien M., and Seidah N.G. Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production. J. Biol. Chem. 276 (2001) 10879-10887
6. Walter J., Fluhrer R., Hartung B., Willem M., Kaether C., Capell A., Lammich S., Multhaup G., and Haass C. Phosphorylation regulates intracellular trafficking of beta-secretase. J. Biol. Chem. 276 (2001) 14634-14641
7. Hong L., Koelsch G., Lin X., Wu S., Terzyan S., Ghosh A.K., Zhang X.C., and Tang J. Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor. Science 290 (2000) 150-153
8. Schmechel A., Strauss M., Schlicksupp A., Pipkorn R., Haass C., Bayer T.A., and Multhaup G. Human BACE forms dimers and colocalizes with APP. J. Biol. Chem. 279 (2004) 39710-39717
9. Westmeyer G.G., Willem M., Lichtenthaler S.F., Lurman G., Multhaup G., Assfalg-Machleidt I., Reiss K., Saftig P., and Haass C. Dimerization of beta-site beta-amyloid precursor protein-cleaving enzyme. J. Biol. Chem. 279 (2004) 53205-53212
10. Kim D.Y., Carey B.W., Wang H., Ingano L.A., Binshtok A.M., Wertz M.H., Pettingell W.H., He P., Lee V.M., Woolf C.J., and Kovacs D.M. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nat. Cell. Biol. 9 (2007) 755-764
11. Willem M., Garratt A.N., Novak B., Citron M., Kaufmann S., Rittger A., DeStrooper B., Saftig P., Birchmeier C., and Haass C. Control of peripheral nerve myelination by the beta-secretase BACE1. Science 314 (2006) 664-666
12. Kitazume S., Tachida Y., Oka R., Kotani N., Ogawa K., Suzuki M., Dohmae N., Takio K., Saido T.C., and Hashimoto Y. Characterization of alpha 2,6-sialyltransferase cleavage by Alzheimer's beta-secretase (BACE1). J. Biol. Chem. 278 (2003) 14865-14871
13. Stockley J.H., and O'Neill C. The proteins BACE1 and BACE2 and beta-secretase activity in normal and Alzheimer's disease brain. Biochem. Soc. Trans. 35 (2007) 574-576
14. Roberds S.L., Anderson J., Basi G., Bienkowski M.J., Branstetter D.G., Chen K.S., Freedman S.B., Frigon N.L., Games D., Hu K., Johnson-Wood K., Kappenman K.E., Kawabe T.T., Kola I., Kuehn R., Lee M., Liu W., Motter R., Nichols N.F., Power M., Robertson D.W., Schenk D., Schoor M., Shopp G.M., Shuck M.E., Sinha S., Svensson K.A., Tatsuno G., Tintrup H., Wijsman J., Wright S., and McConlogue L. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum. Mol. Genet. 10 (2001) 1317-1324
15. Edwards P.D., Albert J.S., Sylvester M., Aharony D., Andisik D., Callaghan O., Campbell J.B., Carr R.A., Chessari G., Congreve M., Frederickson M., Folmer R.H., Geschwindner S., Koether G., Kolmodin K., Krumrine J., Mauger R.C., Murray C.W., Olsson L.L., Patel S., Spear N., and Tian G. Application of fragment-based lead generation to the discovery of novel cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity and high ligand efficiency. J. Med. Chem. 50 (2007) 5912-5925
16. Mu F.T., Callaghan J.M., Steele-Mortimer O., Stenmark H., Parton R.G., Campbell P.L., McCluskey J., Yeo J.P., Tock E.P., and Toh B.H. EEA1, an early endosome-associated protein. EEA1 is a conserved alpha-helical peripheral membrane protein flanked by cysteine "fingers" and contains a calmodulin-binding IQ motif. J. Biol. Chem. 270 (1995) 13503-13511
17. Zhang Y.W., and Xu H. Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism. Curr. Mol. Med. 7 (2007) 687-696