Cognitive profiles of healthy siblings of schizophrenia patients: Application of the cognitive domains of the MATRICS consensus battery

World Journal of Biological Psychiatry

Volumn 10, Issue 4 PART 2, 2009, Pages 452-460

  Nam, Hee Jung ^a   Kim, Nara ^a   Park, Taesung ^b   Oh, Sohee ^b   Jeon, Hyun Ok ^a   Yoon, Se Chang ^a   Lee, Yu Sang ^c   Lee, Woo Kyeong ^c   Ha, Kyooseob ^d   Kim, Ji Hae ^a   Hong, Kyung Sue ^a,e  

^a Sungkyunkwan University School of Medicine   (South Korea)

^b Seoul National University   (South Korea)

^c Yongin Mental Hospital   (South Korea)

^d Seoul National University Bundang Hospital   (South Korea)

^e Samsung Medical Center   (South Korea)

Author keywords

Cognitive deficit; Endophenotype; The Category Fluency Test

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CLINICAL ASSESSMENT TOOL; COGNITION; CONTROLLED STUDY; FEMALE; GENETIC ANALYSIS; HUMAN; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; NEUROPSYCHOLOGICAL TEST; PERFORMANCE; PHENOTYPE; SCHIZOPHRENIA; SCORING SYSTEM; SIBLING; COGNITIVE DEFECT; EDUCATIONAL STATUS; GENETIC PREDISPOSITION; GENETICS; LINGUISTICS; MIDDLE AGED; PSYCHOLOGICAL ASPECT; PSYCHOLOGICAL RATING SCALE; PSYCHOLOGY; PSYCHOMETRY; REFERENCE VALUE; STATISTICS;

ADOLESCENT; ADULT; COGNITION DISORDERS; EDUCATIONAL STATUS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; PSYCHIATRIC STATUS RATING SCALES; PSYCHOMETRICS; REFERENCE VALUES; SCHIZOPHRENIA; SCHIZOPHRENIC LANGUAGE; SCHIZOPHRENIC PSYCHOLOGY; SIBLINGS; VOCABULARY; YOUNG ADULT;

EID: 77449131797     PISSN: 15622975     EISSN: 18141412     Source Type: Journal    
DOI: 10.1080/15622970802314815     Document Type: Article

References (56)

1. Akaike H. 1974. A new look at the statistical model identification. IEEE Trans Automatic Control 19:716-723.
2. Appels MC, Sitskoorn MM, Westers P, Lems E, Kahn RS. 2003. Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patients. Schizophr Res 63:285-293.
3. Asarnow RF, Nuechterlein KH. 1994. Directions for Use of the UCLA Span of Apprehension Program, Version 5.3 for Arrays 3 and 12 Letters, on IBM AT and Fully Compatible Microcomputers. Los Angeles, CA: UCLA Department of Psychiatry and Biobehavioral Sciences.
4. Bilder RM, Goldman RS, Volavka J, Czobor P, Hoptman M, Sheitman B, et al. 2002. Neurocognitive effects of clozapine, olanzapine, risperidone, and haloperidol in patients with chronic schizophrenia or schizoaffective disorder. Am J Psychiatry 159:1018-1028. (Pubitemid 34586949)
5. Bredgaard R, Glenthoj BY. 2000. Information processing and attentional dysfunctions as vulnerability indicators in schizophrenia spectrum disorders. World J Biol Psychiatry 1:5-15.
6. Cannon TD, Zorrilla LE, Shtasel D, Gur RE, Gur RC, Marco EJ, et al. 1994. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch Gen Psychiatry 51:651-661.
7. Cannon TD, Huttunen MO, Lonnqvist J, Tuulio-Henriksson A, Pirkola T, Glahn D, et al. 2000. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia. Am J Hum Genet 67:369-382.
8. Cannon TD, Gasperoni TL, van Erp TG, Rosso IM. 2001. Quantitative neural indicators of liability to schizophrenia: implications for molecular genetic studies. Am J Med Genet 105:16-19.
9. Chen YL, Chen YH, Lieh-Mak F. 2000. Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Res 95:133-148.
10. Davalos DB, Compagnon N, Heinlein S, Ross RG. 2004. Neuropsychological deficits in children associated with increased familial risk for schizophrenia. Schizophr Res 67:123-130.
11. Dollfus S, Lombardo C, Benali K, Halbecq I, Abadie P, Marie RM, et al. 2002. Executive/attentional cognitive functions in schizophrenic patients and their parents: a preliminary study. Schizophr Res 53:93-99.
12. Egan MF, Goldberg TE, Gscheidle T, Weirich M, Rawlings R, Hyde TM, et al. 2001. Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol Psychiatry 50:98-107.
13. Erlenmeyer-Kimling L. 2001. Early neurobehavioral deficits as phenotypic indicators of the schizophrenia genotype and predictors of later psychosis. Am J Med Genet 105:23-24.
14. Faraone SV, Seidman LJ, Kremen WS, Toomey R, Pepple JR, Tsuang MT 2000. Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol Psychiatry 48:120-126.
15. Gasperoni TL, Ekelund J, Huttunen M, Palmer CG, Tuulio-Henriksson A, Lonnqvist J, et al. 2003. Genetic linkage and association between chromosome 1q and working memory function in schizophrenia. Am J Med Genet B Neuropsychiatr Genet 116:8-16.
16. Genderson MR, Dickinson D, Diaz-Asper CM, Egan MF, Weinberger DR, Goldberg TE. 2007. Factor analysis of neurocognitive tests in a large sample of schizophrenic probands, their siblings, and healthy controls. Schizophr Res 94:231-239.
17. Goldberg TE, Torrey EF, Gold JM, Bigelow LB, Ragland RD, Taylor E, et al. 1995. Genetic risk of neuropsychological impairment in schizophrenia: a study of monozygotic twins discordant and concordant for the disorder. Schizophr Res 17:77-84.
18. Golimbet V, Gritsenko I, Alfimova M, Lebedeva I, Lezheiko T, Abramova L, et al. 2006. Association study of COMT gene Val158Met polymorphism with auditory P300 and performance on neurocognitive tests in patients with schizophrenia and their relatives. World J Biol Psychiatry 7:238-245.
19. Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636-645.
20. Green MF, Nuechterlein KH. 2004. The MATRICS initiative: developing a consensus cognitive battery for clinical trials. Schizophr Res 72:1-3.
21. Green MF, Nuechterlein KH, Gold JM, Barch DM, Cohen J, Essock S, et al. 2004. Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MA-TRICS conference to select cognitive domains and test criteria. Biol Psychiatry 56:301-307.
22. Groom MJ, Jackson GM, Calton TG, Andrews HK, Bates AT, Liddle PF, et al. 2008. Cognitive deficits in early-onset schizophrenia spectrum patients and their non-psychotic siblings: a comparison with ADHD. Schizophr Res 99:85-95.
23. Harris JG, Adler LE, Young DA, Cullum CM, Rilling LM, Cicerello A, et al. 1996. Neuropsychological dysfunction in parents of schizophrenics. Schizophr Res 20:253-260.
24. Hoff AL, Svetina C, Maurizio AM, Crow TJ, Spokes K, DeLisi LE. 2005. Familial cognitive deficits in schizophrenia. Am J Med Genet Part B. Neuropsychiatr Genet 133:43-49
25. Johnson JK, Tuulio-Henriksson A, Pirkola T, Huttunen MO, Lonnqvist J, Kaprio J, et al. 2003. Do schizotypal symptoms mediate the relationship between genetic risk for schizophrenia and impaired neuropsychological performance in co-twins of schizophrenic patients? Biol Psychiatry 54:1200-1204.
26. Joo EJ, Joo YH, Hong JP, Hwang S, Maeng SJ, Han JH, et al. 2004. Korean version of the diagnostic interview for genetic studies: Validity and reliability. Compr Psychiatry 45:225-229.
27. Kang Y, Chin J, Na D, Lee J, Park J. 2000. A normative study of the Korean Version of Controlled Oral Word Association Test (COWAT) in the elderly. Kor J Clin Psychol 19:385-392.
28. Keefe RS, Silverman JM, Roitman SE, Harvey PD, Duncan MA, Alroy D, et al. 1994. Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests. Psychiatry Res 53: 1-12.
29. Keefe RS, Sweeney JA, Gu H, Hamer RM, Perkins DO, McEvoy JP, et al. 2007. Effects of olanzapine, quetiapine, and risperidone on neurocognitive function in early psychosis: a randomized, double-blind 52-week comparison. Am J Psychiatry 164:1061-1071.
30. Keri S, Kelemen O, Benedek G, Janka Z. 2001. Different trait markers for schizophrenia and bipolar disorder: a neurocognitive approach. Psychol Med 31:915-922.
31. Kim H. 2001. Assessment of memory disorders using Rey-Kim Memory test. J of Rehab Psychol 8:29-38
32. Kim Y, Oh S, Kim J, Lim Y, Hong S. 2001. Standardization study of Personality Assessment Inventory (PAI): Reliability and Validity. Korean J Clin Psychol 20:311-329.
33. Krabbendam L, Marcelis M, Delespaul P, Jolles J, van Os J. 2001. Single or multiple familial cognitive risk factors in schizophrenia? Am J Med Genet 105:183-188.
34. Laurent A, Moreaud O, Bosson JL, Naegele B, Boucharlat J, Saoud M, et al. 1999. Neuropsychological functioning among non-psychotic siblings and parents of schizophrenic patients. Psychiatry Res 87:147-157.
35. Laurent A, Biloa-Tang M, Bougerol T, Duly D, Anchisi AM, Bosson JL, et al. 2000. Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. Schizophr Res 46:269-283.
36. Lee MA, Jayathilake K, Meltzer HY 1999. A comparison of the effect of clozapine with typical neuroleptics on cognitive function in neuroleptic-responsive schizophrenia. Schizophr Res 37:1-11.
37. Lee JH, Lee KU, Lee DY 2002. Development of the Korean version of the Consortium to Establish a Registry for Alzheimer's Disease Assessment Packet (CERAD-K): clinical and neuropsychological assessment batteries. Gerontol B psychol Sci Soc Sci 57:47-53.
38. Morey LC. 1991. Personality Assessment Inventory Professional Manual. Odessa, FL: Psychological Assessment Resources.
39. Mortimer AM, Joyce E, Balasubramaniam K, Choudhary PC, Saleem PT. 2007. Treatment with amisulpride and olanzapine improve neuropsychological function in schizophrenia. Hum Psychopharmacol 22:445-454
40. Myles-Worsley M, Coon H, McDowell J, Brenner C, Hoff M, Lind B, et al. 1999. Linkage of a composite inhibitory phenotype to a chromosome 22q locus in eight Utah families. Am J Med Genet 88:544-550.
41. Nuechterlein KH, Dawson ME. 1984. Information processing and attentional functioning in the developmental course of schizophrenic disorders. Schizophr Bull 10:160-203.
42. Nuechterlein KH, Asarnow RF. 1999 Degraded Stimulus Continuous Performance Test (DS-CPT): Program for IBM-Compatible Micro-Computers, Version 8.12 [Computer software] Los Angeles: Authors.
43. Nuechterlein KH, Asarnow RF, Subotnik KL, Fogelson DL, Payne DL, Kendler KS, et al. 2002. The structure of schizotypy: relationships between neurocognitive and personality disorder features in relatives of schizophrenic patients in the UCLA Family Study. Schizophr Res 54:121-130.
44. Nuechterlein KH, Barch DM, Gold JM, Goldberg TE, Green MF, Heaton RK. 2004. Identification of separable cognitive factors in schizophrenia. Schizophr Res 72:29-39.
45. Rey R. 1941. L'examen psychologique dans les cas d'encephalo-pathie traumatique Archives de Psychologie 28:286-340.
46. Rey R. 1964. L'examen clinique en psychologie. Paris: Press Universitaire de France.
47. Sitskoorn MM, Aleman A, Ebisch SJ, Appels MC, Kahn RS. 2004. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr Res 71:285-295.
48. Snitz BE, Macdonald AW, 3rd, Carter CS. 2006. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr Bull 32:179-194.
49. Thompson JL, Watson JR, Steinhauer SR, Goldstein G, Pogue-Geile MF. 2005. Indicators of genetic liability to schizophrenia: a sibling study of neuropsychological performance. Schizophr Bull 31:85-96.
50. Trandafir A, Meary A, Schurhoff F, Leboyer M, Szoke A. 2006. Memory tests in first-degree adult relatives of schizophrenic patients: a meta-analysis. Schizophr Res 81:217-226.
51. Tuulio-Henriksson A, Haukka J, Partonen T, Varilo T, Paunio T, Ekelund J, et al. 2002. Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia. Am J Med Genet 114:483-490
52. Tuulio-Henriksson A, Arajarvi R, Partonen T, Haukka J, Varilo T, Schreck M, et al. 2003. Familial loading associates with impairment in visual span among healthy siblings of schizophrenia patients. Biol Psychiatry 54:623-628.
53. Voruganti LP, Awad AG, Parker G, Forrest C, Usmani Y, Fernando ML, et al. 2007. Cognition, functioning and quality of life in schizophrenia treatment: results of a one-year randomized controlled trial of olanzapine and quetiapine. Schizophr Res 96:146-155.
54. Warnick EL, Allen DN. 2005. Verbal and spatial working memory differences among individuals with familial and non-familial risk for schizophrenia. Schizophr Res 77:361-362.
55. Woodward ND, Tibbo P, Purdon SE. 2007. An fMRI investigation of procedural learning in unaffected siblings of individuals with schizophrenia. Schizophr Res 94:306-316.
56. Yeom Y, Park Y, Oh K, Kim J, Lee Y 1992. K-Wechsler Adult Intelligence Scale. Seoul, Korea: Korea Guidance.