Cognitive deficits in early-onset schizophrenia spectrum patients and their non-psychotic siblings: A comparison with ADHD

Schizophrenia Research

Volumn 99, Issue 1-3, 2008, Pages 85-95

  Groom, M J ^a   Jackson, G M ^a   Calton, T G ^a   Andrews, H K ^a   Bates, A T ^a   Liddle, P F ^a   Hollis, C ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

ADHD; Cognitive; High risk; Risk markers; Schizophrenia

Indexed keywords

ADOLESCENT; ARTICLE; ATTENTION DEFICIT DISORDER; CLINICAL FEATURE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HIGH RISK PATIENT; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; MEMORY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; SIBLING; STATISTICAL ANALYSIS;

ADOLESCENT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; COGNITION DISORDERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; NEUROPSYCHOLOGICAL TESTS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; SIBLINGS;

EID: 39249084167     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2007.11.008     Document Type: Article

References (72)

1. Addington J., and Addington D. Cognitive functioning in first-episode schizophrenia. J. Psychiatry Neurosci. 27 3 (2002) 188-192
2. Albus M., Hubmann W., Mohr F., Hecht S., Hinterberger-Weber P., Seitz N.N., et al. Neurocognitive functioning in patients with first-episode schizophrenia: results of a prospective 5-year follow-up study. Eur. Arch. Psychiatry Clin. Neurosci. 256 7 (2006) 442-451
3. Amminger G.P., Pape S., Rock D., Roberts S.A., Ott S.L., Squires-Wheeler E., et al. Relationship between childhood behavioral disturbance and later schizophrenia in the New York high-risk project. Am. J. Psychiatry 156 4 (1999) 525-530
4. Appels M.C., Sitskoorn M.M., Westers P., Lems E., and Kahn R.S. Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patients. Schizophr. Res. 63 3 (2003) 285-293
5. Asarnow R.F., Nuechterlein K.H., Subotnik K.L., Fogelson D.L., Torquato R.D., Payne D.L., et al. Neurocognitive impairments in nonpsychotic parents of children with schizophrenia and attention-deficit/hyperactivity disorder: the University of California, Los Angeles family study. Arch. Gen. Psychiatry 59 11 (2002) 1053-1060
6. Badcock J.C., Dragovic M., Waters F.A., and Jablensky A. Dimensions of intelligence in schizophrenia: evidence from patients with preserved, deteriorated and compromised intellect. J. Psychiatr. Res. 39 1 (2005) 11-19
7. Barr W.B. Schizophrenia and attention deficit disorder two complex disorders of attention. Ann. N.Y. Acad. Sci. 931 (2001) 239-250
8. Bebbington P., and Nayani T. The psychosis screening questionnaire. Intl. J. Methods Psychiatr. Res. 5 1 (1995) 11-19
9. Benton A.L., and Hamsher K. Multilingual Aphasia Examination (1976), University of Iowa, Iowa
10. Brickman A.M., Buchsbaum M.S., Bloom R., Bokhoven P., Paul-Odouard R., Haznedar M.M., et al. Neuropsychological functioning in first-break, never-medicated adolescents with psychosis. J. of Nerv Ment. Dis. 192 9 (2004) 615-622
11. Burgess P., and Shallice T. The Hayling and Brixton Tests (1997), Thames Valley Test Company Limited, Bury St Edmonds
12. Byrne M., Clafferty B.A., Cosway R., Grant E., Hodges A., Whalley H.C., et al. Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia. J. Abnorm. Psychology 112 1 (2003) 38-48
13. Cannon T.D., Zorrilla L.E., Shtasel D., Gur R.E., Gur R.C., Marco E.J., et al. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch. Gen. Psychiatry 51 8 (1994) 651-661
14. Chen W.J., Liu S.K., Chang C.J., Lien Y.J., Chang Y.H., and Hwu H.G. Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am. J. Psychiatry 155 9 (1998) 1214-1220
15. Chen Y.L.R., Chen Y.H.E., and Lieh M.F. Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Res. 95 2 (2000) 133-148
16. Cornblatt B.A., Risch N.J., Faris G., Friedman D., and Erlenmeyer-Kimling L. The continuous performance test, identical pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res. 26 2 (1988) 223-238
17. Cosway R., Byrne M., Clafferty R., Hodges A., Grant E., Morris J., et al. Sustained attention in young people at high risk for schizophrenia. Psychol. Med. 32 2 (2002) 277-286
18. David A.S., Malmberg A., Brandt L., Allebeck P., and Lewis G. IQ and risk for schizophrenia: a population-based cohort study. Psychol. Med. 27 6 (1999) 1311-1323
19. Davidson M.M.D., Reichenberg A.M.A., Rabinowitz J.D.S.W., Weiser M.M.D., Kaplan Z.M.D., and Mark M.M.D. Behavioral and intellectual markers for schizophrenia in apparently healthy male adolescents. Am. J. Psychiatry 156 9 (1999) 1328-1335
20. Dollfus S., Lombardo C., Benali K., Halbecq I., Abadie P., Marie R.M., et al. Executive/attentional cognitive functions in schizophrenic patients and their parents: a preliminary study. Schizophr. Res. 53 1-2 (2002) 93-99
21. Egan M.F., Goldberg T.E., Gscheidle T., Weirich M., Rawlings R., Hyde T.M., et al. Relative risk for cognitive impairments in siblings of patients with schizophrenia. Biol. Psychiatry 50 2 (2001) 98-107
22. Erlenmeyer-Kimling L., Rock D., Roberts S.A., Janal M., Kestenbaum C., Cornblatt B., et al. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York high-risk project. Am. J. Psychiatry 157 9 (2000) 1416-1422
23. Faraone S.V., Seidman L.J., Kremen W.S., Pepple J.R., Lyons M.J., and Tsuang M.T. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a diagnostic efficiency analysis. J. Abnorm. Psychology 104 2 (1995) 286-304
24. Goldberg T.E., Ragland J.D., Torrey E.F., Gold J.M., Bigelow L.B., and Weinberger D.R. Neuropsychological assessment of monozygotic twins discordant for schizophrenia. Arch. Gen. Psychiatry 47 11 (1990) 1066-1072
25. Goodman R. The strengths and difficulties questionnaire: a research note. J. Child Psychol. Psychiatry Allied Discipl. 38 5 (1997) 581-586
26. Gunnell D., Harrison G., Rasmussen F., Fouskakis D., and Tynelius P. Associations between premorbid intellectual performance, early-life exposures and early-onset schizophrenia - cohort study. Br. J. Psychiatry 181 (2002) 298-305
27. Heinrichs R.W. In Search of Madness: Schizophrenia and Neuroscience (2001), Oxford University Press, Oxford
28. Heinrichs R.W., and Zakzanis K.K. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology 12 3 (1998) 426-445
29. Hoff A.L., Svetina C., Maurizio A.M., Crow T.J., Spokes K., and DeLisi L.E. Familial cognitive deficits in schizophrenia. Am. J. Med. Genet. Part B-Neuropsychiatric Genetics 133B 1 (2005) 43-49
30. Hughes C., Kumari V., Soni W., Das M., Binneman B., Drozd S., et al. Longitudinal study of symptoms and cognitive function in chronic schizophrenia. Schizophr. Res. 59 2-3 (2003) 137-146
31. Hughes C., Kumari V., Das M., Zachariah E., Ettinger U., Sumich A., et al. Cognitive functioning in siblings discordant for schizophrenia. Acta Psychiatr. Scand. 111 3 (2005) 185-192
32. Keefe R.S., Silverman J.M., Roitman S.E., Harvey P.D., Duncan M.A., Alroy D., et al. Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests. Psychiatry Res. 53 1 (1994) 1-12
33. Keshavan M.S., Sujata M., Mehra A., Montrose D.M., and Sweeney J.A. Psychosis proneness and ADHD in young relatives of schizophrenia patients. Schizophr. Res. 59 1 (2003) 85-92
34. Kremen W.S., Seidman L.J., Faraone S.V., and Tsuang M.T. Intelligence quotient and neuropsychological profiles in patients with schizophrenia and in normal volunteers. Biol. Psychiatry 50 6 (2001) 453-462
35. Kremen W.S., Seidman L.J., Faraone S.V., and Tsuang M.T. Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia?. J. Int. Neuropsychol. Soc. 9 1 (2003) 79-88
36. Kremen W.S., Lyons M.J., Boake C., Xian H., Jacobson K.C., Waterman B., et al. A discordant twin study of premorbid cognitive ability in schizophrenia. J. Clin. Exp. Neuropsychol. 28 2 (2006) 208-224
37. Laurent A., Moreaud O., Bosson J.L., Naegele B., Boucharlat J., Saoud M., et al. Neuropsychological functioning among non-psychotic siblings and parents of schizophrenic patients. Psychiatry Res. 87 2-3 (1999) 147-157
38. Laurent A., Biloa-Tang M., Bougerol T., Duly D., Anchisi A.M., Bosson J.L., et al. Executive/attentional performance and measures of schizotypy in patients with schizophrenia and in their nonpsychotic first-degree relatives. Schizophr. Res. 46 2-3 (2000) 269-283
39. Laurent A., Rochet T., D'Amato T., Anchisi A.M., Daumal M., Favre P., et al. Vulnerability to schizophrenia. III: Importance and limits of the identical pairs continuous performance test. Encephale 26 2 (2000) 48-55
40. Lezak M.D. Neuropyschological Assessment. 3rd ed. (1995), Oxford University Press, New York
41. Liddle P.F., Ngan E.T., Duffield G., Kho K., and Warren A.J. Signs and symptoms of psychotic illness (SSPI): a rating scale. Br. J. Psychiatry 180 (2002) 45-50
42. McIntosh A.M., Harrison L.K., Forrester K., Lawrie S.M., and Johnstone E.C. Neuropsychological impairments in people with schizophrenia or bipolar disorder and their unaffected relatives. Br. J. Psychiatry 186 (2005) 378-385
43. Miller G.M., and Chapman J.P. Misunderstanding analysis of covariance. J. Abnorm. Psychology 110 1 (2001) 1-40
44. Miller T.J., McGlashan T.H., Rosen J.L., Cadenhead K., Cannon T., Ventura J., et al. Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability. Schizophr. Bull. 29 4 (2003) 703-715
45. Mohamed S., Paulsen J.S., O'Leary D., Arndt S., and Andreasen N. Generalized cognitive deficits in schizophrenia: a study of first-episode patients. Arch. Gen. Psychiatry 56 8 (1999) 749-754 1999 Aug
46. Nathaniel-James D.A., Fletcher P., and Frith C.D. The functional anatomy of verbal initiation and suppression using the Hayling test. Neuropsychologia 35 4 (1997) 559-566
47. Nieuwenstein M.R., Aleman A., and De Haan E.H.F. Relationship between symptom dimensions and neurocognitive functioning in schizophrenia: a meta-analysis of WCST and CPT studies. J. Psychiatr. Res. 35 2 (2001) 119-125
48. Nuechterlein K.H. Vigilance in schizophrenia and related disorders. Handbook of Schizophrenia (1995)
49. Office for National Statistics. The National Statistics Socio-Economic Classification User Manual (2004), Office For National Statistics, London
50. Oie M., and Rund B.R. Neuropsychological deficits in adolescent-onset schizophrenia compared with attention deficit hyperactivity disorder. Am. J. Psychiatry 156 8 (1999) 1216-1222
51. Oie M., Sunde K., and Rund B.R. Contrasts in memory functions between adolescents with schizophrenia or ADHD. Neuropsychologia 37 12 (1999) 1351-1358
52. Oner O., and Munir K. Attentional and neurocognitive characteristics of high-risk offspring of parents with schizophrenia compared with DSM-IV attention deficit hyperactivity disorder children. Schizophr. Res. 76 2-3 (2005) 293-299
53. Riley E.M., McGovern D., Mockler D., Doku V.C.S.O.C., Fannon D.G., et al. Neuropsychological functioning in first-episode psychosis - evidence of specific deficits. Schizophr. Res. 43 1 (2000) 47-55
54. Rund B.R., Oie M., and Sundet K. Backward-masking deficit in adolescents with schizophrenic disorders or attention deficit hyperactivity disorder. Am. J. Psychiatry 153 9 (1996) 1154-1157
55. Rund B.R., Zeiner P., Sundet K., Oie M., and Bryhn G. No vigilance deficit found in either young schizophrenic or ADHD subjects. Scand. J. Psychol. 39 2 (1998) 101-107
56. Rutter M., Bailey A., and Lord C. SCQ: Social Communication Questionnaire (2003), Western Psychological Services, Los Angeles, CA
57. Saykin A.J., Gur R.C., Gur R.E., Mozley P.D., Mozley L.H., Resnick S.M., et al. Neuropsychological function in schizophrenia - selective impairment in memory and learning. Arch. Gen. Psychiatry 48 7 (1991) 618-624
58. Saykin A.J., Shtasel D.L., Gur R.E., Kester D.B., Mozley L.H., Stafiniak P., et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch. Gen. Psychiatry 51 2 (1994) 124-131
59. Shedlack K., Lee G., Sakuma M., Xie S.H., Kushner M., Pepple J., et al. Language processing and memory in ill and well siblings from multiplex families affected with schizophrenia. Schizophr. Res. 25 1 (1997) 43-52
60. Sitskoom M.M., Aleman A., Ebisch S.J.H., Appels M.C.M., and Kahn R.S. Cognitive deficits in relatives of patients with schizophrenia: a meta-analysis. Schizophr. Res. 71 2-3 (2004) 285-295
61. Snitz B.E., Macdonald III A.W., and Carter C.S. Cognitive deficits in unaffected first-degree relatives of schizophrenia patients: a meta-analytic review of putative endophenotypes. Schizophr. Bull. 32 1 (2006) 179-194
62. Szoke A., Schurhoff F., Mathieu F., Meary A., Ionescu S., and Leboyer M. Tests of executive functions in first-degree relatives of schizophrenic patients: a meta-analysis. Psychol. Med. 35 6 (2005) 771-782
63. Taylor E., Schachar R., and Hepstinall E. Manual for Parental Account of Childhood Symptoms Interview (1993), Maudsley Hospital, London
64. Toulopoulou T., Morris R.G., Rabe-Hesketh S., and Murray R.M. Selectivity of verbal memory deficit in schizophrenic patients and their relatives. Am. J. Med. Genet. 116B 1 (2003) 1-7
65. Vitiello B. Long-term effects of stimulant medications on the brain: possible relevance to the treatment of attention deficit hyperactivity disorder. J. Child. Adolesc. Psychopharmacol. 11 1 (2001) 25-34
66. Waters F.A.V., Badcock J.C., Maybery M.T., and Michie P.T. Inhibition in schizophrenia: association with auditory hallucinations. Schizophr. Res. 62 3 (2003) 275-280
67. Wechsler D. The Wechsler Abbreviated Scale of Intelligence (1999), The Psychological Corporation, San Antonio
68. Weickert T.W., Goldberg T.E., Gold J.M., Bigelow L.B., Egan M.F., and Weinberger D.R. Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect. Arch. Gen. Psychiatry 57 9 (2000) 907-913
69. Whyte M.C., Brett C., Harrison L.K., Byrne M., Miller P., Lawrie S.M., et al. Neuropsychological performance over time in people at high risk of developing schizophrenia and controls. Biol. Psychiatry 59 8 (2006) 730-739
70. Wing J.K., Babor T., Brugha T., Burke J., Cooper J.E., Giel R., et al. Scan. Schedules for clinical assessment in neuropsychiatry. Arch. Gen. Psychiatry 47 6 (1990) 589-593
71. Wolf L.E., Cornblatt B.A., Roberts S.A., Shapiro B.M., and Erlenmeyer-Kimling L. Wisconsin card sorting deficits in the offspring of schizophrenics in the New York high-risk project. Schizophr. Res. 57 2-3 (2002) 173
72. Zalla T., Joyce C., Szoke A., Schurhoff F., Pillon B., Komano O., et al. Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res. 121 3 (2004) 207-217