Heritability and number of quantitative trait loci of neurocognitive functions in families with schizophrenia

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 114, Issue 5, 2002, Pages 483-490

  Tuulio Henriksson, Annamari ^a   Haukka, Jari ^a   Partonen, Timo ^a   Varilo, Teppo ^a   Paunio, Tiina ^a   Ekelund, Jesper ^a   Cannon, Tyrone D ^a,b   Meyer, Joanne M ^c   Lönnqvist, Jouko ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

Endophenotypes; Genetics; Heritability; Neurocognition; Schizophrenia

Indexed keywords

ADULT; ARTICLE; COGNITION; CONTROLLED STUDY; FAMILY STUDY; FEMALE; FINLAND; GENE NUMBER; GENETIC SUSCEPTIBILITY; HERITABILITY; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONTE CARLO METHOD; PEDIGREE; PHENOTYPE; PRIORITY JOURNAL; PROBABILITY; QUANTITATIVE ANALYSIS; QUANTITATIVE TRAIT LOCUS; SCHIZOPHRENIA; SEGREGATION ANALYSIS; VERBAL MEMORY; VISUAL MEMORY; WORKING MEMORY;

ADULT; COGNITION; FAMILY HEALTH; FEMALE; HUMANS; MALE; MARKOV CHAINS; MIDDLE AGED; MODELS, GENETIC; MONTE CARLO METHOD; NEUROPSYCHOLOGICAL TESTS; QUANTITATIVE TRAIT, HERITABLE; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 0037043032     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.10480     Document Type: Article

References (58)

1. Multipoint quantitative trait linkage analysis in general pedigrees
2. Heritability of neurocognitive correlates of schizophrenia
3. Defining the phenotype of schizophrenia: Cognitive dysmetria and its neural mechanisms
4. Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-22
5. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers
6. The genetic epidemiology of schizophrenia in a Finnish twin cohort: A population-based modeling study
7. Regional gray matter, white matter, and cerebrospinal fluid distributions in schizophrenic patients, their siblings, and controls
8. The inheritance of neuropsychological dysfunction in twins discordant for schizophrenia
9. Heritability estimates for psychotic disorders
10. Verbal working memory impairment in schizophrenia patients and their first-degree relatives
11. Impaired attention, genetics, and the pathophysiology of schizophrenia
12. Cognitive and behavioral precursors of schizophrenia
13. The dependence of span and delayed response performance on prefrontal cortex
14. Analysis of age-at-onset data with applications to Alzheimer disease pedigrees
15. Relative risk of attention deficits in siblings of patients with schizophrenia
16. Relative risk for cognitive impairments in siblings of patients with schizophrenia
17. Genome-wide scan for schizophrenia in the Finnish population: Evidence for a locus on chromosome 7q22
18. Neurobehavioral deficits in offsprings of schizophrenic patients: Liability indicators and predictors of illness
19. A summary of attentional findings in the New York High-Risk Project
20. Neuropsychological functioning among the nonpsychotic relatives of schizophrenia patients: A diagnostic efficiency analysis
21. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: A 4-year follow-up study
22. Alternative phenotypes for the complex genetics of schizophrenia
23. Neuropsychological assessment of monozygotic twins discordant for schizophrenia
24. Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia, on chromosomes 1q32.2, 5q33.2, and 8p21-22, and provides support for linkage to schizophrenia, on chromosomes 11q23.3-24 and 20q12.1-11.23
25. Working memory and schizophrenia: Evidence for slowed encoding
26. Markov chain Monte Carlo segregation and linkage analysis for oligogenic models
27. Sex differences in neuropsychological functioning of first-episode and chronically ill schizophrenic patients
28. Schizophrenia in the genetic isolate of Finland
29. A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci
30. Clinical features of schizophrenia and linkage to chromosomes 5q, 6p, 8p and 10p in the Irish study of high-density families
31. Single or multiple familial cognitive risk factors in schizophrenia?
32. Schizophrenia and cognitive function
33. Verbal learning and memory in relatives of schizophrenics
34. A polydiagnostic application of operational criteria in psychotic illness: Development and reliability of the OPCRIT system
35. Generalized cognitive deficits in schizophrenia. A study of first-episode patients
36. Estimating and controlling for the effects of volunteer bias with pairs of relatives
37. Spatial working memory deficits in the relatives of schizophrenia patients
38. Genome-wide scan in a nation-wide study sample of schizophrenia families in Finland reveals susceptibility loci on chromosomes 2q and 5q
39. Use of population isolates for mapping complex traits
40. Genetics of childhood disorders: III. Genetics and intelligence
41. Genetics, environment and cognitive abilities: Review and work in progress towards a genome scan for quantitative trait locus associations using DNA pooling
42. Normative neuropsychological test performance: Effects of age, education, gender and ethnicity
43. Thalamic and amygdala-hippocampal volume reductions in first-degree relatives of patients with schizophrenia: An MRI-based morphometric analysis
44. Association of neuropsychological vulnerability markers in relatives of schizophrenic patients
45. Schizophrenia: Genes and environment
46. Neuropsychological processes associated with normal aging
47. The age of human mutation: Genealogical and linkage disequilibrium analysis of the CLN5 mutation in the Finnish population
48. Linkage disequilibrium and demographic history of isolated populations: Finland and a young subpopulation of Kuusamo
49. Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect
50. Segregation analysis of phenotypic components of learning disabilities. I. Nonword memory and digit span
51. Differences in neuropsychological functioning associated with age, education, neurological status, and magnetic resonance imaging. Findings in neurologically healthy elderly individuals