Neuropsychological deficits in children associated with increased familial risk for schizophrenia

Schizophrenia Research

Volumn 67, Issue 2-3, 2004, Pages 123-130

  Davalos, Deana B ^a,b   Compagnon, Nina ^a   Heinlein, Shari ^a,b   Ross, Randal G ^a,b  

^a UNIVERSITY OF COLORADO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cognition; Genetic predisposition; Neuropsychology; Schizophrenia; School age children

Indexed keywords

ADOLESCENT; ARTICLE; CHILD; CHILD BEHAVIOR; CHILD PSYCHOLOGY; COGNITION; CONTROLLED STUDY; DEPTH PERCEPTION; EMOTION; FAMILY HISTORY; FEMALE; GENETIC RISK; HUMAN; INHIBITION (PSYCHOLOGY); MALE; MENTAL TASK; NORMAL HUMAN; PARENT; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE; VERBAL BEHAVIOR; WORKING MEMORY;

EID: 1342343076     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(03)00187-7     Document Type: Article

References (67)

1. American Psychiatric Association Diagnosis and Statistical Manual of Mental Disorders. 4th ed. (DSM-IV):1994;American Psychiatric Association, Washington, DC.
2. Anthony B.J. Piagetian egocentrism, empathy, and affect discrimination in children at high risk for psychosis. Anthony E.J., Koupernik C., Chiland C. The Child and His Family: Vulnerable Children. vol. 4:1978;359-379 Wiley, New York, NY.
3. Blanchard J.J., Neale J.M. The neuropsychological signature of schizophrenia: generalized or differential deficit? American Journal of Psychiatry. 151:1994;40-48.
4. Bollini A.M., Arnold M.C., Keefe R.S.E. Test-retest reliability of the dot test of visuospatial working memory in patients with schizophrenia and controls. Schizophrenia Research. 45(1-2):2000;169-173.
5. Byrne M., Hodges A., Grant E., Owens D.C., Johnstone E.C. Neuropsychological assessment of young people at high genetic risk for developing schizophrenia compared with controls: preliminary findings of the Edinburgh High Risk Study (EHRS). Psychological Medicine. 29:1999;1161-1173.
6. Byrne M., Clafferty B.A., Cosway R., Grant E., Hodges A., Whalley H.C., Lawrie S.M., Owens D.G.C., Johnstone E.C. Neuropsychology, genetic liability, and psychotic symptoms in those at high risk of schizophrenia. Journal of Abnormal Psychology. 112:2003;38-48.
7. Case R., Kurland D.M., Goldberg J. Operational efficiency of short-term memory span. Journal of Experimental Psychology. 33:1982;386-404.
8. Cornblatt B.A. Predictors of schizophrenia and preventive intervention. Breier A., Tran P.V. Current Issues in the Psychopharmacology of Schizophrenia. 2001;389-406 Lippincott Williams and Wilkins Publishers, Philadelphia, PA, US.
9. Cornblatt B.A., Erlenmeyer-Kimling L. Early attentional predictors of adolescent behavioral disturbances in children at risk for schizophrenia. Watt N.F., Anthony E.J., Wynne L.C., Rolf J.E. Children at Risk for Schizophrenia: A Longitudinal Perspective. 1984;198-211 Cambridge Univ. Press, New York.
10. Cornblatt B.A., Erlenmeyer-Kimling L. Global attentional deviance as a marker of risk for schizophrenia: specificity and predictive validity. Journal of Abnormal Psychology. 4:1985;470-486.
11. Cornblatt B.A., Obuchowski M. Update of high risk research: 1987-1997. International Review of Psychiatry. 9:1997;437-447.
12. Cornblatt B.A., Obuchowski M., Roberts S., Pollack S., Erlenmeyer-Kimling L. Cognitive and behavioral precursors of schizophrenia. Development and Psychopathology. 11:1999;487-508.
13. Cosway R., Byrne M., Clafferty R., Hodges A., Grant E., Abukmeil S.S., Lawrie S.M., Miller P., Johnstone E.C. Neuropsychological change in young people at high risk for schizophrenia: results from the first two neuropsychological assessments of the Edinburgh High Risk Study. Psychological Medicine. 30:2000;1111-1121.
14. Daneman M., Carpenter P. Individual differences in working memory and reading. Journal of Verbal Learning and Verbal Behavior. 19:1980;450-466.
15. Daneman M., Carpenter P. Individual differences in comprehending and producing words in context. Journal of Memory and Language. 25:1986;1-18.
16. David A.S., Malmberg A., Brandt L., Allebeck P., Lewis G. IQ and risk for schizophrenia: a population-based cohort study. Psychological Medicine. 27:1997;1311-1323.
17. Dworkin R.H., Cornblatt B.A., Friedmann R., Kaplansky L.M., Lewis J.A., Rinaldi A., Shilliday C., Erlenmeyer-Kimling L. Childhood precursors of affective vs. social deficits in adolescents at risk for schizophrenia. Schizophrenia Bulletin. 19:1993;563-577.
18. Dworkin R.H., Lewis J.A., Cornblatt B.A., Erlenmeyer-Kimling L. Social competence deficits in adolescents at risk for schizophrenia. Journal of Nervous and Mental Disease. 182:1994;103-108.
19. Erlenmeyer-Kimling L., Cornblatt B. Attentional measures in a study of children at high-risk for schizophrenia. Journal of Psychiatry Research. 1:1978;93-98.
20. Erlenmeyer-Kimling L., Roberts S.A., Rock D., Adamo U.H., Shapiro B.M., Pape S. Prediction from longitudinal assessments of high-risk children. Lenzenweger M.F., Dworkin R.H. Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. 1998;427-445 American Psychological Association, Washington, DC.
21. Erlenmeyer-Kimling L., Rock D.R., Roberts S.A., Janal M., Kestenbaum C., Cornblatt B., Hilldoff-Adamo U., Gottesman I.I. Attention, memory, and motor skills as childhood predictors of schizophrenia-related psychoses: the New York high-risk project. American Journal of Psychiatry. 157(9):2000;1416-1422.
22. Finkelstein J. Attention deficits in schizophrenia: endophenotypic markers of vulnerability to the disorder. Dissertation Abstracts International. 59:1999;3689.
23. Friedman D., Cornblatt B.A., Vaughan H., Erlenmeyer-Kimling L. Event-related potentials in children at risk for schizophrenia during two versions of the continuous performance test. Psychiatry Research. 18:1986;161-177.
24. Fuller R., Frith C.D., Jahanshahi M. Reduced negative priming does indicate reduced cognitive inhibition in schizophrenia. Cognitive Neuropsychiatry. 5:2000;21-35.
25. Garmezy N. Attentional processes in adult schizophrenia and in children at risk. Journal of Psychiatric Research. 14:1978;3-34.
26. Hans S.L., Marcus J., Nuechterlein K.H., Asarnow R.F., Styr B., Auerbach J.G. Neurobehavioral deficits at adolescence in children at risk for schizophrenia: the Jerusalem Infant Development Study. Archives of General Psychiatry. 56:1999;741-748.
27. Harris J.G., Adler L.E., Young D.A., Cullum C.M., Rilling L.M., Cicerello A., Intemann P.M., Freedman R. Neuropsychological dysfunction in parents of schizophrenics. Schizophrenia Research. 20:1996;253-260.
28. Harvey P.D. Vulnerability to schizophrenia in adulthood. Ingram R.E., Price J.M. Vulnerability to Psychopathology: Risk Across the Lifespan. 2001;355-381 The Guilford Press, New York, NY, US.
29. Heimberg C., Gur R.E., Erwin R.J., Shtasel D.L., Gur R.C. Facial emotion discrimination: III. Behavioral findings in schizophrenia. Psychiatry Research. 42:1992;253-265.
30. Herrera-Graf M., Dipert Z.J., Hinton R.N. Exploring the effective use of the Vocabulary/Block Design short form with a special school population. Educational and Psychological Measurement. 56:1996;522-528.
31. Heston L.L. Psychiatric disorders in foster home reared children of schizophrenic mothers. British Journal of Psychiatry. 112:1966;819-826.
32. Hutton S.B., Cuthbert I., Crawford T.J., Kennard C., Barnes T.R.E., Joyce E.M. Saccadic hypometria in drug naïve and drug-treated schizophrenic patients: a working memory deficit? Psychophysiology. 38(1):2001;125-132.
33. Iddon J.L., McKenna P.J., Sahakian B.J., Robbins T.W. Impaired generation and use of strategy in schizophrenia: evidence from visuospatial and verbal tasks. Psychological Medicine. 28(5):1998;1049-1062.
34. Kallman F.J. The Genetics of Schizophrenia. 1938;J.J. Augustin, New York.
35. Kallmann F.J., Falek A., Hurzeler M., Erlenmeyer-Kimling L. The developmental aspects of children with two schizophrenic parents. Solomon P., Glueck B.D. Recent Research on Schizophrenia, Psychiatric Research Report. vol. 19:1964;216-263 American Psychiatric Association, Washington, DC.
36. Karatekin C., Asarnow R.F. Working memory in childhood-onset schizophrenia and attention-deficit/hyperactivity disorder. Psychiatry Research. 80(2):1998;165-176.
37. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., Williamson D., Ryan N. Schedule for affective disorders and schizophrenia for school-age children - present and lifetime version (K-SADS-PL): initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry. 36:1997;980-988.
38. Keefe R.S.E., Silverman J.M., Roitman S.E.L., Harvey P.D., Duncan A.M., Alroy D., Siever L.J., Davis K.L., Mohs R.C. Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests. Psychiatry Research. 53(1):1994;1-12.
39. Kety S.S., Rosenthal D., Wender P.H. Mental illness in the biological and adoptive families of schizophrenics. American Journal of Psychiatry. 3:1971;302-306.
40. Kohler C.G., Bilker W., Hagendoorn M., Gur R.E., Gur R.C. Emotion recognition deficit in schizophrenia: association with symptomatology and cognition. Biological Psychiatry. 48:2000;127-136.
41. Laplante L., Everett J., Thomas J. Inhibition through negative priming with Stroop stimuli in schizophrenia. British Journal of Clinical Psychology. 31(3):1992;307-326.
42. Lencer R., Trillenberg-Krecker K., Schwinger E., Arolt V. Schizophrenia spectrum disorders and eye tracking dysfunction in singleton and multiplex schizophrenia families. Schizophrenia Research. 60:2003;33-45.
43. Levy D.L., Holzman P.S., Matthysse S., Mendell N.R. Eyetracking and schizophrenia: a selective review. Schizophrenia Bulletin. 20:1994;47-62.
44. Lior R., Nachson I. Impairments in judgment of chimeric faces by schizophrenic and affective patients. International Journal of Neuroscience. 97(3-4):1999;185-209.
45. MacDonald A.W., Pogue-Geile M.F., Johnson M., Carter C.S. A specific deficit in context processing in the unaffected siblings of patients with schizophrenia. Archives of General Psychiatry. 60:2003;57-65.
46. Matthysse S., Holzman P.S., Lange K. The genetic transmission of schizophrenia: application of Mendelian latent structure analysis to eye tracking dysfunctions in schizophrenia and affective disorder. Journal of Psychiatric Research. 20:1986;57-76.
47. Meehl P.E. Schizotaxia, schizotypy, schizophrenia. American Psychologist. 17:1962;827-838.
48. Mueser K.T., Bellack A.S., Douglas M.S., Morrison R.L. Prevalence and stability of social skill deficits in schizophrenia. Schizophrenia Research. 5:1991;167-176.
49. Nicolson R., Lenane M., Singaracharlu S., Malaspina D., Giedd J.N., Hamburger S.D., Gochman P., Bedwell J., Thaker G.K., Fernandez T., Wudarsky M., Hommer D.W., Rapoport J.L. Premorbid speech and language impairments in childhood-onset schizophrenia: association with risk factors. American Journal of Psychiatry. 157(5):2000;794-800.
50. Nowicki S., Duke M.P. Individual differences in the nonverbal communication of affect: the diagnostic analysis of nonverbal accuracy scale. Journal of Nonverbal Behavior. 18(1):1994;9-35.
51. Nuechterlein K.H. Converging evidence for vigilance deficit as a vulnerability indicator for schizophrenic disorders. Alpert M. Controversies in Schizophrenia: Changes and Constancies: Proceedings of the 74th Annual Meeting of the American Psychopathological Association, New York City, March 1-3, 1984. 1984;175-198 The Guilford Press, New York, NY.
52. Nuechterlein K.H., Asarnow R.F., Subotnik K.L., Fogelson D.L., Ventura J., Torquato R.D., Dawson M.E. Neurocognitive vulnerability factors for schizophrenia: convergences across genetic risk studies and longitudinal trait-state studies. Lenzenweger M.F., Dworkin R.H. Origins and Development of Schizophrenia: Advances in Experimental Psychopathology. 1998;299-327 American Psychological Association, Washington, DC.
53. Passolunghi M.C., Siegel L.S. Short-term memory, working memory, and inhibitory control in children with difficulties in arithmetic problem solving. Journal of Experimental Child Psychology. 80:2001;44-57.
54. Penn D.L., Combs D.R., Ritchie M., Francis J., Cassissi J., Morris S., Townsend M. Emotion recognition in schizophrenia: further investigation of generalized versus specific deficit models. Journal of Abnormal Psychology. 109(3):2000;512-516.
55. Peters E.R., Pickering A.D., Kent A., Glasper A., Irani M., David A.S., Day S., Hemsley D.R. The relationship between cognitive inhibition and psychotic symptoms. Journal of Abnormal Psychology. 109(3):2000;386-395.
56. Ross R.G., Compagnon N. Diagnosis and treatment of psychiatric disorders in children with a schizophrenic parent. Schizophrenia Research. 50:2001;121-129.
57. Ross R.G., Olincy A., Mikulich S.K., Radant A.D., Harris J.G., Waldo M., Compagnon N., Heinlein S., Leonard S., Zerbe G.O., Adler L., Freedman R. Admixture analysis of smooth pursuit eye movements in probands with schizophrenia and their relatives suggests gain and leading saccades are potential endophenotypes. Psychophysiology. 39:2002;809-819.
58. Sullivan E.V., Shear P.K., Zipursky R.B., Sagar H.J., Pfefferbaum A. A deficit profile of executive, memory, and motor functions in schizophrenia. Biological Psychiatry. 36:1994;641-653.
59. Tannock R., Schachar R.J., Carr R.P., Chajczyk D., Logan G.D. Effects of methylphenidate on inhibitory control in hyperactive children. Journal of Abnormal Child Psychology. 17:1989;473-491.
60. Thorndike R.L., Hagen E.P., Sattler J.M. Stanford-Binet Intelligence Scale. 4th ed. 1986;Riverside Publishing, Chicago.
61. Toomey R., Faraone S.V., Seidman L.J., Kremen W.S., Pepple J.R., Tsuang M.T. Association of neuropsychological vulnerability markers in relatives of schizophrenic patients. Schizophrenia Research. 31(23):1998;89-98.
62. Trumbetta S.L., Mueser K.T. Social functioning and its relationship to cognitive deficits over the course of schizophrenia. Keefe R.S.E., McEvoy J.P. Negative Symptom and Cognitive Deficit Treatment Response in Schizophrenia. 2001;33-67 American Psychiatric Press, Washington, DC.
63. Tsang H.W. Applying social skills training in the context of vocational rehabilitation for people with schizophrenia. Journal of Nervous and Mental Disease. 189:2001;90-98.
64. Waldo M.C., Roath M., Levine W., Freedman R. A model program to teach parenting skills to schizophrenic mothers. Hospital and Community Psychiatry. 38:1987;1110-1112.
65. Waldo M.C., Cawthra E., Adler L.E., Dubester S., Staunton M., Nagamoto H., Baker N., Madison A., Simon J., Scherzinger A., Drebing C., Gerhardt G., Freedman R. Auditory sensory gating, hippocampal volume, and catecholamine metabolism in schizophrenics and their siblings. Schizophrenia Research. 12:1993;93-106.
66. Walker E., McGuire M., Bettes B. Recognition and identification of facial stimuli by schizophrenics and patients with affective disorder. British Journal of Clinical Psychology. 23(1):1984;37-44.
67. Wechsler D. Wechsler Intelligence Scale for Children. 3rd ed. 1991;Harcourt Brace Jovanovich, San Antonio, TX.