Cognitive dysfunctions in parents of schizophrenic patients parallel the deficits found in patients

Schizophrenia Research

Volumn 63, Issue 3, 2003, Pages 285-293

  Appels, Melanie C M ^a   Sitskoorn, Margriet M ^a   Westers, Paul ^b   Lems, Elleke ^a   Kahn, René S ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Cognition; Genotypical marker; Parents; Schizophrenia

Indexed keywords

ADULT; ARTICLE; ATTENTION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; FUNCTIONAL ASSESSMENT; HUMAN; LANGUAGE; MAJOR CLINICAL STUDY; MALE; NEUROPSYCHOLOGICAL TEST; PARENT; PHENOTYPE; PRIORITY JOURNAL; PSYCHOMOTOR ACTIVITY; SCHIZOPHRENIA; SKILL; SPEECH ARTICULATION; TASK PERFORMANCE; VERBAL MEMORY;

EID: 0041326874     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(02)00342-0     Document Type: Article

References (49)

1. Andreasen N.C., Flaum M., Arndt S. The Comprehensive Assessment of Symptoms and History (CASH). An instrument for assessing diagnosis and psychopathology. Arch. Gen. Psychiatry. 49:1992;615-623.
2. Benton A.L., Hamsher K. Multilingual Aphasia Examination. 1976;University of Iowa, Iowa City.
3. Blackwood D.H., Glabus M.F., Dunan J., O'Caroll R.E., Muir W.J., Ebmeier K.P. Altered cerebral perfusion measured by SPECT in relatives of patients with schizophrenia. Correlations with memory and P300. Br. J. Psychiatry. 175:1999;357-366.
4. Cannon T.D., Zorilla L.E., Shtasel D., Gur R.E., Gur R.C., Marco E.J., Moberg P., Price R.A. Neuropsychological functioning in siblings discordant for schizophrenia and healthy volunteers. Arch. Gen. Psychiatry. 51:1994;651-661.
5. Cardno A.G., Marshall E.J., Coid B., Macdonald A.M., Ribchester T.R., Davies N.J., Venturi P., Jones L.A., Lewis S.W., Sham P.C., Gottesman I.I., Farmer A.E., McGuffin P., Reveley A.M., Murray R.M. Heritability estimates for psychotic disorders: the Maudsley twin psychosis series. Arch. Gen. Psychiatry. 56:1999;162-168.
6. Chen Y.L., Chen Y.H., Lieh M.F. Semantic verbal fluency deficit as a familial trait marker in schizophrenia. Psychiatry Res. 95:2000;133-148.
7. Conklin H.M., Curtis C.E., Katsanis J., Iacono W.G. Verbal working memory impairment in schizophrenia patients and their first-degree relatives: evidence from the digit span task. Am. J. Psychiatry. 157:2000;275-277.
8. Cornblatt B.A., Risch N.J., Faris G., Friedman D., Erlenmeyer-Kimling L. The Continuous Performance Test, Identical Pairs version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Res. 26:1988;223-238.
9. Cosway R., Byrne M., Clafferty R., Hodges A., Grant E., Morris J., Abukmeil S.S., Lawrie S.M., Miller P., Owens D.G.C., Johnstone E.C. Sustained attention in young people at risk for schizophrenia. Psychol. Med. 32:2002;277-286.
10. Docherty N.M. Cognitive characteristics of the parents of schizophrenic patients. J. Nerv. Ment. Dis. 182:1994;443-451.
11. Dollfus S., Lombardo C., Bénali K., Halbecq I., Abadie P., Marié R.M., Brazo P. Executive/attentional cognitive functions in schizophrenic patients and their parents: a preliminary study. Schizophr. Res. 53:2002;93-99.
12. Egan M.F., Goldberg T.E., Gscheidle T., Weirich M., Bigelow L.B., Weinberger D.R. Relative risk of attention deficits in siblings of patients with schizophrenia. Am. J. Psychiatry. 157:2000;1309-1316.
13. Endicott J., Spitzer R.L. A diagnostic interview: the schedule for affective disorders and schizophrenia. Arch. Gen. Psychiatry. 35:1978;837-844.
14. Faraone S.V., Kremen W.S., Lyons M.J., Pepple J.R., Seidman L.J., Tsuamg M.T. Diagnostic accuracy and linkage analysis: how useful are schizophrenia spectrum phenotypes? Am. J. Psychiatry. 152:1995;1286-1290.
15. Faraone S.V., Seidman L.J., Kremen W.S., Toomey R., Lyons M.J., Tsuang M.T. Neuropsychological functioning among the elderly nonpsychotic relatives of schizophrenic patients. Schizophr. Res. 21:1996;27-31.
16. Faraone S.V., Tsuang M.T., Tsuang D.W. The future of psychiatric genetics. Genetics of Mental Disorders. A Guide for Students, Clinicians, and Researchers. 1999;196-234 The Guilford Press, New York.
17. Faraone S.V., Seidman L.J., Toomey R., Kremen W.S., Pepple J.R., Tsuang M.T. Neuropsychological functioning among the nonpsychotic relatives of schizophrenic patients: a 4-year follow-up study. J. Abnorm. Psychol. 108:1999;176-181.
18. Faraone S.V., Seidman L.J., Kremen W.S., Toomey R., Pepple J.R., Tsuang M.T. Neuropsychologic functioning among the nonpsychotic relatives of schizophrenic patients: the effect of genetic loading. Biol. Psychiatry. 48:2000;120-126.
19. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured Clinical Interview for DSM-IV Axis 1 Disorders - Patient Edition (SCID-I/P) Version 2.0, Dutch Version. 1997;Swets & Zeitlinger, Lisse.
20. Franke P., Maier W., Hain C., Klinger T. Wisconsin Card Sorting Test: an indicator of vulnerability to schizophrenia? Schizophr. Res. 6:1992;243-249.
21. Franke P., Maier W., Hardt J., Hain C. Cognitive functioning and anhedonia in subjects at risk for schizophrenia. Schizophr. Res. 10:1993;77-84.
22. Franke P., Maier W., Hardt J., Hain C., Cornblatt B.A. Attentional abilities and measures of schizotypy: their variation and covariation in schizophrenic patients, their siblings, and normal control subjects. Psychiatry Res. 54:1994;259-272.
23. Goldberg T.E., Ragland J.D., Torrey E.F., Gold J.M., Bigelow L.B., Weinberger D.R. Neuropsychological assessment of monozygotic twins discordant for schizophrenia. Arch. Gen. Psychiatry. 47:1990;1066-1072.
24. Gottesman I.I., Shields J. Genetical puzzle pieces: family studies. Schizophrenia: The Epigenetic Study. 1982;83-98 Cambridge Univ. Press, Cambridge.
25. Green M.F. Neurocognitive indicators of vulnerability to schizophrenia. Schizophrenia from a Neurocognitive Perspective. Probing the Impenetrable Darkness. 1998;Allan & Bacon, Needham Heights.
26. Harris J.G., Adler L.E., Young D.A., Cullum C.M., Rilling L.M., Cicerello A., Intemann P.M., Freedman R. Neuropsychological dysfunction in parents of schizophrenics. Schizophr. Res. 20:1996;253-260.
27. Heaton R.K., Chelune G.J., Talley J.L., Kay G.G., Curtiss G. Wisconsin Card Sorting Test Manual - Revised and Expanded. 1993;PARPsychological Assessment Resources, Inc. USA.
28. Heinrichs R.W., Zakzanis K.K. Neurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 12:1998;426-445.
29. Keefe R.S., Silverman J.M., Roitman S.E., Harvey P.D., Duncan M.A., Alroy D., Siever L.J., Davis K.L., Mohs R.C. Performance of nonpsychotic relatives of schizophrenic patients on cognitive tests. Psychiatry Res. 53:1994;1-12.
30. Kremen W.S., Seidman L.J., Pepple J.R., Lyons M.J., Tsuang M.T., Faraone S.V. Neuropsychological risk indicators for schizophrenia: a review of family studies. Schizophr. Bull. 20:1994;103-119.
31. Laurent A., Saoud M., Bougerol T., D'Amato T., Anchisi A.M., Biloa-Tang M., Dalery J., Rochet T. Attentional deficits in patients with schizophrenia and in their non-psychotic first-degree relatives. Psychiatry Res. 89:1999;147-159.
32. Laurent A., Rochet T., D'Amato T., Anchisi A.M., Daumal M., Favre P., Bougerol T., Dalery J. Vulnerability to schizophrenia: III. Importance and limits of the identical pairs continuous performance test. Encephale. 26:2000;48-55.
33. Luteyn F., Van der Ploeg F.A.E. The Groningen Intelligence Test. 1983;Swets & Zeitlinger, Lisse. in Dutch.
34. Mathews C.A., Reus V.I. Assortative mating in the affective disorders: a systematic review and meta-analysis. Comp. Psychiatry. 42:2001;257-262.
35. McGuffin P., Owen M.J., Farmer A.E. Genetic basis of schizophrenia. Lancet. 346:1995;678-682.
36. Mulder J.L., Dekker R., Dekker P.H. California Verbal Learning Test. 1996;Swets & Zeitlinger, Lisse. Dutch version.
37. Molecular Genetics Initiative: Family Interview for Genetic Studies. 1991;National Institute of Mental Health, Bethesda, MD.
38. Oldfield R.C. The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia. 9:1971;97-113.
39. Parnas J. Assortative mating in schizophrenia: results from the Copenhagen High-Risk Study. Psychiatry. 51:1988;58-64.
40. Pfohl B., Blum N., Zimmerman M. Structured interview for DSM-IV personality SIDP-IV. 1995;University of Iowa, Department of Psychiatry, Iowa.
41. Reitan R.M. Trailmaking test. Manual for administration and Scoring. 1992;Reitan Neuropsychology Laboratory, Tucson.
42. Reitan R.M., Wolfson D. The Halstead-Reitan Neuropsychological Test Battery; Theory and Clinical Interpretation. 1985;Neuropsychology Press, Tuscon, AZ.
43. Saoud M., D'Amato T., Gutknecht C., Triboulet P., Bertaud J.P., Marie-Cardine M., Dalery J., Rochet T. Neuropsychological deficit in siblings discordant for schizophrenia. Schizophr. Bull. 26:2000;893-902.
44. Staal W.G., Hijman R., Hulshoff Pol H.E., Kahn R.S. Neuropsychological dysfunctions in siblings discordant for schizophrenia. Psychiatry Res. 95:2000;227-235.
45. Stinissen J., Willems P.J., Coetsier P., Hulsman W.L.L. Dutch Adaption of the Wechsler Adult Intelligent Scale. 1970;Swets & Zeitlinger, Amsterdam.
46. Thaker G.K. Defining the schizophrenia phenotype. Curr. Psychiatry Rep. 2:2000;398-403.
47. Tiffin J. Purdue Pegboard. 1987;MacMillan/McGraw-Hill, Park Ridge, IL, USA.
48. Tsuang M.T., Stone W.S., Faraone S.V. Schizophrenia: a review of genetic studies. Harv. Rev. Psychiatry. 7:1999;185-207.
49. Verhage F. Revised Scoring Method. 1983;University Hospital Groningen. Department of Neuropsychology, Groningen, The Netherlands.