A chemical genetic approach reveals that p38α MAPK activation by diphosphorylation aggravates myocardial infarction and is prevented by the direct binding of SB203580

Journal of Biological Chemistry

Volumn 285, Issue 5, 2010, Pages 2968-2975

  Kumphune, Sarawut ^a   Bassi, Rekha ^a   Jacquet, Sebastien ^a   Sicard, Pierre ^a   Clark, James E ^a   Verma, Sharwari ^a   Avkiran, Metin ^a   O'Keefe, Stephen J ^b   Marber, Michael S ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION LOOPS; CARDIOPROTECTIVE EFFECT; GENETIC APPROACH; ISOFORMS; KINASE ACTIVITY; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; PHARMACOLOGICAL INHIBITORS; PHOSPHOSPECIFIC ANTIBODIES; THREONINE RESIDUES; TYROSINE RESIDUES; WILD TYPES;

AMINO ACIDS; PHOSPHATASES; PHOSPHORYLATION;

CHEMICAL ACTIVATION;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; DORAMAPIMOD; MITOGEN ACTIVATED PROTEIN KINASE 14; THREONINE; TYROSINE; IMIDAZOLE DERIVATIVE; ISOPROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDINE DERIVATIVE;

AMINO ACID SUBSTITUTION; ANIMAL TISSUE; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART INFARCTION; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

MUS; PYRONIA TITHONUS;

ANIMALS; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN ISOFORMS; PYRIDINES; TYROSINE;

EID: 77449101661     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.079228     Document Type: Article

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