A single mutation at the sheet switch region results in conformational changes favoring λ6 light-chain fibrillogenesis

Journal of Molecular Biology

Volumn 396, Issue 2, 2010, Pages 280-292

  Hernández Santoyo, Alejandra ^a   del Pozo Yauner, Luis ^b,c   Fuentes Silva, Deyanira ^a   Ortiz, Ernesto ^b   Rudiño Piñera, Enrique ^b   Sánchez López, Rosana ^b   Horjales, Eduardo ^d   Becerril, Baltazar ^b   Rodríguez Romero, Adela ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^c INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

AL amyloidosis; Crystal structure; Fibrillogenesis; Thermodynamic stability; 6 subgroup

Indexed keywords

AMINO ACID; AMYLOID; DIMER; DNA; HISTIDINE; IMMUNOGLOBULIN LAMBDA CHAIN; MONOMER; MUTANT PROTEIN; PROLINE; SERINE;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; AMYLOIDOSIS; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA POLYMORPHISM; GENE MUTATION; GENE REARRANGEMENT; GENE SWITCHING; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; THERMODYNAMICS; WILD TYPE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; PHYSIOLOGY; POINT MUTATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

AMYLOID; AMYLOIDOSIS; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN LAMBDA-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; TEMPERATURE; THERMODYNAMICS;

EID: 77449091707     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.11.038     Document Type: Article

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