Influence of the germline sequence on the thermodynamic stability and fibrillogenicity of human lambda 6 light chains

Proteins: Structure, Function and Genetics

Volumn 72, Issue 2, 2008, Pages 684-692

  Del Pozo Yauner, Luis ^a   Ortiz, Ernesto ^a   Sánchez, Rosalba ^a   Sánchez López, Rosana ^a   Güereca, Leopoldo ^a   Murphy, Charles L ^b   Allen, Amy ^b   Wall, Jonathan S ^b   Fernández Velasco, D Alejandro ^c   Solomon, Alan ^b   Becerril, Baltazar ^a,d  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b UNIVERSITY OF TENNESSEE GRADUATE SCHOOL OF MEDICINE   (United States)

^c INSTITUTO DE CIENCIAS FÍSICAS   (Mexico)

^d NONE   (Mexico)

Author keywords

Amyloid; Cation ; Fibrillogenesis; Light chain

Indexed keywords

IMMUNOGLOBULIN LIGHT CHAIN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; GERM LINE; HUMAN; IMMUNOGLOBULIN VARIABLE REGION; IN VITRO STUDY; LIGHT CHAIN; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STABILITY; THERMODYNAMICS; WILD TYPE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GERM CELLS; HUMANS; IMMUNOGLOBULIN LAMBDA-CHAINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; SPECTRUM ANALYSIS; THERMODYNAMICS;

EID: 46449138131     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21934     Document Type: Article

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