Activation of liver X receptor reduces global ischemic brain injury by reduction of nuclear factor-κB

Neuroscience

Volumn 166, Issue 4, 2010, Pages 1101-1109

  Cheng, O ^a,b   Ostrowski, R P ^a   Liu, W ^a   Zhang, J H ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

cyclooxygenase 2; global cerebral ischemia; GW3965; liver X receptors; NF B; rats

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIVER X RECEPTOR; TRANSCRIPTION FACTOR RELA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN INJURY; BRAIN ISCHEMIA; CELL SURVIVAL; CONTROLLED STUDY; DRUG MECHANISM; GENE EXPRESSION; GENE TARGETING; HIPPOCAMPUS; MALE; MAZE TEST; MORTALITY; NERVE CELL LESION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; RAT; SEIZURE; TREATMENT RESPONSE;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; BENZOIC ACIDS; BENZYLAMINES; BRAIN ISCHEMIA; CYCLOOXYGENASE 2; DOWN-REGULATION; ENCEPHALITIS; GENE EXPRESSION REGULATION; HIPPOCAMPUS; MALE; MAZE LEARNING; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; ORPHAN NUCLEAR RECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION FACTOR RELA;

EID: 77349112892     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.01.024     Document Type: Article

References (48)

1. Block F. Global ischemia and behavioural deficits. Prog Neurobiol 58 (1999) 279-295
2. Bright J.J., Kanakasabai S., Chearwae W., and Chakraborty S. PPAR regulation of inflammatory signaling in CNS diseases. PPAR Res 2008 (2008) 658520
3. Candelario-Jalil E., Gonzalez-Falcon A., Garcia-Cabrera M., Alvarez D., Al Dalain S., Martinez G., Leon O.S., and Springer J.E. Assessment of the relative contribution of COX-1 and COX-2 isoforms to ischemia-induced oxidative damage and neurodegeneration following transient global cerebral ischemia. J Neurochem 86 (2003) 545-555
4. Chang L., Zhang Z., Li W., Dai J., Guan Y., and Wang X. Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway. Biochem Biophys Res Commun 357 (2007) 772-778
5. Choi S.H., Langenbach R., and Bosetti F. Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-kappa B pathway and downstream enzymes involved in prostaglandin biosynthesis. J Neurochem 98 (2006) 801-811
6. Clemens J.A., Stephenson D.T., Yin T., Smalstig E.B., Panetta J.A., and Little S.P. Drug-induced neuroprotection from global ischemia is associated with prevention of persistent but not transient activation of nuclear factor-kappaB in rats. Stroke 29 (1998) 677-682
7. Collino M., Aragno M., Mastrocola R., Gallicchio M., Rosa A.C., Dianzani C., Danni O., Thiemermann C., and Fantozzi R. Modulation of the oxidative stress and inflammatory response by PPAR-gamma agonists in the hippocampus of rats exposed to cerebral ischemia/reperfusion. Eur J Pharmacol 530 (2006) 70-80
8. Collins J.L., Fivush A.M., Watson M.A., Galardi C.M., Lewis M.C., Moore L.B., Parks D.J., Wilson J.G., Tippin T.K., Binz J.G., Plunket K.D., Morgan D.G., Beaudet E.J., Whitney K.D., Kliewer S.A., and Willson T.M. Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines. J Med Chem 45 (2002) 1963-1966
9. Ekdahl C.T., Claasen J.H., Bonde S., Kokaia Z., and Lindvall O. Inflammation is detrimental for neurogenesis in adult brain. Proc Natl Acad Sci USA 100 (2003) 13632-13637
10. Fujioka M., Nishio K., Miyamoto S., Hiramatsu K.I., Sakaki T., Okuchi K., Taoka T., and Fujioka S. Hippocampal damage in the human brain after cardiac arrest. Cerebrovasc Dis 10 (2000) 2-7
11. Gabbi C., Warner M., and Gustafsson J.A. Minireview: liver X receptor beta: emerging roles in physiology and diseases. Mol Endocrinol 23 (2009) 129-136
12. Garcia J.H., Wagner S., Liu K.F., and Hu X.J. Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats. Statistical validation. Stroke 26 (1995) 627-634
13. Gerlai R. Behavioral tests of hippocampal function: simple paradigms complex problems. Behav Brain Res 125 (2001) 269-277
14. Ghisletti S., Huang W., Ogawa S., Pascual G., Lin M.E., Willson T.M., Rosenfeld M.G., and Glass C.K. Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma. Mol Cell 25 (2007) 57-70
15. Green A.R., and Shuaib A. Therapeutic strategies for the treatment of stroke. Drug Discov Today 11 (2006) 681-693
16. Guerra-Crespo M., Gleason D., Sistos A., Toosky T., Solaroglu I., Zhang J.H., Bryant P.J., and Fallon J.H. Transforming growth factor-alpha induces neurogenesis and behavioral improvement in a chronic stroke model. Neuroscience 160 (2009) 470-483
17. Hughes R.N. The value of spontaneous alternation behavior (SAB) as a test of retention in pharmacological investigations of memory. Neurosci Biobehav Rev 28 (2004) 497-505
18. Ji L., Nazarali A.J., and Paterson P.G. Protein-energy malnutrition increases activation of the transcription factor, nuclear factor kappaB, in the gerbil hippocampus following global ischemia. J Nutr Biochem 19 (2008) 770-777
19. Joseph S.B., Castrillo A., Laffitte B.A., Mangelsdorf D.J., and Tontonoz P. Reciprocal regulation of inflammation and lipid metabolism by liver X receptors. Nat Med 9 (2003) 213-219
20. Kainu T., Kononen J., Enmark E., Gustafsson J.A., and Pelto-Huikko M. Localization and ontogeny of the orphan receptor OR-1 in the rat brain. J Mol Neurosci 7 (1996) 29-39
21. Karhunen H., Jolkkonen J., Sivenius J., and Pitkanen A. Epileptogenesis after experimental focal cerebral ischemia. Neurochem Res 30 (2005) 1529-1542
22. Kusaka G., Ishikawa M., Nanda A., Granger D.N., and Zhang J.H. Signaling pathways for early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 24 (2004) 916-925
23. Lipton P. Ischemic cell death in brain neurons. Physiol Rev 79 (1999) 1431-1568
24. Magnoni S., Baker A., George S.J., Duncan W.C., Kerr L.E., McCulloch J., and Horsburgh K. Differential alterations in the expression and activity of matrix metalloproteinases 2 and 9 after transient cerebral ischemia in mice. Neurobiol Dis 17 (2004) 188-197
25. Matchett G.A., Calinisan J.B., Matchett G.C., Martin R.D., and Zhang J.H. The effect of granulocyte-colony stimulating factor in global cerebral ischemia in rats. Brain Res 1136 (2007) 200-207
26. Morales J.R., Ballesteros I., Deniz J.M., Hurtado O., Vivancos J., Nombela F., Lizasoain I., Castrillo A., and Moro M.A. Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke. Circulation 118 (2008) 1450-1459
27. Ninomiya Y., Yasuda T., Kawamoto M., Yuge O., and Okazaki Y. Liver X receptor ligands inhibit the lipopolysaccharide-induced expression of microsomal prostaglandin E synthase-1 and diminish prostaglandin E2 production in murine peritoneal macrophages. J Steroid Biochem Mol Biol 103 (2007) 44-50
28. Ostrowski R.P., Colohan A.R., and Zhang J.H. Mechanisms of hyperbaric oxygen-induced neuroprotection in a rat model of subarachnoid hemorrhage. J Cereb Blood Flow Metab 25 (2005) 554-571
29. Ostrowski R.P., Graupner G., Titova E., Zhang J., Chiu J., Dach N., Corleone D., Tang J., and Zhang J.H. The hyperbaric oxygen preconditioning-induced brain protection is mediated by a reduction of early apoptosis after transient global cerebral ischemia. Neurobiol Dis 29 (2008) 1-13
30. Pascual G., Fong A.L., Ogawa S., Gamliel A., Li A.C., Perissi V., Rose D.W., Willson T.M., Rosenfeld M.G., and Glass C.K. A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-gamma. Nature 437 (2005) 759-763
31. Popp E., and Bottiger B.W. Cerebral resuscitation: state of the art, experimental approaches and clinical perspectives. Neurol Clin 24 (2006) 73-87 vi
32. Pulsinelli W.A., and Brierley J.B. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10 (1979) 267-272
33. Rehni A.K., Bhateja P., and Singh N. Diethyl dithiocarbamic acid, a possible nuclear factor kappa B inhibitor, attenuates ischemic postconditioning-induced attenuation of cerebral ischemia-reperfusion injury in mice. Can J Physiol Pharmacol 87 (2009) 63-68
34. Repa J.J., and Mangelsdorf D.J. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu Rev Cell Dev Biol 16 (2000) 459-481
35. Sasaki T., Kitagawa K., Yamagata K., Takemiya T., Tanaka S., Omura-Matsuoka E., Sugiura S., Matsumoto M., and Hori M. Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice. J Cereb Blood Flow Metab 24 (2004) 107-113
36. Schultz J.R., Tu H., Luk A., Repa J.J., Medina J.C., Li L., Schwendner S., Wang S., Thoolen M., Mangelsdorf D.J., Lustig K.D., and Shan B. Role of LXRs in control of lipogenesis. Genes Dev 14 (2000) 2831-2838
37. Shimamura N., Matchett G., Solaroglu I., Tsubokawa T., Ohkuma H., and Zhang J. Inhibition of integrin alphavbeta3 reduces blood-brain barrier breakdown in focal ischemia in rats. J Neurosci Res 84 (2006) 1837-1847
38. Sironi L., Mitro N., Cimino M., Gelosa P., Guerrini U., Tremoli E., and Saez E. Treatment with LXR agonists after focal cerebral ischemia prevents brain damage. FEBS Lett 582 (2008) 3396-3400
39. -deficient mice after experimental intracerebral hemorrhage. J Neurosci Res 86 (2008) 3240-3245
40. Ueno T., Sawa Y., Kitagawa-Sakakida S., Nishimura M., Morishita R., Kaneda Y., Kohmura E., Yoshimine T., and Matsuda H. Nuclear factor-kappa B decoy attenuates neuronal damage after global brain ischemia: a future strategy for brain protection during circulatory arrest. J Thorac Cardiovasc Surg 122 (2001) 720-727
41. Wang Y.Y., Dahle M.K., Steffensen K.R., Reinholt F.P., Collins J.L., Thiemermann C., Aasen A.O., Gustafsson J.A., and Wang J.E. Liver X receptor agonist GW3965 dose-dependently regulates LPS-mediated liver injury and modulates post-transcriptional TNFalpha production and p38 MAPK activation in liver macrophages. Shock 32 (2009) 548-553
42. Webster C.M., Kelly S., Koike M.A., Chock V.Y., Giffard R.G., and Yenari M.A. Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia. Neurobiol Dis 33 (2009) 301-312
43. Whitney K.D., Watson M.A., Collins J.L., Benson W.G., Stone T.M., Numerick M.J., Tippin T.K., Wilson J.G., Winegar D.A., and Kliewer S.A. Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol Endocrinol 16 (2002) 1378-1385
44. Xiang Z., Thomas S., and Pasinetti G. Increased neuronal injury in transgenic mice with neuronal overexpression of human cyclooxygenase-2 is reversed by hypothermia and rofecoxib treatment. Curr Neurovasc Res 4 (2007) 274-279
45. Yamaguchi M., Calvert J.W., Kusaka G., and Zhang J.H. One-stage anterior approach for four-vessel occlusion in rat. Stroke 36 (2005) 2212-2214
46. Yatsushige H., Ostrowski R.P., Tsubokawa T., Colohan A., and Zhang J.H. Role of c-Jun N-terminal kinase in early brain injury after subarachnoid hemorrhage. J Neurosci Res 85 (2007) 1436-1448
47. Zhang N., Ahsan M.H., Zhu L., Sambucetti L.C., Purchio A.F., and West D.B. Regulation of IkappaBalpha expression involves both NF-kappaB and the MAP kinase signaling pathways. J Inflamm (Lond) 2 (2005) 10
48. Zhu Y., Saito K., Murakami Y., Asano M., Iwakura Y., and Seishima M. Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia. Neurosci Lett 393 (2006) 122-126