Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells

British Journal of Pharmacology

Volumn 159, Issue 4, 2010, Pages 928-938

  Zhang, Xiao Hong ^a,b   Yokoo, Hiroki ^a   Nishioka, Hiroshi ^b   Fujii, Hajime ^b   Matsuda, Naoyuki ^a   Hayashi, Toshio ^c   Hattori, Yuichi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b Amino Up Chemical Co   (Japan)

^c NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Akt; Endothelial cells; Endothelial nitric oxide synthase (eNOS); Hyperglycaemia; Polyphenol; Protein kinase C (PKC)

Indexed keywords

BETA ACTIN; BRADYKININ; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; OLIGONOL; POLYPHENOL DERIVATIVE; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; REACTIVE OXYGEN METABOLITE; SERINE; SUPEROXIDE DISMUTASE; THREONINE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL CELL; AORTA; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; SWINE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BRADYKININ; CARDIOVASCULAR AGENTS; CATECHIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; GLUCOSE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHENOLS; PHOSPHORYLATION; PROTEIN KINASE C-EPSILON; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SERINE; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE; SWINE; THREONINE; TIME FACTORS;

EID: 77249157808     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00594.x     Document Type: Article

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