TGF-β enhances alcohol dependent hepatocyte damage via down-regulation of alcohol dehydrogenase I

Journal of Hepatology

Volumn 52, Issue 3, 2010, Pages 407-416

  Ciuclan, Loredana ^a   Ehnert, Sabrina ^b   Ilkavets, Iryna ^a   Weng, Hong Lei ^a   Gaitantzi, Haristi ^a   Tsukamoto, Hidekazu ^c   Ueberham, Elke ^d   Meindl Beinker, Nadja M ^a   Singer, Manfred V ^a   Breitkopf, Katja ^a   Dooley, Steven ^a  

^a MEDICAL FACULTY MANNHEIM HEIDELBERG UNIVERSITY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alcohol metabolism; ALKs; Hepatocytes; Liver fibrosis; Mouse model; Smad7; Steatosis; TGF

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; CYTOCHROME P450 2E1; GLUTATHIONE PEROXIDASE 1; HYDROGENASE; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; VASOPRESSIN V1 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; FIBROGENESIS; GENE EXPRESSION; GENE SILENCING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LIPID PEROXIDATION; LIPID STORAGE; LIVER; LIVER CELL DAMAGE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; VALIDATION PROCESS; WESTERN BLOTTING;

ALCOHOL DEHYDROGENASE; ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DOWN-REGULATION; DRUG-INDUCED LIVER INJURY; ETHANOL; HEPATOCYTES; LIPID METABOLISM; LIPID PEROXIDATION; MALE; MICE; MICE, INBRED C57BL; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

EID: 77249150883     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2009.12.003     Document Type: Article

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