Endocrinology of Obesity

Veterinary Clinics of North America - Small Animal Practice

Volumn 40, Issue 2, 2010, Pages 205-219

  Kil, Dong Yong ^a   Swanson, Kelly S ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Cats; Dogs; Endocrinology; Hormonal abnormalities; Obesity

Indexed keywords

ADIPONECTIN; AMYLIN; CHOLECYSTOKININ; CORTICOSTERONE; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; ESTROGEN; GHRELIN; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GROWTH HORMONE; INSULIN; INTERLEUKIN 6; LEPTIN; LUTEINIZING HORMONE; PANCREAS POLYPEPTIDE; PEPTIDE YY; PROLACTIN; PROTIRELIN; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; TESTOSTERONE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; BODY MASS; CAT; CYTOKINE RELEASE; DISEASE ASSOCIATION; DOG; DOMESTIC ANIMAL; ENDOCRINE DISEASE; GROWTH HORMONE DEFICIENCY; HORMONE RESISTANCE; HYPERINSULINEMIA; HYPERPROLACTINEMIA; HYPOTHALAMUS HYPOPHYSIS SYSTEM; HYPOTHYROIDISM; MEDICAL LITERATURE; NONHUMAN; OBESITY; REVIEW; WEIGHT REDUCTION;

ANIMALS; CAT DISEASES; CATS; DOG DISEASES; DOGS; ENDOCRINE SYSTEM DISEASES; OBESITY;

ANIMALIA; CANIS FAMILIARIS;

EID: 77249132356     PISSN: 01955616     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cvsm.2009.10.004     Document Type: Review

References (114)

1. Sikaris K.A. The clinical biochemistry of obesity. Clin Biochem Rev 25 3 (2004) 165-181
2. Lund E.M., Amstrong P.J., Kirk C.A., et al. Prevalence and risk factors for obesity in adult cats from private US veterinary practices. Int J Appl Res Vet Med 3 2 (2005) 88-96
3. Lund E.M., Amstrong P.J., Kirk C.A., et al. Prevalence and risk factors for obesity in adult dogs from private US veterinary practices. Int J Appl Res Vet Med 4 2 (2005) 177-186
4. Laflamme D.P. Understanding and managing obesity in dogs and cats. Vet Clin North Am Small Anim Pract 36 6 (2006) 1283-1295
5. Scott-Moncrieff J.C. Clinical signs and concurrent diseases of hypothyroidism in dogs and cats. Vet Clin North Am Small Anim Pract 37 4 (2007) 709-722
6. Glass A.R., Burman K.D., Dahms W.T., et al. Endocrine function in human obesity. Metabolism 30 1 (1981) 89-104
7. Nam S.Y., Lee E.J., Kim K.R., et al. Effect of obesity on total and free insulin-like growth factor (IGF)-1, and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin, and growth hormone. Int J Obes 21 5 (1997) 355-359
8. Luque R.M., and Kineman R.D. Impact of obesity on the growth hormone axis: evidence for a direct inhibitory effect of hyperinsulinemia on pituitary function. Endocrinology 147 6 (2006) 2754-2763
9. Rasmussen M.H., Hvidberg A., Juul A., et al. Massive weight loss restores 24-hour growth hormone release profiles and serum insulin-like growth factor-I concentrations in obese subjects. J Clin Endocrinol Metab 80 4 (1995) 1407-1415
10. Scacchi M., Pincelli A.I., and Cavagnini F. Growth hormone in obesity. Int J Obes 23 3 (1999) 260-271
11. Lee E.J., Kim K.R., Lee H.C., et al. Acipimox potentiates growth hormone response to growth hormone-releasing hormone by decreasing serum free fatty acid levels in hyperthyroidism. Metabolism 44 11 (1995) 1509-1512
12. Kratzsch J., Dehmel B., Pulzer F., et al. Increased serum GHBP levels in obese pubertal children and adolescents: relationship to body composition, leptin and indicators of metabolic disturbances. Int J Obes 21 12 (1997) 1130-1136
13. Douyon L., and Schteingart D.E. Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion. Endocrinol Metab Clin North Am 31 1 (2002) 173-189
14. Argente J., Caballo N., Barrios V., et al. Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: effect of short- and long-term weight reduction. J Clin Endocrinol Metab 82 7 (1997) 2076-2083
15. Gayet C., Bailhache E., Dumon H., et al. Insulin resistance and changes in plasma concentration of TNF, IGF-1, and NEFA in dogs during weight gain and obesity. J Anim Physiol Anim Nutr 88 3 (2004) 157-165
16. Yamka R.M., Friesen K.G., and Frantz N.Z. Identification of canine markers related to obesity and the effects of weight loss on the markers of interest. Int J Appl Res Vet Med 4 4 (2006) 282-292
17. Martin L.J.M., Siliart B., Dumon H.J.W., et al. Hormonal disturbance associated with obesity in dogs. J Anim Physiol Anim Nutr 90 9 (2006) 355-360
18. Guillaume-Gentil C., Rohner-Jeanrenaud F., Abramo F., et al. Abnormal regulation of the hypothalamo-pituitary-adrenal axis in the genetically obese fa/fa rat. Endocrinology 126 4 (1990) 1873-1879
19. Vicennati V., Ceroni L., Genghini S., et al. Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity. Obesity (Silver Spring) 14 2 (2006) 235-243
20. Roelfsema F., Kok P., Frolich M., et al. Disordered and increased adrenocorticotropin secretion with diminished adrenocorticotropin potency in obese premenopausal women. J Clin Endocrinol Metab 94 8 (2009) 2991-2997
21. Pasquali R., Cantobelli S., Casimirri F., et al. The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77 2 (1993) 341-346
22. Fox C.S., Pencina M.J., D'Agostino R.B., et al. Relations of thyroid function to body weight: cross-sectional and longitudinal observations in a community-based sample. Arch Intern Med 168 6 (2008) 587-592
23. Roti E., Minelli R., and Salvi M. Thyroid hormone metabolism in obesity. Int J Obes Relat Metab Disord 24 Suppl 2 (2000) S113-S115
24. Kokkoris P., and Pi-Sunyer F.X. Obesity and endocrine disease. Endocrinol Metab Clin North Am 32 4 (2003) 895-914
25. Daminet S., Jeusette I., Duchateau L., et al. Evaluation of thyroid function in obese dogs and in dogs undergoing a weight loss protocol. J Vet Med A Physiol Pathol Clin Med 50 4 (2003) 213-218
26. Ferguson D.C., Caffall Z., and Hoenig M. Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats. J Endocrinol 194 2 (2007) 267-273
27. Pinkney J.H., Goodrick S.J., Katz J., et al. Leptin and the pituitary-thyroid axis: a comparative study in lean, obese, hypothyroid and hyperthyroid subjects. Clin Endocrinol 49 5 (1998) 583-588
28. Reinehr T., and Andler W. Thyroid hormones before and after weight loss in obesity. Arch Dis Child 87 4 (2002) 320-323
29. Feldt-Rasmussen U. Thyroid and leptin. Thyroid 17 5 (2007) 413-419
30. Kok P., Roelfsema F., Frölich M., et al. Prolactin release is enhanced in proportion to excess visceral fat in obese women. J Clin Endocrinol Metab 89 9 (2004) 4445-4449
31. Doknic M., Pekic S., Zarkovic M., et al. Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptine. Eur J Endocrinol 147 1 (2002) 77-84
32. Kopelman P.G. Physiopathology of prolactin secretion in obesity. Int J Obes Relat Metab Disord 24 Suppl 2 (2000) S104-S108
33. Donders S.H., Pieters G.F., Heevel J.G., et al. Disparity of thyrotropin (TSH) and prolactin responses to TSH-releasing hormone in obesity. J Clin Endocrinol Metab 61 1 (1985) 56-59
34. Lala V.R., Ray A., Jamias P., et al. Prolactin and thyroid status in prepubertal children with mild to moderate obesity. J Am Coll Nutr 7 5 (1988) 361-366
35. Martin L.J., Siliart B., Dumon H.J., et al. Spontaneous hormonal variations in male cats following gonadectomy. J Feline Med Surg 8 5 (2006) 309-314
36. Pasquali R., Patton L., and Gambineri A. Obesity and infertility. Curr Opin Endocrinol Diabetes Obes 14 6 (2007) 482-487
37. Kyrou I., and Tsigo C. Chronic stress, visceral obesity and gonadal dysfunction. Hormones 7 4 (2008) 287-293
38. Vermeulen A., Kaufman J.M., Deslypere J.P., et al. Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men. J Clin Endocrinol Metab 76 5 (1993) 1140-1146
39. Ivandić A., Prpić-Krizevac I., Sucić M., et al. Hyperinsulinemia and sex hormones in healthy premenopausal women: relative contribution of obesity, obesity type, and duration of obesity. Metabolism 47 1 (1998) 13-19
40. Smith S.R. The endocrinology of obesity. Endocrinol Metab Clin North Am 25 4 (1996) 921-942
41. Beijerink N.J., Buijtels J.J., Okkens A.C., et al. Basal and GnRH-induced secretion of FSH and LH in anestrous versus ovariectomized bitches. Theriogenology 67 5 (2007) 1039-1045
42. Günzel-Apel A.R., Seefeldt A., Eschricht F.M., et al. Effects of gonadectomy on prolactin and LH secretion and the pituitary-thyroid axis in male dogs. Theriogenology 71 5 (2009) 746-753
43. Hoenig M. Comparative aspects of diabetes mellitus in dogs and cats. Mol Cell Endocrinol 197 1-2 (2002) 221-229
44. Appleton D.J., Rand J.S., and Sunvold G.D. Insulin sensitivity decreases with obesity, and lean cats with low insulin sensitivity are at greatest risk of glucose intolerance with weight gain. J Feline Med Surg 3 4 (2001) 211-228
45. Fettman M.J., Stanton C.A., Banks L.L., et al. Effects of weight gain and loss on metabolic rate, glucose tolerance, and serum lipids in domestic cats. Res Vet Sci 64 1 (1998) 11-16
46. Hoenig M., Thomaseth K., Waldron M., et al. Insulin sensitivity, fat distribution, and adipocytokine response to different diets in lean and obese cats before and after weight loss. Am J Physiol Regul Integr Comp Physiol 292 1 (2007) R227-R234
47. Bergman R.N., Kim S.P., Hsu I.R., et al. Abdominal obesity: role in the pathophysiology of metabolic disease and cardiovascular risk. Am J Med 120 Suppl 1 (2007) S3-S8
48. Rand J.S., Fleeman L.M., Farrow H.A., et al. Canine and feline diabetes mellitus: nature or nurture?. J Nutr 134 Suppl 8 (2004) S2072-S2080
49. Ellmerer M., Hamilton-Wessler M., Kim S.P., et al. Reduced access to insulin-sensitive tissues in dogs with obesity secondary to increased fat intake. Diabetes 55 6 (2006) 1769-1775
50. Houseknecht K.L., Baile C.A., Matteri R.L., et al. The biology of leptin: a review. J Anim Sci 76 5 (1998) 1405-1420
51. Serisier S., Gayet C., Leray V., et al. Hypertriglyceridaemic insulin-resistant obese dog model: effects of high-fat diet depending on age. J Anim Physiol Anim Nutr 92 4 (2008) 419-425
52. Malewiak M.I., Griglio S., Kalopissis A.D., et al. Oleate metabolism in isolated hepatocytes from lean and obese Zucker rats. Influence of a high fat diet and in vitro response to glucagon. Metabolism 32 7 (1983) 661-668
53. Starke A.A., Erhardt G., Berger M., et al. Elevated pancreatic glucagon in obesity. Diabetes 33 3 (1984) 277-280
54. Solerte S.B., Rondanelli M., Giacchero R., et al. Serum glucagon concentration and hyperinsulinaemia influence renal haemodynamics and urinary protein loss in normotensive patients with central obesity. Int J Obes Relat Metab Disord 23 9 (1999) 997-1003
55. Young A. Inhibition of glucagon secretion. Adv Pharmacol 52 (2005) 151-171
56. Reda T.K., Geliebter A., and Pi-Sunyer F.X. Amylin, food intake, and obesity. Obes Res 10 10 (2002) 1087-1091
57. Reinehr T., de Sousa G., Niklowitz P., et al. Amylin and its relation to insulin and lipids in obese children before and after weight loss. Obesity (Silver Spring) 15 8 (2007) 2006-2011
58. O'Brien T.D. Pathogenesis of feline diabetes mellitus. Mol Cell Endocrinol 197 1-2 (2002) 213-219
59. Lutz T.A., and Rand J.S. Pathogenesis of feline diabetes mellitus. Vet Clin North Am Small Anim Pract 25 3 (1995) 527-552
60. Hameed S., Dhillo W.S., and Bloom S.R. Gut hormones and appetite control. Oral Dis 15 1 (2009) 18-26
61. Lassmann V., Vague P., Vialettes B., et al. Low plasma levels of pancreatic polypeptide in obesity. Diabetes 29 6 (1980) 428-430
62. Lieverse R.J., Masclee A.A., Jansen J.B., et al. Plasma cholecystokinin and pancreatic polypeptide secretion in response to bombesin, meal ingestion and modified sham feeding in lean and obese persons. Int J Obes Relat Metab Disord 18 2 (1994) 123-127
63. Reinehr T., Enriori P.J., Harz K., et al. Pancreatic polypeptide in obese children before and after weight loss. Int J Obes 30 10 (2006) 1476-1481
64. Glaser B., Zoghlin G., Pienta K., et al. Pancreatic polypeptide response to secretin in obesity: effects of glucose intolerance. Horm Metab Res 20 5 (1988) 288-292
65. Lassmann V., Cabrerizzo G.L., Vialettes B., et al. Impaired pancreatic polypeptide response to insulin hypoglycemia in obese subjects. Horm Metab Res 17 12 (1985) 663-666
66. Radin M.J., Sharkey L.C., and Holycross B.J. Adipokines: a review of biological and analytical principles and an update in dogs, cats, and horses. Vet Clin Pathol 38 2 (2009) 1-21
67. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 22 (1998) 763-770
68. Jeusette I.C., Detilleux J., Shibata H., et al. Effects of chronic obesity and weight loss on plasma ghrelin and leptin concentrations in dogs. Res Vet Sci 79 2 (2005) 169-175
69. Jeusette I.C., Lhoest E.T., Istasse L.P., et al. Influence of obesity on plasma lipid and lipoprotein concentrations in dogs. Am J Vet Res 66 1 (2005) 81-86
70. Ishioka K., Soliman M.M., Sagawa M., et al. Experimental and clinical studies on plasma leptin in obese dogs. J Vet Med Sci 64 4 (2002) 349-353
71. Ishioka K., Hosoya K., Kitagawa H., et al. Plasma leptin concentration in dogs: effects of body condition score, age, gender and breeds. Res Vet Sci 82 1 (2007) 11-15
72. Sagawa M.M., Nakadomo F., Honjoh T., et al. Correlation between plasma leptin concentration and body fat content in dogs. Am J Vet Res 63 1 (2002) 7-10
73. Nishii N., Nodake H., Takasu M., et al. Postprandial changes in leptin concentrations of cerebrospinal fluid in dogs during development of obesity. Am J Vet Res 67 12 (2006) 2006-2011
74. Halaas J.L., Gajiwala K.S., Maffei M., et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 5223 (1995) 543-546
75. Scarpace P.J., and Zhang Y. Leptin resistance: a predisposing factor for diet-induced obesity. Am J Physiol Regul Integr Comp Physiol 296 3 (2009) R493-R500
76. English P.J., Ghatei M.A., Malik I.A., et al. Food fails to suppress ghrelin levels in obese humans. J Clin Endocrinol Metab 87 6 (2002) 2984-2987
77. Houseknecht K.L., Mantzoros C.S., Kuliawat R., et al. Evidence for leptin binding to proteins in serum of rodents and humans: modulation with obesity. Diabetes 45 11 (1996) 1638-1643
78. Hu E., Liang P., and Spiegelman B.M. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem 271 18 (1996) 10697-10703
79. Ishioka K., Omachi A., Sagawa M., et al. Canine adiponectin: cDNA structure, mRNA expression in adipose tissues and reduced plasma levels in obesity. Res Vet Sci 80 2 (2006) 127-132
80. Ishioka K., Omachi A., Sasaki N., et al. Feline adiponectin: molecular structures and plasma concentrations in obese cats. J Vet Med Sci 71 2 (2009) 189-194
81. Yamauchi T., Kamon J., Waki H., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7 8 (2001) 941-946
82. Bastard J.P., Maachi M., Lagathu C., et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 17 1 (2006) 4-12
83. Gayet C., Leray V., Saito M., et al. The effects of obesity-associated insulin resistance on mRNA expression of peroxisome proliferator-activated receptor-gamma target genes, in dogs. Br J Nutr 98 3 (2007) 497-503
84. Garaulet M., Hernández-Morante J.J., de Heredia F.P., et al. Adiponectin, the controversial hormone. Public Health Nutr 10 10A (2007) 1145-1150
85. Kadowaki T., and Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 26 3 (2005) 439-451
86. Sinha M.K., Songer T., Xiao Q., et al. Analytical validation and biological evaluation of a high molecular-weight adiponectin ELISA. Clin Chem 53 12 (2007) 2144-2151
87. Schober F., Neumeier M., Weigert J., et al. Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release. Biochem Biophys Res Commun 361 4 (2007) 968-973
88. Rea R., and Donnelly R. Resistin: an adipocyte-derived hormone. Has it a role in diabetes and obesity?. Diabetes Obes Metab 6 3 (2004) 163-170
89. Savage D.B., Sewter C.P., Klenk E.S., et al. Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes 50 10 (2001) 2199-2202
90. Steppan C.M., Bailey S.T., Bhat S., et al. The hormone resistin links obesity to diabetes. Nature 409 6818 (2001) 307-312
91. Vozarova de Courten B., Degawa-Yamauchi M., Considine R.V., et al. High serum resistin is associated with an increase in adiposity but not a worsening of insulin resistance in Pima Indians. Diabetes 53 5 (2004) 1279-1284
92. Weisberg S.P., McCann D., Desai M., et al. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112 12 (2003) 1796-1808
93. Coppack S.W. Pro-inflammatory cytokines and adipose tissue. Proc Nutr Soc 60 3 (2001) 349-356
94. Inadera H. The usefulness of circulating adipokine levels for the assessment of obesity-related health problems. Int J Med Sci 5 5 (2008) 248-262
95. Miller C., Bartges J., Cornelius L., et al. Tumor necrosis factor-alpha levels in adipose tissue of lean and obese cats. J Nutr 128 Suppl 12 (1998) S2751-S2752
96. Hoenig M., McGoldrick J.B., deBeer M., et al. Activity and tissue-specific expression of lipases and tumor-necrosis factor alpha in lean and obese cats. Domest Anim Endocrinol 30 4 (2006) 333-344
97. Yudkin J.S., Kumari M., Humphries S.E., et al. Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?. Atherosclerosis 148 2 (2000) 209-214
98. Sowers M., Jannausch M., Stein E., et al. C-reactive protein as a biomarker of emergent osteoarthritis. Osteoarthr Cartil 10 8 (2002) 595-601
99. Muccioli G., Tschöp M., Papotti M., et al. Neuroendocrine and peripheral activities of ghrelin: implications in metabolism and obesity. Eur J Pharmacol 440 2-3 (2002) 235-254
100. Tschöp M., Weyer C., Tataranni P.A., et al. Circulating ghrelin levels are decreased in human obesity. Diabetes 50 4 (2001) 707-709
101. Zwirska-Korczala K., Konturek S.J., Sodowski M., et al. Basal and postprandial plasma levels of PYY, ghrelin, cholecystokinin, gastrin and insulin in women with moderate and morbid obesity and metabolic syndrome. J Physiol Pharmacol 58 Suppl 1 (2007) 13-35
102. Konopko-Zubrzycka M., Baniukiewicz A., Wróblewski E., et al. The effect of intragastric balloon on plasma ghrelin, leptin, and adiponectin levels in patients with morbid obesity. J Clin Endocrinol Metab 94 5 (2009) 1644-1649
103. Cummings D.E., Purnell J.Q., Frayo R.S., et al. A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 50 8 (2001) 1714-1719
104. Druce M.R., Wren A.M., Park A.J., et al. Ghrelin increases food intake in obese as well as lean subjects. Int J Obes 29 9 (2005) 1130-1136
105. Huda M.S., Wilding J.P., and Pinkney J.H. Gut peptides and the regulation of appetite. Obes Rev 7 2 (2006) 163-182
106. Baranowska B., Radzikowska M., Wasilewska-Dziubinska E., et al. Disturbed release of gastrointestinal peptides in anorexia nervosa and in obesity. Diabetes Obes Metab 2 2 (2000) 99-103
107. Milewicz A., Bidzińska B., Mikulski E., et al. Influence of obesity and menopausal status on serum leptin, cholecystokinin, galanin and neuropeptide Y levels. Gynecol Endocrinol 14 3 (2000) 196-203
108. Mojsov S., Kopczynski M.G., and Habener J.F. Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem 265 14 (1990) 8001-8008
109. Ranganath L.R., Beety J.M., Morgan L.M., et al. Attenuated GLP-1 secretion in obesity: cause or consequence?. Gut 38 6 (1996) 916-919
110. Ranganath L., Norris F., Morgan L., et al. Inhibition of carbohydrate-mediated glucagon-like peptide-1 (7-36) amide secretion by circulating non-esterified fatty acids. Clin Sci 96 4 (1999) 335-342
111. Verdich C., Toubro S., Buemann B., et al. The role of postprandial releases of insulin and incretin hormones in meal-induced satiety: effect of obesity and weight reduction. Int J Obes Relat Metab Disord 25 8 (2001) 1206-1214
112. Näslund E., and Hellström P.M. Glucagon-like peptide-1 in the pathogenesis of obesity. Drug News Perspect 11 2 (1998) 92-97
113. Grandt D., Schimiczek M., Beglinger C., et al. Two molecular forms of peptide YY (PYY) are abundant in human blood: characterization of a radioimmunoassay recognizing PYY 1-36 and PYY 3-36. Regul Pept 51 2 (1994) 151-159
114. Batterham R.L., Cohen M.A., Ellis S.M., et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349 10 (2003) 926-928