Low molecular weight adiponectin negatively correlates with the waist circumference and monocytic IL-6 release

Biochemical and Biophysical Research Communications

Volumn 361, Issue 4, 2007, Pages 968-973

  Schober, Franziska ^a   Neumeier, Markus ^a   Weigert, Johanna ^a   Wurm, Sylvia ^a   Wanninger, Josef ^a   Schäffler, Andreas ^a   Dada, Ashraf ^a   Liebisch, Gerhard ^a   Schmitz, Gerd ^a   Aslanidis, Charalampos ^a   Buechler, Christa ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Adiponectin isoforms; Body mass index; IL 6; Monocytes

Indexed keywords

ACARBOSE; ACETYLSALICYLIC ACID; ADIPONECTIN; FIBRIC ACID DERIVATIVE; GLITAZONE DERIVATIVE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6; METFORMIN; SULFONYLUREA DERIVATIVE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MOLECULAR WEIGHT; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; WAIST CIRCUMFERENCE;

ADIPONECTIN; ADULT; AGED; BODY MASS INDEX; BODY WEIGHTS AND MEASURES; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; MOLECULAR WEIGHT; MONOCYTES; OBESITY; PROTEIN ISOFORMS;

EID: 34547892695     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.07.106     Document Type: Article

References (21)

1. Lara-Castro C., Fu Y., Chung B.H., and Garvey W.T. Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease. Curr. Opin. Lipidol. 18 (2007) 263-270
2. Gil-Campos M., Canete R.R., and Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin. Nutr. 23 (2004) 963-974
3. Richards A.A., Stephens T., Charlton H.K., Jones A., Macdonald G.A., Prins J.B., and Whitehead J.P. Adiponectin multimerization is dependent on conserved lysines in the collagenous domain: evidence for regulation of multimerization by alterations in posttranslational modifications. Mol. Endocrinol. 20 (2006) 1673-1687
4. Tsao T.S., Tomas E., Murrey H.E., Hug C., Lee D.H., Ruderman N.B., Heuser J.E., and Lodish H.F. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity: different oligomers activate different signal transduction pathways. J. Biol. Chem. 278 (2003) 50810-50817
5. Hara K., Horikoshi M., Yamauchi T., Yago H., Miyazaki O., Ebinuma H., Imai Y., Nagai R., and Kadowaki T. Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care 29 (2006) 1357-1362
6. Fisher F.F., Trujillo M.E., Hanif W., Barnett A.H., McTernan P.G., Scherer P.E., and Kumar S. Serum high molecular weight complex of adiponectin correlates better with glucose tolerance than total serum adiponectin in Indo-Asian males. Diabetologia 48 (2005) 1084-1087
7. Devaraj S., and Jialal I. Alpha tocopherol supplementation decreases serum C-reactive protein and monocyte interleukin-6 levels in normal volunteers and type 2 diabetic patients. Free Radic. Biol. Med. 29 (2000) 790-792
8. Wulster-Radcliffe M.C., Ajuwon K.M., Wang J., Christian J.A., and Spurlock M.E. Adiponectin differentially regulates cytokines in porcine macrophages. Biochem. Biophys. Res. Commun. 316 (2004) 924-929
9. Neumeier M., Weigert J., Schaffler A., Wehrwein G., Muller-Ladner U., Scholmerich J., Wrede C., and Buechler C. Different effects of adiponectin isoforms in human monocytic cells. J. Leukoc. Biol. 79 (2006) 803-808
10. Saijo S., Nagata K., Nakano Y., Tobe T., and Kobayashi Y. Inhibition by adiponectin of IL-8 production by human macrophages upon coculturing with late apoptotic cells. Biochem. Biophys. Res. Commun. 334 (2005) 1180-1183
11. Abke S., Neumeier M., Weigert J., Wehrwein G., Eggenhofer E., Schaffler A., Maier K., Aslanidis C., Scholmerich J., and Buechler C. Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes. Cardiovasc Diabetol 5 (2006) 17
12. Wang Y., Xu L.Y., Lam K.S., Lu G., Cooper G.J., and Xu A. Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin. Proteomics 6 (2006) 3862-3870
13. Yokota T., Oritani K., Takahashi I., Ishikawa J., Matsuyama A., Ouchi N., Kihara S., Funahashi T., Tenner A.J., Tomiyama Y., and Matsuzawa Y. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood 96 (2000) 1723-1732
14. Rovin B.H., and Song H. Chemokine induction by the adipocyte-derived cytokine adiponectin. Clin. Immunol. 120 (2006) 99-105
15. Gavrila A., Chan J.L., Yiannakouris N., Kontogianni M., Miller L.C., Orlova C., and Mantzoros C.S. Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies. J. Clin. Endocrinol. Metab. 88 (2003) 4823-4831
16. Aso Y., Yamamoto R., Wakabayashi S., Uchida T., Takayanagi K., Takebayashi K., Okuno T., Inoue T., Node K., Tobe T., Inukai T., and Nakano Y. Comparison of serum high-molecular weight (HMW) adiponectin with total adiponectin concentrations in type 2 diabetic patients with coronary artery disease using a novel enzyme-linked immunosorbent assay to detect HMW adiponectin. Diabetes 55 (2006) 1954-1960
17. Basu R., Pajvani U.B., Rizza R.A., and Scherer P.E. Selective downregulation of the high molecular weight form (HMW) of adiponectin in hyperinsulinemia and in Type 2 diabetes: differential regulation from non-diabetic subjects. Diabetes (2007)
18. Ebinuma H., Miyazaki O., Yago H., Hara K., Yamauchi T., and Kadowaki T. A novel ELISA system for selective measurement of human adiponectin multimers by using proteases. Clin. Chim. Acta 372 (2006) 47-53
19. Andreozzi F., Laratta E., Cardellini M., Marini M.A., Lauro R., Hribal M.L., Perticone F., and Sesti G. Plasma interleukin-6 levels are independently associated with insulin secretion in a cohort of Italian-Caucasian nondiabetic subjects. Diabetes 55 (2006) 2021-2024
20. Muller S., Martin S., Koenig W., Hanifi-Moghaddam P., Rathmann W., Haastert B., Giani G., Illig T., Thorand B., and Kolb H. Impaired glucose tolerance is associated with increased serum concentrations of interleukin 6 and co-regulated acute-phase proteins but not TNF-alpha or its receptors. Diabetologia 45 (2002) 805-812
21. Fernandez-Real J.M., Vayreda M., Richart C., Gutierrez C., Broch M., Vendrell J., and Ricart W. Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J. Clin. Endocrinol. Metab. 86 (2001) 1154-1159