Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance

Free Radical Research

Volumn 44, Issue 3, 2010, Pages 241-248

  Li, L ^a   Willets, R S ^a   Polidori, M C ^b   Stahl, W ^c   Nelles, G ^d   Sies, H ^c,e   Griffiths, H R ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d St Elisabeth Hospital   (Germany)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Alzheimer's dementia; Folate; Homocysteine; Inflammation; LDL oxidation; Mild cognitive impairment; Vascular dementia

Indexed keywords

ALBUMIN; APOLIPOPROTEIN E; C REACTIVE PROTEIN; FOLIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PYRIDOXINE;

AGED; ALBUMIN BLOOD LEVEL; ALZHEIMER DISEASE; ARTICLE; COGNITION; CONTROLLED STUDY; DISEASE PREDISPOSITION; DISEASE SEVERITY; DNA POLYMORPHISM; FEMALE; FOLIC ACID BLOOD LEVEL; FOLIC ACID DEFICIENCY; HUMAN; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; MILD COGNITIVE IMPAIRMENT; MULTIINFARCT DEMENTIA; OXIDATION; PHENOTYPE; VITAMIN BLOOD LEVEL;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; BIOLOGICAL MARKERS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; COGNITION DISORDERS; DEMENTIA, VASCULAR; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; OXIDATION-REDUCTION;

EID: 77249115735     PISSN: 10715762     EISSN: 10292470     Source Type: Journal    
DOI: 10.3109/10715760903440153     Document Type: Article

References (37)

1. Fenech M. The role of folic acid and Vitamin B12 in genomic stability of human cells. Mutat Res 2001;475:57-67.
2. Cravo M. Alcohol, methylenetetrahydrofolate 677C->T genotype, and low folate intake: concurrent causes for hyperho-mocysteinemia, Am J Clin Nutr 2005;82:3-4.
3. Lievers KJA, Kluijtmans LAJ, Blom HJ. Genetics of hyperho-mocysteinaemia in cardiovascular disease. Ann Clin Biochem 2003;40:46-59.
4. Selhub J. The many facets of hyperhomocysteinemia: studies from the Framingham cohorts. J Nutr 2006;136:1726S-1730S.
5. Seshadri S. Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease? J Alzheimer's Dis 2006;9:393-398.
6. De Deyn PP, Goeman J, Engelborghs S, Hauben U, D'Hooge R, Baro F, Pickut BA. From neuronal and vascular impairment to dementia. Pharmacopsychiatry 1999;32 (Suppl 1):17-24.
7. Scott TM, Tucker KL, Bhadelia A, Benjamin B, Patz S, Bhade-lia R, Liebson E, Price LL, Griffith J, Rosenberg I, Folstein MF. Homocysteine and B vitamins relate to brain volume and white-matter xhanges in geriatric patients with psychiatric disorders. Am J Geriatr Psychiatry 2004;12:631-638.
8. Griffiths HR, Møller L, Bartosz G, Bast A, Bertoni-Freddari C, Collins A, Cooke M, Coolen S, Haenen G, Hoberg AM, Loft S, Lunec J, Olinski R, Parry J, Pompella A, Poulsen H, Verhagen H, Astley SB. Biomarkers. Molec Asp Med 2002; 23:101-208.
9. Nakano E, Taiwo FA, Nugent D, Griffiths HR, Aldred S, Paisi M, Kwok M, Bhatt P, Hill MHE, Moat S, Powers HJ. Downstream effects on human low density lipoprotein of homo-cysteine exported from endothelial cells in an in vitro system. J Lipid Res 2005;46:484-493.
10. Papatheodorou L, Weiss N. Vascular oxidant stress and infl am-mation in hyperhomocysteinemia. Antiox Redox Signal 2007; 9:1941-1958.
11. Cacabelos R, Fernandez-Novoa L, Corzo L, Amado L, Pichel V, Lombardi V, Kubota Y. Phenotypic profi les and functional genomics in Alzheimer's disease and in dementia with a vascular component. Neurol Res 2004;26:459-480.
12. Stojakovic T, Scharnagl H, Marz W. ApoE: crossroads between Alzheimer's disease and atherosclerosis. Semin Vasc Med 2004;4:279-285.
13. Ravaglia G, Paola F, Maioli F, Martelli M, Montesi F, Bastagli L, Bianchin M, Chiappelli M, Tumini E, Bolondi L, Licastro F. Interleukin-1[beta] and interleukin-6 gene polymorphisms as risk factors for AD: a prospective study. Exp Gerontol 2006;41:85-92.
14. Gil L, Siems W, Mazurek B, Gross J, Schroeder P, Voss P, Grune T. Age-associated analysis of oxidative stress parameters in human plasma and erthrocytes. Free Radic Res 2006;40:495-505
15. Griffiths HR. Chemical modifi cations of biomolecules by oxi-dants. In: The handbook of environmental chemistry. Reactions, processes. Ed. Tilman Grune. Berlin: Springer; 2005. p. 33-62.
16. Polidori MC, Griffi ths HR, Mariani E, Mecocci P. Hallmarks of protein oxidative damage in neurodegenerative diseases: focus on Alzheimer's disease. Amino Acids 2007;32:553-559.
17. Reddy VP, Zhu X, Perry G, Smith MA. Oxidative stress in diabetes and Alzheimer's disease. J Alzheimers Dis 2009;16: 763-774.
18. Moreira PI, Duarte AI, Santos MS, Rego AC, Oliveira CR. An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer's disease. J Alzheimers Dis 2009;16:741-761.t
19. Mangialasche F, Polidori MC, Monastero R, Ercolani S, Camarda C, Cecchetti R, Mecocci P. Biomarkers of oxidative and nitro sative damage in Alzheimer's disease and mild cognitive impairment. Ageing Res Rev 2009;8:285-305.
20. Griffi ths HR, Aldred S, Dale C, Nakano E, Kitas GD, Grant MM, Nugent D, Taiwo FA, Li L, Powers J. Homocysteine from endothelial cells promotes LDL nitration and scavenger receptor uptake. Free Radic Biol Med 2006;40:488-500.
21. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, Ritchie K, Rossor M, Thal L, Winblad B. Current concepts in mild cognitive impairment. Arch Neurol 2001;58: 1985-1992.
22. Anlasik T, Sies H, Griffi ths HR, Mecocci P, Stahl W, Polidori MC. Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects. Br J Nutr 2005;94:639-642.
23. Folstein MF, Robins LN, Helzer JE. The mini-mental state examination. Arch Gen Psychiatry 1983;40:812.
24. Clarke R, Refsum H, Birks J, Evans JG, Johnston C, Sherliker P, Ueland PM, Schneede J, McPartlin J, Nexo E, Scott JM. Screening for vitamin B-12 and folate defi ciency in older persons. Am J Clin Nutr 2003;77:1241-1247.
25. Terpstra AHM. Isolation of serum chylomicrons prior to density gradient ultracentrifugation of other serum lipoprotein classes. Anal Biochem 1985;150:221-227.
26. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. Measurement of protein using bicinchoninic acid. Anal Biochem 1985;150:76-85.
27. Carty JL, Bevan R, Waller H, Mistry N, Cooke MC, Lunec J, Griffiths HR. The effects of vitamin C supplementation on protein oxidation in healthy volunteers. Biochem Biophys Res Commun 2000;273:729-735
28. te Poele-Pothoff M, van den Berg M, Franken DG, Boers GH, Jakobs C, de Kroon IF, Eskes TK, Trijbels JM, Blom HJ. Three different methods for the determination of total homo-cysteine in plasma. Ann Clin Biochem1995;32:218-220.
29. Watanabe T, Koba S, Kawamura M, Itokawa M, Idei T, Nakagawa Y, Iguchi T, Katagiri T. Small dense low-density lipoprotein and carotid atherosclerosis in relation to vascular dementia. Metabolism 2004;3:476-482.
30. Ohmura H, Mokuno H, Sawano M, Hatsumi C, Mitsugi Y, Watanabe Y, Daida H, Yamaguchi H. Lipid compositional differences of small, dense low-density lipoprotein particle infl uence its oxidative susceptibility: possible implication of increased risk of coronary artery disease in subjects with phenotype B. Metabolism 2002;51:1081-1087.
31. Navazo MDP, Daviet L, Ninio E, McGregor JL. Identifi cation on human CD36 of a domain (155-183) implicated in binding oxidized low-density lipoproteins (Ox-LDL). Arterioscler Thromb Vasc Biol 1996;16:1033-1039.
32. Shemer R, Walsh A, Eisenberg S, Breslow JL, Razin A. Tissue-specifi c methylation patterns and expression of the human apolipoprotein AI gene. J Biol Chem 265:1990:1010-1015.
33. Cramer C, Haan MN, Galea S, Langa KM, Kalbfleisch JD. Use of statins and incidence of dementia and cognitive impairment without dementia in a cohort study. Neurology 2008; 71:344-350.
34. Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JCS, Montine TJ. Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology 2007;69:878-885.
35. Chauhan NB, Siegel GJ, Feinstein DL. Effects of lovastatin and pravastatin on amyloid processing and infl ammatory response in TgCRND8 brain. Neurochem Res 2004;29: 1897-1911.
36. McNulty H, Scott JM. Intake and status of folate and related B-vitamins: considerations and challenges in achieving optimal status. Br J Nutr 2008;99(Suppl 3):S48-S54.
37. Refsum H, Smith AD. Low vitamin B-12 status in confi rmed Alzheimer's disease as revealed by serum holotranscobalamin, J Neurol Neurosurg Psychiatry 2003;74:959-961.