Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage

Cell Division

Volumn 5, Issue , 2010, Pages

  Bagchi, Srilata ^a   Raychaudhuri, Pradip ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

EID: 76949086340     PISSN: None     EISSN: 17471028     Source Type: Journal    
DOI: 10.1186/1747-1028-5-3     Document Type: Review

References (38)

1. Wahl GM, Carr AM. The evolution of diverse biological responses to DNA damage:insight from yeast and p53. Nat Cell Biol 2001, 3:277-284.
2. Schuler M, Green DR. Transcription, apoptosis and p53: catch-22. Trends in Genet 2005, 21:182-187.
3. Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M. Transcriptional Repression of the anti-apoptotic surviving gene by wild type p53. J Biol Chem 2001, 277:3247-3257. 10.1074/jbc.M106643200, 11714700.
4. Chipuk JE, Green DR. P53's believe it or not: Lessons on transcription-independent death. J Clinic Immun 2003, 23:355-361.
5. Baptiste-Okoh N, Barsotti AM, Prives C. Caspase 2 is both required for p53-mediated apoptosis and downregulated by p53 in a p21-dependent manner. Cell Cycle 2008, 7:1133-1138.
6. Sohn D, Essmann F, Schulze-Osthoff K, Janicke RU. p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation. Cancer Res 2006, 66:11254-11262. 10.1158/0008-5472.CAN-06-1569, 17145870.
7. Gartel AL, Tyner AL. The role of cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002, 1:639-649.
8. Le HV, Minn AJ, Massague J. Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells. J Biol Chem 2005, 280:32018-32025. 10.1074/jbc.M504689200, 16002406.
9. Hallstrom TC, Nevins JR. Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci USA 2003, 100:10848-10853. 10.1073/pnas.1831408100, 196891, 12954980.
10. Gartel AL, Goufman E, Najmabadi F, Tyner AL. A role for E2F1 in Ras activation of p21(WAF1/CIP1) transcription. Oncogene 2000, 19:961-964. 10.1038/sj.onc.1203411, 10702805.
11. Lukovic D, Komoriya A, Packard BZ, Ucker DS. Caspase activity is not sufficient to execute cell death. Exp Cell Res 2003, 289:384-395. 10.1016/S0014-4827(03)00289-1, 14499640.
12. Stoyanova T, Yoon T, Kopanja D, Mokyr MB, Raychaudhuri P. The xeroderma pigmentosum group E gene product DDB2 activates nucleotide excision repair by regulating the level of p21Waf1/Cip1. Mol Cell Biol 2008, 28:177-187. 10.1128/MCB.00880-07, 2223305, 17967871.
13. Shiyanov P, Nag A, Raychaudhuri P. Cullin 4A associates with the UV-damaged DNA-binding protein DDB. J Biol Chem 1999, 274:35309-35312. 10.1074/jbc.274.50.35309, 10585395.
14. Chu G. Global genomic repair and p53 in a dance after DNA damage. Cancer Biol Ther 2002, 1:150-151.
15. Stoyanova S, Roy N Kopanja D, Bagchi S, Raychaudhuri P. DDB2 decides cell fate following DNA damage. Proc Natl Acad Sci USA 2009, 106:10690-10695. 10.1073/pnas.0812254106, 2705559, 19541625.
16. Chen X, Barton LF, Chi Y, Clurman BE, Roberts JM. Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome. Mol Cell 2007, 26:843-852. 10.1016/j.molcel.2007.05.022, 2031223, 17588519.
17. Li X, Amazit L, Long W, Lonard DM, Monaco JJ, O'Malley BW. Ubiquitin- and ATP-independent proteolytic turnover of p21 by the REGgamma-proteasome pathway. Mol Cell 2007, 26:831-842. 10.1016/j.molcel.2007.05.028, 17588518.
18. Jin Y, Lee H, Zeng SX, Dai MS, Lu H. Mdm2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J 2003, 22:6365-6577. 10.1093/emboj/cdg600, 291841, 14633995.
19. Yu ZK, Gervais JL, Zhang H. Human CUL-1 associates with SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins. Proc Natl Acad Sci USA 2003, 95:11324-11329.
20. Bornstein G, Bloom J, Sitry-Shevah D, Nakayama K, Pagano M, Hershko A. Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem 2003, 278:25752-25757. 10.1074/jbc.M301774200, 12730199.
21. Sarmento LM, Huang H, Limon A, Gordon W, Ferandez J, Tavares MJ, Miele L, Cardoso AA, Classon M, Carlesso N. Notch1 modulates timing of G1-S progression by inducing SKP2 transcription and p27Kip1 degradation. J Exp Med 2005, 202:157-168. 10.1084/jem.20050559, 2212905, 15998794.
22. Wang W, Nacusi L, Sheaff RJ, Liu X. Ubiquitination of p21Cip1/Waf1 by SCFSKP2: Substrate requirement and ubiquitination site selection. Biochemistry 2005, 44:14553-14564. 10.1021/bi051071j, 16262255.
23. Amador V, Ge S, Santamaria P G, Guardavaccaro D, Pagano M. APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Mol Cell 2007, 27:462-473. 10.1016/j.molcel.2007.06.013, 2000825, 17679094.
24. Abbas T, Sivaprasad U, Terai K, Amador V, Pagano M, Dutta A. PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Genes Dev 2008, 22:2496-2506. 10.1101/gad.1676108, 2546691, 18794347.
25. Nishitani H, Shiomi Y, Lida H, Michishita M, Takami T, Tsurimoto T. CDK inhibitor p21 is degraded by a proliferating cell nuclear antigen-coupled Cul4-DDB1-Cdt2 pathway during S phase and after UV irradiation. J Biol Chem 2008, 283:29045-29052. 10.1074/jbc.M806045200, 2662008, 18703516.
26. Lee JY, Yu SJ, Park YG, Kim J, Sohn J. Glycogen synthase kinase 3beta phosphorylates p21WAF1/CIP1 for proteosomal degradation after UV irradiation. Mol Cell Biol 2007, 27:3187-3198. 10.1128/MCB.01461-06, 1899930, 17283049.
27. Lee H, Zeng SH, Lu H. UV induces p21 rapid turnover independently of ubiquitin and Skp2. J Biol Chem 2006, 281:26876-26883. 10.1074/jbc.M605366200, 16803887.
28. Cang Y, Zhang J, Nicholas S A, Kim A L, Zhou P, Goff SP. DDB1 is essential for genomic stability in developing epidermis. Proc Natl Acad Sci USA 2007, 104:2733-2737. 10.1073/pnas.0611311104, 1797626,1797626, 17301228.
29. Shiyanov P, Hayes SA, Donepudi M, Nichols AF, Linn S, Slagle BL, Raychaudhuri P. The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription. Mol Cell Biol 1999, 19:4935-4943. 84302, 10373543.
30. Itoh T, Cado D, Kamide R, Linn S. DDB2 gene disruption leads to skin tumors and resistance to apoptosis after exposure to ultraviolet light but not a chemical carcinogen. Proc Natl Acad Sci USA 2004, 101:2052-2057. 10.1073/pnas.0306551101, 357050, 14769931.
31. Itoh T, O'Shea C, Linn S. Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 gene: mutual regulatory interactions between p48(DDB2) and p53. Mol Cell Biol 2003, 23:7540-7553. 10.1128/MCB.23.21.7540-7553.2003, 207631, 14560002.
32. Giono LE, Manfredi JJ. Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest. Mol Cell Biol 2007, 27:4166-4178. 10.1128/MCB.01967-06, 1900019, 17371838.
33. Tang J, Chu G. Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein. DNA Repair 2002, 1:601-616. 10.1016/S1568-7864(02)00052-6, 12509284.
34. El-Mahdy MA, Zhu Q, Wang QE, Wani G, Praetorius-Ibba M, Wani AA. Cullin 4A-mediated proteolysis of DDB2 protein at DNA damage sites regulates in vivo lesion recognition by XPC. J Biol Chem 2006, 281:13404-13411. 10.1074/jbc.M511834200, 16527807.
35. Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapic-Otrin V, Levine AS. The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Proc Natl Acad Sci USA 2006, 103:2588-2563. 10.1073/pnas.0511160103, 1413840, 16473935.
36. Wang H, Zhai L, Xu J, Joo HY, Jackson S, Erdjument-Bromage H, Tempst P, Xiong Y, Zhang Y. Histone H3 and H4 Ubiquitylation by the CUL4-DDB-ROC1 Ubiquitin Ligase Facilitates Cellular Response to DNA Damage. Mol Cell 2006, 22:383-394. 10.1016/j.molcel.2006.03.035, 16678110.
37. Havens CG, Walters JC. Docking of a specialized PIP box onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4-Cdt2. Mol Cell 2009, 35:93-104. 10.1016/j.molcel.2009.05.012, 19595719.
38. Barakat BM, Wang QE, Han C, Milum K, Yin DT, Zhao Q, Wani G, Arafa ES, El-Mahdy MA, Wani AA. Overexpression of DDB2 enhances the sensitivity of human ovarian cancer cells to cisplatin by augmenting cellular apoptosis. Int J Cancer 2009,