-
1
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P., Alberti K.G., and Shaw J. Global and societal implications of the diabetes epidemic. Nature 414 (2001) 782-787
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
Alberti, K.G.2
Shaw, J.3
-
2
-
-
0032489358
-
Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance
-
Kahn B.B. Type 2 diabetes: when insulin secretion fails to compensate for insulin resistance. Cell 92 (1998) 593-596
-
(1998)
Cell
, vol.92
, pp. 593-596
-
-
Kahn, B.B.1
-
3
-
-
0035936763
-
New perspectives into the molecular pathogenesis and treatment of type 2 diabetes
-
Saltiel A.R. New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104 (2001) 517-529
-
(2001)
Cell
, vol.104
, pp. 517-529
-
-
Saltiel, A.R.1
-
4
-
-
0035316142
-
Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport
-
Carvalho E., Jansson P.A., Nagaev I., et al. Insulin resistance with low cellular IRS-1 expression is also associated with low GLUT4 expression and impaired insulin-stimulated glucose transport. FASEB J. 15 (2001) 1101-1103
-
(2001)
FASEB J.
, vol.15
, pp. 1101-1103
-
-
Carvalho, E.1
Jansson, P.A.2
Nagaev, I.3
-
5
-
-
0030890580
-
Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
-
Rondinone C.M., Wang L.M., Lonnroth P., et al. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA 94 (1997) 4171-4175
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 4171-4175
-
-
Rondinone, C.M.1
Wang, L.M.2
Lonnroth, P.3
-
6
-
-
0031984952
-
Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
-
Anai M., Funaki M., Ogihara T., et al. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats. Diabetes 47 (1998) 13-23
-
(1998)
Diabetes
, vol.47
, pp. 13-23
-
-
Anai, M.1
Funaki, M.2
Ogihara, T.3
-
7
-
-
2642683510
-
Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
-
Kerouz N.J., Horsch D., Pons S., et al. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J. Clin. Invest. 100 (1997) 3164-3172
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 3164-3172
-
-
Kerouz, N.J.1
Horsch, D.2
Pons, S.3
-
8
-
-
64349124502
-
Glucose transporter 4 and insulin receptor substrate-1 messenger RNA expression in omental and subcutaneous adipose tissue in women
-
Veilleux A., Blouin K., Rheaume C., et al. Glucose transporter 4 and insulin receptor substrate-1 messenger RNA expression in omental and subcutaneous adipose tissue in women. Metabolism 58 (2009) 624-631
-
(2009)
Metabolism
, vol.58
, pp. 624-631
-
-
Veilleux, A.1
Blouin, K.2
Rheaume, C.3
-
9
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguirre V., Werner E.D., Giraud J., et al. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277 (2002) 1531-1537
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
Werner, E.D.2
Giraud, J.3
-
10
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah O.J., Wang Z., and Hunter T. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14 (2004) 1650-1656
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
11
-
-
0036830636
-
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
-
Rui L., Yuan M., Frantz D., et al. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J. Biol. Chem. 277 (2002) 42394-42398
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42394-42398
-
-
Rui, L.1
Yuan, M.2
Frantz, D.3
-
12
-
-
14544271905
-
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
-
Gual P., Le Marchand-Brustel Y., and Tanti J.F. Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochimie 87 (2005) 99-109
-
(2005)
Biochimie
, vol.87
, pp. 99-109
-
-
Gual, P.1
Le Marchand-Brustel, Y.2
Tanti, J.F.3
-
13
-
-
23844472598
-
Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus
-
Maeda S., Tsukada S., Kanazawa A., et al. Genetic variations in the gene encoding TFAP2B are associated with type 2 diabetes mellitus. J. Hum. Genet. 50 (2005) 283-292
-
(2005)
J. Hum. Genet.
, vol.50
, pp. 283-292
-
-
Maeda, S.1
Tsukada, S.2
Kanazawa, A.3
-
14
-
-
67651236725
-
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution
-
Lindgren C.M., Heid I.M., Randall J.C., et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 5 (2009) e1000508
-
(2009)
PLoS Genet.
, vol.5
-
-
Lindgren, C.M.1
Heid, I.M.2
Randall, J.C.3
-
15
-
-
69749102466
-
The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents
-
Nordquist N., Gokturk C., Comasco E., et al. The transcription factor TFAP2B is associated with insulin resistance and adiposity in healthy adolescents. Obesity (Silver Spring) 17 (2009) 1762-1767
-
(2009)
Obesity (Silver Spring)
, vol.17
, pp. 1762-1767
-
-
Nordquist, N.1
Gokturk, C.2
Comasco, E.3
-
16
-
-
33845978428
-
Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression
-
Ikeda K., Maegawa H., Ugi S., et al. Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression. J. Biol. Chem. 281 (2006) 31245-31253
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 31245-31253
-
-
Ikeda, K.1
Maegawa, H.2
Ugi, S.3
-
17
-
-
77950866139
-
Transcription factor AP-2β inhibits expression and secression of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes
-
10.1038/ijo.2009.295
-
Fuke T., Yoshizaki T., Kondo M., et al. Transcription factor AP-2β inhibits expression and secression of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes. Int. J. Obes. (Lond.) (2009) 10.1038/ijo.2009.295
-
(2009)
Int. J. Obes. (Lond.)
-
-
Fuke, T.1
Yoshizaki, T.2
Kondo, M.3
-
18
-
-
63849109129
-
Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression
-
Kondo M., Maegawa H., Obata T., et al. Transcription factor activating protein-2beta: a positive regulator of monocyte chemoattractant protein-1 gene expression. Endocrinology 150 (2009) 1654-1661
-
(2009)
Endocrinology
, vol.150
, pp. 1654-1661
-
-
Kondo, M.1
Maegawa, H.2
Obata, T.3
-
19
-
-
77954143887
-
Relationship between the expression of transcriptional factor TFAP2B and that of adipokines in subcutaneous and omental adipose tissues
-
10.1038/oby.2009.442
-
Ugi S., Nishio Y., Yamamoto H., et al. Relationship between the expression of transcriptional factor TFAP2B and that of adipokines in subcutaneous and omental adipose tissues. Obesity (Silver Spring) (2009) 10.1038/oby.2009.442
-
(2009)
Obesity (Silver Spring)
-
-
Ugi, S.1
Nishio, Y.2
Yamamoto, H.3
-
20
-
-
33645507246
-
The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes
-
Tao Y., Maegawa H., Ugi S., et al. The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes. Endocrinology 147 (2006) 1685-1696
-
(2006)
Endocrinology
, vol.147
, pp. 1685-1696
-
-
Tao, Y.1
Maegawa, H.2
Ugi, S.3
-
21
-
-
4544314719
-
Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes
-
Ugi S., Imamura T., Maegawa H., et al. Protein phosphatase 2A negatively regulates insulin's metabolic signaling pathway by inhibiting Akt (protein kinase B) activity in 3T3-L1 adipocytes. Mol. Cell. Biol. 24 (2004) 8778-8789
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 8778-8789
-
-
Ugi, S.1
Imamura, T.2
Maegawa, H.3
-
22
-
-
0033553415
-
Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance
-
Egawa K., Sharma P.M., Nakashima N., et al. Membrane-targeted phosphatidylinositol 3-kinase mimics insulin actions and induces a state of cellular insulin resistance. J. Biol. Chem. 274 (1999) 14306-14314
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 14306-14314
-
-
Egawa, K.1
Sharma, P.M.2
Nakashima, N.3
-
23
-
-
0029096089
-
Characterization and regulation of the mouse insulin receptor substrate gene promoter
-
Araki E., Haag III B.L., Matsuda K., et al. Characterization and regulation of the mouse insulin receptor substrate gene promoter. Mol. Endocrinol. 9 (1995) 1367-1379
-
(1995)
Mol. Endocrinol.
, vol.9
, pp. 1367-1379
-
-
Araki, E.1
Haag III, B.L.2
Matsuda, K.3
-
24
-
-
12544256299
-
Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells
-
Hashimoto T., Nakamura T., Maegawa H., et al. Regulation of ATP-sensitive potassium channel subunit Kir6.2 expression in rat intestinal insulin-producing progenitor cells. J. Biol. Chem. 280 (2005) 1893-1900
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 1893-1900
-
-
Hashimoto, T.1
Nakamura, T.2
Maegawa, H.3
-
25
-
-
0034022637
-
Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus
-
Satoda M., Zhao F., Diaz G.A., et al. Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus. Nat. Genet. 25 (2000) 42-46
-
(2000)
Nat. Genet.
, vol.25
, pp. 42-46
-
-
Satoda, M.1
Zhao, F.2
Diaz, G.A.3
-
26
-
-
0034836484
-
Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation
-
Zhao F., Weismann C.G., Satoda M., et al. Novel TFAP2B mutations that cause Char syndrome provide a genotype-phenotype correlation. Am. J. Hum. Genet. 69 (2001) 695-703
-
(2001)
Am. J. Hum. Genet.
, vol.69
, pp. 695-703
-
-
Zhao, F.1
Weismann, C.G.2
Satoda, M.3
-
27
-
-
0024199329
-
Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements
-
Williams T., Admon A., Luscher B., et al. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes Dev. 2 (1988) 1557-1569
-
(1988)
Genes Dev.
, vol.2
, pp. 1557-1569
-
-
Williams, T.1
Admon, A.2
Luscher, B.3
-
28
-
-
0035798538
-
Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties
-
Zhao F., Satoda M., Licht J.D., et al. Cloning and characterization of a novel mouse AP-2 transcription factor, AP-2delta, with unique DNA binding and transactivation properties. J. Biol. Chem. 276 (2001) 40755-40760
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 40755-40760
-
-
Zhao, F.1
Satoda, M.2
Licht, J.D.3
-
29
-
-
0029119180
-
Cloning and characterization of a second AP-2 transcription factor: AP-2 beta
-
Moser M., Imhof A., Pscherer A., et al. Cloning and characterization of a second AP-2 transcription factor: AP-2 beta. Development 121 (1995) 2779-2788
-
(1995)
Development
, vol.121
, pp. 2779-2788
-
-
Moser, M.1
Imhof, A.2
Pscherer, A.3
-
30
-
-
0032779156
-
Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM
-
Carvalho E., Jansson P.A., Axelsen M., et al. Low cellular IRS 1 gene and protein expression predict insulin resistance and NIDDM. FASEB J. 13 (1999) 2173-2178
-
(1999)
FASEB J.
, vol.13
, pp. 2173-2178
-
-
Carvalho, E.1
Jansson, P.A.2
Axelsen, M.3
-
31
-
-
14544269997
-
Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue
-
Serrano R., Villar M., Martinez C., et al. Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue. J. Mol. Endocrinol. 34 (2005) 153-161
-
(2005)
J. Mol. Endocrinol.
, vol.34
, pp. 153-161
-
-
Serrano, R.1
Villar, M.2
Martinez, C.3
-
32
-
-
70349557826
-
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
-
Rung J., Cauchi S., Albrechtsen A., et al. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. Nat. Genet. 41 (2009) 1110-1115
-
(2009)
Nat. Genet.
, vol.41
, pp. 1110-1115
-
-
Rung, J.1
Cauchi, S.2
Albrechtsen, A.3
-
33
-
-
0344412860
-
The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians
-
Kovacs P., Hanson R.L., Lee Y.H., et al. The role of insulin receptor substrate-1 gene (IRS1) in type 2 diabetes in Pima Indians. Diabetes 52 (2003) 3005-3009
-
(2003)
Diabetes
, vol.52
, pp. 3005-3009
-
-
Kovacs, P.1
Hanson, R.L.2
Lee, Y.H.3
|