메뉴 건너뛰기




Volumn 20, Issue 3, 2010, Pages 195-210

Extensive splicing of transcripts encoding the bile acid-conjugating enzyme UGT2B4 modulates glucuronidation

Author keywords

Alternative splicing; Bile acids; Glucuronosyltransferase; UGT; UGT2B; UGT2B4

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 2B4; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 76749156700     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e328336ef1c     Document Type: Article
Times cited : (20)

References (41)
  • 1
    • 0037062982 scopus 로고    scopus 로고
    • Alternative pre-mRNA splicing and proteome expansion in metazoans
    • Maniatis T, Tasic B. Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 2002; 418:236-243.
    • (2002) Nature , vol.418 , pp. 236-243
    • Maniatis, T.1    Tasic, B.2
  • 2
    • 38349085591 scopus 로고    scopus 로고
    • Regulation of alternative splicing by reversible protein phosphorylation
    • Stamm S. Regulation of alternative splicing by reversible protein phosphorylation. J Biol Chem 2008; 283:1223-1227.
    • (2008) J Biol Chem , vol.283 , pp. 1223-1227
    • Stamm, S.1
  • 3
    • 12144287461 scopus 로고    scopus 로고
    • Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22
    • Kampa D, Cheng J, Kapranov P, Yamanaka M, Brubaker S, Cawley S, et al. Novel RNAs identified from an in-depth analysis of the transcriptome of human chromosomes 21 and 22. Genome Res 2004; 14:331-342.
    • (2004) Genome Res , vol.14 , pp. 331-342
    • Kampa, D.1    Cheng, J.2    Kapranov, P.3    Yamanaka, M.4    Brubaker, S.5    Cawley, S.6
  • 4
    • 0347623371 scopus 로고    scopus 로고
    • Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays
    • Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. Science 2003; 302:2141-2144.
    • (2003) Science , vol.302 , pp. 2141-2144
    • Johnson, J.M.1    Castle, J.2    Garrett-Engele, P.3    Kan, Z.4    Loerch, P.M.5    Armour, C.D.6
  • 5
    • 60149110358 scopus 로고    scopus 로고
    • Pre-mRNA processing reaches back to transcription and ahead to translation
    • Moore MJ, Proudfoot NJ. Pre-mRNA processing reaches back to transcription and ahead to translation. Cell 2009; 136:688-700.
    • (2009) Cell , vol.136 , pp. 688-700
    • Moore, M.J.1    Proudfoot, N.J.2
  • 6
    • 0034721644 scopus 로고    scopus 로고
    • Protein diversity from alternative splicing: A challenge for bioinformatics and post-genome biology
    • Black DL. Protein diversity from alternative splicing: a challenge for bioinformatics and post-genome biology. Cell 2000; 103:367-370.
    • (2000) Cell , vol.103 , pp. 367-370
    • Black, D.L.1
  • 7
    • 0035252410 scopus 로고    scopus 로고
    • Alternative splicing: Increasing diversity in the proteomic world
    • Graveley BR. Alternative splicing: increasing diversity in the proteomic world. Trends Genet 2001; 17:100-107.
    • (2001) Trends Genet , vol.17 , pp. 100-107
    • Graveley, B.R.1
  • 9
    • 0034680792 scopus 로고    scopus 로고
    • Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine
    • Strassburg CP, Kneip S, Topp J, Obermayer-Straub P, Barut A, Tukey RH, Manns MP. Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine. J Biol Chem 2000; 275:36164-36171.
    • (2000) J Biol Chem , vol.275 , pp. 36164-36171
    • Strassburg, C.P.1    Kneip, S.2    Topp, J.3    Obermayer-Straub, P.4    Barut, A.5    Tukey, R.H.6    Manns, M.P.7
  • 10
    • 33745240359 scopus 로고    scopus 로고
    • Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1
    • Barker DF, Husain A, Neale JR, Martini BD, Zhang X, Doll MA, et al. Functional properties of an alternative, tissue-specific promoter for human arylamine N-acetyltransferase 1. Pharmacogenet Genomics 2006; 16:515-525.
    • (2006) Pharmacogenet Genomics , vol.16 , pp. 515-525
    • Barker, D.F.1    Husain, A.2    Neale, J.R.3    Martini, B.D.4    Zhang, X.5    Doll, M.A.6
  • 11
    • 33846449521 scopus 로고    scopus 로고
    • Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues
    • Turman CM, Hatley JM, Ryder DJ, Ravindranath V, Strobel HW. Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues. Expert Opin Drug Metab Toxicol 2006; 2:399-418.
    • (2006) Expert Opin Drug Metab Toxicol , vol.2 , pp. 399-418
    • Turman, C.M.1    Hatley, J.M.2    Ryder, D.J.3    Ravindranath, V.4    Strobel, H.W.5
  • 12
    • 35448942716 scopus 로고    scopus 로고
    • The cytochrome P450 aromatase lacking exon 5 is associated with a phenotype of nonclassic aromatase deficiency and is also present in normal human steroidogenic tissues
    • Pepe CM, Saraco NI, Baquedano MS, Guercio G, Vaiani E, Marino R, et al. The cytochrome P450 aromatase lacking exon 5 is associated with a phenotype of nonclassic aromatase deficiency and is also present in normal human steroidogenic tissues. Clin Endocrinol (Oxf) 2007; 67:698-705.
    • (2007) Clin Endocrinol (Oxf) , vol.67 , pp. 698-705
    • Pepe, C.M.1    Saraco, N.I.2    Baquedano, M.S.3    Guercio, G.4    Vaiani, E.5    Marino, R.6
  • 13
    • 34548546444 scopus 로고    scopus 로고
    • Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis
    • Bauer M, Herbarth O, Rudzok S, Schmucking E, Muller A, Aust G, Grabsch C. Diversity of common alternative splicing variants of human cytochrome P450 1A1 and their association to carcinogenesis. Int J Oncol 2007; 31:211-218.
    • (2007) Int J Oncol , vol.31 , pp. 211-218
    • Bauer, M.1    Herbarth, O.2    Rudzok, S.3    Schmucking, E.4    Muller, A.5    Aust, G.6    Grabsch, C.7
  • 14
    • 33846442350 scopus 로고    scopus 로고
    • Regulation of the UGT1A1 bilirubin-conjugating pathway: Role of a new splicing event at the UGT1A locus
    • Levesque E, Girard H, Journault K, Lepine J, Guillemette C. Regulation of the UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology 2007; 45:128-138.
    • (2007) Hepatology , vol.45 , pp. 128-138
    • Levesque, E.1    Girard, H.2    Journault, K.3    Lepine, J.4    Guillemette, C.5
  • 15
    • 38449095074 scopus 로고    scopus 로고
    • Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity
    • Girard H, Levesque E, Bellemare J, Journault K, Caillier B, Guillemette C. Genetic diversity at the UGT1 locus is amplified by a novel 3' alternative splicing mechanism leading to nine additional UGT1A proteins that act as regulators of glucuronidation activity. Pharmacogenet Genomics 2007; 17:1077-1089.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 1077-1089
    • Girard, H.1    Levesque, E.2    Bellemare, J.3    Journault, K.4    Caillier, B.5    Guillemette, C.6
  • 16
    • 59149088381 scopus 로고    scopus 로고
    • The impact of microRNAs and alternative splicing in pharmacogenomics
    • Passetti F, Ferreira CG, Costa FF. The impact of microRNAs and alternative splicing in pharmacogenomics. Pharmacogenomics J 2009; 9:1-13.
    • (2009) Pharmacogenomics J , vol.9 , pp. 1-13
    • Passetti, F.1    Ferreira, C.G.2    Costa, F.F.3
  • 17
    • 0034128936 scopus 로고    scopus 로고
    • Human UDP-glucuronosyltransferases:metabolism, expression, and disease
    • Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 2000; 40:581-616.
    • (2000) Annu Rev Pharmacol Toxicol , vol.40 , pp. 581-616
    • Tukey, R.H.1    Strassburg, C.P.2
  • 18
    • 0035115599 scopus 로고    scopus 로고
    • Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract
    • Tukey RH, Strassburg CP. Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract. Mol Pharmacol 2001; 59:405-414.
    • (2001) Mol Pharmacol , vol.59 , pp. 405-414
    • Tukey, R.H.1    Strassburg, C.P.2
  • 19
    • 0034695410 scopus 로고    scopus 로고
    • Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4
    • Turgeon D, Carrier JS, Levesque E, Beatty BG, Belanger A, Hum DW. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4. J Mol Biol 2000; 295:489-504.
    • (2000) J Mol Biol , vol.295 , pp. 489-504
    • Turgeon, D.1    Carrier, J.S.2    Levesque, E.3    Beatty, B.G.4    Belanger, A.5    Hum, D.W.6
  • 21
    • 0031229611 scopus 로고    scopus 로고
    • Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase
    • Monaghan G, Burchell B, Boxer M. Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase. Mamm Genome 1997; 8:692-694.
    • (1997) Mamm Genome , vol.8 , pp. 692-694
    • Monaghan, G.1    Burchell, B.2    Boxer, M.3
  • 23
    • 0024579299 scopus 로고
    • Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture
    • Fournel-Gigleux S, Jackson MR, Wooster R, Burchell B. Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture. FEBS Lett 1989; 243:119-122.
    • (1989) FEBS Lett , vol.243 , pp. 119-122
    • Fournel-Gigleux, S.1    Jackson, M.R.2    Wooster, R.3    Burchell, B.4
  • 24
    • 0026591504 scopus 로고
    • Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
    • Ritter JK, Chen F, Sheen YY, Lubet RA, Owens IS. Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives. Biochemistry 1992; 31:3409-3414.
    • (1992) Biochemistry , vol.31 , pp. 3409-3414
    • Ritter, J.K.1    Chen, F.2    Sheen, Y.Y.3    Lubet, R.A.4    Owens, I.S.5
  • 25
    • 33745471487 scopus 로고    scopus 로고
    • FXR: A target for cholestatic syndromes?
    • Cai SY, Boyer JL. FXR: a target for cholestatic syndromes? Expert Opin Ther Targets 2006; 10:409-421.
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 409-421
    • Cai, S.Y.1    Boyer, J.L.2
  • 27
    • 0029809062 scopus 로고    scopus 로고
    • Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids
    • Beaulieu M, Levesque E, Hum DW, Belanger A. Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. J Biol Chem 1996; 271:22855-22862.
    • (1996) J Biol Chem , vol.271 , pp. 22855-22862
    • Beaulieu, M.1    Levesque, E.2    Hum, D.W.3    Belanger, A.4
  • 28
    • 0344784391 scopus 로고    scopus 로고
    • Isolation and characterization of a human orphan UDP- glucuronosyltransferase,UGT2B11
    • Beaulieu M, Levesque E, Hum DW, Belanger A. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11. Biochem Biophys Res Commun 1998; 248:44-50.
    • (1998) Biochem Biophys Res Commun , vol.248 , pp. 44-50
    • Beaulieu, M.1    Levesque, E.2    Hum, D.W.3    Belanger, A.4
  • 29
    • 0030795936 scopus 로고    scopus 로고
    • Isolation and characterization of UGT2B15(Y85): A UDP glucuronosyltransferase encoded by a polymorphic gene
    • Levesque E, Beaulieu M, Green MD, Tephly TR, Belanger A, Hum DW. Isolation and characterization of UGT2B15(Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 1997; 7:317-325.
    • (1997) Pharmacogenetics , vol.7 , pp. 317-325
    • Levesque, E.1    Beaulieu, M.2    Green, M.D.3    Tephly, T.R.4    Belanger, A.5    Hum, D.W.6
  • 30
    • 0032812606 scopus 로고    scopus 로고
    • Characterization and substrate specificity of UGT2B4 (E458): A UDP glucuronosyl-transferase encoded by a polymorphic gene
    • Levesque E, Beaulieu M, Hum DW, Belanger A. Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyl-transferase encoded by a polymorphic gene. Pharmacogenetics 1999; 9:207-216.
    • (1999) Pharmacogenetics , vol.9 , pp. 207-216
    • Levesque, E.1    Beaulieu, M.2    Hum, D.W.3    Belanger, A.4
  • 31
    • 33745242349 scopus 로고    scopus 로고
    • The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver
    • Epub 2006 April 1224
    • Girard H, Villeneuve L, Court MH, Fortier LC, Caron P, Hao Q, et al. The novel UGT1A9 intronic I399 polymorphism appears as a predictor of 7-ethyl-10-hydroxycamptothecin glucuronidation levels in the liver. Drug Metab Dispos 2006; 34:1220-1228. [Epub 2006 April 1224].
    • (2006) Drug Metab Dispos , vol.34 , pp. 1220-1228
    • Girard, H.1    Villeneuve, L.2    Court, M.H.3    Fortier, L.C.4    Caron, P.5    Hao, Q.6
  • 32
    • 6344248683 scopus 로고    scopus 로고
    • Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium
    • Lepine J, Bernard O, Plante M, Tetu B, Pelletier G, Labrie F, et al. Specificity and regioselectivity of the conjugation of estradiol, estrone, and their catecholestrogen and methoxyestrogen metabolites by human uridine diphospho-glucuronosyltransferases expressed in endometrium. J Clin Endocrinol Metab 2004; 89:5222-5232.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 5222-5232
    • Lepine, J.1    Bernard, O.2    Plante, M.3    Tetu, B.4    Pelletier, G.5    Labrie, F.6
  • 33
    • 0035799361 scopus 로고    scopus 로고
    • Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase
    • Levesque E, Turgeon D, Carrier JS, Montminy V, Beaulieu M, Belanger A. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. Biochemistry 2001; 40:3869-3881.
    • (2001) Biochemistry , vol.40 , pp. 3869-3881
    • Levesque, E.1    Turgeon, D.2    Carrier, J.S.3    Montminy, V.4    Beaulieu, M.5    Belanger, A.6
  • 34
    • 0027431814 scopus 로고
    • Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4
    • Pillot T, Ouzzine M, Fournel-Gigleux S, Lafaurie C, Radominska A, Burchell B, et al. Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4. J Biol Chem 1993; 268:25636-25642.
    • (1993) J Biol Chem , vol.268 , pp. 25636-25642
    • Pillot, T.1    Ouzzine, M.2    Fournel-Gigleux, S.3    Lafaurie, C.4    Radominska, A.5    Burchell, B.6
  • 35
    • 0032147023 scopus 로고    scopus 로고
    • Determinants of UDP glucuronosyltransferase membrane association and residency in the endoplasmic reticulum
    • Meech R, Mackenzie PI. Determinants of UDP glucuronosyltransferase membrane association and residency in the endoplasmic reticulum. Arch Biochem Biophys 1998; 356:77-85.
    • (1998) Arch Biochem Biophys , vol.356 , pp. 77-85
    • Meech, R.1    MacKenzie, P.I.2
  • 36
    • 0035834673 scopus 로고    scopus 로고
    • Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications
    • Ghosh SS, Sappal BS, Kalpana GV, Lee SW, Chowdhury JR, Chowdhury NR. Homodimerization of human bilirubin-uridine-diphosphoglucuronate glucuronosyltransferase-1 (UGT1A1) and its functional implications. J Biol Chem 2001; 276:42108-42115.
    • (2001) J Biol Chem , vol.276 , pp. 42108-42115
    • Ghosh, S.S.1    Sappal, B.S.2    Kalpana, G.V.3    Lee, S.W.4    Chowdhury, J.R.5    Chowdhury, N.R.6
  • 37
    • 76749138564 scopus 로고    scopus 로고
    • The modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions
    • [Epub ahead of print]
    • Bellemare J, Rouleau M, Harvey M, Guillemette C. The modulation of the human glucuronosyltransferase UGT1A pathway by splice isoform polypeptides is mediated through protein-protein interactions. J Biol Chem 2009. [Epub ahead of print].
    • (2009) J Biol Chem
    • Bellemare, J.1    Rouleau, M.2    Harvey, M.3    Guillemette, C.4
  • 38
    • 77957154281 scopus 로고    scopus 로고
    • Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines
    • [Epub ahead of print]
    • Bellemare J, Rouleau M, Harvey M, Tetu B, Guillemette C. Alternative-splicing forms of the major phase II conjugating UGT1A gene negatively regulate glucuronidation in human carcinoma cell lines. Pharmacogenomics J 2009. [Epub ahead of print].
    • (2009) Pharmacogenomics J
    • Bellemare, J.1    Rouleau, M.2    Harvey, M.3    Tetu, B.4    Guillemette, C.5
  • 39
    • 54549123309 scopus 로고    scopus 로고
    • VEGF-A splicing: The key to anti-angiogenic therapeutics?
    • Harper SJ, Bates DO. VEGF-A splicing: the key to anti-angiogenic therapeutics? Nat Rev Cancer 2008; 8:880-887.
    • (2008) Nat Rev Cancer , vol.8 , pp. 880-887
    • Harper, S.J.1    Bates, D.O.2
  • 40
    • 55749107288 scopus 로고    scopus 로고
    • Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene
    • Innocenti F, Liu W, Fackenthal D, Ramirez J, Chen P, Ye X, et al. Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene. Pharmacogenet Genomics 2008; 18:683-697.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 683-697
    • Innocenti, F.1    Liu, W.2    Fackenthal, D.3    Ramirez, J.4    Chen, P.5    Ye, X.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.