Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase

Mammalian Genome

Volumn 8, Issue 9, 1997, Pages 692-694

  Monaghan, Gemma ^a   Burchell, Brian ^a   Boxer, Maureen ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; GLUCURONOSYLTRANSFERASE; ISOENZYME; PRIMER DNA;

ANIMAL; ARTICLE; EXON; GENETICS; HUMAN; INTRON; METABOLISM; METHODOLOGY; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; RAT; SEQUENCE HOMOLOGY;

ANIMALS; BILE ACIDS AND SALTS; DNA PRIMERS; EXONS; GLUCURONOSYLTRANSFERASE; HUMANS; INTRONS; ISOENZYMES; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; RATS; SEQUENCE HOMOLOGY, NUCLEIC ACID;

ANIMALIA;

EID: 0031229611     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900539     Document Type: Article

References (17)

1. Breathnach R, Chambon P (1981) Organization and expression of eukaryotic split genes coding for proteins. Annu Rev Biochem 50, 349-383
2. Burchell B, Coughtrie MHW (1989) UDP-Glucuronosyltransferases. Pharmacol Ther 43, 261-289
3. Burchell B, Nehert DW, Nelson DR, Bock KW, Iyanagi T, Jansen PLM, Lancet T, Mulder GJ, Roy Chowdhury J, Siest G, Tephly TR, Mackenzie PI (1991) The UDP-glucuronosyltransferase gene superfamily. Suggested nomenclature based on evolutionary divergence. DNA Cell Biol 10, 487-494
4. Cavalier-Smith T (1991) Intron phylogeny: a new hypothesis. Trends Genet 7, 145-148
5. Fournel-Gigleux S, Jackson MR, Wooster R, Burchell B (1989) Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture. FEBS Lett 243, 119-122
6. Grimsby J, Chen K, Wang I-J, Lan NC, Shih JC (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Null Acad Sci USA 88, 3637-3641
7. Haque SJ, Petersen DD, Nebert DW, Mackenzie PI (1991) Isolation, sequence and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP-glucuronosyltransferase that metabolizes etiocholanolone and androsterone. DNA Cell Biol 10, 515-524
8. Harding D, Jackson MR, Wooster R, Fournel-Gigleux S, Burchell B (1988) Cloning of human UDP-glucuronosyltransferase cDNAs. In Cellular and Molecular Aspects of Glucuronidation, G Siest, J Magdalou, B Burchell, eds. (INSERM/John Libbey Eurotext, Montrouge, France) 173, pp 13-20
9. Hawkins JD (1988) A survey of intron and exon lengths. Nucleic Acids Res 21, 9893-9908
10. Jackson MR, McCarthy LR, Harding D, Wilson S, Coughtrie MWH, Burchell B (1987) Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA. Biochem J 242, 581-588
11. Jin C-J, Miners JO, Lillywhite KJ, Mackenzie PI (1993) cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem Biophys Res Commun 194, 496-503
12. Monaghan G (1994) Gene structure and physical mapping of the human UDP-glucuronosyltransferase subfamily 2 genes. PhD thesis, University of Dundee, Scotland
13. Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (1994) Isolation of a human YAC contig encompassing a cluster of UGT2B genes and its regional localization to chromosome 4q13. Genomics 23, 496-199
14. Ritter JK, Chen F, Sheen YY, Lubet RA, Owens IS (1992a) Two human liver cDNAs encode UDP-glucuronosyltransferase with 2 log differences in activity towards parallel substrates including hyodeoxycholic acid and certain estrogen derivatives. Biochemistry 31, 3409-3414
15. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (1992b) A novel locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isoenzymes with identical carboxyl termini. J Biol Chem 287, 3257-3261
16. Rottmann WH, Deselms KR, Nicolas J, Camerato T, Holman PS, Green CJ, Tolan DR (1987) The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones. Biochimie 69, 137-145
17. Tephly TR, Burchell B (1990) UDP-Glucuronosyltransferases: a family of detoxifying enzymes. Trends Pharmacol Sci 11, 276-279