Diversity of common alternative splicing variants of human Cytochrome P450 1A1 and their association to carcinogenesis

International Journal of Oncology

Volumn 31, Issue 1, 2007, Pages 211-218

  Bauer, Mario ^a   Herbarth, Olf ^a   Rudzok, Susanne ^a   Schmücking, Eike ^a   Müller, Andrea ^a   Aust, Gabriela ^b   Gräbsch, Carolin ^a  

^a HELMHOLTZ CENTRE FOR ENVIRONMENTAL RESEARCH UFZ   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Alternative splicing; Cytochrome P450 1A1; Human epithelial tumour cell line; Human leukocytes

Indexed keywords

CYTOCHROME P450 1A1; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; CELL TRANSFORMATION; EPIDEMIOLOGY; EXON; GENE EXPRESSION; GENETICS; HUMAN; MOLECULAR GENETICS; NEOPLASM; NUCLEOTIDE SEQUENCE; RISK; SEQUENCE ANALYSIS; TUMOR CELL LINE;

ALTERNATIVE SPLICING; BASE SEQUENCE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CYTOCHROME P-450 CYP1A1; EPIDEMIOLOGY, MOLECULAR; EXONS; GENE EXPRESSION; HUMANS; MOLECULAR SEQUENCE DATA; NEOPLASMS; RISK; RNA, MESSENGER; SEQUENCE ANALYSIS, RNA;

EID: 34548546444     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.31.1.211     Document Type: Article

References (44)

1. Kim JH, Stansbury KH, Walker NJ, Trush MA, Strickland PT and Sutter TR: Metabolism of benzo[a]pyrene and benzo[a]pyrene-7,8-diol by human cytochromeP450 1B1. Carcinogenesis 19: 1847-1853, 1998.
2. Shimada T, Tsumura F and Yamazaki H: Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos 27: 1274-1280, 1999.
3. Neber DW, Dalton TP, Okey AB and Gonzalez FJ: Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer. J Biol Chem 279: 23847-23850, 2004.
4. Roberts-Thomson SJ, McManus ME, Tukey RH, Gonzalez FF and Holder GM: The catalytic activity of four expressed human cytochrome P450s towards benzo[a]pyrene and the isomers of its proximate carcinogen. Biochem Biophys Res Commun 192: 1373-1379, 1993.
5. Nebert DW, Roe AL, Dieter MZ, Solis WA, Yang Y and Dalton TP: Role of the aromatic hydrocarbon receptor and [Ah] gene battery in the oxidative stress response, cell cycle control, and apoptosis. Biochem Pharmacol 59: 65-85, 2000.
6. Iwanari M, Nakajima M, Kizu R, Hayakawa K and Yokoi T: Induction of CYP1A1, CYP1A2, and CYP1B1 mRNAs by nitropolycyclic aromatic hydrocarbons in various human tissue-derived cells: chemical-, cytochrome P450 isoform-, and cell-specific differences. Arch Toxicol 76: 287-298, 2002.
7. Mollerup S, Berge G, Baera R, Skaug V, Hewer A. Phillips DH, Stangeland L and Haugen A: Sex differences in risk of lung cancer: expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts. Int J Cancer 119: 741-744, 2006.
8. Kim JH, Sherman ME, Curriero FC, Guengerich FP, Strickland PT and Sutter TR: Expression of cytochromes P450 1A1 and 1B1 in human lung from smokers, non-smokers, and ex-smokers. Toxicol Appl Pharmacol 199: 210-219, 2004.
9. Zhang KL, Ma JX, Chen XY, Sun Y, Kong QY, Liu J and Li H: Frequent CYP1A1 expression in gastric cancers and their related lesions. Oncol Rep 12: 1335-1340, 2004.
10. Nagara NS, Beckers S, Mensah JK, Waigel S, Vigneswaran N and Zacharias W: Cigarette smoke condensate induces cytochromes P450 and aldo-keto reductases in oral cancer cells. Toxicol Lett 165: 182-194, 2006.
11. Parkinson A: Biotransformation of xenobiotics. In: Casarett and Doull's Toxicology, The Basic Science of Poisons. 6th edition. Klaassen CD (ed). McGraw-Hill Professional, 2001.
12. Goda R, Nagai D, Akiyama Y, Nishikawa K, Ikemoto I, Aizawa Y, Nagata K and Yamazoe Y: Detection of a new Noxidized metabolite of flutamide, N-[4-nitro-3-(trifluoromethyl) phenyl]hydroxylamine, in human liver microsomes and urine of prostate cancer patients. Drug Metab Dispos 34: 6828-6835, 2006.
13. Haas S, Pierl C, Harth V, Pesch B, Rabstein S, Bruning T, Ko Y, Hamann U, Justenhoven C, Brauch H and Fischer HP: Expression of xenobiotic and steroid hormone metabolizing enzymes in human breast carcinomas. Int J Cancer 23: [Epub ahead of print] 2006.
14. Iscan M, Klaavuniemi T, Coban T, Kapucuoglu N, Pelkonen O and Raunio H: The expression of cytochrome P450 enzymes in human breast tumours and normal breast tissue. Breast Cancer Res Treat 70: 47-54, 2001.
15. Hellmold H, Rylander T, Magnusson M, Reihner E, Warner M and Gustafsson JA: Characterization of cytochrome P450 enzymes in human breast tissue from reduction mammaplasties. J Clin Endocrinol Metab 83: 886-895, 1998.
16. Parkinson A and Hurwitz A: Omeprazole and the induction of human cytochrome P-450: a response to concerns about potential adverse effects. Gastroenterology 100: 1157-1164, 1991.
17. Furukawa M, Nishimura M, Ogino D, Chiba R, Ikai I, Ueda N, Naito S, Kuribayashi S, Moustafa MA, Uchida T, Sawada H, Kamataki T, Funae Y and Fukumoto M: Cytochrome p450 gene expression levels in peripheral blood mononuclear cells in comparison with the liver. Cancer Sci 95: 520-529, 2004.
18. Ali S, El-Rayes BF, Heilbrun LK, Sarkar FH, Ensley JF, Kucuk O and Philip PA: Cytochrome p450 and glutathione transferase expression in squamous cell cancer. Clin Cancer Res 10: 4412-4416, 2004.
19. Leung YK, Lau KM, Mobley J, Jiang Z and Ho SM: Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res 65: 3726-3734, 2005.
20. Little CD, Nau MM, Carney DN, Gazdar AF and Minna JD: Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306: 194-196, 1983.
21. Turner AM, Zsebo KM, Martin F, Jacobsen FW, Bennett LG and Broudy VC: Nonhematopoietic tumor cell lines express stem cell factor and display c-kit receptors. Blood 80: 374-381, 1992.
22. Lieber M, Smith B, Szakal A, Nelson-Rees W and Todaro G: A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 17: 62-70, 1976.
23. Bepler G, Koehler A, Kiefer P, Havemann K, Beisenherz K, Jaques G, Gropp C and Haeder M: Characterization of the state of differentiation of six newly established human non-small-cell lung cancer cell lines. Differentiation 37: 158-171, 1988.
24. Asahi Y, Kubonishi I, Imamura J, Kamioka M, Matsushita H, Furihata M, Ohtsuki Y and Miyoshi I: Establishment of a clonal cell line producing granulocyte colony-stimulating factor and parathyroid hormone-related protein from a lung cancer patient with leukocytosis and hypercalcemia. Jpn J Cancer Res 87: 451-458, 1996.
25. Heidtmann HH, Salge U, Havemann K, Kirschke H and Wiederanders B: Secretion of a latent, acid activatable cathepsin L precursor by human non-small cell lung cancer cell lines. Oncol Res 5: 441-451, 1993.
26. Takaki T: An epithelial cell line (KNS-62) derived from a brain metastasis of bronchial squamous cell carcinoma. J Cancer Res Clin Oncol 96: 27-33, 1980.
27. Gazdar AF, Linnoila RI, Kurita Y, Oie HK, Mulshine JL, Clark JC and Whitsett JA: Peripheral airway cell differentiation in human lung cancer cell lines. Cancer Res 50: 5481-5487, 1990.
28. Brower M, Carney DN, Oie HK, Gazdar AF and Minna JD: Growth of cell lines and clinical specimens of human non-small cell lung cancer in a serum-free defined medium. Cancer Res 46: 798-806, 1986.
29. Ellison M, Woodhouse D, Hillyard C, Dowsett M, Coombes RC, Gilby ED, Greenberg PB and Neville AM: Immunoreactive calcitonin production by human lung carcinoma cells in culture. Br J Cancer 32: 373-379, 1975.
30. Aden DP, Fogel A, Plotkin S, Damjanov I and Knowles BB: Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line. Nature 282: 615-616, 1979.
31. Simon WE, Albrecht M, Hansel M, Dietel M and Holzel F: Cell lines derived from human ovarian carcinomas: growth stimulation by gonadotropic and steroid hormones. J Natl Cancer Inst 70: 839-845, 1983.
32. Denissenko MF, Pao A, Tang M and Pfeifer GP: Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53. Science 274: 430-432, 1996.
33. Bauer M, Herbarth O, Aust G and Graebsch C: Molecular cloning and expression of novel alternatively spliced cytochrome P450 2E1 mRNAs in humans. Mol Cell Biochem 280: 201-207, 2005.
34. Bauer M, Herbarth O, Aust G, Hengstler JG, Graebsch C and Schmuecking E: Expression pattern and novel splicing variants of Glutathione S-transferase isoenzymes of human lung and hepatocyte cell lines. Cell Tissue Res 324: 423-432, 2006.
35. Hastings ML and Krainer AR: Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol 13: 302-309, 2001.
36. Karpova AY, Howley PM and Ronco LV: Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene. Genes Dev 14: 2813-2818, 2000.
37. Van der Houven van Oordt W, Diaz-Meco MT, Lozano J, Krainer AR, Moscat J and Caceres JF: The MKK(3/6)-p38-signaling cascade alters the subcellular distribution of hnRNPA1 and modulates alternative splicing regulation. J Cell Biol 149: 307-316, 2000.
38. Philips AV and Cooper TA: RNA processing and human disease. Cell Mol Life Sci 57: 235-249, 2000.
39. Ars E, Serra E, Garcia J, Kruyer H, Gaona A, Lazaro C and Estivill X: Mutations affecting mRNA splicing are the most common molecular defects in patients with neurofibromatosis type 1. Hum Mol Genet 9: 237-247, 2000.
40. Teraoka SN, Telatar M, Becker-Catania S, Liang T, Onengut S, Tolun A, Chessa L, Sanal O, Bernatowska E, Gatti RA and Concannon P: Splicing defects in the ataxia-telangiectasia gene, ATM: underlying mutations and consequences. Am J Hum Genet 64: 1617-1631, 1999.
41. Burset M, Seledtsov IA and Solovyev VV: Analysis of canonical and non-canonical splice sites in mammalian genomes. Nucleic Acids Res 28: 4364-4375, 2000.
42. Burge CB, Tuschl T and Sharp PA: Splicing of precursors to mRNAs by the spliceosomes. In: The RNA world. Gesteland RF, Cech TR and Atkins JF (eds). Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp525-560, 1999.
43. Burset M, Seledtsov IA and Solovyev VV: SpliceDB: database of canonical and non-canonical mammalian splice sites. Nucleic Acids Res 29: 255-259, 2001.
44. Cartegni L, Wang J, Zhu Z, Zhang MQ and Krainer AR: ESEfinder: a web resource to identify exonic splicing enhancers. Nucleic Acids Res 31: 3568-3571, 2003.