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Volumn 20, Issue 1, 2010, Pages 33-43

The potential of chitosan for pulmonary drug delivery

Author keywords

Chitosan; Gene delivery; Microspheres; Nanoparticles; Pulmonary drug administration

Indexed keywords

ALPHA INTERFERON; BECLOMETASONE; BECLOMETASONE DIPROPIONATE; CHITOSAN; CHITOSAN DERIVATIVE; ELCATONIN; FLUORESCEIN ISOTHIOCYANATE; HEPARIN; HYALURONIC ACID; INSULIN; MANNITOL; NANOPARTICLE; OCTREOTIDE; RIFAMPICIN; SALBUTAMOL; TERBUTALINE SULFATE; THEOPHYLLINE;

EID: 76749099834     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(10)50004-2     Document Type: Review
Times cited : (58)

References (92)
  • 1
    • 85031338804 scopus 로고    scopus 로고
    • Taylor G., Kellaway I. - Pulmonary drug delivery. - In: Drug Delivery and Targeting. For Pharmacists and Pharmaceutical Scientists, A. Hillery, A. Lloyd A., J. Swarbrick Eds., Taylor & Francis, New York, 2001, pp. 269-300.
    • Taylor G., Kellaway I. - Pulmonary drug delivery. - In: Drug Delivery and Targeting. For Pharmacists and Pharmaceutical Scientists, A. Hillery, A. Lloyd A., J. Swarbrick Eds., Taylor & Francis, New York, 2001, pp. 269-300.
  • 3
    • 0348202333 scopus 로고    scopus 로고
    • Formulation of proteins and peptides for inhalation
    • Clark A. - Formulation of proteins and peptides for inhalation. - Drug Delivery Systems & Science, 2, 73-77, 2002.
    • (2002) Drug Delivery Systems & Science , vol.2 , pp. 73-77
    • Clark, A.1
  • 4
    • 17444377960 scopus 로고    scopus 로고
    • Antitubercular inhaled therapy: Opportunities, progress and challenges
    • Pandey R., Khuller G.K. - Antitubercular inhaled therapy: opportunities, progress and challenges. - Journal of Antimicrobial Chemotherapy, 55, 430-435, 2005.
    • (2005) Journal of Antimicrobial Chemotherapy , vol.55 , pp. 430-435
    • Pandey, R.1    Khuller, G.K.2
  • 5
    • 76749102832 scopus 로고    scopus 로고
    • Nano- and microparticulate carriers for pulmonary drug delivery
    • Applications, M.N.V. Kumar Ed, American Scientific Publishers, Valencia
    • Grenha A., Carrión-Recio D., Teijeiro-Osorio D., Seijo B., Remuñán-López C. - Nano- and microparticulate carriers for pulmonary drug delivery. - In: Handbook of Particulate Drug Delivery, Vol. 2 (Applications), M.N.V. Kumar Ed., American Scientific Publishers, Valencia, 2008, pp.165-192.
    • (2008) Handbook of Particulate Drug Delivery , vol.2 , pp. 165-192
    • Grenha, A.1    Carrión-Recio, D.2    Teijeiro-Osorio, D.3    Seijo, B.4    Remuñán-López, C.5
  • 7
    • 36749061351 scopus 로고    scopus 로고
    • Advances and challenges of nanotechnology-based drug delivery systems
    • Jiang W., Kim B.Y., Rutka J.T., Chan W.C. - Advances and challenges of nanotechnology-based drug delivery systems. - Expert Opinion in Drug Delivery, 4, 621-633, 2007.
    • (2007) Expert Opinion in Drug Delivery , vol.4 , pp. 621-633
    • Jiang, W.1    Kim, B.Y.2    Rutka, J.T.3    Chan, W.C.4
  • 11
    • 33745091826 scopus 로고    scopus 로고
    • Chitin and chitosan: Functional biopolymers from marine crustaceans
    • Kurita K. - Chitin and chitosan: functional biopolymers from marine crustaceans. - Marine Biotechnology, 8, 203-226, 2006.
    • (2006) Marine Biotechnology , vol.8 , pp. 203-226
    • Kurita, K.1
  • 12
    • 0000163809 scopus 로고
    • Chitin
    • Aspinall G.O. Ed, Academic Press, Orlando
    • Muzzarelli R.A.A. - Chitin. - In: The Polysaccharides, Aspinall G.O. Ed., Academic Press, Orlando, 1985, pp. 417-450.
    • (1985) The Polysaccharides , pp. 417-450
    • Muzzarelli, R.A.A.1
  • 14
    • 0030748702 scopus 로고    scopus 로고
    • Human enzymatic activities related to the therapeutic administration of chitin derivatives
    • Muzzarelli R.A.A. - Human enzymatic activities related to the therapeutic administration of chitin derivatives. - Cellular and Molecular Life Sciences, 53, 131-140, 1997.
    • (1997) Cellular and Molecular Life Sciences , vol.53 , pp. 131-140
    • Muzzarelli, R.A.A.1
  • 16
    • 85031338823 scopus 로고    scopus 로고
    • Dornish M., Hagen A., Hansson E., Peucheur C., Vedier F., Skaugrud O. - Safety of Protasan: ultrapure chitosan salts for biomedical and pharmaceutical use. - In: Advances in Chitin Science., A. Domard, G.A.F. Roberts, K.M., Varum Eds., Jacques Andre Publisher, Lyon, 1997, pp. 664-670.
    • Dornish M., Hagen A., Hansson E., Peucheur C., Vedier F., Skaugrud O. - Safety of Protasan: ultrapure chitosan salts for biomedical and pharmaceutical use. - In: Advances in Chitin Science., A. Domard, G.A.F. Roberts, K.M., Varum Eds., Jacques Andre Publisher, Lyon, 1997, pp. 664-670.
  • 17
    • 0028071051 scopus 로고
    • Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2)
    • Artursson P., Lindmark T., Davis S.S., Ilium L. - Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). - Pharmaceutical Research, 11, 1358-1361, 1994.
    • (1994) Pharmaceutical Research , vol.11 , pp. 1358-1361
    • Artursson, P.1    Lindmark, T.2    Davis, S.S.3    Ilium, L.4
  • 18
    • 0343150936 scopus 로고    scopus 로고
    • The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III. Effects of chitosan glutamate and carbomer on epithelial tight junctions in vitro
    • Borchard G., Luessen H.L., De Boer G.A., Verhoef J.C., Lehr CM., Junginger H.E. - The potential of mucoadhesive polymers in enhancing intestinal peptide drug absorption. III. Effects of chitosan glutamate and carbomer on epithelial tight junctions in vitro. - Journal of Controlled Release, 39, 131-138, 1996.
    • (1996) Journal of Controlled Release , vol.39 , pp. 131-138
    • Borchard, G.1    Luessen, H.L.2    De Boer, G.A.3    Verhoef, J.C.4    Lehr, C.M.5    Junginger, H.E.6
  • 20
    • 0033300109 scopus 로고    scopus 로고
    • Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration
    • Fernández-Urrusuno R., Romaní D., Calvo P., Vila-Jato J.L., Alonso M.J. - Development of a freeze-dried formulation of insulin-loaded chitosan nanoparticles intended for nasal administration. - S T P Pharma Sciences, 9, 429-436, 1999.
    • (1999) S T P Pharma Sciences , vol.9 , pp. 429-436
    • Fernández-Urrusuno, R.1    Romaní, D.2    Calvo, P.3    Vila-Jato, J.L.4    Alonso, M.J.5
  • 21
    • 0035859983 scopus 로고    scopus 로고
    • Chitosan nanoparticles: A new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A
    • DeCampos A., Sánchez A., Alonso M.J. - Chitosan nanoparticles: a new vehicle for the improvement of the delivery of drugs to the ocular surface. Application to cyclosporin A. - International Journal of Pharmaceutics, 224, 159-168, 2001.
    • (2001) International Journal of Pharmaceutics , vol.224 , pp. 159-168
    • DeCampos, A.1    Sánchez, A.2    Alonso, M.J.3
  • 22
    • 11844282711 scopus 로고    scopus 로고
    • Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
    • Yamamoto H., Kuno Y., Sugimoto S., Takeuchi H., Kawashima Y. - Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. - Journal of Controlled Release, 102, 373-381, 2005.
    • (2005) Journal of Controlled Release , vol.102 , pp. 373-381
    • Yamamoto, H.1    Kuno, Y.2    Sugimoto, S.3    Takeuchi, H.4    Kawashima, Y.5
  • 24
    • 27144541896 scopus 로고    scopus 로고
    • The potential of chitosan for the oral administration of peptides
    • Prego C., Torres D., Alonso M.J. - The potential of chitosan for the oral administration of peptides. - Expert Opinion in Drug Delivery, 2, 843-854, 2005.
    • (2005) Expert Opinion in Drug Delivery , vol.2 , pp. 843-854
    • Prego, C.1    Torres, D.2    Alonso, M.J.3
  • 25
    • 0034578096 scopus 로고    scopus 로고
    • Preparation and solubility in acid and water of partially deacetylated chitins
    • Cho Y.W., Jang J., Park C.R., Ko S.W. Preparation and solubility in acid and water of partially deacetylated chitins. - Biomacromolecules, 1, 609-614, 2000.
    • (2000) Biomacromolecules , vol.1 , pp. 609-614
    • Cho, Y.W.1    Jang, J.2    Park, C.R.3    Ko, S.W.4
  • 26
    • 0036244458 scopus 로고    scopus 로고
    • Lung lining liquid, The hidden depths
    • Walters D.V. - Lung lining liquid, The hidden depths. - Biology of the Neonate, 81 (Supp. 1), 2-5, 2002.
    • (2002) Biology of the Neonate , vol.81 , Issue.SUPP. 1 , pp. 2-5
    • Walters, D.V.1
  • 28
    • 0028558163 scopus 로고
    • Water soluble derivatives obtained by controlled chemical modifications of chitosan
    • Le Dung P., Milas P., Rinaudo M., Desbrières J. - Water soluble derivatives obtained by controlled chemical modifications of chitosan. - Carbohydrate Polymers, 24, 209-214, 1994.
    • (1994) Carbohydrate Polymers , vol.24 , pp. 209-214
    • Le Dung, P.1    Milas, P.2    Rinaudo, M.3    Desbrières, J.4
  • 29
    • 0242522338 scopus 로고    scopus 로고
    • N-succinyl-chitosan as a drug carrier: Water-insoluble and water-soluble conjugates
    • Kato Y., Onishi H., Machida Y. - N-succinyl-chitosan as a drug carrier: water-insoluble and water-soluble conjugates. - Biomaterials, 25, 907-915, 2004.
    • (2004) Biomaterials , vol.25 , pp. 907-915
    • Kato, Y.1    Onishi, H.2    Machida, Y.3
  • 30
    • 0346735298 scopus 로고    scopus 로고
    • Thiolated chitosan: Development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system
    • Bernkop-Schnurch A., Guggi D., Pinter Y. - Thiolated chitosan: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. - Journal of Controlled Release, 94, 177-186, 2004.
    • (2004) Journal of Controlled Release , vol.94 , pp. 177-186
    • Bernkop-Schnurch, A.1    Guggi, D.2    Pinter, Y.3
  • 36
    • 37349101929 scopus 로고    scopus 로고
    • Gene delivery using chitosan, trimethyl chitosan or polyethyleneglycol-graft- trimethyl chitosan block copolymers: Establishment of structure-activity relationships in vitro
    • Germershaus O., Mao S., Sitterberg J., Bakowsky U., Kissel T. - Gene delivery using chitosan, trimethyl chitosan or polyethyleneglycol-graft- trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro. - Journal of Controlled Release, 125, 145-154, 2007.
    • (2007) Journal of Controlled Release , vol.125 , pp. 145-154
    • Germershaus, O.1    Mao, S.2    Sitterberg, J.3    Bakowsky, U.4    Kissel, T.5
  • 37
    • 33646349221 scopus 로고    scopus 로고
    • A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: Properties and in vitro transfection studies
    • Hu F., Zhao M., Yuan H., You J., Du Y., Zeng S. - A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: properties and in vitro transfection studies. - International Journal of Pharmaceutics, 315, 158-166, 2006.
    • (2006) International Journal of Pharmaceutics , vol.315 , pp. 158-166
    • Hu, F.1    Zhao, M.2    Yuan, H.3    You, J.4    Du, Y.5    Zeng, S.6
  • 38
    • 33748784063 scopus 로고    scopus 로고
    • Issa M.M., Köping-Höggard M., Tømmeraas K., Varum K.M., Christensen B.E., Strand S.P., Artursson P. - Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. - Journal of Controlled Release, 115, 103-112, 2006.
    • Issa M.M., Köping-Höggard M., Tømmeraas K., Varum K.M., Christensen B.E., Strand S.P., Artursson P. - Targeted gene delivery with trisaccharide-substituted chitosan oligomers in vitro and after lung administration in vivo. - Journal of Controlled Release, 115, 103-112, 2006.
  • 42
    • 11844282711 scopus 로고    scopus 로고
    • Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions
    • Yamamoto H, Kuno Y, Sugimoto S, Takeuchi H, Kawashima Y. - Surface-modified PLGA nanosphere with chitosan improved pulmonary delivery of calcitonin by mucoadhesion and opening of the intercellular tight junctions. - Journal of Controlled Release, 102, 373-381, 2005.
    • (2005) Journal of Controlled Release , vol.102 , pp. 373-381
    • Yamamoto, H.1    Kuno, Y.2    Sugimoto, S.3    Takeuchi, H.4    Kawashima, Y.5
  • 45
    • 21744457648 scopus 로고    scopus 로고
    • Carrier-based strategies for targeting protein and peptide drugs to the lungs
    • Cryan S.A. - Carrier-based strategies for targeting protein and peptide drugs to the lungs. - AAPS Journal, 7, E20-E41, 2005.
    • (2005) AAPS Journal , vol.7
    • Cryan, S.A.1
  • 47
    • 20444378399 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of novel microparticulates based on hyaluronan and chitosan hydroglutamate
    • Lim S.T., Forbes B., Martin G.P., Brown MB. - In vivo and in vitro characterization of novel microparticulates based on hyaluronan and chitosan hydroglutamate. - AAPS PharmsciTech., 2, 14, 2001.
    • (2001) AAPS PharmsciTech , vol.2 , pp. 14
    • Lim, S.T.1    Forbes, B.2    Martin, G.P.3    Brown, M.B.4
  • 48
    • 29244456136 scopus 로고    scopus 로고
    • Enhancement of bronchial octreotide absorption by chitosan and N-trimethylchitosan shows linear in vitro/in vivo correlation
    • Florea B.I., Thanou M., Junginger H.E., Borchard G. - Enhancement of bronchial octreotide absorption by chitosan and N-trimethylchitosan shows linear in vitro/in vivo correlation. - Journal of Controlled Release, 110, 353-361, 2006.
    • (2006) Journal of Controlled Release , vol.110 , pp. 353-361
    • Florea, B.I.1    Thanou, M.2    Junginger, H.E.3    Borchard, G.4
  • 49
    • 30544453617 scopus 로고    scopus 로고
    • Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of lnterferon-a in rats
    • Yamada K., Odomi M., Okada N., Fujita T., Yamamoto A. - Chitosan oligomers as potential and safe absorption enhancers for improving the pulmonary absorption of lnterferon-a in rats. - Journal of Pharmaceutical Sciences, 94, 2432-2440, 2005.
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , pp. 2432-2440
    • Yamada, K.1    Odomi, M.2    Okada, N.3    Fujita, T.4    Yamamoto, A.5
  • 50
    • 1242314681 scopus 로고    scopus 로고
    • Uptake and cytotoxicity of chitosan molecules and nanoparticles: Effects of molecular weight and degree of deacetylation
    • Huang M., Khor E., Lim L.Y. - Uptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylation. - Pharmaceutical Research, 21, 344-353, 2004.
    • (2004) Pharmaceutical Research , vol.21 , pp. 344-353
    • Huang, M.1    Khor, E.2    Lim, L.Y.3
  • 52
    • 1842479868 scopus 로고    scopus 로고
    • Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis
    • Bivas-Benita M., Van Meijgaarden K.E., Franken K.L.M.C., Junginger H.E., Borchard G., Ottenhoff TH.M., Geluk A. - Pulmonary delivery of chitosan-DNA nanoparticles enhances the immunogenicity of a DNA vaccine encoding HLA-A*0201-restricted T-cell epitopes of Mycobacterium tuberculosis. - Vaccine, 22, 1609-1615, 2004.
    • (2004) Vaccine , vol.22 , pp. 1609-1615
    • Bivas-Benita, M.1    Van Meijgaarden, K.E.2    Franken, K.L.M.C.3    Junginger, H.E.4    Borchard, G.5    Ottenhoff, T.M.6    Geluk, A.7
  • 55
  • 57
    • 21344446211 scopus 로고    scopus 로고
    • Polymer nanostructures
    • H.S. Nalwa Ed, American Scientific Publishers
    • Dai L. - Polymer nanostructures. - In: Encyclopedia of Nanoscience and Nanotechnology, H.S. Nalwa Ed., American Scientific Publishers, 2004, pp. 763-769.
    • (2004) Encyclopedia of Nanoscience and Nanotechnology , pp. 763-769
    • Dai, L.1
  • 58
    • 0031904113 scopus 로고    scopus 로고
    • Recent advances in pulmonary drug delivery using large, porous inhaled particles
    • Edwards D.A, Ben-Jebria A., Langer R. - Recent advances in pulmonary drug delivery using large, porous inhaled particles. - Journal of Applied Physiology, 84, 379-385, 1998.
    • (1998) Journal of Applied Physiology , vol.84 , pp. 379-385
    • Edwards, D.A.1    Ben-Jebria, A.2    Langer, R.3
  • 60
    • 0032926859 scopus 로고    scopus 로고
    • Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs
    • Ben-Jebria A., Chen D., Eskew M.L., Vanbever R., Langer R., Edwards D.A. - Large porous particles for sustained protection from carbachol-induced bronchoconstriction in guinea pigs - Pharmaceutical Research, 16, 555-61, 1999.
    • (1999) Pharmaceutical Research , vol.16 , pp. 555-561
    • Ben-Jebria, A.1    Chen, D.2    Eskew, M.L.3    Vanbever, R.4    Langer, R.5    Edwards, D.A.6
  • 64
    • 42049094490 scopus 로고    scopus 로고
    • Pharmaceutical particle engineering viaspray drying (Expert Review)
    • Vehring R. - Pharmaceutical particle engineering viaspray drying (Expert Review). - Pharmaceutical Research, 25, 9999-1022, 2008.
    • (2008) Pharmaceutical Research , vol.25 , pp. 9999-1022
    • Vehring, R.1
  • 66
    • 0037151427 scopus 로고    scopus 로고
    • Formulation factors in preparing BTM-chitosan microspheres by spray drying method
    • Huang Y.C., Yeh M.K., Chiang C.H - Formulation factors in preparing BTM-chitosan microspheres by spray drying method. - International Journal of Pharmaceutics, 242, 239-242, 2002.
    • (2002) International Journal of Pharmaceutics , vol.242 , pp. 239-242
    • Huang, Y.C.1    Yeh, M.K.2    Chiang, C.H.3
  • 67
    • 0037820592 scopus 로고    scopus 로고
    • The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method
    • Huang Y.C., Yeh M.K., Cheng S.N., Chiang C.H. - The characteristics of betamethasone-loaded chitosan microparticles by spray-drying method. - Journal of Microencapsulation, 20, 459-472, 2003.
    • (2003) Journal of Microencapsulation , vol.20 , pp. 459-472
    • Huang, Y.C.1    Yeh, M.K.2    Cheng, S.N.3    Chiang, C.H.4
  • 69
    • 33644827603 scopus 로고    scopus 로고
    • Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates
    • Corrigan D.O., Healy A.M., Corrigan O.I. - Preparation and release of salbutamol from chitosan and chitosan co-spray dried compacts and multiparticulates. - European Journal of Pharmaceutics and Biopharmaceutics, 62, 295-305, 2006.
    • (2006) European Journal of Pharmaceutics and Biopharmaceutics , vol.62 , pp. 295-305
    • Corrigan, D.O.1    Healy, A.M.2    Corrigan, O.I.3
  • 70
    • 0031008878 scopus 로고    scopus 로고
    • Chan H.K., Clark A., Gonda I., Mumenthaler M., Hsu C. - Spray dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery. - Pharm. Respir., 14, 431-437, 1997.
    • Chan H.K., Clark A., Gonda I., Mumenthaler M., Hsu C. - Spray dried powders and powder blends of recombinant human deoxyribonuclease (rhDNase) for aerosol delivery. - Pharm. Respir., 14, 431-437, 1997.
  • 71
    • 0035936969 scopus 로고    scopus 로고
    • Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance
    • Bosquillon C., Lombry C., Preat V., Vanbever R. - Influence of formulation excipients and physical characteristics of inhalation dry powders on their aerosolization performance. - Journal of Controlled Release, 70, 329-339, 2001.
    • (2001) Journal of Controlled Release , vol.70 , pp. 329-339
    • Bosquillon, C.1    Lombry, C.2    Preat, V.3    Vanbever, R.4
  • 72
    • 51649123816 scopus 로고    scopus 로고
    • Chitosan and β-cyclodextrin microspheres as pulmonary sustained delivery systems
    • University of Technology, Materials Science Edition
    • Zhang W., Chen X., Li P., He Q., Zhou H., Cha D.- Chitosan and β-cyclodextrin microspheres as pulmonary sustained delivery systems. - Journal of Wuhan University of Technology, Materials Science Edition, 23, 541-546, 2008.
    • (2008) Journal of Wuhan , vol.23 , pp. 541-546
    • Zhang, W.1    Chen, X.2    Li, P.3    He, Q.4    Zhou, H.5    Cha, D.6
  • 74
    • 39449131163 scopus 로고    scopus 로고
    • PLGA, chitosan or chitosan-coated PLGA microparticles for alveolar delivery? A comparative study of particle stability during nebulization
    • Manca M.L., Mourtas S., Dracopoulos V., Fadda A.M., Antimisiaris S.G. - PLGA, chitosan or chitosan-coated PLGA microparticles for alveolar delivery? A comparative study of particle stability during nebulization. - Colloids and Surfaces B: Biointerfaces, 62, 220-231, 2008.
    • (2008) Colloids and Surfaces B: Biointerfaces , vol.62 , pp. 220-231
    • Manca, M.L.1    Mourtas, S.2    Dracopoulos, V.3    Fadda, A.M.4    Antimisiaris, S.G.5
  • 77
    • 0030779190 scopus 로고    scopus 로고
    • Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines
    • Calvo P., Remuñán-López C., Vila-Jato J.L., Alonso M.J. - Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. - Pharmaceutical Research, 14, 1431-1436, 1997.
    • (1997) Pharmaceutical Research , vol.14 , pp. 1431-1436
    • Calvo, P.1    Remuñán-López, C.2    Vila-Jato, J.L.3    Alonso, M.J.4
  • 79
    • 64149091646 scopus 로고    scopus 로고
    • New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules
    • Teijeiro-Osorio D., Remunán-López C., Alonso M.J. - New generation of hybrid poly/oligosaccharide nanoparticles as carriers for the nasal delivery of macromolecules. - Biomacromolecules, 10, 243-249, 2009.
    • (2009) Biomacromolecules , vol.10 , pp. 243-249
    • Teijeiro-Osorio, D.1    Remunán-López, C.2    Alonso, M.J.3
  • 82
  • 83
    • 0034915353 scopus 로고    scopus 로고
    • Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta and gamma-cyclodextrins
    • Arima H., Kihara F., Hirayama F., Uekema K. - Enhancement of gene expression by polyamidoamine dendrimer conjugates with alpha-, beta and gamma-cyclodextrins. - Bioconjugate Chemistry, 12, 476-484, 2001.
    • (2001) Bioconjugate Chemistry , vol.12 , pp. 476-484
    • Arima, H.1    Kihara, F.2    Hirayama, F.3    Uekema, K.4
  • 85
    • 14244265907 scopus 로고    scopus 로고
    • Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery
    • Forrest M.L., Gabrielson N., Pack D.W. - Cyclodextrin-polyethylenimine conjugates for targeted in vitro gene delivery. - Biotechnology and Bioengineering, 89, 416-423, 2005.
    • (2005) Biotechnology and Bioengineering , vol.89 , pp. 416-423
    • Forrest, M.L.1    Gabrielson, N.2    Pack, D.W.3
  • 87
    • 38949151545 scopus 로고    scopus 로고
    • De La Fuente M., Seijo B., Alonso M.J. - Design of novel polysaccharide nanostructures for gene delivery. - Nanotechnology, 19, 0751065 (9 p), 2008.
    • De La Fuente M., Seijo B., Alonso M.J. - Design of novel polysaccharide nanostructures for gene delivery. - Nanotechnology, 19, 0751065 (9 p), 2008.
  • 88
    • 0142090707 scopus 로고    scopus 로고
    • Sustained expression in mammalian cells with DNA complexes and chitosan nanoparticles
    • Li X.W., Lee D.K.L., Chan A.S.C., Alpar H.O. - Sustained expression in mammalian cells with DNA complexes and chitosan nanoparticles. - Biochim. Biophys. Acta, 1630, 7-18, 2003.
    • (2003) Biochim. Biophys. Acta , vol.1630 , pp. 7-18
    • Li, X.W.1    Lee, D.K.L.2    Chan, A.S.C.3    Alpar, H.O.4
  • 89
    • 0042074074 scopus 로고    scopus 로고
    • Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs
    • Surendrakumar K., Martin G.P., Hodgers E.C.M., Jansen M., Blair J.A. - Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs. - Journal of Controlled Release, 91, 385-394, 2003.
    • (2003) Journal of Controlled Release , vol.91 , pp. 385-394
    • Surendrakumar, K.1    Martin, G.P.2    Hodgers, E.C.M.3    Jansen, M.4    Blair, J.A.5
  • 91
    • 34547093165 scopus 로고    scopus 로고
    • Chitosan nanoparticle-loaded mannitol microspheres: Structure and surface characterisation
    • Grenha A., Seijo B., Serra C., Remuñán-López C. - Chitosan nanoparticle-loaded mannitol microspheres: structure and surface characterisation. - Biomacromolecules, 8, 2072-2079, 2006.
    • (2006) Biomacromolecules , vol.8 , pp. 2072-2079
    • Grenha, A.1    Seijo, B.2    Serra, C.3    Remuñán-López, C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.