The threshold dose for liver tumor promoting effects of dicyclanil in ICR mice

Journal of Toxicological Sciences

Volumn 35, Issue 1, 2010, Pages 69-78

  Jin, Meilan ^a,b   Dewa, Yasuaki ^a   Kawai, Masaomi ^a,c   Nishimura, Jihei ^a   Saegusa, Yukie ^a,c   Kemmochi, Sayaka ^a,c   Harada, Tomoaki ^a   Shibutani, Makoto ^a   Mitsumori, Kunitoshi ^a  

^a TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c GIFU UNIVERSITY   (Japan)

Author keywords

Dicyclanil; ROS generation; Threshold dose

Indexed keywords

CYCLINE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; DICYCLANIL; DIETHYLNITROSAMINE; GAMMA GLUTAMYLTRANSFERASE; MESSENGER RNA; PYRIMIDINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HISTOPATHOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; LIVER CARCINOGENESIS; LIVER MICROSOME; LIVER TUMOR; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; TUMOR PROMOTION;

MUS;

EID: 76749083432     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.35.69     Document Type: Article

References (33)

1. Asare, G.A., Mossanda, K.S., Kew, M.C., Paterson, A.C., Kahler-Venter, C.P. and Siziba, K. (2006): Hepatocellular carcinoma caused by iron overload: a possible mechanism of direct hepatocarcinogenicity. Toxicology, 219, 41-52.
2. Chen, D., Yan, R. and Ye, Y. (1998): Influence of compensatory hepatocyte proliferation on the caricnogenesis of N-nitrosodimethylamine. Zhonghua. Bing. Li. Xue. Za. Zhi., 27, 105-108.
3. Delia Porta, G., Dragani, T. A. and Manenti, G. (1987): Two-stage liver carcinogenesis in the mouse. Toxicol. Pathol., 15, 229-234.
4. Dewa, Y, Nishimura, J., Muguruma, M., Jin, M., Saegusa, Y, Okamura, T., Tasaki, M., Umemura, T. and Mitsumori, K. (2008): β-Naphthoflavone enhances oxidative stress responses and the induction of preneoplastic lesions in a diethylnitrosamine-initiated hepatocarcinogenesis model in partially hepatectomized rats. Toxicology, 244, 179-189.
5. Guengerich, F.P. and Shimada, T. (1991): Oxidation of toxic and carcinogenic chemicals by human cytochrome P-450 enzymes. Chem. Res. Toxicol., 4, 391-407.
6. Kasai, H. (1997): Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat. Res., 387, 147-163.
7. Kawai, M., Saegusa, Y, Dewa, Y, Nishimura, J., Kemmochi, S., Harada, T, Ishii, Y, Umemura, T, Shibutani, M. and Mitsumori, K. (2009): Elevation of cell proliferation via generation of reactive oxygen species by piperonyl butoxide contributes to its liver tumor promoting effects in mice. Arch. Toxicol. (in press).
8. Kenmochi, Y., Takahashi, M., Moto, M., Muguruma, M., Nishimura, J., Jin, M., Kohno, T., Yokouchi, Y. and Mitsumori, K. (2007): Reactive oxygen species are possibly involved in the mechanism of flumequine-induced hepatocarcinogenesis in mice. J. Toxicol. Pathol., 20, 55-64.
9. Kinoshita, A., Wanibuchi, H., Imaoka, S., Ogawa, M., Matsuda, C, Morimura, K., Funae, Y and Fukushima, S. (2002): Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by Phenobarbital: association with expression profiles of p21(WAF/Cipl), cyclin Dl and Ogg1. Carcinogenesis, 23, 341-349.
10. Kinoshita, A., Wanibuchi, H., Morimura, K., Wei, M., Shen, J., Imaoka, S., Funae, Y and Fukushima, S. (2003): Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression. Carcinogenesis, 24, 1389-1399.
11. LeBel, C.P, Ali, S.F., McKee, M. and Bondy, S.C. (1990): Organometal-induced increases in oxygen reactive species: the potential of 2′,7′-dichloro fluorescin diacetate as an index of neurotoxic damage. Toxicol. Appl. Pharmacol., 104, 17-24.
12. Lee, G.H., Nomura, K. and Kitagawa, T. (1989): Comparative study of diethylnitrosamine-initiated two-stage hepatocarcinogenesis in C3H, C57BL and BALB mice promoted by various hepatopromoters. Carcinogenesis, 10, 2227-2230.
13. Lin, PH., Lin, C.H., Huang, C.C. Chuang, M.C. and Lin, P. (2007): 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly (ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines. Toxicol. Lett., 172, 146-158.
14. Loguercio, C, and Federico, A. (2003): Oxidative stress in viral and alcoholic hepatitis. Free. Radic. Biol. Med., 34, 1-10.
15. Moriya, K., Nakagawa, K., Santa, T, Shintani, Y, Fujie, H, Miyoshi, H, Tsutsumi, T, Miyazawa, T, Ishibashi, K., Horie, T, Imai, K., Todoroki, T, Kimura, S. and Koike, K. (2001): Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res., 61, 4365-4370.
16. Moto, M., Okamura, M., Muguruma, M., Ito, T, Jin, M., Kashida, Y and Mitsumori, K. (2006a): Gene expression analysis on the dicyclanil induced hepatocellular tumors in mice. Toxicol. Pathol., 34, 744-751.
17. Moto, M., Okamura, M., Muto, T, Kashida, Y, Machida, N. and Mitsumori, K. (2005): Molecular pathological analysis on the mechanism of liver carcinogenesis in dicyclanil-treated mice. Toxicology, 207, 419-436.
18. Moto, M., Umemura, T, Okamura, M., Muguruma, M., Ito, T, Jin, M., Kashida, Y and Mitsumori, K. (2006b): Possible involvement of oxidative stress in dicyclanil-induced hepatocarcinogenesis in mice. Arch. Toxicol., 80, 694-702.
19. Nakae, D., Kobayashi, Y, Akai, H, Andoh, N., Sato, H, Ohashi, K, Tsutsumi, M. and Konishi, Y (1997): Involvement of 8-hydroxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine. Cancer Res., 57, 1281-1287.
20. Paolini, M., Pozzetti, L., Pedulli, G.F., Cipollone, M., Mesirca, R. and Cantelli-Forti, G (1996): Paramagnetic resonance in detecting carcinogenic risk from cytochrome P450 overexpression. J. Invest. Med., 44, 470-473.
21. Parola, M. and Robino, G (2001): Oxidative stress-related molecules and liver fibrosis. J. Hepatol., 35, 297-306.
22. Peraino, C, Richards, W.L. and Stevens, F.J. (1983): Multistage hepatocarcinogenesis. Environ. Health Perspect, 50, 1-53.
23. Puntarulo, S. and Cederbaum, A.I. (1998): Production of reactive oxygen species by microsomes enriched in specific human cytochrome P450 enzymes. Free. Radic. Biol. Med., 24, 1324-1330.
24. Rutenburg, A.M., Kim, H, Fischbein, J.W., Hanker, J.S., Wasserkrug, H.L. and Seligman, A.M. (1969): Histochemical and ultrastructural demonstration of γ-glutamyl transpeptidase activity. J. Histochem. Cytochem., 17, 517-526.
25. Schlezinger, J.J., White, R.D. and Stegeman, J.J. (1999) Oxidative inactivation of cytochrome P-450 1A (CYP1A) stimulated by 3,3′,4,4′- tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol. Pharmacol., 56, 588-597.
26. Serron, S.C, Dwivedi, N. and Backes, W.L. (2000): Ethylbenzene induces microsomal oxygen free radical generation: antibody-directed characterization of the responsible cytochrome P450 enzymes. Toxicol. Appl. Pharmacol., 164, 305-311.
27. Shibutani, S., Takeshita, M. and Grollman, A.P (1991). Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG Nature, 349, 431-434.
28. Szejda, P., Parce, J.W., Seeds, M.S. and Bass, D.A. (1984) Flow cytometric quantitation of oxidative product formation by polymorphonuclear leukocytes during phagocytosis. J. Immunol., 133, 3303-3307.
29. Trush, M.A. and Kensler, T.W. (1991): An overview of the relationship between oxidative stress and chemical carcinogenesis. Free Radic. Biol. Med., 10, 201-209.
30. Valgimigli, L., Pedulli, G.F. and Paolini, M. (2001): Measurement of oxidative stress by Epr radical-probe technique. Free Radic. Biol. Med., 31, 708-716.
31. WHO (2000): Toxicological evaluation of certain veterinary drug residues in food, fifty-fourth meeting of the joint FAO/WHO expert committee on food additives. WHO Food Additive Series 45, pp.75-89, International Programme on Chemical Safety World Health Organization, Geneva.
32. Wiseman, H. and Halliwell, B. (1996): Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem. J., 313, 17-29.
33. Yoshida, M., Miyajima, K., Shiraki, K., Ando, J., Kudoh, K., Nakae, D., Takahashi, M. and Maekawa, A. (1999): Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice. Cancer Lett., 141, 99-107.