Hepatotoxicity and consequently increased cell proliferation are associated with flumequine hepatocarcinogenesis in mice

Cancer Letters

Volumn 141, Issue 1-2, 1999, Pages 99-107

  Yoshida, Midori ^a   Miyajima, Katsuhiro ^a   Shiraki, Katsuhisa ^a   Ando, Jin ^a   Kudoh, Kayoko ^a   Nakae, Dai ^b   Takahashi, Masakazu ^a   Maekawa, Akihiko ^a  

^a SASAKI INSTITUTE   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cell proliferation; Flumequine; Hepatocarcinogenesis; Hepatotoxicity; Mouse

Indexed keywords

CYTOCHROME P450; DIETHYLNITROSAMINE; FLUMEQUINE; PHENOBARBITAL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CARCINOGENESIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

ADENOMA; ANIMALS; ANTI-INFECTIVE AGENTS; CARCINOGENICITY TESTS; CELL DIVISION; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 ENZYME SYSTEM; DEOXYGUANOSINE; DIETHYLNITROSAMINE; FLUOROQUINOLONES; IMMUNOHISTOCHEMISTRY; LIVER; LIVER NEOPLASMS; MALE; MICE; PHENOBARBITAL; PROLIFERATING CELL NUCLEAR ANTIGEN; QUINOLIZINES; STEROID HYDROXYLASES;

ANIMALIA;

EID: 0033017830     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00088-9     Document Type: Article

References (21)

1. Albrecht R. Development of antibacterial agents of the nalidixic acid type. Prog. Drug Res. 21:1977;9-104.
2. Ames B.N., Gold L.S., Willett W.C. The causes and prevention of cancer. Proc. Natl. Acad. Sci. USA. 92:1995;5258-5265.
3. Beer D.G., Pitot H.C. Biological markers characterizing the development of preneoplastic and neoplastic lesions in rodent liver. Arch. Toxicol. 10:1987;68-80.
4. Butterworth B.E., Slaga T.J., Fairland W., McClain M. Chemically induced cell proliferation: implications for risk assessment. Prog. Clin. Biol. Res. 369:1991;1-546.
5. Gangolli S.D., Lake B.G., Evans J.G. The histopathology and biochemistry of phenobarbitone-induced nodules in C3H mice. Arch. Toxicol. Suppl. 10:1987;95-107.
6. Harada T. Current status of international standardization of nomenclature and diagnostic criteria for proliferative lesions of the liver in the mouse. J. Toxicol. Pathol. 9:1996;229-232.
7. Hattori Y., Nishigori C., Tanaka T., Uchida K., Nikaido O., Osawa T., Hiai H., Imamura S., Toyokuni S. 8-Hydroxy-2′-deoxyguanosine is increased in epidermal cells of hairless mice after chronic ultraviolet B exposure. J. Invest. Dermatol. 107:1997;733-737.
8. Hirouchi Y., Iwata H., Enomoto M. An immunohistochemical study on the proliferative, preneoplastic and neoplastic hepatocellular lesions by short- and mid-term experiments in mice exposed to hepatocarcinogenesis. J. Toxicol. Pathol. 9:1996;249-261.
9. Nakae M. Involvement of 8-hydorxyguanine formation in the initiation of rat liver carcinogenesis by low dose levels of N-nitrosodiethylamine. Cancer Res. 57:1997;1281-1287.
10. Okamoto S., Ochi H. Monoclonal antibody to 8-hydroxy-2′-deoxyguanosine and hybridomas producing the monoclonal antibody. Chem. Abstr. 1992;129859a.
11. Parkinson A. An overview of current cytochrome P450 technology for assessing the safety and efficacy of new materials. Toxicol. Pathol. 24:1996;45-57.
12. Popp J.A., Cattley R.C. Hepatobiliary system. Haschek W.A., Rousseaux C.G. Handbook of Toxicologic Pathology. 1991;279-314 Academic Press Inc, San Diego, CA.
13. Shigenaga M.K., Ames B.N. Assays for 8-hydroxy-2′-deoxyguanosine: a biomarker of in vivo oxidative DNA damage. Free Rad. Biol. Med. 10:1991;211-216.
14. Tamano S., Merlino G.T., Ward J.M. Rapid development of hepatic tumors in transforming growth factor α transgenic mice associated with increased cell proliferation in precancerous hepatocellular lesions initiated by N-nitrosodiethylamine and promoted by phenobarbital. Carcinogenesis. 15:1994;1791-1798.
15. Flumequine. WHO Food Additives Series: 33, Toxicological Evaluation of Certain Veterinary Drug Residues in Food. 1994;World Health Organization, Geneva. The forty-second meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), pp. 35-54.
16. Toyokuni S., Tanaka T., Hattori Y., Nishiyama Y., Yoshida A., Uchida K., Hiai H., Ochi H., Osawa T. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: its application to the ferric nitrilotriacetate-induced renal carcinogenesis model. Lab. Invest. 76:1997;365-374.
17. Umemura T., Sai K., Takagi A., Hasegawa R., Kurokawa Y. Formation of 8-hydroxydeoxyguanosine (8-OHdG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA). Carcinogenesis. 11:1990;345-347.
18. Umemura T., Sai-Kato K., Takagi A., Hasegawa R., Kurokawa Y. Oxidative DNA damage and cell proliferation in the livers of B6C3F1 mice exposed to pentachlorophenol in their diet. Fundam. Appl. Toxicol. 3:1996;285-289.
19. Ward J.M., Fox J.G., Anver M.R., Haines D.C., George C.V., Collins M.J. Jr., Gorelick P.L., Nagashima K., Gonda M.A., Gilden R.V., Tully J.G., Russell R.J., Benveniste R.E., Paster B.J., Dewhirst F.E., Donovan J.C., Anderson L.M., Rice J.M. Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species. J. Natl. Cancer. Inst. 86:1994;1222-1227.
20. Ward J.M., Shibata M., Devor D.E. Emerging issues in mouse liver carcinogenesis. Toxicol. Pathol. 24:1996;129-137.
21. Ying T.S., Sarma D.S.R., Farber E. Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. Cancer Res. 41:1981;2096-2102.