Hepatocellular carcinoma caused by iron overload: A possible mechanism of direct hepatocarcinogenicity

Toxicology

Volumn 219, Issue 1-3, 2006, Pages 41-52

  Asare, George A ^a   Mossanda, Kensese S ^b   Kew, Michael C ^a   Paterson, Alan C ^c   Kahler Venter, Christina P ^b   Siziba, Kwanele ^d  

^a SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^b SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY   (South Africa)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d National Centre for Occupational Health   (South Africa)

Author keywords

African dietary iron overload; Ferrocene; Hereditary haemochromatosis; Iron free neoplastic foci; Lipid peroxidation; Oxidative damage; Reactive oxygen species; Wistar albino rats

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 ISOPROSTANE; DNA; FERROCENE; HYDROPEROXIDE; MALONALDEHYDE;

AMES TEST; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL ANALYSIS; CONTROLLED STUDY; DIET; DNA DENATURATION; DNA STRAND BREAKAGE; IRON OVERLOAD; LIPID PEROXIDATION; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RAT;

ALPHA-FETOPROTEINS; ANIMALS; DNA DAMAGE; DNA HELICASES; ELECTROPHORESIS, GEL, PULSED-FIELD; FLUOROMETRY; IMMUNOHISTOCHEMISTRY; IRON; IRON OVERLOAD; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; MUTAGENICITY TESTS; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SALMONELLA TYPHIMURIUM; SUPEROXIDES; TRANSAMINASES;

ANIMALIA;

EID: 31044433625     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.11.006     Document Type: Article

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