SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing

Journal of Investigative Dermatology

Volumn 128, Issue 7, 2008, Pages 1821-1829

  Zhu, Bing Mei ^a   Ishida, Yuko ^b   Robinson, Gertraud W ^a   Pacher Zavisin, Margit ^a   Yoshimura, Akihiko ^c   Murphy, Philip M ^b   Hennighausen, Lothar ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; GLYCOPROTEIN GP 130; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; EPIDERMIS; GENE DELETION; IMMUNOCOMPETENT CELL; KERATINOCYTE; LOXP SITE; MALE; MOUSE; MOUSE MAMMARY TUMOR ONCOVIRUS; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; SKIN INJURY; SOCS3 GENE; TRANSGENE; WOUND HEALING; WOUND HEALING IMPAIRMENT;

EID: 45349102930     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/sj.jid.5701224     Document Type: Article

References (32)

1. Arakawa S, Hatano Y, Katagiri K (2004) Differential expression of mRNA for Th1 and Th2 cytokine-associated transcription factors and suppressors of cytokine signalling in peripheral blood mononuclear cells of patients with atopic dermatitis. Clin Exp Immunol 135:505-10
2. Diegelmann RF, Evans MC (2004) Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci 9:283-9
3. Eckert RL, Welter JF (1996) Transcription factor regulation of epidermal keratinocyte gene expression. Mol Biol Rep 23:59-70
4. Gallucci RM, Simeonova PP, Matheson JM, Kommineni C, Guriel JL, Sugawara T et al. (2000) Impaired cutaneous wound healing in interleukin-6- deficient and immunosuppressed mice. FASEB J 14:2525-31
5. Gallucci RM, Sugawara T, Yucesoy B, Berryann K, Simeonova PP, Matheson JM et al. (2001) Interleukin-6 treatment augments cutaneous wound healing in immunosuppressed mice. J Interferon Cytokine Res 21:603-9
6. Goren I, Linke A, Muller E, Pfeilschifter J, Frank S (2006) The suppressor of cytokine signaling-3 is upregulated in impaired skin repair: implications for keratinocyte proliferation. J Invest Dermatol 126:477-85
7. Grose R, Werner S (2003) Wound healing studies in transgenic and knockout mice. A review. Methods Mol Med 78:191-216
8. Hirano T, Ishihara K, Hibi M (2000) Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors. Oncogene 19:2548-56
9. Ishida Y, Kondo T, Takayasu T, Iwakura Y, Mukaida N (2004) The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. J Immunol 172:1848-55
10. Kim I, Mogford JE, Chao JD, Mustoe TA (2001) Wound epithelialization deficits in the transforming growth factor-alpha knockout mouse. Wound Repair Regen 9:386-90
11. Lin ZQ, Kondo T, Ishida Y, Takayasu T, Mukaida N (2003) Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice. J Leukoc Biol 73:713-21
12. Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O, Lee DC (1993) TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell 73:263-78
13. Mann GB, Fowler KJ, Gabriel A, Nice EC, Williams RL, Dunn AR (1993) Mice with a null mutation of the TGF alpha gene have abnormal skin architecture, wavy hair, and curly whiskers and often develop corneal inflammation. Cell 73:249-61
14. Mori R, Kondo T, Ohshima T, Ishida Y, Mukaida N (2002) Accelerated wound healing in tumor necrosis factor receptor p55-deficient mice with reduced leukocyte infiltration. FASEB J 16:963-74
15. Murray PJ (2007) The JAK-STAT signaling pathway: input and output integration. J Immunol 178:2623-9
16. Quadros MR, Peruzzi F, Kari C, Rodeck U (2004) Complex regulation of signal transducers and activators of transcription 3 activation in normal and malignant keratinocytes. Cancer Res 64:3934-9
17. Ramirez A, Page A, Gandarillas A, Zanet J, Pibre S, Vidal M et al. (2004) A keratin K5Cre transgenic line appropriate for tissue-specific or generalized Cre-mediated recombination. Genesis 39:52-7
18. Repertinger SK, Campagnaro E, Fuhrman J, El-Abaseri T, Yuspa SH, Hansen LA (2004) EGFR enhances early healing after cutaneous incisional wounding. J Invest Dermatol 123:982-9
19. Sano S, Chan KS, Carbajal S, Clifford J, Peavey M, Kiguchi K et al. (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11:43-9
20. Sano S, Itami S, Takeda K, Tarutani M, Yamaguchi Y, Miura H et al. (1999) Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis. EMBO J 18:4657-68
21. Schultz GS, White M, Mitchell R, Brown G, Lynch J, Twardzik DR et al. (1987) Epithelial wound healing enhanced by transforming growth factor-alpha and vaccinia growth factor. Science 235:350-2
22. Shirakata Y, Kimura R, Nanba D, Iwamoto R, Tokumaru S, Morimoto C et al. (2005) Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing. J Cell Sci 118:2363-70
23. Sibilia M, Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234-8
24. Takeda K, Akira S (2000) STAT family of transcription factors in cytokine-mediated biological responses. Cytokine Growth Factor Rev 11:199-207
25. Tarnawski AS, Jones MK (1998) The role of epidermal growth factor (EGF) and its receptor in mucosal protection, adaptation to injury, and ulcer healing: involvement of EGF-R signal transduction pathways. J Clin Gastroenterol 27(Suppl 1):S12-20
26. Tokumaru S, Sayama K, Shirakata Y, Komatsuzawa H, Ouhara K, Hanakawa Y et al. (2005a) Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-37. J Immunol 175:4662-8
27. Tokumaru S, Sayama K, Yamasaki K, Shirakata Y, Hanakawa Y, Yahata Y et al. (2005b) SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration. Biochem Biophys Res Commun 327:100-5
28. Toyoda M, Takayama H, Horiguchi N, Otsuka T, Fukusato T, Merlino G et al. (2001) Overexpression of hepatocyte growth factor/scatter factor promotes vascularization and granulation tissue formation in vivo. FEBS Lett 509:95-100
29. Wagner KU, McAllister K, Ward T, Davis B, Wiseman R, Hennighausen L (2001) Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice. Transgenic Res 10:545-53
30. Wagner KU, Wall RJ, St-Onge L, Gruss P, Wynshaw-Boris A, Garrett L et al. (1997) Cre-mediated gene deletion in the mammary gland. Nucleic Acids Res 25:4323-30
31. Yasukawa H, Ohishi M, Mori H, Murakami M, Chinen T, Aki D et al. (2003) IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages. Nat Immunol 4:551-6
32. Zhao L, Hart S, Cheng J, Melenhorst JJ, Bierie B, Ernst M et al. (2004) Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK. J Biol Chem 279:44093-100