3-(Arylsulfonyl)-1-(azacyclyl)-1H-indoles are 5-HT6 receptor modulators

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1657-1660

  Bernotas, Ronald C ^a   Antane, Schuyler ^b   Shenoy, Rajesh ^c   Le, Van Duc ^c   Chen, Ping ^c   Harrison, Boyd L ^b   Robichaud, Albert J ^b   Zhang, Guo Ming ^d   Smith, Deborah ^d   Schechter, Lee E ^d  

^a PFIZER INC   (United States)

^b Discovery Analytical Chemistry Chemical and Screening Sciences   (United States)

^c Neuroscience Research   (United States)

^d Albany Molecular Research   (United States)

Author keywords

5 HT6; Agonist; Antagonist; Cyclase; Indole; Serotonin; Sulfone

Indexed keywords

ADENYLATE CYCLASE; INDOLE DERIVATIVE; PIPERIDINE; PYRROLIDINE DERIVATIVE; SEROTONIN 6 ANTAGONIST; SEROTONIN AGONIST;

ARTICLE; BINDING AFFINITY; CYCLIZATION; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS;

HUMANS; INDOLES; LIGANDS; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONES;

EID: 76649112028     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.073     Document Type: Article

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