Discovery of N1-(6-Chloroimidazo[2,1-b][1,3]-thiazole-5- sulfonyl)tryptamine as a potent, selective, and orally active 5-HT6 receptor agonist

Journal of Medicinal Chemistry

Volumn 50, Issue 23, 2007, Pages 5535-5538

  Cole, Derek C ^a   Stock, Joseph R ^a   Lennox, William J ^a   Bernotas, Ronald C ^b   Ellingboe, John W ^a   Boikess, Steve ^b   Coupet, Joseph ^b   Smith, Deborah L ^b   Leung, Louis ^b   Zhang, Guo Ming ^b   Feng, Xidong ^a   Kelly, Michael F ^a   Galante, Rocco ^a   Huang, Pingzhong ^a   Dawson, Lee A ^b   Marquis, Karen ^b   Rosenzweig Lipson, Sharon ^b   Beyer, Chad E ^b   Schechter, Lee E ^b  

^a WYETH RESEARCH   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 ETHYL 5 METHOXY N,N DIMETHYLTRYPTAMINE; 4 AMINO N [2,6 BIS(METHYLAMINO) 4 PYRIMIDINYL]BENZENESULFONAMIDE; 4 AMINOBUTYRIC ACID; 5 BROMOINDOLE AMINOGUANIDINE; 5 CHLORO 2 METHYL 3 (1,2,3,6 TETRAHYDROPYRIDIN 4 YL) 1H INDOLE; 5 CHLORO N [4 METHOXY 3 (1 PIPERAZINYL)PHENYL] 3 METHYL 2 BENZOTHIOPHENESULFONAMIDE; ANTISENSE OLIGONUCLEOTIDE; CYCLIC AMP; INDOLE DERIVATIVE; ION CHANNEL; LYSERGIDE; N1 (6 CHLOROIMIDAZO[2,1 B][1,3]THIAZOLE 5 SULFONYL)TRYPTAMINE; SAX 187; SCOPOLAMINE; SEROTONIN 6 AGONIST; SEROTONIN 6 ANTAGONIST; SEROTONIN 6 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TRITIUM; TRYPTAMINE DERIVATIVE; UNCLASSIFIED DRUG; WAY 181187; N(1) (6 CHLOROIMIDAZO(2,1 B)(1,3)THIAZOLE 5 SULFONYL)TRYPTAMINE; N(1)-(6-CHLOROIMIDAZO(2,1-B)(1,3)THIAZOLE-5-SULFONYL)TRYPTAMINE; SEROTONIN RECEPTOR; THIAZOLE DERIVATIVE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DOG; DRINKING BEHAVIOR; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FRONTAL CORTEX; HELA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; ISOTOPE LABELING; LIVER MICROSOME; MONKEY; NEUROPHARMACOLOGY; NEUROTRANSMISSION; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; POLYDIPSIA; PSYCHOPHARMACOLOGY; RAT; SEROTONINERGIC SYSTEM; SINGLE DRUG DOSE; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; CHO CELL; CRICETULUS; FRONTAL LOBE; HAMSTER; HAPLORHINI; IN VITRO STUDY; METABOLISM; MICRODIALYSIS; MOUSE; ORAL DRUG ADMINISTRATION; RADIOASSAY; SOLUBILITY; SYNTHESIS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHO CELLS; CRICETINAE; CRICETULUS; DOGS; FRONTAL LOBE; GAMMA-AMINOBUTYRIC ACID; HAPLORHINI; HUMANS; MICE; MICRODIALYSIS; MICROSOMES, LIVER; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TRYPTAMINES;

EID: 36148929397     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070521y     Document Type: Article

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