Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound library

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 5, 2010, Pages 1685-1688

  Glass, LaTeca S ^a   Bapat, Aditi ^b   Kelley, Mark R ^b   Georgiadis, Millie M ^a,b   Long, Eric C ^a  

^a INDIANA UNIVERSITY   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytotoxicity; DNA binding; Fluorescent intercalator displacement (FID); High throughput screening

Indexed keywords

ANTINEOPLASTIC AGENT; CONGOCIDINE; DACTINOMYCIN;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL; CELL DEATH; CELL PROLIFERATION; CYTOTOXICITY; DNA BINDING; DNA SEQUENCE; DRUG SCREENING; DRUG STRUCTURE; GLIOBLASTOMA; HIGH THROUGHPUT FLUORESCENT INTERCALATOR DISPLACEMENT; HUMAN; HUMAN CELL; MELTING POINT; MOLECULE; REAGIN TEST;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOMATION; CELL LINE, TUMOR; DNA; DRUG DISCOVERY; FLUORESCENT DYES; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INTERCALATING AGENTS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 76649085808     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.033     Document Type: Article

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