The renal effects of blood glucose-lowering plant-derived extracts in diabetes mellitusan overview

Renal Failure

Volumn 32, Issue 1, 2010, Pages 132-138

  Mapanga, R F ^a   Musabayane, C T ^a  

^a University of KwaZulu Natal Faculty of Health Sciences   (South Africa)

Author keywords

Diabetes mellitus; Diabetic nephropathy; Medicinal plants; Renal function

Indexed keywords

ADVANCED GLYCATION END PRODUCT; ALAGEBRIUM; AMINOGUANIDINE; ANTIDIABETIC AGENT; BACCOPA MONNIERI EXTRACT; COPTIS CHINENSIS EXTRACT; CORNI FRUCTUS EXTRACT; CORNUS OFFICINALIS EXTRACT; CURCUMA LONGA EXTRACT; GARLIC EXTRACT; GINGER EXTRACT; GONGRONEMA LATIFOLIUM EXTRACT; HELICRYSIUM CERES EXTRACT; HYPOXIS HEMEROCALLIDEA EXTRACT; JAWARISHI ZAROONI SADA EXTRACT; METFORMIN; MOMORDICA CHARANTIA EXTRACT; OLEANOLIC ACID; OPUNTHIA MEGACANTHA EXTRACT; PANAX QUINQUEFOLIUM EXTRACT; PERSEA AMERICANA EXTRACT; PHELLODENDRON AMURENSE EXTRACT; PLANT EXTRACT; PROTEIN KINASE C; PYRIDOXAMINE; RESVERATROL; RHEUM EMODI EXTRACT; SCLEROCARYA BIRREA EXTRACT; STELECHOCARPUS CAULIFLORUS EXTRACT; UNCLASSIFIED DRUG; VIGNA ANGULARIS EXTRACT;

ANTIOXIDANT ACTIVITY; ATHEROSCLEROSIS; AVOCADO; CLINICAL FEATURE; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; GLOMERULUS FILTRATION RATE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPERTENSION; HYPOXIS; KIDNEY FUNCTION; KIDNEY STRUCTURE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; RENAL PROTECTION; RETINOPATHY; REVIEW; RHUBARB; RISK FACTOR; SIGNAL TRANSDUCTION;

EID: 76449121984     PISSN: 0886022X     EISSN: 15256049     Source Type: Journal    
DOI: 10.3109/08860220903367585     Document Type: Review

References (83)

1. Selby JV, FitzSimmons SC, Newman JM, Katz PP, Sepe S, Showstack J. The natural history and epidemiology of diabetic nephropathy. Implications for prevention and control. JAMA 1990;263(14):1954-1960.
2. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med. 1993; 329:977-986.
3. Rossing P. Promotion, prediction and prevention of progression of nephropathy in type 1 diabetes mellitus. Diabet Med. 1998;15:900-919. (Pubitemid 28500243)
4. Ismail N, Becker B, Strzelczyk P, Ritz E. Renal disease and hypertension in non-insulin-dependent diabetes mellitus. Kidney Int. 1999;55(1):1-28.
5. Heart Outcomes Prevention Evaluation Study Investigators. Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: Results of the HOPE study and MICRO-HOPE substudy. Lancet. 2000;355 (9200):253-259.
6. Mogensen CE, Neldam S, Tikkanen I, et al. Randomized controlled trial of dual blockade of rennin-angiotensin system in patients with hypertension, microalbuminiria and non-insulin dependent diabetes in Candesartan and Lisinopril Microalbuminuria (CALM) study. BMJ. 2000;321 (7274): 1440-1444.
7. Yusuf S, Dagenais G, Pogue J, Bosh J, Sleight P. Vitamin E supplementation and cardiovascular events in high-risk populations. The Heart Outcomes Prevention Study Investigators. N Engl J Med. 2000;342:154-160. (Pubitemid 30051646)
8. Brenner BM, Cooper ME, de Zeeuw D, et al. RENAAL Study Investigators. N Engl J Med. 2001;345(12):861-869.
9. Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med. 2001;345(12):851-860.
10. Nakagawa T, Yokozawa T, Terasawa K, Nakanishi K. Therapeutic usefulness of Keishi-bukuryo-gan for diabetic nephropathy. J Pharm Pharmacol. 2003;55(2):219-227.
11. Yokozawa T, Kim HY, Yamabe N. Amelioration of diabetic nephropathy by dried Rehmannie radix (Di Huang) extract. Am J Chin Med. 2004;32(6):829-839.
12. Marles R, Farnsworth N. Plants as sources of antidiabetic agents. In: Wagner H, Farnsworth NR (eds.). Economic and medicinal plant research. Vol.6. Academic Press Ltd., London, UK; 1994:149-187.
13. Wang TG, Ng TB. Natural products with hypoglycemic, hypotensive, hypocholestrolemic, antiatherosclerotic and antithrombotic activities. Life Sci. 1999;65(25):2663-2677.
14. Sharma SB, Nasir A, Prabhu KM. Murthy PS, Dev G. Hypoglycaemic and hypolipidaemic effect of ethanolic extract of seeds of Eugenia jambolana in alloxan-induced diabetic rabbits. J Ethnopharmacol. 2003;85(2-3):201-206.
15. Li W, Dai RJ, et al. Antihyperglycaemic effect of Cephalotaxus sinensis leaves and GLUT-4 translocation facilitating activity of its flavonoid constituents. Biol Pharm Bull. 2007;30(6):1123-1129.
16. Kim YY, Kang KM, Chung SH. Long-term administration of Sopungsungiwon (SP) prevents diabetic nephropathy in Zucker diabetic fatty rats. Arch Pharmaceut Res. 2002; 25(6):917-922.
17. Yamabe N, Yokozawa T. Activity of the Chinese prescription Hachimi-jio-gan against renal damage in the Otsuka Long Evans Tokushima fatty rat: A model of human type 2 diabetes mellitus. J Pharm Pharmacol. 2006;58(4):535-545.
18. Musabayane CT, Gondwe M, Kamadyaapa DR, Chuturgoon AA, Ojewole JAO. Effects of Ficus thonningii (Blume) [Moraceae] stem-bark ethanolic extract on blood glucose, cardiovascular and kidney functions of rats, and on kidney cell lines of the proximal (LLC-PK1) and distal tubules (MDBK). Ren Fail. 2007;29(4):389-397.
19. Gondwe M, Kamadyaapa DR, Tufts MA, Chuturgoon AA, Musabayane CT. Sclerocarya birrea [(A. Rich.) Hochst.] [Anacardiaceae] stem-bark ethanolic extract (SBE) modulates blood glucose, glomerular filtration rate (GFR) and mean arterial blood pressure (MAP) of STZ-induced diabetic rat. Phytomedicine. 2008;15:699-709.
20. Bwititi P, Musabayane CT, Nhachi, CFB. Effects of Opuntia megacantha on blood glucose and kidney function in streptozotocin diabetic rats. J Ethnopharmacol. 2000;69(3):247-252.
21. Musabayane CT, Ndhlovu CE, Balment RJ. Renal fluid and electrolyte handling in streptozotocin-diabetic rats. Ren Fail. 1995;17(2):107-116.
22. Rabkin R. Diabetic nephropathy. Clin Cornerstone. 2003;5(2):1-11.
23. Gnudi L, Thomas SM, Viberti G. Mechanical forces in diabetic kidney disease: A trigger for impaired glucose metabolism. J Am Soc Nephrol. 2007;18:2226-2232.
24. Bloomgarden ZT. Diabetic nephropathy. Diabetes Care. 2008;31(4):823-827.
25. Oh YK, Joo KW, Lee JW, Jeon US, Lim CS, Han JS, Knepper MA, Na KY. Altered renal sodium transporter expression in an animal model of type 2 diabetes mellitus. J Korean Med Sci. 2007;22(6):1034-1041.
26. Kumar GS, Shetty AK, Salimath PV. Modulatory effect of bitter gourd (Momordica charantia LINN.) on alterations in kidney heparan sulfate in streptozotocin-induced diabetic rats. J Ethnopharmacol. 2008;115(2):276-283.
27. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001;414(6865):813-820.
28. Sheetz MJ, King GL. Molecular understanding of hyperglycaemia's adverse effects for diabetes complications. JAMA. 2002;288(20):2579-2588.
29. Cooper ME, Gilbert RE, Epstein M. Pathophysiology of diabetic nephropathy. Metabolism. 1998;47(12 Suppl. 1):3-6.
30. Brands MW, Fitzgerald SM, Hewitt WH, Hailman AE. Decreased cardiac output at the onset of diabetes: Renal mechanisms and peripheral vasoconstriction. Am J Physiol Endo Metab. 2000;278(5):E917-E924.
31. Lehmann R, Schleicher ED. Molecular mechanism of diabetic nephropathy. Clin Chim Acta. 2000;297(1-2):135-144.
32. Rao NK, Nammi S. Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. Seeds in streptozotocin-induced diabetic rats. BMC Complement Altern Med. 2006;6:17.
33. Soulis-Liparota T, Cooper M, Papazoglou D, Clarke B, Jerums G. Retardation by aminoguanidine of development of albuminuria, mesangial expansion, and tissue fluorescence in streptozotocin-induced diabetic rat. Diabetes. 1991;40(10): 1328-1334.
34. Yeh CH, Sturgis L, Haidacher J, et al. Requirement for p38 and p44/p42 mitogen- activated protein kinase in RAGEmediated nuclear factor-kappaB transcriptional activation and cytokine secretion. Diabetes. 2001;50(6):1495-1504.
35. Yamagishi S, Inagaki Y, Okamoto T, Amano S, Koga K, Takeuchi M. Advanced glycation end products inhibit de novo protein synthesis and induce TGF-beta overexpression in proximal tubular cells. Kidney Int. 2003;63(2):464-473.
36. Yonekura H, Yamamoto Y, Sakurai S, Watanabe T, Yamamoto H. Roles of the receptor for advanced glycation end products in diabetes-induced vascular injury. J Pharmacol Sci. 2005;97(3):305-311. (Pubitemid 40515743)
37. DeGroot J. (2004). The AGE of the matrix: Chemistry, consequence and cure. Curr Opin Pharmacol. 4(3):301-305.
38. Hartog JWL, Voors AA, Bakker SJL, Smit AJ, van Veldhuisen DJ. Advanced glycation end-products (AGEs) and heart failure: Pathophysiology and clinical implications. Eur J Heart Fail. 2007;9(12):1146-1155.
39. Fan Q, Kobayashi M, Yamashita M, et al. Candesartan reduced advanced glycation end-products accumulation and diminished nitro-oxidative stress in type 2 diabetic KK/Ta mice. Nephrol Dial Transplant. 2004;19(12): 3012-3021.
40. Ihara Y, Egashira, K, Nakano K, et al. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol. 2007;43(4):455-464.
41. Lassila M, Seah KK, Allen T, et al. Accelerated nephropathy in diabetic apolipoprotein E-knockout mouse: Role of advanced glycation. J Am Soc Nephrol. 2004;15(8):2125-2138.
42. Tanaka Y, Iwamoto H, Onuma T, Kawamori R. Inhibitory effect of metformin on formation of advanced glycation end products. Curr Therapeutic Res. 1997;58(10): 693-697.
43. Rahbar S, Figarola JL. Novel inhibitors of advanced glycation end-products. Arch Biochem Biophys. 2003;419(1):63-79.
44. Kim HY, Kang KS, Yamabe N, Nagai R, Yokozawa T. Protective effect of heat-processed American ginseng against diabetic renal damage in rats. J Agri Food Chem. 2007; 55(21):8491-8497.
45. Wirasathien L, Pengsuparp T, Suttisri R. Ueda H, Moriyasu M, Kawanishi K. Inhibitors of aldose reductase and advanced glycation end-products formation from the leaves of Stelechocarpus cauliflorus R.E. Fr. Phytomedicine. 2007;14(7-8):546-550.
46. Vincent AM, Russell JW, Low P, Feldman EL. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocr Rev. 2004;25(4):612-628.
47. Dunlop M. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl. 2000; 77:S3-S12.
48. Lorenzi M. The polyol pathway as a mechanism for diabetic retinopathy: Attractive, elusive, and resilient. Exp Diabetes Res. 2007;2007:61038.
49. Wei-ha L, Zi-qing H, Hong N, et al. Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase. Chin Medical J. 2008;121(8):706-712.
50. Evcimen ND, King GL. The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol. Res. 2007;55:408-510.
51. Aiello LP. The potential role of PKC in diabetic retinopathy and macular oedema. Surv Ophthalmol. 2002;47 (Suppl. 2):S263-S269.
52. Khan ZA, Chakrabarti S. Cellular signalling and potential new treatment targets in diabetic retinopathy. Exp Diabetes Res. 2007;2007:31867.
53. Ganz MB, Saksa B, Saxena R, Sedor JR. PDGF and IL-1 induce and activate specific protein kinase C isoforms in mesangial cells. Am J Physiol. 1996;40:F108-F113.
54. Feng W, Ding W, Qian Q, Chai Z. Use of the enriched stable isotope Cr-50 as a tracer to study the metabolism of chromium (III) in normal and diabetic rats. Biol Trace Elem Res. 1998;63(2):129-138.
55. Fujita H, Omori S, Ishikura K, Hida M, Awazu M. ERK and p38 mediate high-glucose induced hypertrophy and TGFbeta expression in renal tubular cells. Am J Physiol Renal Physiol. 2004;286(1):F120-F126.
56. Noh H, King GL. The role of protein kinase C in diabetic nephropathy. Kidney Int Suppl. 2007;106:S49-S53.
57. Ganz MB, Hawkins K, Reilly RF. High glucose induces the activity and expression of Na+/H+ exchange in glomerular mesangial cells. Am J Physiol Renal Physiol. 2000;278: F91-F96.
58. Ishi H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by oral PKC ß inhibitor. Science. 1996;272(5562):728- 731.
59. Tuttle KR, Bakris GL, Toto RD, McGill JB, Hu K, Anderson PW. The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care 2005;28(11):2686-2690.
60. Lôpez-Franco O, Suzuki Y, Sanjun G, et al. Nuclear factor KB inhibitors as potential novel anti-inflammatory agents for the treatment of immune glomerulonephritis. Am J Pathol. 2002;161(4):1497-1505.
61. Häkkinen SH, Kärenlampi SO, Heinonen IM, Mykkänen HM, Törrönen AR. J Agri Food Chem. 1999;47(6):2274-2279.
62. Arts IC, van de Putte B, Hollman PC. Catechin contents of foods commonly consumed in The Netherlands. 1. Fruits, vegetables, staple foods, and processed foods. J Agric Food Chem. 2000;48(5):1746-1751. (Pubitemid 30331519)
63. Varadkar P, Dubey P, Krishna M, Verma, N. Modulation of radiation-induced protein kinase C activity by phenolics. J Radiol Pro. 2001;21(4):361-370.
64. Kandaswami C, Lee LT, Lee LP, et al. The antitumor activities of flavinoids. In Vivo. 2005;19(5):895-909.
65. Grover JK, Rathi SS, Dawar R. Traditional Indian antidiabetic plants attenuate progression of renal damage in streptozotocin-induced diabetic mice. J Ethnopharmacol. 2001; 76(3):233-238.
66. Musabayane CT, Xozwa K, Ojewole JAO. Effects of Hypoxis hemerocallidea (Fisch. & C.A. Mey.) [Hypoxidaceae] corm (African Potato) aqueous extract on renal electrolyte and fluid handling in the rat. Renal Failure. 2005;27(5):763-770.
67. Ong ES. Extraction methods and chemical standardization of botanicals and herbal preparations. J Chromatogr B. 2004; 812:23-33.
68. Wang X, Guan S, Liu R, et al. HPLC determination of four triterpenoids in rat urine after administration of total triterpenoids from Ganoderma lucidum. J Pharm Biomed Anal. 2007;43:1185-1190.
69. Cheng X, Shin YG, Levine BS, Smith AC, Tomaszewsk JE, van Breemen RB. Qualitative analysis of betulininc acid in mouse, rat and dog plasma using electrospray liquid chromatography/ mass spectrometry. Rapid Commun Mass Spectrom. 2003;17:2089-2092.
70. Musabayane CT, Mahlalela N, Shode FO, Ojewole JAO. Effects of Syzygium cordatum (Hochst.)[Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocininduced diabetic rats. J Ethnopharmacol. 2005;97(3): 485-490.
71. Kapoor R, Srivastava S, Kakkar P. (2009). Bacopa monnieri modulates antioxidant responses in brain and kidney of diabetic rats. Environ Toxicol Pharmacol. 2009;27(1):62-69.
72. Yokozawa T, Yamabe N, Ki HY, et al. Protective effects of morroniside isolated from Corni fructus against renal damage in streptozotocin-induced diabetic rats. Biol Pharm Bull. 2008;31(7):1422-1428.
73. Ugochukwu NH, Cobourne MK. Modification of renal oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with extracts from Gongronema latifolium leaves. Clin Chim Acta. 2003;336(1-2):78-81.
74. Alam MM, Javedi K, Jafri MA. Effect of Rheum emodi (Revandi Hindi) on renal functions in rats. J Ethnopharmacol. 2005;96:121-125.
75. Sato S, Yamate J, Hori Y, Hatai A, Nozawa M, Sagai M. Protective effect of polyphenol-containing azuki bean (Vigna angularis) seed coats on the renal cortex in streptozotocin- induced diabetic rats. J Nutr Biochem. 2005;16(9): 547-553. (Pubitemid 41188035)
76. Musabayane CT, Munjeri O, Mdege ND. Effects of Helichrysum ceres on renal function and blood pressure in the rat. Renal Failure. 2003;25(1):5-14.
77. Mapanga RF, Tufts MA, Shode FO, Musabayane CT. Renal effects of plant-oleanolic acid in streptozotocin-induced diabetic rats. Renal Failure. 2009;31(6): 481-491.
78. Gondwe M, Kamadyaapa DR, Tufts MA, Chuturgoon AA, Ojewole JAO, Musabayane CT. Effects of Persea americana (Mill) [Lauraceae] ["Avocado"] ethanolic extract on blood glucose and kidney function in streptozotocin- induced diabetic rats and on kidney cell lines of the proximal (LLC-PK1) and distal tubules (MDBK). Methods Find Expl Clin Pharmacol. 2008; 30(1):25-35.
79. Afzal M, Khan NA, Ghufran A, Iqbal A, Inamuddin M. Diuretic and nephroprotective effect of Jawarish Zarooni Sada-a polyherbal unani formulation. J Ethnopharmacol. 2004;91:219-223.
80. Yamabe N, Kang KS, Goto E, Tanaka T, Yokozawa T. Beneficial effect of Corni fructus, a constituent of hachimijio- gan on advanced glycation end product-mediated renal injury in streptozotocin-treated diabetic rats. Biol Pharm Bull. 2007;30(3):520-526.
81. Chiu J, Khan ZA, Farhangkhoee H, Chakrabarti S. Curcumin prevents diabetes-associated abnormalities in the kidneys by inhibiting p300 and nuclear factor-kb. Nutrition. 2009; 25(9):964-972.
82. Al-Qattan K, Thomson M, Ali M. Garlic (Allium sativum) and ginger (Zingiber officinale) attenuate structural nephropathy progression in streptozotocin-induced diabetic rats. Eur e-J Clin Nutr Metab. 2008;3:e62-e71.
83. Bwititi PT, Machakaire T, Nhachi CFB, Musabayane CT. Effects of Opuntia megacantha leaves extract on renal electrolyte and fluid handling in streptozotocin (STZ)-diabetic rats. Renal Failure. 2001;23(2):49-58.