Inhibitory effect of metformin on formation of advanced glycation end products

Current Therapeutic Research - Clinical and Experimental

Volumn 58, Issue 10, 1997, Pages 693-697

  Tanaka, Yasushi ^a   Iwamoto, Hisahiko ^b   Onuma, Tomio ^a   Kawamori, Ryuzo ^a  

^a JUNTENDO UNIVERSITY   (Japan)

^b TOKUYAMA CORPORATION   (Japan)

Author keywords

Advanced glycation end products; Amino guanidine; Antidiabetic drug; Metformin

Indexed keywords

METFORMIN;

ARTICLE; DRUG EFFECT; DRUG POTENCY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE METABOLISM; GLYCATION; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL;

EID: 0030670743     PISSN: 0011393X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0011-393X(97)80103-8     Document Type: Article

References (12)

1. Stumvoll M, Nurjahan N, Perriello G, et al. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. NEJM. 1995;333:550-554.
2. Defronzo RA, Goodman AM, and The Multicenter Metformin Study Group. Efficacy of metformin in patients with non-insulin-dependent diabetes mellitus. NEJM. 1995;333: 541-549.
3. Brownlee M, Vlassara KA, Ulrich P, Cerami A. Aminoguanidine prevents diabetes-induced arterial wall protein cross-linking. Science. 1986;232:1629-1632.
4. Horiuchi S, Araki T, Morino Y. Immunochemical approach to characterize advanced glycation end products of Maillard reaction. J Biol Chem. 1991;1266:7329-7332.
5. Taneda S, Monnier VM. ELISA of pentosidine, an advanced glycation end product, in biological specimens. Clin Chem. 1994;40:1766-1773.
6. e-(carboxymethyl)lysine is a dominant advanced glycation end product (AGE) antigen in tissue proteins. Biochemistry. 1995;34: 10872-10878.
7. e-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of Maillard reaction. Biochemistry. 1996;35:8075-8083.
8. e-(carboxymethyl)lysine in human tissues in diabetes and aging. J Clin Invest. 1997;99:457-468.
9. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
10. Bailey CJ, Path MRC, Turner RC. Drug therapy: Metformin. NEJM. 1996;334:574-579.
11. Bowman MA, Simell OG, Peck AB, et al. Pharmacokinetics of aminoguanidine administration and effects on the diabetes frequency in nonobese diabetic mice. J Pharmacol Exp Ther. 1996;279:790-794.
12. Wilcock C, Bailey CJ. Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica. 1994;24:49-57.