Structure and function of mRNA export adaptors

Biochemical Society Transactions

Volumn 38, Issue 1, 2010, Pages 232-236

  Walsh, Matthew J ^a   Hautbergue, Guillaume M ^a   Wilson, Stuart A ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

ALY; MRNA export; NXF1; RNA binding and export factor (REF); Serine and argininerich protein (SR protein); TAP

Indexed keywords

ADAPTOR PROTEIN; MESSENGER RNA; PROTEIN MEX67P; PROTEIN NXF1; PROTEIN TAP; RECEPTOR PROTEIN; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE OVEREXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN RNA BINDING; PROTEIN STABILITY; PROTEIN STRUCTURE; RNA BINDING; RNA INTERFERENCE; RNA PROCESSING; RNA STRUCTURE; RNA TRANSCRIPTION; RNA TRANSLATION;

ANIMALS; HUMANS; MODELS, MOLECULAR; NUCLEAR PROTEINS; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; PROTEIN CONFORMATION; RNA TRANSPORT; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSCRIPTION FACTORS;

EID: 76449113368     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0380232     Document Type: Article

References (45)

1. Fribourg, S., Braun, I.C., Izaurralde, E. and Conti, E. (2001) Structural basis for the recognition of a nucleoporin FG repeat by the NTF2-like domain of the TAP/p15 mRNA nuclear export factor. Mol. Cell 8, 645-656
2. Hargous, Y., Hautbergue, G.M., Tintaru, A.M., Skrisovska, L., Golovanov, A.P., Stevenin, J., Lian, L.Y., Wilson, S.A. and Allain, F.H. (2006) Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8. EMBO J. 25, 5126-5137
3. Gruter, P., Tabernero, C., von Kobbe, C., Schmitt, C., Saavedra, C., Bachi, A., Wilm, M., Felber, B.K. and Izaurralde, E. (1998) TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus. Mol. Cell 1, 649-659.
4. Gwizdek, C., Iglesias, N., Rodriguez, M.S., Ossareh-Nazari, B., Hobeika, M., Divita, G., Stutz, F. and Dargemont, C. (2006) Ubiquitin-associated domain of Mex67 synchronizes recruitment of the mRNA export machinery with transcription. Proc. Natl. Acad. Sci. U.S.A. 103, 16376-16381
5. Liker, E., Fernandez, E., Izaurralde, E. and Conti, E. (2000) The structure of the mRNA export factor TAP reveals a cis arrangement of a non-canonical RNP domain and an LRR domain. EMBO J. 19, 5587-5598
6. Hautbergue, G.M., Hung, M.L., Golovanov, A.P., Lian, L.Y. and Wilson, S.A. (2008) Mutually exclusive interactions drive handover of mRNA from export adaptors to TAP. Proc. Natl. Acad. Sci. U.S.A. 105, 5154-5159
7. Braun, I.C., Herold, A., Rode, M., Conti, E. and Izaurralde, E. (2001) Overexpression of TAP/p15 heterodimers bypasses nuclear retention and stimulates nuclear mRNA export. J. Biol. Chem. 276, 20536-20543
8. Jin, L., Guzik, B.W., Bor, Y.C., Rekosh, D. and Hammarskjold, M.L. (2003) Tap and NXT promote translation of unspliced mRNA. Genes Dev. 17, 3075-3086
9. Lund, M.K. and and Guthrie, C. (2005) The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim. Mol. Cell 20, 645-651
10. Zenklusen, D., Vinciguerra, P., Strahm, Y. and Stutz, F. (2001) The yeast hnRNP-like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p. Mol. Cell. Biol. 21, 4219-4232
11. Longman, D., Johnstone, I.L. and Cáceres, J.F. (2003) The Ref/Aly proteins are dispensable for mRNA export and development in Caenorhabditis elegans. RNA 9, 881-891
12. Gatfield, D. and Izaurralde, E. (2002) REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export. J. Cell Biol. 159, 579-588
13. Katahira, J., Inoue, H., Hurt, E. and Yoneda, Y. (2009) Adaptor Aly and co-adaptor Thoc5 function in the Tap-p15-mediated nuclear export of HSP70 mRNA. EMBO J. 28, 556-567
14. Huang, Y., Gattoni, R., Stevenin, J. and Steitz, J.A. (2003) SR splicing factors serve as adapter proteins for TAP-dependent mRNA export. Mol. Cell 11, 837-843
15. Tintaru, A.M., Hautbergue, G.M., Hounslow, A.M., Hung, M.L., Lian, L.Y., Craven, C.J. and Wilson, S.A. (2007) Structural and functional analysis of RNA and TAP binding to SF2/ASF. EMBO Rep. 8, 756-762
16. Lai, M.C. and Tarn, W.Y. (2004) Hypophosphorylated ASF/SF2 binds TAP and is present in messenger ribonucleoproteins. J. Biol. Chem. 279, 31745-31749
17. Huang, Y., Yario, T.A. and Steitz, J.A. (2004) A molecular link between SR protein dephosphorylation and mRNA export. Proc. Natl. Acad. Sci. U.S.A. 101, 9666-9670
18. Zolotukhin, A.S., Tan, W., Bear, J., Smulevitch, S. and Felber, B.K. (2002) U2AF participates in the binding of TAP (NXF1) to mRNA. J. Biol. Chem. 277, 3935-3942
19. Lai, D., Sakkas, D. and Huang, Y. (2006) The fragile X mental retardation protein interacts with a distinct mRNA nuclear export factor NXF2. RNA 12, 1446-1449
20. Kim, M., Bellini, M. and Ceman, S. (2009) Fragile X mental retardation protein FMRP binds mRNAs in the nucleus. Mol. Cell. Biol. 29, 214-228
21. Zhang, M., Wang, Q. and Huang, Y. (2007) Fragile X mental retardation protein FMRP and the RNA export factor NXF2 associate with and destabilize Nxf1 mRNA in neuronal cells. Proc. Natl. Acad. Sci. U.S.A. 104, 10057-10062
22. Bachi, A., Braun, I.C., Rodrigues, J.P., Pante, N., Ribbeck, K., von Kobbe, C., Kutay, U., Wilm, M., Gorlich, D., Carmo-Fonseca, M. et al. (2000) The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. RNA 6, 136-158
23. Lai, M.C., Lee, Y.H. and Tarn, W.Y. (2008) The DEAD-box RNA helicase DDX3 associates with export messenger ribonucleoproteins as well as tip-associated protein and participates in translational control. Mol. Biol. Cell 19, 3847-3858
24. Farny, N.G., Hurt, J.A. and Silver, P.A. (2008) Definition of global and transcript-specific mRNA export pathways in metazoans. Genes Dev. 22, 66-78
25. Gilbert, W. and Guthrie, C. (2004) The Glc7p nuclear phosphatase promotes mRNA export by facilitating association of Mex67p with mRNA. Mol. Cell 13, 201-212
26. Pérez-Alvarado, G.C., Martinez-Yamout, M., Allen, M.M., Grosschedl, R., Dyson, H.J. and Wright, P.E. (2003) Structure of the nuclear factor ALY: insights into post-transcriptional regulatory and mRNA nuclear export processes. Biochemistry 42, 7348-7357
27. Golovanov, A.P., Hautbergue, G.M., Tintaru, A.M., Lian, L.Y. and Wilson, S.A. (2006) The solution structure of REF2-I reveals interdomain interactions and regions involved in binding mRNA export factors and RNA. RNA 12, 1933-1948
28. Strasser, K. and Hurt, E. (2001) Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p. Nature 413, 648-652
29. Luo, M., Zhou, Z., Magni, K., Christoforides, C., Rappsilber, J., Mann, M. and Reed, R. (2001) Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly. Nature 413, 644-647
30. Fleckner, J., Zhang, M., Valcarcel, J. and Green, M.R. (1997) U2AF65 recruits a novel human DEAD box protein required for the U2 snRNP-branchpoint interaction. Genes Dev. 11, 1864-1872
31. Strasser, K., Masuda, S., Mason, P., Pfannstiel, J., Oppizzi, M., Rodriguez-Navarro, S., Rondon, A.G., Aguilera, A., Struhl, K., Reed, R. et al. (2002) TREX is a conserved complex coupling transcription with messenger RNA export. Nature 417, 304-308
32. Johnson, S.A., Cubberley, G. and Bentley, D.L. (2009) Cotranscriptional recruitment of the mRNA export factor Yra1 by direct interaction with the 3′ end processing factor Pcf11. Mol. Cell 33, 215-226
33. Saguez, C. and Jensen, T.H. (2009) Assembly of export-competent mRNP: it's all about being connected. Mol. Cell 33, 139-140
34. Saguez, C., Schmid, M., Olesen, J.R., Ghazy, M.A., Qu, X., Poulsen, M.B., Nasser, T., Moore, C. and Jensen, T.H. (2008) Nuclear mRNA surveillance in THO/sub2 mutants is triggered by inefficient polyadenylation. Mol. Cell 31, 91-103
35. Rougemaille, M., Dieppois, G., Kisseleva-Romanova, E., Gudipati, R.K., Lemoine, S., Blugeon, C., Boulay, J., Jensen, T.H., Stutz, F., Devaux, F. and Libri, D. (2008) THO/Sub2p functions to coordinate 3′ end processing with gene-nuclear pore association. Cell 135, 308-321
36. Yoh, S.M., Cho, H., Pickle, L., Evans, R.M. and Jones, K.A. (2007) The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export. Genes Dev. 21, 160-174
37. Del Rosario, B.C. and Pemberton, L.F. (2008) Nap1 links transcription elongation, chromatin assembly, and messenger RNP complex biogenesis. Mol. Cell. Biol. 28, 2113-2124
38. Cheng, H., Dufu, K., Lee, C.S., Hsu, J.L., Dias, A. and Reed, R. (2006) Human mRNA export machinery recruited to the 5b end of mRNA. Cell 127, 1389-1400
39. Masuda, S., Das, R., Cheng, H., Hurt, E., Dorman, N. and Reed, R. (2005) Recruitment of the human TREX complex to mRNA during splicing. Genes Dev. 19, 1512-1517
40. Taniguchi, I. and Ohno, M. (2008) ATP-dependent recruitment of export factor Aly/REF onto intronless mRNAs by RNA helicase UAP56. Mol. Cell. Biol. 28, 601-608
41. Wilmes, G.M., Bergkessel, M., Bandyopadhyay, S., Shales, M., Braberg, H., Cagney, G., Collins, S.R., Whitworth, G.B., Kress, T.L., Weissman, J.S. et al. (2008) A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing. Mol. Cell 32, 735-746
42. Fischer, T., Strasser, K., Racz, A., Rodriguez-Navarro, S., Oppizzi, M., Ihrig, P., Lechner, J. and Hurt, E. (2002) The mRNA export machinery requires the novel Sac3p-Thp1p complex to dock at the nucleoplasmic entrance of the nuclear pores. EMBO J. 21, 5843-5852
43. Kiesler, E., Miralles, F. and Visa, N. (2002) HEL/UAP56 binds cotranscriptionally to the Balbiani ring pre-mRNA in an intron-independent manner and accompanies the BR mRNP to the nuclear pore. Curr. Biol. 12, 859-862
44. Vinciguerra, P., Iglesias, N., Camblong, J., Zenklusen, D. and Stutz, F. (2005) Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export. EMBO J. 24, 813-823
45. Iglesias, N. and Stutz, F. (2008) Regulation of mRNP dynamics along the export pathway. FEBS Lett. 582, 1987-1996